LOCUS       NM_183031               2942 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus G protein-coupled receptor 183 (Gpr183), mRNA.
ACCESSION   NM_183031
VERSION     NM_183031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell (2024) In press
   PUBMED   39708807
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Fessler,M.B., Madenspacher,J.H., Baker,P.J., Hilligan,K.L.,
            Bohrer,A.C., Castro,E., Meacham,J., Chen,S.H., Johnson,R.F.,
            McDonald,J.G., Martin,N.P., Tucker,C.J., Mahapatra,D., Cesta,M. and
            Mayer-Barber,K.D.
  TITLE     Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early
            SARS-CoV-2 Pathogenesis in Mice
  JOURNAL   Am J Respir Cell Mol Biol 69 (6), 638-648 (2023)
   PUBMED   37578898
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Qi,Z., Zhong,W., Jiao,B., Chen,K., Yang,X., Wang,L., Zeng,W.,
            Huang,J. and Xie,J.
  TITLE     Activation of G-protein-coupled receptor 183 initiates inflammatory
            pain via macrophage CCL22 secretion
  JOURNAL   Eur J Pharmacol 954, 175872 (2023)
   PUBMED   37353188
  REMARK    GeneRIF: Activation of G-protein-coupled receptor 183 initiates
            inflammatory pain via macrophage CCL22 secretion.
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Zhang,F., Zhang,B., Ding,H., Li,X., Wang,X., Zhang,X., Liu,Q.,
            Feng,Q., Han,M., Chen,L., Qi,L., Yang,D., Li,X., Zhu,X., Zhao,Q.,
            Qiu,J., Zhu,Z., Tang,H., Shen,N., Wang,H. and Wei,B.
  TITLE     The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to
            Limit IFN Response and Systemic Lupus Erythematosus
  JOURNAL   Adv Sci (Weinh) 10 (27), e2207108 (2023)
   PUBMED   37469011
  REMARK    GeneRIF: The Oxysterol Receptor EBI2 Links Innate and Adaptive
            Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Pereira,J.P., Kelly,L.M., Xu,Y. and Cyster,J.G.
  TITLE     EBI2 mediates B cell segregation between the outer and centre
            follicle
  JOURNAL   Nature 460 (7259), 1122-1126 (2009)
   PUBMED   19597478
  REMARK    GeneRIF: important role for EBI2 in promoting B cell localization
            in the outer follicle, and show that differential expression of
            this receptor helps position B cells appropriately for mounting
            T-dependent antibody responses
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Gatto,D., Paus,D., Basten,A., Mackay,C.R. and Brink,R.
  TITLE     Guidance of B cells by the orphan G protein-coupled receptor EBI2
            shapes humoral immune responses
  JOURNAL   Immunity 31 (2), 259-269 (2009)
   PUBMED   19615922
  REMARK    GeneRIF: EBI2 provides a previously uncharacterized dimension to B
            cell migration that is crucial for coordinating rapid versus
            long-term antibody responses.
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138693.1, AK141593.1 and BB525541.2.
            
            On Feb 25, 2006 this sequence version replaced NM_183031.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY219549.1, AK156005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AK138693.1         3-91
            90-764              AK141593.1         2-676
            765-1821            AK141593.1         678-1734
            1822-2641           AK141593.1         1736-2555
            2642-2942           BB525541.2         397-697
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.86 cM"
     gene            1..2942
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="G protein-coupled receptor 183"
                     /db_xref="GeneID:321019"
                     /db_xref="MGI:MGI:2442034"
     exon            1..141
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..2942
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1239
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="EBV-induced G-protein coupled receptor 2 homolog;
                     Epstein-Barr virus induced gene 2; epstein-Barr
                     virus-induced G-protein coupled receptor 2 homolog"
                     /codon_start=1
                     /product="G-protein coupled receptor 183"
                     /protein_id="NP_898852.2"
                     /db_xref="CCDS:CCDS27343.1"
                     /db_xref="GeneID:321019"
                     /db_xref="MGI:MGI:2442034"
                     /translation="MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVG
                     NLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRV
                     TALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTL
