LOCUS       NM_008154               2159 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G-protein coupled receptor 3 (Gpr3), mRNA.
ACCESSION   NM_008154
VERSION     NM_008154.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Huang,Y., Rafael Guimaraes,T., Todd,N., Ferguson,C., Weiss,K.M.,
            Stauffer,F.R., McDermott,B., Hurtle,B.T., Saito,T., Saido,T.C.,
            MacDonald,M.L., Homanics,G.E. and Thathiah,A.
  TITLE     G protein-biased GPR3 signaling ameliorates amyloid pathology in a
            preclinical Alzheimer's disease mouse model
  JOURNAL   Proc Natl Acad Sci U S A 119 (40), e2204828119 (2022)
   PUBMED   36161942
  REMARK    GeneRIF: G protein-biased GPR3 signaling ameliorates amyloid
            pathology in a preclinical Alzheimer's disease mouse model.
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Masuda,S., Tanaka,S., Shiraki,H., Sotomaru,Y., Harada,K., Hide,I.,
            Kiuchi,Y. and Sakai,N.
  TITLE     GPR3 expression in retinal ganglion cells contributes to neuron
            survival and accelerates axonal regeneration after optic nerve
            crush in mice
  JOURNAL   Neurobiol Dis 172, 105811 (2022)
   PUBMED   35809764
  REMARK    GeneRIF: GPR3 expression in retinal ganglion cells contributes to
            neuron survival and accelerates axonal regeneration after optic
            nerve crush in mice.
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Shiraki,H., Tanaka,S., Guo,Y., Harada,K., Hide,I., Yasuda,T. and
            Sakai,N.
  TITLE     Potential role of inducible GPR3 expression under stimulated T cell
            conditions
  JOURNAL   J Pharmacol Sci 148 (3), 307-314 (2022)
   PUBMED   35177210
  REMARK    GeneRIF: Potential role of inducible GPR3 expression under
            stimulated T cell conditions.
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Tanaka,S., Shimada,N., Shiraki,H., Miyagi,T., Harada,K., Hide,I.
            and Sakai,N.
  TITLE     GPR3 accelerates neurite outgrowth and neuronal polarity formation
            via PI3 kinase-mediating signaling pathway in cultured primary
            neurons
  JOURNAL   Mol Cell Neurosci 118, 103691 (2022)
   PUBMED   34871769
  REMARK    GeneRIF: GPR3 accelerates neurite outgrowth and neuronal polarity
            formation via PI3 kinase-mediating signaling pathway in cultured
            primary neurons.
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   Sveidahl Johansen,O., Ma,T., Hansen,J.B., Markussen,L.K.,
            Schreiber,R., Reverte-Salisa,L., Dong,H., Christensen,D.P., Sun,W.,
            Gnad,T., Karavaeva,I., Nielsen,T.S., Kooijman,S., Cero,C.,
            Dmytriyeva,O., Shen,Y., Razzoli,M., O'Brien,S.L., Kuipers,E.N.,
            Nielsen,C.H., Orchard,W., Willemsen,N., Jespersen,N.Z., Lundh,M.,
            Sustarsic,E.G., Hallgren,C.M., Frost,M., McGonigle,S., Isidor,M.S.,
            Broholm,C., Pedersen,O., Hansen,J.B., Grarup,N., Hansen,T.,
            Kjaer,A., Granneman,J.G., Babu,M.M., Calebiro,D., Nielsen,S.,
            Ryden,M., Soccio,R., Rensen,P.C.N., Treebak,J.T., Schwartz,T.W.,
            Emanuelli,B., Bartolomucci,A., Pfeifer,A., Zechner,R., Scheele,C.,
            Mandrup,S. and Gerhart-Hines,Z.
  TITLE     Lipolysis drives expression of the constitutively active receptor
            GPR3 to induce adipose thermogenesis
  JOURNAL   Cell 184 (13), 3502-3518 (2021)
   PUBMED   34048700
  REMARK    GeneRIF: Lipolysis drives expression of the constitutively active
            receptor GPR3 to induce adipose thermogenesis.
