LOCUS       NM_177383               2297 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 21 (Gpr21), mRNA.
ACCESSION   NM_177383
VERSION     NM_177383.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Riddy,D.M., Kammoun,H.L., Murphy,A.J., Bosnyak-Gladovic,S., De la
            Fuente Gonzalez,R., Merlin,J., Ziemann,M., Fabb,S., Pierce,T.L.,
            Diepenhorst,N., Rueda,P., El-Osta,A., Gautier,J.F., Venteclef,N.,
            Charman,W.N., Christopoulos,A., Sexton,P.M., Summers,R.J.,
            Febbraio,M.A., Delerive,P. and Langmead,C.J.
  TITLE     Deletion of GPR21 improves glucose homeostasis and inhibits the
            CCL2-CCR2 axis by divergent mechanisms
  JOURNAL   BMJ Open Diabetes Res Care 9 (2) (2021)
   PUBMED   34782333
  REMARK    GeneRIF: Deletion of GPR21 improves glucose homeostasis and
            inhibits the CCL2-CCR2 axis by divergent mechanisms.
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Leonard,S., Kinsella,G.K., Benetti,E. and Findlay,J.B.C.
  TITLE     Regulating the effects of GPR21, a novel target for type 2 diabetes
  JOURNAL   Sci Rep 6, 27002 (2016)
   PUBMED   27243589
  REMARK    GeneRIF: GPR21 is up-regulated in type 2 diabetes model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Osborn,O., Oh,D.Y., McNelis,J., Sanchez-Alavez,M., Talukdar,S.,
            Lu,M., Li,P., Thiede,L., Morinaga,H., Kim,J.J., Heinrichsdorff,J.,
            Nalbandian,S., Ofrecio,J.M., Scadeng,M., Schenk,S., Hadcock,J.,
            Bartfai,T. and Olefsky,J.M.
  TITLE     G protein-coupled receptor 21 deletion improves insulin sensitivity
            in diet-induced obese mice
  JOURNAL   J Clin Invest 122 (7), 2444-2453 (2012)
   PUBMED   22653059
  REMARK    GeneRIF: GPR21 has a critical function in coordinating macrophage
            proinflammatory activity in the context of obesity-induced insulin
            resistance
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Gardner,J., Wu,S., Ling,L., Danao,J., Li,Y., Yeh,W.C., Tian,H. and
            Baribault,H.
  TITLE     G-protein-coupled receptor GPR21 knockout mice display improved
            glucose tolerance and increased insulin response
  JOURNAL   Biochem Biophys Res Commun 418 (1), 1-5 (2012)
   PUBMED   22155242
  REMARK    GeneRIF: these findings suggest that GPR21 may play an important
            role in regulating body weight and glucose metabolism.
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK048682.1.
            
            On Oct 3, 2009 this sequence version replaced NM_177383.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048682.1, AK139361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2297              AK048682.1         2-2298
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..2297
                     /gene="Gpr21"
                     /gene_synonym="C230004C13Rik"
                     /note="G protein-coupled receptor 21"
                     /db_xref="GeneID:338346"
                     /db_xref="MGI:MGI:2441890"
     exon            1..74
                     /gene="Gpr21"
                     /gene_synonym="C230004C13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            75..2297
                     /gene="Gpr21"
                     /gene_synonym="C230004C13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1509
                     /gene="Gpr21"
                     /gene_synonym="C230004C13Rik"
                     /note="G protein-coupled receptor GPR21"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 21"
                     /protein_id="NP_796357.1"