                     PLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCK
                     LFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALEC
                     GARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSA
                     PEENSREMTESQMMIHSKASNGR"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="hexamer: AATATA"
     regulatory      1551..1556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="hexamer: AATATA"
     polyA_site      1568
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="major polyA site"
     polyA_site      1585
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
     regulatory      2626..2631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="hexamer: AATAAA"
     polyA_site      2645
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="hexamer: AGTAAA"
     polyA_site      2724
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
ORIGIN      
        1 agtcacagga tgacaggaaa aaggcaccac cataaaagga cgcctgctcg atcactctta
       61 aagcaacatg cccagcttag ctaactccat tctgagcaaa cacggactgc cacaacggag
      121 gtcctagcca ccttctgata ttgactgtga ccactggata cagaaatggc taacaatttc
      181 actaccccac tggcaacgtc tcatggcaat aactgtgatc tctatgccca ccacagcaca
      241 gccagggtat taatgcctct gcattacagc ctggtcttca tcattgggct ggtgggaaac
      301 ctgctggcct tggttgtcat tgttcaaaac agaaaaaaaa tcaactcaac cactctctat
      361 tcaatgaact tggtcatttc tgacatcctg tttaccacag ctttacccac tcggatagcc
      421 tactatgcgc tgggctttga ttggaggata ggtgatgccc tgtgccgggt aactgctctg
      481 gtgttctaca tcaacacgta cgcaggtgtg aacttcatga cttgcttgag catagaccgc
      541 ttcttcgctg tggtgcaccc tctgcgctac aacaagatta aaagaatcga atacgcaaag
      601 ggtgtctgcc tgtccgtctg gattctggtc tttgctcaaa cactgccgct gctcctcacc
      661 cctatgtcta aggaggaggg agacaagacc acttgcatgg agtatccaaa ctttgaaggg
      721 acagcgtccc tgccgtggat tctgctcgga gcctgtctgc tgggctacgt gctgcctatc
      781 acagtcattc tcctgtgtta ctctcagatc tgctgcaaac tcttcaggac tgccaagcag
      841 aacccactca ccgagaaatc tggtgtgaac aaaaaggctc tcaacacaat tatcctcatc
      901 attgtcgtgt tcatcctgtg cttcacgccc taccacgtgg ccatcattca gcacatgata
      961 aagatgctct gctcccctgg agccctggag tgtggggcga gacattcctt ccagatctct
     1021 ctgcacttca cggtgtgcct gatgaacttc aactgctgca tggacccgtt catatacttc
     1081 tttgcatgca aagggtataa gagaaaggtc atgaagatgc tcaaacgtca agtgagtgtg
     1141 tcgatctcca gcgcagtgag gtcagcccct gaagagaatt cgcgggaaat gacagagtct
     1201 cagatgatga tccactccaa ggcctccaat ggaaggtaaa ggcacttggg acttcacagc
     1261 acagcaagct gcgggatggg ccccgcccac cgactggtcg gctcccaacc aggatgcctt
     1321 ccactgccgc cccaccggcc aatgcactga gatccagacc agatcgagga gacaaaaaag
     1381 caagttcaac ttcataaatg aaatataatg tatataaagg aaggctctca taagtctcaa
     1441 tgtaaaaaga aattctttgt gaaattacta tttcttgtca atagtttggc aaaagacgac
     1501 taattgcact gtatattgcc agtgtaaaaa tgttaatact gtaatatatg aatatatttc
     1561 ttaatttaca cctctttcaa ttttagatat tgtctcctta gtaatatgtt tttgtttgtt
     1621 tgcttgtttg tttgttttgt tctgagacaa atgttttaag aaacattttg tgagataaag
     1681 aacaggatcg aacaagagta ttaatatgta actgtcaacc accagcagaa cttctaagta
     1741 taattaatag aaggtatatt tgaagaacaa cggtagaaat gctggtgatg acagaggtga
     1801 cagaagcatc aagcccttcc ctgagcaccc aggatagtgc ctttggacca ctgctcggaa
     1861 acacgacagg ggctcccaca cagcatccac tgaaaacatg tgcacgtgct accttccttt
     1921 ctggaataga aaacatgcat acatgctttg ggacttctgt tcagctggta gtgcctggta
     1981 tctacacagt ggtagagtag gctatgagaa ctggagcaat ggggattaca attataactg
     2041 ccatgcttgc gtaagtaact caggcagtta atgaacaatt tgtaaattag tagttttcag
     2101 gaattttttc ctttttgtat gtttgcctgc atacaagtca gtgtaccaca tgtgagcagt
     2161 gcctgcaaaa gccagaagag ggtgtcagat cccctgggac tagagttaca gatgattgtg
     2221 tgtcattacg gaggtgctga aaatcaaaca cggatcctcc ggaagagcag ctagtgcttt
     2281 taaccactgt accttctcta aaaaatgttt tttccccctt ttgagacaga gtctagctat
     2341 gtcagtcttg caggcctgga agtctctatg tagacagact agccttagac tggcatatga
     2401 acctcctgcc tccttagtga tggaaccaca ggtgtgcacc atgtcctgct gcgattctct
     2461 gtaatgttac acacctgctt atacaaatac tttaatgtgt gcagcatggt cttcctaagt
     2521 tcctaagcac tgtttgcctg ctcaaatttg ctatgttcca gccctaaaat ttctccagta
     2581 cagtatctca cttggcaatg atatcaattt atataatagg gaaggaataa aacactatac
     2641 tatgagccat aatttcaatt tttattgagc tgtatgccca ggaaatattt catttgagta
     2701 aaattaacct gcttggtctt ttgagacaga gtctcattat atagctcaag gctaccctgc
     2761 aactcatttt gtatcccagg caaatattaa actaaagatc ttcctcaggc acatacttgt
     2821 aaccccaaca cctgggaggc taaggcagaa aaattgctga gtcggaggct agcttgtact
     2881 agggttatat acatattata gcaagctcct acttcaaaaa gaaaaataaa atgtcctgtg
     2941 tt
//
