LOCUS       NM_027677               5231 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor 39 (Gpr39), mRNA.
ACCESSION   NM_027677
VERSION     NM_027677.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Ramadoss,S., Qin,J., Tao,B., Thomas,N.E., Cao,E., Wu,R.,
            Sandoval,D.R., Piermatteo,A., Grunddal,K.V., Ma,F., Li,S., Sun,B.,
            Zhou,Y., Wan,J., Pellegrini,M., Holst,B., Lusis,A.J.,
            Gordts,P.L.S.M. and Deb,A.
  TITLE     Bone-marrow macrophage-derived GPNMB protein binds to orphan
            receptor GPR39 and plays a critical role in cardiac repair
  JOURNAL   Nat Cardiovasc Res 3 (11), 1356-1373 (2024)
   PUBMED   39455836
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5231)
  AUTHORS   Zi,Z. and Rao,Y.
  TITLE     Discoveries of GPR39 as an evolutionarily conserved receptor for
            bile acids and of its involvement in biliary acute pancreatitis
  JOURNAL   Sci Adv 10 (5), eadj0146 (2024)
   PUBMED   38306436
  REMARK    GeneRIF: Discoveries of GPR39 as an evolutionarily conserved
            receptor for bile acids and of its involvement in biliary acute
            pancreatitis.
REFERENCE   4  (bases 1 to 5231)
  AUTHORS   Bai,H.H., Wang,K.L., Zeng,X.R., Li,J., Li,Y., Xu,J.Y., Zhang,Y.,
            Jiang,H.F., Yang,X., Suo,Z.W. and Hu,X.D.
  TITLE     GPR39 regulated spinal glycinergic inhibition and mechanical
            inflammatory pain
  JOURNAL   Sci Adv 10 (5), eadj3808 (2024)
   PUBMED   38306424
REFERENCE   5  (bases 1 to 5231)
  AUTHORS   Zhang,L., Sunchen,S., Lu,C., Xu,F. and Dong,H.
  TITLE     Zinc-sensing receptor activation induces endothelium-dependent
            hyperpolarization-mediated vasorelaxation of arterioles
  JOURNAL   Biochem Pharmacol 219, 115961 (2024)
   PUBMED   38049010
  REMARK    GeneRIF: Zinc-sensing receptor activation induces
            endothelium-dependent hyperpolarization-mediated vasorelaxation of
            arterioles.
REFERENCE   6  (bases 1 to 5231)
  AUTHORS   Egerod,K.L., Holst,B., Petersen,P.S., Hansen,J.B., Mulder,J.,
            Hokfelt,T. and Schwartz,T.W.
  TITLE     GPR39 splice variants versus antisense gene LYPD1: expression and
            regulation in gastrointestinal tract, endocrine pancreas, liver,
            and white adipose tissue
  JOURNAL   Mol Endocrinol 21 (7), 1685-1698 (2007)
   PUBMED   17488974
REFERENCE   7  (bases 1 to 5231)
  AUTHORS   Tremblay,F., Perreault,M., Klaman,L.D., Tobin,J.F., Smith,E. and
            Gimeno,R.E.
  TITLE     Normal food intake and body weight in mice lacking the G
            protein-coupled receptor GPR39
  JOURNAL   Endocrinology 148 (2), 501-506 (2007)
   PUBMED   17095592
  REMARK    GeneRIF: Our phenotypic characterization suggests that GPR39 is not
            a major modulator of food intake in mice, although a more subtle
            role cannot be excluded.
REFERENCE   8  (bases 1 to 5231)
  AUTHORS   Yasuda,S., Miyazaki,T., Munechika,K., Yamashita,M., Ikeda,Y. and
            Kamizono,A.
