LOCUS       NM_011823               1898 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Mus musculus G protein-coupled receptor 34 (Gpr34), mRNA.
ACCESSION   NM_011823
VERSION     NM_011823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Lin LL, Song GJ, Zhang H, Yin Y, Xin SM, Ding L and Li Y.
  TITLE     GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal
  JOURNAL   Neuroscience 528, 129-139 (2023)
   PUBMED   37557947
  REMARK    GeneRIF: GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal.
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W and Zhou
            R.
  TITLE     GPR34-mediated sensing of lysophosphatidylserine released by
            apoptotic neutrophils activates type 3 innate lymphoid cells to
            mediate tissue repair
  JOURNAL   Immunity 54 (6), 1123-1136 (2021)
   PUBMED   34107271
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Sayo A, Konishi H, Kobayashi M, Kano K, Kobayashi H, Hibi H, Aoki J
            and Kiyama H.
  TITLE     GPR34 in spinal microglia exacerbates neuropathic pain in mice
  JOURNAL   J Neuroinflammation 16 (1), 82 (2019)
   PUBMED   30975169
  REMARK    GeneRIF: The Inhibition of GPR34-mediated signal by GPR34 gene
            deletion reduced nerve injury-induced neuropathic pain by
            suppressing pro-inflammatory responses of microglia without
            affecting their morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Tokizane K, Konishi H, Makide K, Kawana H, Nakamuta S, Kaibuchi K,
            Ohwada T, Aoki J and Kiyama H.
  TITLE     Phospholipid localization implies microglial morphology and
            function via Cdc42 in vitro
  JOURNAL   Glia 65 (5), 740-755 (2017)
   PUBMED   28181299
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Rue,L., Banez-Coronel,M., Creus-Muncunill,J., Giralt,A.,
            Alcala-Vida,R., Mentxaka,G., Kagerbauer,B., Zomeno-Abellan,M.T.,
            Aranda,Z., Venturi,V., Perez-Navarro,E., Estivill,X. and Marti,E.
  TITLE     Targeting CAG repeat RNAs reduces Huntington's disease phenotype
            independently of huntingtin levels
  JOURNAL   J Clin Invest 126 (11), 4319-4330 (2016)
   PUBMED   27721240
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y,
            Nakamura S, Otani Y, Ohwada T and Aoki J.
  TITLE     GPR34 is a receptor for lysophosphatidylserine with a fatty acid at
            the sn-2 position
  JOURNAL   J Biochem 151 (5), 511-518 (2012)
   PUBMED   22343749
  REMARK    GeneRIF: The present studies confirm that GPR34 is a cellular
            receptor for LysoPS, especially with a fatty acid at the sn-2
            position.
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Liebscher I, Muller U, Teupser D, Engemaier E, Engel KM, Ritscher
            L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S,
            Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schoneberg T and
            Schulz A.
  TITLE     Altered immune response in mice deficient for the G protein-coupled
            receptor GPR34
  JOURNAL   J Biol Chem 286 (3), 2101-2110 (2011)
   PUBMED   21097509
  REMARK    GeneRIF: GPR34-deficient mice showed significantly increased paw
            swelling in the delayed type hypersensitivity test and higher
            pathogen burden in extrapulmonary tissues after pulmonary infection
            with Cryptococcus neoformans compared with wild-type mice.
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Engemaier E, Rompler H, Schoneberg T and Schulz A.
  TITLE     Genomic and supragenomic structure of the nucleotide-like
            G-protein-coupled receptor GPR34
  JOURNAL   Genomics 87 (2), 254-264 (2006)
   PUBMED   16338117
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   Schulz A and Schoneberg T.
  TITLE     The structural evolution of a P2Y-like G-protein-coupled receptor
  JOURNAL   J Biol Chem 278 (37), 35531-35541 (2003)
   PUBMED   12835326
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G
            and Gudermann T.
  TITLE     A novel subgroup of class I G-protein-coupled receptors
  JOURNAL   Biochim Biophys Acta 1446 (1-2), 57-70 (1999)
   PUBMED   10395919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671117.6.
            
            [WARNING] On Dec 4, 2023 this sequence was replaced by NM_011823.5.