REFERENCE   6  (bases 1 to 2159)
  AUTHORS   Hinckley,M., Vaccari,S., Horner,K., Chen,R. and Conti,M.
  TITLE     The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP
            signaling and maintenance of meiotic arrest in rodent oocytes
  JOURNAL   Dev Biol 287 (2), 249-261 (2005)
   PUBMED   16229830
  REMARK    GeneRIF: the cAMP levels required for maintaining meiotic arrest in
            mouse and rat oocytes are dependent on the expression of Gpr3
            and/or Gpr12
REFERENCE   7  (bases 1 to 2159)
  AUTHORS   Ledent,C., Demeestere,I., Blum,D., Petermans,J., Hamalainen,T.,
            Smits,G. and Vassart,G.
  TITLE     Premature ovarian aging in mice deficient for Gpr3
  JOURNAL   Proc Natl Acad Sci U S A 102 (25), 8922-8926 (2005)
   PUBMED   15956199
  REMARK    GeneRIF: Gpr3-defective mice may constitute a relevant model of
            premature ovarian failure due to early oocyte aging.
REFERENCE   8  (bases 1 to 2159)
  AUTHORS   Mehlmann,L.M., Saeki,Y., Tanaka,S., Brennan,T.J., Evsikov,A.V.,
            Pendola,F.L., Knowles,B.B., Eppig,J.J. and Jaffe,L.A.
  TITLE     The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian
            oocytes
  JOURNAL   Science 306 (5703), 1947-1950 (2004)
   PUBMED   15591206
  REMARK    GeneRIF: the GPR3 receptor is a link in communication between the
            somatic cells and oocyte of the ovarian follicle and is crucial for
            the regulation of meiosis
REFERENCE   9  (bases 1 to 2159)
  AUTHORS   Wang,Q., Zhao,J., Brady,A.E., Feng,J., Allen,P.B., Lefkowitz,R.J.,
            Greengard,P. and Limbird,L.E.
  TITLE     Spinophilin blocks arrestin actions in vitro and in vivo at G
            protein-coupled receptors
  JOURNAL   Science 304 (5679), 1940-1944 (2004)
   PUBMED   15218143
REFERENCE   10 (bases 1 to 2159)
  AUTHORS   Saeki,Y., Ueno,S., Mizuno,R., Nishimura,T., Fujimura,H., Nagai,Y.
            and Yanagihara,T.
  TITLE     Molecular cloning of a novel putative G protein-coupled receptor
            (GPCR21) which is expressed predominantly in mouse central nervous
            system
  JOURNAL   FEBS Lett 336 (2), 317-322 (1993)
   PUBMED   8262253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB851645.1, AK140302.1 and AI854631.1.
            
            On May 23, 2007 this sequence version replaced NM_008154.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140302.1, AK158917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BB851645.1         2-30
            30-2142             AK140302.1         1-2113
            2143-2159           AI854631.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.24 cM"
     gene            1..2159
                     /gene="Gpr3"
                     /gene_synonym="Gpcr20; Gpcr21; Gpcr3"
                     /note="G-protein coupled receptor 3"
                     /db_xref="GeneID:14748"
                     /db_xref="MGI:MGI:101908"
     exon            1..118
                     /gene="Gpr3"
                     /gene_synonym="Gpcr20; Gpcr21; Gpcr3"
                     /inference="alignment:Splign:2.1.0"
     exon            119..2143
