LOCUS       NM_175191               4544 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus G protein-coupled receptor 22 (Gpr22), mRNA.
ACCESSION   NM_175191
VERSION     NM_175191.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4544)
  AUTHORS   Chang,C.C., Chen,C.H., Hsu,S.Y. and Leu,S.
  TITLE     Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac
            injury in mice with acute myocardial infarction
  JOURNAL   BMC Cardiovasc Disord 24 (1), 287 (2024)
   PUBMED   38816768
  REMARK    GeneRIF: Cardiomyocyte-specific overexpression of GPR22 ameliorates
            cardiac injury in mice with acute myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4544)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4544)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4544)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 4544)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4544)
  AUTHORS   Adams,J.W., Wang,J., Davis,J.R., Liaw,C., Gaidarov,I., Gatlin,J.,
            Dalton,N.D., Gu,Y., Ross,J. Jr., Behan,D., Chien,K. and Connolly,D.
  TITLE     Myocardial expression, signaling, and function of GPR22: a
            protective role for an orphan G protein-coupled receptor
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (2), H509-H521 (2008)
   PUBMED   18539757
  REMARK    GeneRIF: Demonstrate GRR22 expression in mouse heart. Identified a
            protective role for GPR22 in response to hemodynamic stress
            resulting from increased afterload.
REFERENCE   7  (bases 1 to 4544)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 4544)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089509.1, AK048077.1 and AK034194.1.
            
            [WARNING] On Feb 10, 2025 this sequence was replaced by
            NM_175191.6.
            
            On Jan 3, 2019 this sequence version replaced NM_175191.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BC089509.1         44-46
            4-2698              AK048077.1         2-2696
            2699-4537           BC089509.1         2743-4581
            4538-4544           AK034194.1         4535-4541
FEATURES             Location/Qualifiers
     source          1..4544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.69 cM"
     gene            1..4544
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="G protein-coupled receptor 22"
                     /db_xref="GeneID:73010"
                     /db_xref="MGI:MGI:1920260"
     exon            1..384
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1375
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..4544
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1401..2699
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="probable G-protein coupled receptor 22"
                     /codon_start=1
                     /product="G-protein coupled receptor 22"
                     /protein_id="NP_780400.3"
                     /db_xref="CCDS:CCDS25866.3"
                     /db_xref="GeneID:73010"
                     /db_xref="MGI:MGI:1920260"
                     /translation="MCFSPVLEINMQSESNVTVRDDIDDIDTNMYQPLSYPLSFQVSL
                     TGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVI
                     LLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVML
                     MTSIWIFSFFSFLIPFIEVNFFSLQSGNTWANKTLLCVSTSEYYTELGMYYHLLVQIP
                     IFFFTVIVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLATHETTDMSQSSGG
                     RNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFKMSLLIISTFLLCWTPISVLNTT
                     ILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEAD
                     PMPNNAVIHNSWIDPKRNKKVTYEDSEIREKCLVPQVVTD"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="major polyA site"
     regulatory      4356..4361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4382
                     /gene="Gpr22"
                     /gene_synonym="2900068K05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcactctgc aaaagctgct cggagcaggc ttccctctcc agagcagtgc ccttcctttt
       61 cagaaagcct ggatccgaat gctgtctcag gagacaagaa gccttcagta tgctaaatta
      121 ctttcattac gcattttcag atgcttattg actccacagt aggaagagtg agaggctgct
      181 gcagccgaag cagcactaca tattctatac attagcaggg ctgctgaaac aatggcacag
      241 tagatacatt tccattaagg tcgcttggaa gagattttta taaccctttt cccccagccc
      301 ttgtactttc aaatcaacag aatgaatcaa tcaaaactgg aaatgcttca actacatcag
      361 gaactcgtca gctctttagc agagggccca cacctaattc agtatacaca actgacaatt
      421 tgaagactgc aactgactga gaggctcgct agcctctgaa ccacagacta ccagatattc
      481 ttgtaacaca tgattttaag acactaagga gttaaagcct cagattagct gtgctggaac
      541 ggaacaagct gacagcatcc caagacgatg ctacatagac taaccacgaa aagaaaaaaa
      601 tagaactgta aaagcctgaa gaccaactgg tgagcgtttt aaaaggaaga tctcacactt