  TITLE     Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal
            bovine serum
  JOURNAL   J Recept Signal Transduct Res 27 (4), 235-246 (2007)
   PUBMED   17885920
  REMARK    GeneRIF: GPR39 functions as a Gq-coupled Zn2+-sensing receptor
REFERENCE   9  (bases 1 to 5231)
  AUTHORS   Moechars,D., Depoortere,I., Moreaux,B., de Smet,B., Goris,I.,
            Hoskens,L., Daneels,G., Kass,S., Ver Donck,L., Peeters,T. and
            Coulie,B.
  TITLE     Altered gastrointestinal and metabolic function in the
            GPR39-obestatin receptor-knockout mouse
  JOURNAL   Gastroenterology 131 (4), 1131-1141 (2006)
   PUBMED   17030183
  REMARK    GeneRIF: obestatin plays a functional role in the regulation of
            gastrointestinal and metabolic function through interaction with
            the GPR39 receptor
REFERENCE   10 (bases 1 to 5231)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140425.3 and AC153655.4.
            
            On Oct 13, 2022 this sequence version replaced NM_027677.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085285.1, SRR13948564.5411178.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1205              AC140425.3         143939-145143       c
            1206-5231           AC153655.4         23620-27645         c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 54.7 cM"
     gene            1..5231
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /note="G protein-coupled receptor 39"
                     /db_xref="GeneID:71111"
                     /db_xref="MGI:MGI:1918361"
     exon            1..1205
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1720
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /codon_start=1
                     /product="G-protein coupled receptor 39"
                     /protein_id="NP_081953.2"
                     /db_xref="CCDS:CCDS48344.1"
                     /db_xref="GeneID:71111"
                     /db_xref="MGI:MGI:1918361"
                     /translation="MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVG
                     ILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTP
                     SYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVW
                     VTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWE
                     VFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRT
                     ARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFY
                     LSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPL
                     IFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTPENS
                     LQEQEV"
     exon            1206..5231
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /note="hexamer: AATAAA"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2698
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /note="major polyA site"
     polyA_site      2709
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
     regulatory      5205..5210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5231
                     /gene="Gpr39"
                     /gene_synonym="4933415E13Rik"
ORIGIN      
        1 agtgccaggg acctggaagg gagaggagga tccgccgcca gacagagttc tgcggctctt
