LOCUS       NM_008158               2712 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 27 (Gpr27), mRNA.
ACCESSION   NM_008158 XM_916445
VERSION     NM_008158.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Dolanc,D., Zorec,T.M., Smole,Z., Maver,A., Horvat,A., Pillaiyar,T.,
            Trkov Bobnar,S., Vardjan,N., Kreft,M., Chowdhury,H.H. and Zorec,R.
  TITLE     The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3
            Embryonic Cells and Astrocytes
  JOURNAL   Cells 11 (6), 1009 (2022)
   PUBMED   35326460
  REMARK    GeneRIF: The Activation of GPR27 Increases Cytosolic L-Lactate in
            3T3 Embryonic Cells and Astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Chopra,D.G., Yiv,N., Hennings,T.G., Zhang,Y. and Ku,G.M.
  TITLE     Deletion of Gpr27 in vivo reduces insulin mRNA but does not result
            in diabetes
  JOURNAL   Sci Rep 10 (1), 5629 (2020)
   PUBMED   32221326
  REMARK    GeneRIF: Deletion of Gpr27 in vivo reduces insulin mRNA but does
            not result in diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Ku,G.M., Pappalardo,Z., Luo,C.C., German,M.S. and McManus,M.T.
  TITLE     An siRNA screen in pancreatic beta cells reveals a role for Gpr27
            in insulin production
  JOURNAL   PLoS Genet 8 (1), e1002449 (2012)
   PUBMED   22253604
  REMARK    GeneRIF: we identify a novel GPCR regulator of both insulin
            secretion and insulin promoter activity - Gpr27.
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Vadasz,C., Saito,M., Gyetvai,B.M., Oros,M., Szakall,I.,
            Kovacs,K.M., Prasad,V.V., Morahan,G. and Toth,R.
  TITLE     Mapping of QTLs for oral alcohol self-administration in B6.C and
            B6.I quasi-congenic RQI strains
  JOURNAL   Neurochem Res 32 (7), 1099-1112 (2007)
   PUBMED   17273929
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122929.4 and BX523686.1.
            
            On Feb 24, 2018 this sequence version replaced NM_008158.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.4424180.1,
                                        SRR7652917.91220.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2179              AC122929.4         158665-160843       c
            2180-2712           BX523686.1         2-534               c
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 46.22 cM"
     gene            1..2712
                     /gene="Gpr27"
                     /note="G protein-coupled receptor 27"
                     /db_xref="GeneID:14761"
                     /db_xref="MGI:MGI:1202299"
     exon            1..2700
                     /gene="Gpr27"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1452
                     /gene="Gpr27"
                     /note="super conserved receptor expressed in brain 1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 27"
                     /protein_id="NP_032184.1"
                     /db_xref="CCDS:CCDS20387.1"
                     /db_xref="GeneID:14761"
                     /db_xref="MGI:MGI:1202299"
                     /translation="MANASEPGGGGSGGGAEAAALGLRLATLSLLLCVSLAGNVLFAL
                     LIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPGALGCKLLA
                     FLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFP
                     PVLDGGGADDEDAPCALEQRPDGAPGALGFLLLLAAVVGATHLVYLRLLFFIHDRRKM
                     RPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLV
                     LEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQ
                     AGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr27"
