LOCUS       NM_001146330            3796 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus G protein-coupled receptor 52 (Gpr52), transcript
            variant 1, mRNA.
ACCESSION   NM_001146330 XM_017321886 XM_885170
VERSION     NM_001146330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Zhang,C., Kukelova,D., Sigrist,H., Hengerer,B., Kratzer,R.F.,
            Mracek,P., Omrani,A., von Heimendahl,M. and Pryce,C.R.
  TITLE     Orphan receptor-GPR52 inverse agonist efficacy in ameliorating
            chronic stress-related deficits in reward motivation and phasic
            accumbal dopamine activity in mice
  JOURNAL   Transl Psychiatry 14 (1), 363 (2024)
   PUBMED   39242529
  REMARK    GeneRIF: Orphan receptor-GPR52 inverse agonist efficacy in
            ameliorating chronic stress-related deficits in reward motivation
            and phasic accumbal dopamine activity in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Krieg,P.F., Sonner,J.K., Kurelic,R., Engler,J.B., Scharenberg,M.F.,
            Bauer,S., Nikolaev,V.O. and Friese,M.A.
  TITLE     GPR52 regulates cAMP in T cells but is dispensable for
            encephalitogenic responses
  JOURNAL   Front Immunol 13, 1113348 (2023)
   PUBMED   36761164
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Wada,M., Yukawa,K., Ogasawara,H., Suzawa,K., Maekawa,T.,
            Yamamoto,Y., Ohta,T., Lee,E. and Miki,T.
  TITLE     GPR52 accelerates fatty acid biosynthesis in a ligand-dependent
            manner in hepatocytes and in response to excessive fat intake in
            mice
  JOURNAL   iScience 24 (4), 102260 (2021)
   PUBMED   33796846
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Hatzipantelis,C.J., Lu,Y., Spark,D.L., Langmead,C.J. and
            Stewart,G.D.
  TITLE     beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal
            Cortical Neurons
  JOURNAL   ACS Chem Neurosci 11 (14), 2077-2084 (2020)
   PUBMED   32519845
  REMARK    GeneRIF: beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in
            Frontal Cortical Neurons.
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Song,H., Li,H., Guo,S., Pan,Y., Fu,Y., Zhou,Z., Li,Z., Wen,X.,
            Sun,X., He,B., Gu,H., Zhao,Q., Wang,C., An,P., Luo,S., Hu,Y.,
            Xie,X. and Lu,B.
  TITLE     Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's
            disease-associated phenotypes
  JOURNAL   Brain 141 (6), 1782-1798 (2018)
   PUBMED   29608652
  REMARK    GeneRIF: This study demonstrated that the Knocking-out Gpr52
            significantly reduces mutant HTT levels in the striatum and rescues
            Huntington's disease-associated behavioural phenotypes in a
            knock-in Huntington's disease mouse model expressing endogenous
            mutant Htt.
            Erratum:[Brain. 2020 Sep 1;143(9):e78. doi: 10.1093/brain/awaa192..
            PMID: 32746456]
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   Nishiyama,K., Suzuki,H., Maruyama,M., Yoshihara,T. and Ohta,H.
  TITLE     Genetic deletion of GPR52 enhances the locomotor-stimulating effect
            of an adenosine A2A receptor antagonist in mice: A potential role
            of GPR52 in the function of striatopallidal neurons
  JOURNAL   Brain Res 1670, 24-31 (2017)
   PUBMED   28583861
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Yao,Y., Cui,X., Al-Ramahi,I., Sun,X., Li,B., Hou,J., Difiglia,M.,
            Palacino,J., Wu,Z.Y., Ma,L., Botas,J. and Lu,B.
  TITLE     A striatal-enriched intronic GPCR modulates huntingtin levels and
            toxicity
  JOURNAL   Elife 4, e05449 (2015)
   PUBMED   25738228
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Komatsu,H., Maruyama,M., Yao,S., Shinohara,T., Sakuma,K.,
            Imaichi,S., Chikatsu,T., Kuniyeda,K., Siu,F.K., Peng,L.S., Zhuo,K.,
            Mun,L.S., Han,T.M., Matsumoto,Y., Hashimoto,T., Miyajima,N.,
            Itoh,Y., Ogi,K., Habata,Y. and Mori,M.
  TITLE     Anatomical transcriptome of G protein-coupled receptors leads to
            the identification of a novel therapeutic candidate GPR52 for
            psychiatric disorders
  JOURNAL   PLoS One 9 (2), e90134 (2014)
   PUBMED   24587241
  REMARK    GeneRIF: GPR52 has the potential of being a therapeutic psychiatric
            receptor.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117787.8.