            
            On Jul 27, 2007 this sequence version replaced NM_011823.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033675.1, AK039528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL671117.6         161442-161553
            113-181             AL671117.6         162162-162230
            182-1898            AL671117.6         167815-169531
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 8.55 cM"
     gene            1..1898
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
                     /note="G protein-coupled receptor 34"
                     /db_xref="GeneID:23890"
                     /db_xref="MGI:MGI:1346334"
     exon            1..112
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            113..181
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..1898
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1401
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
                     /note="G-protein-coupled receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 34"
                     /protein_id="NP_035953.3"
                     /db_xref="CCDS:CCDS30028.1"
                     /db_xref="GeneID:23890"
                     /db_xref="MGI:MGI:1346334"
                     /translation="MTTTSVDSWLCSSHGMHFITNYSDQASQNFSGVPNVTSCPMDEK
                     LLSTVLTTFYSVIFLVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPF
                     RIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRRAIT
                     TKQSIYVCCIVWTVALAGFLTMIILTLKKGGHNSTMCFHYRDRHNAKGEAIFNFVLVV
                     MFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYH
                     AFRFIYISSQLNVSSCYWKEIIHKTNEIMLVFSSFNSCLDPVMYFLMSSNIRKIMCQL
                     LFRRFQSEASRSESTSEFKPGHSLHDLSVTVKMPQYSTKGN"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
     polyA_site      1896
                     /gene="Gpr34"
                     /gene_synonym="Lypsr1"
ORIGIN      
        1 gaagagaact ctagccaatt gcaccaccac caccggatgg aagagcccag ctgacacaac
       61 ctggtctagg gagttttggg tttactcctt ttacttcagg aaagcttcaa ctcagttcct
      121 gcagcttctg aagtatggcc tgaatagatt cagtcattat tataagtcca ttgtcaaata
      181 ggaaaatctg aagacacaaa gaagtacaaa gagcatgtca tttagctctc ctcctgatag
      241 ttacagaaga cgttgagaag tcacactgta acaatgacta ctacttcagt tgacagctgg
      301 ctttgctcct ctcatggaat gcactttata actaattata gtgaccaagc ctcacaaaat
      361 ttctcaggag tgccaaatgt cactagctgt ccaatggatg aaaaattact atctactgtg
      421 ttaacaacct tctactctgt tatattcctc gtgggactgg ttggaaacat cattgccctc
      481 tatgtatttc tgggcattca ccgtaaaaga aattccattc aaatttatct acttaatgtg
      541 gctgttgcag accttctact catcttctgc ctccctttcc gcataatgta tcacatcaac
      601 caaaacaagt ggacactagg tgtgattctt tgtaaagttg tggggacact attttacatg
      661 aacatgtaca ttagcattat tttgcttggg tttatcagtt tggatcgcta tataaaaatc
      721 aatcggtcta tacaacaaag aagggcaata accaccaagc aaagtattta tgtttgctgt
      781 atagtatgga cggttgctct tgctggattt ctaactatga tcattttgac actgaagaag
      841 ggaggtcata attccacaat gtgtttccat tacagagaca gacataatgc aaagggagaa
      901 gcaattttta actttgttct tgtagtaatg ttctggctta ttttcctact gataatcctc
      961 tcatatatta agattggcaa gaatctactg aggatttcta aacggaggtc aaaatttcca
     1021 aactctggca aatatgctac aacagcccgg aactccttta ttgtactgat catttttact
     1081 atatgctttg tgccttacca tgcctttcgg ttcatttaca tttcttcaca gctaaatgtg
     1141 tcctcttgtt attggaagga aatcattcac aaaactaacg agatcatgct ggttttctcc
     1201 tctttcaaca gttgcctgga tcctgtcatg tatttcctga tgtccagtaa tattcgcaaa
     1261 atcatgtgtc aacttctttt tagaaggttt caaagtgaag caagcagaag tgaaagcact
     1321 tcagaattta agccaggaca ttccttgcat gatctgtccg tgacagtcaa aatgccccag
     1381 tacagcacta agggtaattg aggcaaatgt actaaaatga atgatataaa acagtctctt
     1441 catttcttga ggttggtaaa attatcgaac aaagtcctaa tatgcccaaa actcagatct
     1501 ttagaagtga tctttcactt gcttaattgc aaagtagttc aaagcaaaga aaagcttaca
     1561 ttaatcccta gattttagaa ctgtatgtag aattttcaca gaatacattg ttaagctaac
     1621 acttttaaca acggttacaa tgttaagtga agttcatgga tttaacaaca aaacagatga
     1681 aatgtcattg tttttttttt ccaagtcact aaagagttac taaagttagg cacttaatac
     1741 taattttaaa tatgtctaaa aataaagtaa tctggggact gagttgaaat gtcagtgaac
     1801 atgagtatta cttcaaaatc ttacatcact tgatgctata ttcatttatg tctaaatctc
     1861 tgctaacaga tgaaaataat aaaattctaa taaaagtg
//