                     /note="hexamer: AATATA"
     polyA_site      2700
                     /gene="Gpr27"
                     /note="major polyA site"
ORIGIN      
        1 agagccaaga ggcgcggcgg cggaggagga acgggaggag gacgcggagc atgcgggggg
       61 ctgcaggcct gcccgcagtg aagcccgccg cgcccagggc gcagggagtg gccgtcgcct
      121 cctgcgcgca ccgcgactga gatggcggcg gcggcggcgc ggccgaggcg cgccgagccc
      181 ccggggcagg gccggccggg cgcgggctga caaccccgcg ggccgggaga gctagcgtgg
      241 aggagcgcag gccccggggc ggcctacggc gagcggcgag ggccggcggg gaggaggagg
      301 agcacggccg cgatggcgaa cgctagtgag ccgggcggcg gcggcagcgg cggaggggcc
      361 gaggctgccg cgctgggcct taggctggcc acgctcagcc tgctgctgtg cgtgagcctg
      421 gcgggcaacg tgctgttcgc gctgctcatc gtgcgggagc gcagcctgca ccgcgcgccg
      481 tactacctgc tgctcgacct gtgcctggcc gacgggctgc gcgcgctcgc ctgcctcccg
      541 gccgtcatgc tggcggcgcg gcgcgcggcg gccgcggcgg ggacgccgcc gggcgcgctg
      601 ggctgcaagc tgctggcctt cctggccgca ctcttctgct tccacgcggc cttcctgctg
      661 ctgggcgtgg gcgtcacccg ctacctggcc atcgcgcacc accgcttcta cgccgagcgc
      721 ctggccggct ggccgtgcgc cgcgatgctg gtgtgcgccg cctgggcgct ggctttggcc
      781 gcggccttcc cgccggtgct ggacggcggt ggcgcggacg acgaggacgc gccgtgcgcc
      841 ctggagcagc gacccgacgg cgccccgggt gcgctaggct tcctgctgct cctggccgcg
      901 gtggtgggcg ccacgcacct cgtctacctc cgcctgctct tcttcatcca cgaccgccgc
      961 aagatgcgac ccgcgcgcct ggtgcccgcc gtcagccacg actggacctt ccacggcccg
     1021 ggcgccaccg gtcaggcggc cgccaactgg acggcgggct tcggccgcgg gcccacgcca
     1081 cctgcgctcg tgggcatcag gcctgcaggc ccgggccgcg gcgcccggcg cctcctggtg
     1141 ctggaggagt tcaagacgga gaagaggctg tgcaagatgt tctacgccat cacgctgctc
     1201 ttcctgctcc tctggggccc ctatgtggtg gccagttacc tgcgcgtcct ggtgcgcccg
     1261 ggagctgtcc cgcaggccta cctgacagcc tcggtgtggc tgacattcgc gcaggccggc
     1321 atcaaccccg tggtgtgttt cctcttcaac cgggagctga gggactgttt ccgagcccag
     1381 tttccctgct gccagagccc ccaggccacg caggccaccc tcccctgcga cctgaaaggc
     1441 attggtttgt gaagcgcgct ctgccaccca ggctccctct ggcttcgatt gtgaccgctc
     1501 atctttccct tctgtcccgt tgtctggttt ttctctgctg ccttcaggag actctgaaag
     1561 tggacacgca cttggattgt atagacccct gttctggggc cgggggaggg atgctgaggt
     1621 cccgttctgt cctttaatta tactttcttc ctgacagtag gccctgcagt ctttttgtac
     1681 tggtaccgac ttcttttctt ccacgtgtga tttttttttt tttttaaata aaggctacac
     1741 tggttttatt catgcaaagt ttcctagaga ccatggccag ttttctacag aggctatttt
     1801 tgacaacctc aagtggcatt acctttgcgt tgcagtgaag gagagcgagc taggagatgt
     1861 tggagatgga agagagggac agagttgtct aaagtcccct cagaactgca ggccacaggg
     1921 ccaggtgagc tgtgtgcctt gtttgggggg tgtgggggac ttctcccagt ggtgacactg
     1981 aactttagga gaaaatgcga atgggtagga ggacggtctt atttgagtca cttaaggagc
     2041 aaggtctggg gccctgtgta agttattata aaacaatgca tcagcaaaca gctgctctgt
     2101 agaccagtct tggatggaaa ctttctgtga gactgtgact tttaaacagt aaaaagtgtt
     2161 ttggatagta atgtggagaa aaaaaaaaca gtattgcatg tgtttgtacc gattgtgatt
     2221 tgcggatggg gtgggctctg gagggcagaa aaatacaggt ttgtttgggt taggggtttg
     2281 ggggattttc ccccccaata aaaagttaaa atacttttgt ggaaatggct tgtgctttga
     2341 taagcccagt tttactctgt attatgagct aattttccct ctgaagactt gtctgtggtt
     2401 aagaagatat gggatataac ggtgcctctc ccaggagaca agcattttcc tgcggtgttt
     2461 gctaagttag gtggtgctgt tctactcatg gctgttttca atgattaata agaaaccata
     2521 atttaaaata cgatctcttt gttagacatt gtcacttgac accgaaggac ttcattgcaa
     2581 gtactgtata atactttttg cttaaactgc tctgttttta ttaatgtaac ttgcgttttg
     2641 aagatttcta tctgtacttc tctttgcatt acacaaatat accagtattt tcactctgga
     2701 aaaaaaaaaa aa
//