       61 actcagagtt gagtagggag gtcagagcct cctccggact ggtccctcct cacccggagt
      121 gactatctcc aaaccccacc gccacccact gcgtcgccag ggattctagg gtgaattatt
      181 ccaggaagtt acaatgagag agccgaaaaa ctaagtcact cctggccagc caaccacagt
      241 gacagaaaag tgttgcgccc acgctggtga gttgcggggc ttctttggga ggccgaagaa
      301 agggcagtgg agacatttgg ggacctggtg gtctgggtct ctcttcctca tggcttcatc
      361 cagtggctcc aaccacatct gctcccgtgt catcgatcac agccatgttc ctgaatttga
      421 ggtggccact tggatcaaaa tcaccctcat cttggtgtac ctgatcatct ttgtggtagg
      481 catcttgggc aacagcgtca ccatcagggt tacgcaggta ttgcagaaga agggctattt
      541 gcagaaggag gtgacagatc acatggtcag tttggcttgt tcagatatct tggtcttttt
      601 gattggcatg cccatggagt tctacagcat catttggaac cccctgacca cacccagcta
      661 tgctctgtcc tgtaagctcc acacgttcct ctttgagacg tgcagctacg ccacactgct
      721 gcacgtgctg accctcagct ttgagcgcta cattgccatt tgtcatccct tcaagtataa
      781 agcagtgtct ggacctcgcc aggtgaaact gctgattggc tttgtatggg tcacctccgc
      841 cctggtggca ctgcctttgc tctttgccat gggtatcgag taccctctgg taaacgtacc
      901 cactcacaag ggactcaact gcaacctctc tcgcacccgc caccacgatg aacctggaaa
      961 ctccaatatg tccatctgca cgaacctctc caaccgttgg gaggtcttcc agtccagcat
     1021 ctttggggcc tttgctgttt acctggtggt cctggcgtct gtggctttca tgtgttggaa
     1081 tatgatgaaa gtgctaatga agagcaagca gggcactctt gcagggaccg ggccacagct
     1141 ccagctgagg aagtcagaga gtgaggagag ccggacagca agaagacaga ccatcatatt
     1201 cctgagactg attgtggtga cgttggccgt gtgttggatg cccaatcaga tccgacggat
     1261 catggctgca gcaaaaccca aacatgactg gaccagaacg tacttcaggg catacatgat
     1321 cctcctgccc ttctctgata ccttcttcta cctcagctct gtggtcaacc ctctcctcta
     1381 caacgtgtcc tctcagcagt tccggaaggt gttctggcag gtgctctgct gccgcctgac
     1441 tctgcagcat gccaaccaag agaaacgcca gcgtgcccgc ttcatctcca ccaaggacag
     1501 caccagctca gcccgcagcc ccctcatctt cctagcctcc cggcgcagta actcttcctc
     1561 caggagaact aacaaggttt tcttaagcac ttttcagact gaggccaagc ctggagaggc
     1621 taagccccag cccttgagtc ctgagtcacc acagactggc tcagagacca aaccagctgg
     1681 gtccacccca gaaaatagtt tacaggagca ggaagtatga atggcaagtt cagaagcctt
     1741 gagccgaaac tggctctccc ctcccgcaaa agcaaagtta ccttcacgca gcagcagtct
     1801 ctgaatagac tgtgactcct actgggacag aatggaagct caaggctttg ggaaaggcag
     1861 atgcgtatct caatgacttc taagggctgg ttcttccagg ctagccttgg cggtggttaa
     1921 ccagattggg atgggagggt ctggactttc tgctccatgc ttttttcttc aactacacac
     1981 agaaattcag aatgaattgg ttcagagctt acaaaagtat ttgtgcacgg caatcttgcg
     2041 ttacttgaaa ggagggaaca aaaagactcc cttgtctacc cagaataaaa ggacacccag
     2101 aagagactcg ggaaggtgag agacgaaggg ccagacaggt gaggcagcag gggttggcat
     2161 ctcctttagc ttcagcagtg tgccaagcag agggctaagt ggaagaacag gagagtggtg
     2221 agaagccctg gcctgatggc cgaggcagag ctgcctctct tcttgggcct cggcccattg
     2281 caaagagggg tgttgcagca gctgatgcac acggagttca gtttcccagg ggaacagaag
     2341 gactggtacc cagctgaagc aatgagacag gctgctgacg atgcacacga cttccggtac
     2401 atgatcccta taacacaggc ccagagaagt ggggttagca tatgtgatct gcagtccagc
     2461 tatctctttg tgcccaaatc tgagtgcata acctttcctt aactcctccc acagaaaggg
     2521 ctcttatctc ctgatctggg agatggttca ggggataaga attctcagac ttattggagt
     2581 ctgggagttc ttttgggtgg gcatggaggt caccaaacac acagaactta tggtgaatgt