                     /gene="Gpr3"
                     /gene_synonym="Gpcr20; Gpcr21; Gpcr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr3"
                     /gene_synonym="Gpcr20; Gpcr21; Gpcr3"
                     /note="putative"
     polyA_site      2142
                     /gene="Gpr3"
                     /gene_synonym="Gpcr20; Gpcr21; Gpcr3"
                     /note="putative"
ORIGIN      
        1 gactcacgcc gcgtctcccg cggccgcggg ggcttcttgg ggtccgcgca caccttgctc
       61 tgccagaacc tgagtggagg cgccccgcgg cccggccgca cccggtcctg agccaccggt
      121 accatgatgt ggggagcagg aagctctatg gcctggttct cagctggctc aggcagtgtg
      181 aacgtgagca gcgtggaccc agtagaggaa cccacaggcc cagctacact gctgccctct
      241 cccagggcct gggatgtggt gctgtgcatc tcaggcaccc tggtgtcctg cgagaacgcg
      301 ctggtggtgg ccatcattgt gggcactcct gccttccgcg cccccatgtt cctgctggtg
      361 ggtagcttgg ccgtagcaga cctgctggca ggcctgggcc tggtcctgca ctttgcggct
      421 gacttctgca ttggctcacc agagatgagc ttgatgctgg tcggcgtgct agcaatggcc
      481 ttcactgcca gcatcggcag cctgctggcc attaccgttg accgctacct ttccctgtac
      541 aatgctctca cttactactc agagacaacg gtaactcgga cttatgtgat gctggccttg
      601 gtgtgggtgg gtgccctggg cctggggctg gttcccgtgc tggcctggaa ctgccgggat
      661 ggcctgacca cgtgtggtgt ggtctatcca ctctccaaga accatctggt ggttctggcc
      721 atcgccttct tcatggtgtt tggcatcatg ttgcagctct atgcccagat ctgccgcatc
      781 gtctgccgcc atgcccagca gatcgccctc caacgacacc tgctgcctgc ctctcactac
      841 gtggccaccc gcaagggcat cgccacattg gctgtggtgc ttggcgcctt tgctgcctgt
      901 tggttgccct tcactgtcta ctgcctcctg ggagatgccg actctccccg tctctacacc
      961 tatcttaccc tgctcccagc cacctacaac tccatgatca accctgtcat ctacgccttt
     1021 cgcaaccaag atgtgcagaa ggtgctgtgg gccatctgct gctgctgttc cacttccaag
     1081 attccattcc ggtcccggtc ccctagtgat gtctagtttc atcctggtga acctgtggct
     1141 ttgactacta tagaactcca gagtgttagg tccaccaggg cttaattcca atccccagct
     1201 ccacgccctt aagacccagc tggttctgga gttctaggac gttgggtgtt ttaggatctt
     1261 attcaagatt cctgcggggg gcccacccca gctgaccgcg tggctctaga atgttccaga
     1321 tggtcagggt cccactcgga aatgtctcac agcccaagtg gtttgcagtt ccagaaggct
     1381 gggaatttta cagtaccatt ccaagtcctt gatcttcctt cccagaaact tgaccttgat
     1441 catgtcgctt ttgaatttcg aagctccaga gtcagaggtt aatcacttag ttgcctagat
     1501 gagagaaaga tttatctcta tatatgtgga catacagaga aggtttattt atttatttat
     1561 tatttattta tttataaatt tgcttatggg tggtaagggg gaaaaaagag acctacacct
     1621 agaaatctag ctcatatcag ggtatcctca gcctccatga ccccatttct gacctcagtt
     1681 tccgaagggg gcgggatgga aaaagagaaa ccacgtattt tgttattttt gcttattttt
     1741 tatcagagaa atcatagaaa ccagagcctc ctccccaggc ccgcactgct cgggtttgca
     1801 gggagaacac accagcctct ggttttttat ttttttaaga agccatcacc tgagcaaccg
     1861 agaattcctc tgcgctgagg cccggcttcc ctctggtggc catttggggg aattgcaaac
     1921 cgacaaggca gtcgggattg taaaatgcac ccccatctct cactccagcc tggctttcag
     1981 cgccacagcc atggcctggg ggccaggcct taccctgagg tgcccgagag gaggcgggac
     2041 aagagccagt acccccaccc ctctgccaat cgggttatgg cccccagtgc attcctgttc
     2101 agtccccaac cctactcaat aaaaaaaaaa tggttttttt ggaaaaaaaa aaaaaaaaa
//
