LOCUS       NM_022320               4072 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus G protein-coupled receptor 35 (Gpr35), transcript
            variant 1, mRNA.
ACCESSION   NM_022320
VERSION     NM_022320.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4072)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   2  (bases 1 to 4072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4072)
  AUTHORS   Cheng,L., Wu,H., Cai,X., Zhang,Y., Yu,S., Hou,Y., Yin,Z., Yan,Q.,
            Wang,Q., Sun,T., Wang,G., Yuan,Y., Zhang,X., Hao,H. and Zheng,X.
  TITLE     A Gpr35-tuned gut microbe-brain metabolic axis regulates
            depressive-like behavior
  JOURNAL   Cell Host Microbe 32 (2), 227-243 (2024)
   PUBMED   38198925
  REMARK    GeneRIF: A Gpr35-tuned gut microbe-brain metabolic axis regulates
            depressive-like behavior.
REFERENCE   4  (bases 1 to 4072)
  AUTHORS   Miyamoto,K., Sujino,T., Harada,Y., Ashida,H., Yoshimatsu,Y.,
            Yonemoto,Y., Nemoto,Y., Tomura,M., Melhem,H., Niess,J.H.,
            Suzuki,T., Suzuki,T., Suzuki,S., Koda,Y., Okamoto,R., Mikami,Y.,
            Teratani,T., Tanaka,K.F., Yoshimura,A., Sato,T. and Kanai,T.
  TITLE     The gut microbiota-induced kynurenic acid recruits GPR35-positive
            macrophages to promote experimental encephalitis
  JOURNAL   Cell Rep 42 (8), 113005 (2023)
   PUBMED   37590143
REFERENCE   5  (bases 1 to 4072)
  AUTHORS   De Giovanni,M., Dang,E.V., Chen,K.Y., An,J., Madhani,H.D. and
            Cyster,J.G.
  TITLE     Platelets and mast cells promote pathogenic eosinophil recruitment
            during invasive fungal infection via the 5-HIAA-GPR35
            ligand-receptor system
  JOURNAL   Immunity 56 (7), 1548-1560 (2023)
   PUBMED   37279752
REFERENCE   6  (bases 1 to 4072)
  AUTHORS   Ronkainen,V.P., Tuomainen,T., Huusko,J., Laidinen,S., Malinen,M.,
            Palvimo,J.J., Yla-Herttuala,S., Vuolteenaho,O. and Tavi,P.
  TITLE     Hypoxia-inducible factor 1-induced G protein-coupled receptor 35
            expression is an early marker of progressive cardiac remodelling
  JOURNAL   Cardiovasc Res 101 (1), 69-77 (2014)
   PUBMED   24095869
  REMARK    GeneRIF: Cardiac expression of GPR35 is regulated by hypoxia
            through activation of HIF-1.
REFERENCE   7  (bases 1 to 4072)
  AUTHORS   Min,K.D., Asakura,M., Liao,Y., Nakamaru,K., Okazaki,H.,
            Takahashi,T., Fujimoto,K., Ito,S., Takahashi,A., Asanuma,H.,
            Yamazaki,S., Minamino,T., Sanada,S., Seguchi,O., Nakano,A.,
            Ando,Y., Otsuka,T., Furukawa,H., Isomura,T., Takashima,S.,
            Mochizuki,N. and Kitakaze,M.
  TITLE     Identification of genes related to heart failure using global gene
            expression profiling of human failing myocardium
  JOURNAL   Biochem Biophys Res Commun 393 (1), 55-60 (2010)
   PUBMED   20100464
REFERENCE   8  (bases 1 to 4072)
  AUTHORS   Wang,J., Simonavicius,N., Wu,X., Swaminath,G., Reagan,J., Tian,H.
            and Ling,L.
  TITLE     Kynurenic acid as a ligand for orphan G protein-coupled receptor
            GPR35
  JOURNAL   J Biol Chem 281 (31), 22021-22028 (2006)
   PUBMED   16754668
REFERENCE   9  (bases 1 to 4072)
  AUTHORS   Horikawa,Y., Oda,N., Cox,N.J., Li,X., Orho-Melander,M., Hara,M.,
            Hinokio,Y., Lindner,T.H., Mashima,H., Schwarz,P.E., del
            Bosque-Plata,L., Horikawa,Y., Oda,Y., Yoshiuchi,I., Colilla,S.,
            Polonsky,K.S., Wei,S., Concannon,P., Iwasaki,N., Schulze,J.,
            Baier,L.J., Bogardus,C., Groop,L., Boerwinkle,E., Hanis,C.L. and
            Bell,G.I.