            
            On or before Feb 14, 2019 this sequence version replaced
            XM_017321886.1, NM_001146330.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.144890.1,
                                           SRR1660821.107005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               AC117787.8         98479-99018
            541-3796            AC117787.8         100211-103466
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..3796
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /note="G protein-coupled receptor 52"
                     /db_xref="GeneID:620246"
                     /db_xref="MGI:MGI:3643278"
     exon            1..540
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /inference="alignment:Splign:2.1.0"
     exon            541..3796
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /inference="alignment:Splign:2.1.0"
     CDS             760..1845
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /note="probable G-protein coupled receptor 52"
                     /codon_start=1
                     /product="G-protein coupled receptor 52"
                     /protein_id="NP_001139802.1"
                     /db_xref="CCDS:CCDS87900.1"
                     /db_xref="GeneID:620246"
                     /db_xref="MGI:MGI:3643278"
                     /translation="MNESRWTEWRILNMSSSIVNVSEHHSCPLGFGHYSVEDVCIFET
                     VVIVLLTFLIISGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLLVGVTCLVPTLSLL
                     HYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRI
                     CIIMIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTCFIVCLLYAPAALV
                     VCFTYFHIFKICRQHTKEINDRRARFPSHEVEASREAGHSPDRRYAMVLFRITSVFYM
                     LWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSET
                     MCTSCVCAKDQEAQDPKPRRRANSCSI"
     regulatory      3761..3766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /note="hexamer: AATAAA"
     polyA_site      3788
                     /gene="Gpr52"
                     /gene_synonym="EG620246"
                     /note="major polyA site"
ORIGIN      
        1 agcagcagca gacagtggct caggtggagg cagcaagact gagaaactgt aaagaatctc
       61 ccggcagctt cccgatagct gcatcacagt aaatcggact tctgaatcta gcaacccagt
      121 ctcgcagccg atcagagtga atgtccatga gaagcatcac cttattcctg taacgagaac
      181 tattttctga taagtggaac tcagcatgtc caaggaggac tagcccgtgg ctgacagaaa
      241 aggactgcct gaatgatgtg ttgctgcacg agacaataac tttgagaaga atgctttctg
      301 ttaagctgct acattgttcc tgaaggaaag gttttcattt ctagtgcatg ctagttcttc
      361 aaaagctgtg acaacaaaga gtgacaagag actccctgaa ttgtttatac ttgggggaaa
      421 gactttggca aatgttaaca cggtgccaga atgaccttgg aagcctttcg gatggattct
      481 gccctgccac aatcgcagta tgtcaaagtc caggatttaa atccatcttg atgttttgag
      541 ctcaccctcc tcccttatcc cccaaagctg agatgtgcca ctggtgaact aaggctgatg
      601 aagaaacctg agcacactgt gggatgctca gctgtaatac aggcactggc actttctact
      661 gaagcaggtt ctgagacact gatttgcaga gtttaacaga tgctggcccg ggcacctgct
      721 tgttggagcc aaagctgcaa actcccttaa tttcaagcca tgaatgaatc caggtggact
      781 gaatggagga tcctgaacat gagcagtagc attgtgaatg tgtccgagca ccactcctgc
      841 cctcttggat ttggtcacta cagtgtggag gatgtctgca tctttgagac agttgtcatt
      901 gtcttgctga catttctgat catctctggg aatttaacag tcatctttgt ctttcactgt
      961 gctccgctgt tacaccatta tactaccagc tactttatac agaccatggc atacgctgac
     1021 ctcctcgttg gagttacctg cttggttcct actctgtccc ttcttcatta ctctacaggt