     2641 tgttccaaca gagattttag ttgctggtgt ccatgaataa agagctatta aaatcaaagt
     2701 ctcccctcac cactctgtgt gtgcaatgca tgtgtatatg ttcatacatg caatgtatgt
     2761 atatatgttc atgtatgcaa tgtatgtgta tatgtgagtg cagtatcctc agattccaga
     2821 agagggaatt ggattcgttt ggaattggag ttacaggcag ttgtgagctg tcttaaggag
     2881 gtgttgggag ctaaactcaa gtcctctgca tccttgtaac catctctcct gcccctacac
     2941 tcagcttttt aatatgggtt ctaaggatca aagaaagtta agccctcatg gttgcaatgg
     3001 caaacacatt accgatgcag ccatgtctcc agcaacaatg tctattttaa agtcagctcc
     3061 taatttatac tagacaacaa ggtttttctt tcctttgtta ctgtttaaac catctcacgc
     3121 tagcagcaca gacaacatat ccagatatta ttttcattat cacctaataa gtggccatag
     3181 agagatggct accaaccagg aatttattaa atccaaagag caaatcccaa agggagcaat
     3241 cccactgtct attgtaggga cttcactttt aggggtagac taagtttaaa gggcaaatag
     3301 agaggcacta gcaggcaccg acagcatgct caggacaatc tgttctctgg gaaagcctgg
     3361 ttctctggaa gaagttttga ccccaggaca agttgaatca aagagctggt tcttgatgac
     3421 aggtgctgtg gtaacagaat gtttcccaag ggactgggaa atgattcagt gggcaaagag
     3481 cttgccatgc aagcaggaaa ccctgagtta agatccccag aactctaaga gaaaacccca
     3541 ggtgtgctaa cacaagccta gctcctccca cactctacat gagaaggcag aagggattcc
     3601 tggagcttag tgtccagctg gcctaacgat gcaggttcag agagagacta atatggagaa
     3661 gtagttgaga cagacacctg atattgaccc ctagcttcct cacacatgtg cacacaacac
     3721 acaaatgcac ctgcatgtac atgttcactc acccacacat acaaagaagc ttcctgaagg
     3781 gaccacagaa ctcactcatc ttcaggagtc atctatgatg agcatgtgat ttttattttt
     3841 taagctatga gtttactaca gttaagcaat agtgacagtg ataacaagcc tagcaggcat
     3901 gaggccctag gttccactca gcactgcata catgggttgt agtatgcatt cttgtaaccc
     3961 tagcacttgg gaggtagagg catgggagtt catgggagtt catcctcagc tacattgtca
     4021 gtttgacgat atctggacta cataaggtcc tgtctcaaag gagttacaat tttaatagcc
     4081 ccgtgtaagg gccgtcctgg atgtcaggca ctgtacaggt ggctatcata tgccagctta
     4141 cttagttcca tttataaatt tagatatagt gtgcccttga aaggcctgtg tagaaaaagt
     4201 ttggttccca gcatggagag ctaggaggtg ggtacaggga gaggtctcag gtcacagcat
     4261 gtgtactcct aaagaggaca gttgtgaccc ctctccctcc ctgtcatgtg tgtgtgtgtg
     4321 tgtgtgtgtg tgtgtgtatg tgtgtgtgtg tgtgtgtgtg tacatacgtg gaggccagaa
     4381 ggaaatctca gatgccctca ggaaccaccc atcttgattt ttgaggtaag gtctctcact
     4441 gttccgatta gactacactg agtggccagt gagcctgaag tccctgaaat cataagcatg
     4501 taccaccaca tacggatttg tttaaagcat gtgttctggg aatcaaactc gggctcacat
     4561 gcttgcacat tgctgactga gagatctcca cagccctttc aaaactgtta gcccaaacaa
     4621 gtctttcttc tcccgacatt gattaatgta agcattgtgt gcattttaag cacacagtga
     4681 tgacaagctg actagcgtgg cttgaaagta ctagggtgaa gggtcacatg atcttctcta
     4741 tcgtgcagat ccagagcctg ggagctagtt actgaggctt agtaacttgc acaggtccca
     4801 tcatcagact ctctcctgtc atctgctata gaacctttca cagtgacagc tgtagcttga
     4861 gtgagaaata ccctccatag gctcatgtga tcagcatttg gtctctgggt agcggcactg
     4921 cttggaaagg ttctagagca tttagagaag gctggaggaa gtggatcact ggagatcagc
     4981 catgatgttt gatagcctgg tcctatttct tgtgtgaatg ctgcttcctg actacagatg
     5041 cattgtgctc ttgctatctg ccctgtgatg gactgtatcc ttcttaaact taagctgtac
     5101 caacctagtg tcacagcaca gctgtggatg tggcccaaca catttgtgga tggtaatgtc
     5161 atatcataat gtcaaaagcc tggacagtcc tgcatgtgtg ccaaaataaa cctttcagat
     5221 ttttgtgtca a
//