  TITLE     Genetic variation in the gene encoding calpain-10 is associated
            with type 2 diabetes mellitus
  JOURNAL   Nat Genet 26 (2), 163-175 (2000)
   PUBMED   11017071
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):502]
REFERENCE   10 (bases 1 to 4072)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119846.14.
            
            On Oct 19, 2022 this sequence version replaced NM_022320.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034870.1, BC027429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AC119846.14        37721-38094         c
            375-4072            AC119846.14        30767-34464         c
FEATURES             Location/Qualifiers
     source          1..4072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.65 cM"
     gene            1..4072
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /note="G protein-coupled receptor 35"
                     /db_xref="GeneID:64095"
                     /db_xref="MGI:MGI:1929509"
     exon            1..374
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /inference="alignment:Splign:2.1.0"
     exon            375..4072
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1308
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /note="KYNA receptor; kynurenic acid receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 35"
                     /protein_id="NP_071715.3"
                     /db_xref="CCDS:CCDS15182.1"
                     /db_xref="GeneID:64095"
                     /db_xref="MGI:MGI:1929509"
                     /translation="MNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCY
                     RMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSI
                     SLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFC
                     FSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMV
                     WANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYY
                     YMAREFQEASKPATSSNTPHKSQDSQILSLT"
     polyA_site      2861
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /note="major polyA site"
     regulatory      4053..4058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /note="hexamer: ATTAAA"
     polyA_site      4072
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
ORIGIN      
        1 agacggttca ctctttgttt ccagagcaaa tgcattcttt gccgcttctc tgtaggtgtc
       61 agccaaggtg gcaggttcca gcttcccttc cagaaatccc cacctttcag cacagcctca
      121 gggctgggga aaacagtgca ggcggtgggg gtggggagct gccgcctccc ctttgctgtc
      181 gtcaataagc ccaacagtcg ctccacttac aggcgggctt aagtggctgg ccgtcctcag
      241 ccccggggag aacaggtgga tgccttcatg tagttggggc ttctacacgg gccagaccta
      301 catgagatgt atcacttgat gctgggctgg aggctatcag ctgaatgagg ctggactggg
      361 gtccgtcaga tgagccctag gaccatgaat agtacaacct gtaacagcac cctcacgtgg
      421 cctgcttccg tcaacaactt cttcatcatc tactcagcct tgctgctggt gctgggcctg
      481 ctgctcaaca gcgtggcact ctgggtattc tgctatcgca tgcaccagtg gacagagacc
      541 cgcatctata tgaccaacct ggctgtggcc gacctctgcc tgctctgctc cttgccattt
      601 gtgctgtact ccctgaaata tagttcttca gacacacccg tctgccagct ctcacagggc
      661 atctacctgg ccaacagata catgagcata agcctggtca ctgccattgc tgtggaccgc
      721 tatgtggcag tgcggcatcc cctgcgtgcg cgtgagctgc ggtccccgag acaggctgca
      781 gcagtgtgtg tggccctttg ggtgatagtg gtcacctccc tggtagtgcg ctggcgcctg
      841 gggatgcagg agggtggctt ctgcttcagc agccaaaccc ggcgcaattt cagcaccact
      901 gccttctcac tgctgggatt ctacctgccg ctggccatcg tggtcttctg ctctttgcag
      961 gtagtgactg tgctatcgag aaggccagcc gctgatgtgg ggcaggcaga ggccacccaa
     1021 aaggccaccc acatggtctg ggccaacttg gctgtgtttg tcatctgctt cctgcccttg
     1081 catgtggtcc tgaccgtgca ggtctccctg aacctcaata cctgtgctgc ccgagacacc