                     /db_xref="CCDS:CCDS16004.1"
                     /db_xref="GeneID:338346"
                     /db_xref="MGI:MGI:2441890"
                     /translation="MNSTWDGNQSSHPFCLLALGYLETVRFCLLEVLIIVFLTVLIIS
                     GNIIVIFVFHCAPLLNHHSTSYFIQTMAYADLLVGVSCLVPSLSLLYYPLPIEEAMTC
                     QVFGFVVSVLKSISMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLV
                     FLPSFFHWGKPGYHGDVFQWCAESWHTNSYFTLFIVMMLYAPAALIVCFTYFNIFRIC
                     QQHTKEISERQARFSSQNGETGEPQTCPDKRYAMVLFRITSVFYVLWLPYIIYFLLES
                     STGCSSRLASFLTTWLAISNSFCNCIIYSLSNSVFQRGLKGLSGSLCTSCASHTTAKD
                     PYTVRCKGPPNGSHI"
ORIGIN      
        1 attcctgcat tgcaaggctt tcggttaagg atgtattgtg gcttttgttt ggatttcagc
       61 atgcagaatc acagctgttc agaggagact cattacaact cctgctgaag ctactaatct
      121 tcctccctct gcccctcccc cacccacact tggcctgaag acactgtccc cagtttgcct
      181 tactcccttg ctatgtgttt ggtgaaactg gcagtatggc tgcgtctggg actggccaga
      241 caactgctgt tggctttccc tattccagga agaatttaaa gggaaattgt acagcaggca
      301 gtatacccac cacagcagca acctcaggaa cgtgatgact agggctccct ggctttgtca
      361 caggcatgca aagctgactg cagtgacagt agctgctcct gagaactgag acagcagcca
      421 ggtggcagca tgaagtgaga gccagttcct gagcacgaga tgaactccac ctgggatggt
      481 aatcagagca gccatccttt ctgtcttctg gcactgggct acttggaaac tgtcaggttc
      541 tgtcttttgg aagtgctgat tattgtcttt ctaactgtat tgattatttc tggcaacatc
      601 attgtgattt ttgtgtttca ctgtgcacct ctgttgaacc atcattctac aagttatttt
      661 attcagacaa tggcatatgc tgacctcttg gttggggtaa gctgcctggt cccttcctta
      721 tcactcctct actaccctct tccgattgag gaggccatga cttgccaagt atttggtttt
      781 gtagtgtcag ttctgaagag tatctctatg gcttctctgg cctgtatcag cattgataga
      841 tatattgcca tcactaagcc tttaacctat aataccctgg ttactccctg gagactacgc
      901 ctctgtattt ttctgatttg gctgtattcc accctggtct tcctgccttc cttcttccac
      961 tggggtaaac ccggatatca tggagatgta tttcagtggt gtgcagagtc ctggcacacc
     1021 aactcctact tcacattgtt catcgtgatg atgctgtacg ccccagctgc cctcattgtc
     1081 tgcttcacgt atttcaacat cttccgcatc tgccagcagc acacaaaaga aatcagcgaa
     1141 aggcaagccc gattcagcag ccagaatggg gagactgggg aaccccagac ctgtccagat
     1201 aagcgctatg ccatggtcct attcagaatc accagtgtgt tttatgtcct ctggttgcca
     1261 tacatcatct acttcttgct ggagagttct actggctgca gcagccgcct tgcatccttc
     1321 ctgactacct ggcttgctat tagtaacagt ttctgcaact gtatcattta cagtctctcc
     1381 aacagtgttt tccagcgagg actaaagggc ctttcagggt ctctgtgtac ttcttgtgca
     1441 agtcacacca cagccaagga cccttacaca gttaggtgca aaggaccccc taatggatct
     1501 catatctgag gggggctcat atattcagtc gctctatttt caaggagaaa ggatggcttt
     1561 ggttcagttt tttttctctc catctctgct tccagttcac tagagaagta agagcagcta
     1621 cagactatcc agataacctt catagtttgc agaagttgct tcctaaatga gatttaaaat
     1681 tagaagaatc aggatcataa aaagaatcac tcttgatcca gtttttgaaa tgtcatggaa
     1741 gtgactacag ttctcagatt caaaaggagt aaagccatag ttgacacctc tccccactgg
     1801 cgtggctgaa tctgggtgtg aaaagcatca gcatgttaaa aataaccatt ttcttgcccc
     1861 tttctggatt cttaaatgca agttggaatt tatgtgcaat tggttatctt ctaacagaaa
     1921 atattaacat atattgatga actagcaagg attttcttta tctgtgccaa aatataactg
     1981 tactgcaagt ttcagcattc atttggatag tgaaatattt tcttttcttg ccttttgaga
     2041 gcaatctcca taggatgagt aatgtgagca cggaatatta ctttatagag ttttgaaatg
     2101 aagcaactgt gcagtgaagc catacagtgt gtgagagcca gctgctttca cgacatgctt
     2161 ctgagcatcg tgagcatgtg tgcagtaatg acattacagt gctctttctg ggcctctgtc
     2221 tgtaaatatt gagaatgtgt acactgagtt ggatttttta taacaaaatg tatttaatct
     2281 aaataaataa tagaggg
//