     1081 gtccatgagt cattgacttg ccaggtgttt ggatatatta tttcagttct aaaaagcgtg
     1141 tctatggcat gtcttgcttg catcagtgtg gatcgatatc ttgcaataac caagcctcta
     1201 tcctacaatc aactggtcac tccttgtcgc ctgagaattt gcattattat gatttggatt
     1261 tactcctgcc taattttctt gccttccttt tttggctggg gcaaacctgg ttaccatggt
     1321 gacatttttg aatggtgtgc cacatcttgg cttaccagtg cctattttac ttgctttatt
     1381 gtttgtttac tttatgctcc tgctgccttg gttgtctgct tcacttactt tcacattttc
     1441 aaaatttgcc ggcagcacac caaagagata aatgaccgga gggccagatt ccctagtcac
     1501 gaggtagagg cctctaggga agcagggcac agccctgacc gtcgctacgc catggtttta
     1561 tttaggataa ctagcgtgtt ttacatgctg tggcttccat atattattta ctttcttcta
     1621 gaaagttctc gtgtcttgga caatcccaca ctgtccttct taaccacctg gcttgcgata
     1681 agcaatagtt tttgtaactg tgtaatatac agcctctcca acagtgtttt ccgccttggc
     1741 ctccgaaggc tttctgaaac aatgtgcaca tcttgtgtgt gtgcgaagga tcaggaagca
     1801 caagatccca aacctaggag acgggcaaat tcctgctcca tttgaagaga attacgtagt
     1861 caatcaaatg taatgtgaca gtggttttgg attgtattct tgattcattt ggaaatttgc
     1921 cctgaagaaa tatttatgtg aatagttgac catgaagtga agaatgggat taaagatctt
     1981 ttttatttcc ttttgtgtaa gtcaaaaaga atgggaaagg atgtttgaag aataatctta
     2041 taagagaatt acagcttgtg aatatatgtt cagtgtttga tcctcatcac tgatgataga
     2101 agaggaactt caagtctaca aaataggaac agaccccttg ttatctctct ctctgtgtcc
     2161 tctctgcctg tgtgtctgtc ttctatttag tcttattctc tgttcttact ccttagactt
     2221 gtgggagtta ctgtttgtta acttcccttt gtgagaagtg ctagtacgta tctgtggcca
     2281 agtgtcgcct tgccgtcagt gttgagacat gtcagtctac atgagttgtg ttgcctttag
     2341 agaggatgca cagtgttacg ttttgttatc tgtcatacaa accctgtgcc tatgttcatg
     2401 tcatcatccc catagcacag attcctacta caaacagaac ggagcagtat cttttcttct
     2461 gtgtagaagg ccatttcgtt ttctctccct tttctcagca cctgctattg ctctttcagt
     2521 ttgtctccaa tcctgtggga cacattctag aagtgtctta gctgatgaaa gaatcctctg
     2581 tatgaggcag tcaagagggt aaacaagtta tttttcgaac aaagcaatct agcagctggg
     2641 aggttgtatt taatacctca gtggattttg aaaacatttt taccagcttt cctttgaagt
     2701 tagtttgggt gcctaaagta aagtcctctt ggttatagtg aagatttttt ttttaatttt
     2761 ctctataaag cccacaataa tactattgca gatgcagatt actccccagt agtgatatat
     2821 tactctgtgt gctacccagg atgcccttta gaaaaagcct gacactgcaa tgatagccta
     2881 ggtctgcagc agttcactgt cacatccatt attcctttgt gttgtatgta tttgcatatt
     2941 ctatattttt tacaaaaata taagttatat tacatgatct gtgcctaatg ttttcttagc
     3001 acaattcaga tatcaatgtt gtttaaggtg tcaacattga aaaacatata tatggactac
     3061 ctttaaagtg aaaaatactt ttgtgtcatt gttattcaga tatttatatt agatgaagct
     3121 gcattcttac agtggctggg aatgtagtat acttataaaa agcagttaga tatgtcagta
     3181 ttttgttttc aaatgcagag atgaagttat tttttagtgt gttacctgag tgtactaata
     3241 agttgggggt tgaggctcag ccatagtaaa gcggatgtga gcagagcagc ttgtgttctt
     3301 accctaaact tttgactgga agaggtttga tactttctac cacactgctg aggagttttc
     3361 ttcagacttt tgtgttttat gaaaagtatt taatgaagcg tgcctgtggc tctgacacag
     3421 aagcccacca tgtctgcatc ctggtgtttt tacttcagca gtctgttaaa gagatgttgt
     3481 cactttatta aggttgtttt gaacccctgt atatttttta aatatgtaag aaaggtttaa
     3541 aataaataat aaaatagtat tctatatatc aaaaccagat tttgtatcag tcagtttact
     3601 gaaactccag gaataagagt tccttgggaa atcagaatca aattgttgtg tacttcatag
     3661 atgagggttg tgtggagtct tgtttgctgt ttgcagtgat atcatagatg aattgaggtg
     3721 taccatttta aacagtattt ctatttcttc acatatgata aataaattct ccaatattat
     3781 tcgtattatt caggaa
//