      661 taatatagca gaattatgga cactattgat tgtgcaagaa acagtgaagc aaaaacttca
      721 aaaaggagaa tgtcatgatg tgccagcaag caaaacaaag ctttagcaaa ggtttttctg
      781 cactatttag atattcatat caattggtat gactaataga gttttccatc tgagctttat
      841 gaccaattat gcatcctctt ctaatgagaa caaaccgaat taaatagcag atggttttta
      901 tcaaaagagc gtgtactgga tttataatat aaagcaaatt atgtgatcaa gaaatcattt
      961 ccaaacaatg agacctgctg cagacagagc ctgaaaacaa atggatatct aaatgcattt
     1021 tagaagctag agacgggatg tttccttttc tattttcaca tattctggaa aataaagaga
     1081 tacaatcttt tatttcttca aaaagaaaat gcaatttcta tcatttgatg aagtttcatt
     1141 tgcctgaaaa ttatgtgctg ttctttagat atccattagc caactaaatc tcatcataca
     1201 actcaagtac tcaaatagca aatgaatgaa ttcctacaaa acatgaaata aaacacagct
     1261 actccactgt taccaggaaa aaaaaattca tgtcagaatt gtcaatgaca tcatgtatca
     1321 atttgtggaa aactaccatg gtgagcccaa aggcccataa agcaacagta aacaggcaaa
     1381 acaccaactg ctccaaaaga atgtgttttt ctcctgttct ggaaatcaac atgcagtctg
     1441 aatcaaacgt cacggtgcga gatgacattg atgacatcga caccaatatg taccaaccac
     1501 tgtcataccc actaagcttt caagtgtctc tcactggatt tctcatgtta gagatcgtgc
     1561 tggggcttgg cagcaacctt accgtcctgg tactttactg catgaaatcc aacttaatca
     1621 actctgtcag taacattatt acaatgaacc tccatgtact tgatgtcata atttgtgtgg
     1681 gatgcattcc tctaactata gtgatccttc tgctctcact ggagagtaac actgctctca
     1741 tctgctgttt ccacgaagct tgtgtttcct ttgcaagtgt ttcgacagca atcaacgttt
     1801 ttgctattac tctggacaga tatgacatct ctgtaaaacc tgcaaacaga attctgacaa
     1861 tgggcagagc tgtaatgcta atgacatcca tttggatttt ttctttcttc tcattcctga
     1921 ttcccttcat tgaagtaaat tttttcagtc ttcaaagtgg aaatacatgg gcaaacaaga
     1981 cactgctgtg tgtcagtaca agtgaatact atactgagct cgggatgtac tatcaccttt
     2041 tggtgcagat ccccatcttc ttcttcacag ttatagtcat gttgatcaca tacactaaga
     2101 tactccaggc tcttaacatc cgcataggca ctagattctc aacaggacag aagaagaaag
     2161 cccgaaagaa aaagacaatc tctctagcta cacatgagac cacagacatg tcacaaagca
     2221 gtggtgggag gaatgtcgtg tttggtgtga gaacttcagt ttctgtaata attgccctcc
     2281 ggcgagccgt gaaacgccac cgggaacgac gagaacggca gaaaagagtc ttcaaaatgt
     2341 cgttattgat tatttctaca tttcttctct gttggacacc aatttctgtt ttaaatacca
     2401 ccattctatg tttaggccca agtgaccttt tagtaaaatt aagattgtgt tttctagtca
     2461 tggcttatgg aacaacgata ttccaccctc tcttgtatgc attcaccaga caaaagtttc
     2521 aaaaggtctt aaagagtaag atgaaaaagc gagttgtttc catagttgaa gctgatccca
     2581 tgcctaataa cgctgtaata cacaactcat ggatagatcc taaaagaaac aaaaaggtta
     2641 cctatgaaga cagtgaaata agagagaaat gtttagtacc tcaggttgtc acagactaga
     2701 gagaagtctc agcgccacca aatacattca gaagagtttt aaatttaaat tgtaaaaatg
     2761 aaattactgc caaatgttag agaaaacatt ctaggtattg gttatgttgt aaattttcaa
     2821 tgtgaatgtc aattagatta ggtcatatat atatactcaa tttcttcatt atttaatgta
     2881 tttgttgcat ggcagtttgt taaaaagtaa tatcatgtgt atattttgtc aatattatgt
     2941 ccatcagaag atatccatgt aagtcatatt ttctaaagaa taaatatgta gccttaaaag
     3001 agtgtataac tttaaaatgt aactgacaca ggtatctacg tttttaaaaa caatgtatga
     3061 ggtctattat ttctaagcca cgaactacag atatatttat atggtgacaa gttgcataaa
     3121 gtatttaaca caaaaaaatt ataggctcaa aaaaatcaaa gcaagatttt ctgtaccact
     3181 atgctatgtt tctgataatg accaacttgt tataatattt taacaatgaa ataatgaact
     3241 atatataaac cttatttctt ttgaatgtag aaaatgtaga ctatattagt atttcaaaac
     3301 cataagtcaa tgaataaata aatcctatat atgcacacaa aaatagggaa actttaaaat
     3361 tcaagtttac tataaaaaga agagactgaa ttctattaca agggtaatat gcctactata
     3421 caaaggaacc aacaataaag ggagggaaga aagccacagt aacaccagcc ttattcctcc
     3481 ttcctcattt ggcctgattc tacagcaaat gtcctaggct aaaagaaaag actggtctta
     3541 aaagcctgca ataaagaaat ttttcactta actctacact attttgtata caagacgtta
     3601 accacacaaa tagggagact gagaagaaga tgagaaccat ttctgtcact gtagaaaagc
     3661 ctaacacagc cagatgtttc taattttgga tacatagcaa cttatgtgag gcagaattta
     3721 tacaacattc cttccaagcc ttcaaaatac agcagctctg tctccagtct ctaggagatt
     3781 aaactaataa taaattgtgt cacatttctg ttcctccacc atgtaactta gacattattc
     3841 tcttaaatcc tcaattctta ttggaaaatt attattcatt gtaattatag attgtaatta
     3901 tagattgcta ttttcatagc aaacaagaat ttcttacttg ttataataat ctggcaatgc
     3961 atagtaatac caaaacttag caacagctta tttaaaatag gtaagtacct gctatatata
     4021 acgagatagc ttgacaataa ttattctata ttttaaatac tatatgaact aaatgaagta
     4081 acatactttt taaatttaaa agatcatgtt aaacaagtta atatgcatca ctttttacac
     4141 aatggtgaga ctcatctaat caacctcact gacctgcctc gtccctgggg gaatgaatgt
     4201 gatactgcag cttgaaatca ctaaggtttc tggaaaatta aattgattta ttttgattat
     4261 aatactagag tgtcaaaact tggcaaaggc ctacctttct tctgctttat gaaattttaa
     4321 aaaatgctac agtttgataa attgtagcat aatcaaataa aatttatttt tgaaacctaa
     4381 aattaaaact taatggtgtt aagaattttt tcactgaatg taaacatttg gcctacaata
     4441 tatcctaact gttaattaga acttttaatg cattttgtac ttggacttcc aagcataagt
     4501 taaaatacta acacctagat ttataaagtc ttgattttaa aaac
//