     1141 ttcagccgtg ccctgtccat cacaggtaaa ctctcagaca ccaactgctg cctggatgcc
     1201 atctgttact actacatggc cagagagttc caggaagcgt ccaagccagc cacgtcttcc
     1261 aacacacccc acaagagcca agattcccag atcctgagcc tcacctagaa gaagtgaaca
     1321 catgccaagg gccagaggaa cctgtgatgt gagcaaggag ccctggatca gcctgaacct
     1381 cctgtggggt ctgagcactc taggagaccc agttggacta gagaggctgc atctgctccc
     1441 ctgaaaggac cagaggactc aggctctaac gtccgacctg agggaccctg gaacaagacc
     1501 acatatctcc cattccagat ctagaaaccc tgggcaccag aatggggcct tgatggctag
     1561 ccactgagtt taggatacac ccctccccag agttggtcct ggcaaggtcc tctgtcacct
     1621 agatgcaagt gatgagagat aaaggacaga catacggctc agagaaccag gagacatctt
     1681 tccagaggac cctcaaatgg cttcttcctt ttaggacctt taaacttcat gccacatgta
     1741 gggttgggca aaagggcagc agctgtggtc tggcaggctg tcctccaagg cccatgactg
     1801 tcactgttgc tccagctctg tattatgagg gttccagctc aggagaccca gtggtcataa
     1861 catcatgttg agcaatcgga cctgagcctc ttctggttat ttccattcta tagtgggact
     1921 gttgattcct gaggacagtg gctatggtag aggtctctgg agtttattgt gaggaagatt
     1981 gctgtttggt attcatgctc tctgaggatg tggccccagg cttcgaggat ctctggagta
     2041 aaggatgagc cacaaagcca gctttgagtc aggagcacat ttggagatgt ggtagccctg
     2101 ggcttccccc tcaatgcttt gatttttgtc ttggtccaaa tgctacagct gtacccagag
     2161 ccagagcccc tccagctcag gggagggggg tactggctct ccctactctc tacccctact
     2221 tcatccaagg cctactgcct aactgacccc tttttttgta tgaccttttc tacaaaaacc
     2281 aaaaatctgt tcatccttca gacaccagag aaaggattcc actcaagtat aaattggtga
     2341 actgatttcc tggagttact tacaaaagca cggtgactct tgggtgctca gtcactgaaa
     2401 agcctcactc agcatagata acaatcccca aactgcaccg ctagattacc aatccccact
     2461 aaacttccac ctcacacaca cacttggaca cctgacctgc tccagacaaa aatgtgccta
     2521 gggtgtgagg aagctgtggc tgcgacccaa ggtgtgctga ccctcttcgc tctgccaagg
     2581 actactaaca gcttcatgat catcagccta ttcgccacag ccgtattttg cttgtttcac
     2641 tggcatgact gtaggccgag ctgttctgtg gatcagagca gcgcttttcc tgttcactgc
     2701 tgatgatcat cctaagccag agaaatggct tctctgccac actggcccac tctccctcca
     2761 gttctcacat cccctccacc ctctgttctg cagtattatc taaaccttca ccttggaagg
     2821 aagggatggt gtatctatat aatatcaaga tataggatcc acacgtgtgt gcctatggtt
     2881 cttttctgag tcttacgcct ctagactaca acagcagaca actattctaa gtagcttgcc
     2941 ggtgatagaa acaaagcatc aggaggggag aaatagatca tttggggccc ccatagcacc
     3001 ccctagtgtg cagtagtggg tcccctgccc acagaaccag cacagcatct gccttgatgc
     3061 agacactcta ccttcctctg gtaacctcag ctttagggga aaatcccacg cccccacagg
     3121 ctagccttgg ccatctgtcc aaatgatgca gaagacggga ggtagaaaat gaaggacaat
     3181 ctttacacaa aagctgcaaa attagcacac taaaaaatta aagttaaatg gctcatctgg
     3241 catgggtgcc agcaaccaag cctggcaacc tgagttcaaa tcccagaaac taacatgtgc
     3301 taggaaagag ccaagccaca agttgttctc tggccccaac acatcctcca aataaaaact
     3361 aaataaatgt caaatagcac gctatataaa aacaaaacaa aacaaaaacc tgttggcagg
     3421 ctggagagat gatggttcag tggttaagag cactgactgc tcttccagag gtcccaaatt
     3481 caactcccag aaaccatatg gtggctcaca accatctata atgggatctg atgccctctt
     3541 ctggtatgtc taaagagcta cagtgtgctc atatacataa aataaataaa tctttaaaaa
     3601 aatactattg gcaaagagga aggctgagcc cctgtacctc cactgcccaa ggccaactag
     3661 aactggtgtc agagacactg gagttagtgt ggggacactc cagaacatct gaaggtaacc
     3721 tgtgacttgt taaaaactgc atttgacaaa gctttcatga gaaagctcat gctatatgaa
     3781 taacttccgc taaagcccac tctgagtact ggctagtttt gctttgtttt gtcaacttga
     3841 cacaagctag agtcctctga aaaaagggaa ccaatgacaa ttgagaaaat tcttctgtaa
     3901 gactggcatg taggcagtcc tgtttcttta atgagtaact gatatgggct ttgttcataa
     3961 tagccagaaa ctggaaataa cctagatgcc cctcaacaga agaatggatg aagaaaatgt
     4021 cctactttta cacaatggaa tactactcaa ccattaaaaa atggcatcat ta
//
