LOCUS       NM_007412               1694 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 182 (Gpr182), mRNA.
ACCESSION   NM_007412
VERSION     NM_007412.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Bonnavion,R., Liu,S., Kawase,H., Roquid,K.A. and Offermanns,S.
  TITLE     Large chemokine binding spectrum of human and mouse atypical
            chemokine receptor GPR182 (ACKR5)
  JOURNAL   Front Pharmacol 14, 1297596 (2023)
   PUBMED   38026988
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Melgrati,S., Gerken,O.J., Artinger,M., Radice,E., Szpakowska,M.,
            Chevigne,A., D'Uonnolo,G., Antonello,P., Thelen,S., Pelczar,P.,
            Legler,D.F. and Thelen,M.
  TITLE     GPR182 is a broadly scavenging atypical chemokine receptor
            influencing T-independent immunity
  JOURNAL   Front Immunol 14, 1242531 (2023)
   PUBMED   37554323
  REMARK    GeneRIF: GPR182 is a broadly scavenging atypical chemokine receptor
            influencing T-independent immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Melgrati,S., Radice,E., Ameti,R., Hub,E., Thelen,S., Pelczar,P.,
            Jarrossay,D., Rot,A. and Thelen,M.
  TITLE     Atlas of the anatomical localization of atypical chemokine
            receptors in healthy mice
  JOURNAL   PLoS Biol 21 (5), e3002111 (2023)
   PUBMED   37159457
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Jahnke,G.D., Miller,M.J., Martinez,A., Montuenga,L. and Cuttitta,F.
  TITLE     Adrenomedullin expression in the mouse mammary gland: evidence for
            the mature form in milk
  JOURNAL   J Mol Endocrinol 19 (3), 279-289 (1997)
   PUBMED   9460649
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Montuenga,L.M., Martinez,A., Miller,M.J., Unsworth,E.J. and
            Cuttitta,F.
  TITLE     Expression of adrenomedullin and its receptor during embryogenesis
            suggests autocrine or paracrine modes of action
  JOURNAL   Endocrinology 138 (1), 440-451 (1997)
   PUBMED   8977434
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Kapas,S., Catt,K.J. and Clark,A.J.
  TITLE     Cloning and expression of cDNA encoding a rat adrenomedullin
            receptor
  JOURNAL   J Biol Chem 270 (43), 25344-25347 (1995)
   PUBMED   7592696
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Saeki,Y., Ueno,S., Mizuno,R., Nishimura,T., Fujimura,H., Nagai,Y.
            and Yanagihara,T.
  TITLE     Molecular cloning of a novel putative G protein-coupled receptor
            (GPCR21) which is expressed predominantly in mouse central nervous
            system
  JOURNAL   FEBS Lett 336 (2), 317-322 (1993)
   PUBMED   8262253
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY121440.1, BC125279.1, BY590401.1 and BB806742.1.
            
            On Nov 8, 2006 this sequence version replaced NM_007412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031480.1, BC125279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               BY121440.1         2-200
            200-1505            BC125279.1         71-1376
            1506-1679           BY590401.1         291-464
            1680-1694           BB806742.1         175-189
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 75.07 cM"
     gene            1..1694
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /note="G protein-coupled receptor 182"
                     /db_xref="GeneID:11536"
                     /db_xref="MGI:MGI:109545"
     exon            1..199
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /inference="alignment:Splign:2.1.0"
     exon            200..1694
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1412
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /note="G10D; adrenomedullin receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 182"
                     /protein_id="NP_031438.2"
                     /db_xref="CCDS:CCDS36084.1"
                     /db_xref="GeneID:11536"
                     /db_xref="MGI:MGI:109545"
                     /translation="MSVIPSPRPVSTLEPDNDFRDIHNWTELLHLFNQTFTDCHIEFN
                     ENTKHVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAIADLGIILSL
                     PVWMLEVMLEYTWLWGSFSCRFIHYFYLVNMYSSIFFLTCLSIDRYVTLTNTSPSWQR
                     HQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSA
                     TILGFLLPFLLIAVFNILTACRLRRQRQTESRRHCLLMWAYIVVFAICWLPYQVTMLL
                     LTLHGTHIFLHCHLVNLLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRY
                     LPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHPIRNVQASSPPPNTSPTL
                     CNSVAS"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /note="hexamer: AATAAA"
     polyA_site      1677
                     /gene="Gpr182"
                     /gene_synonym="Admr; AM-R; G10-D; Gpcr17; Gpcr22; MB10;
                     NOW"
                     /note="major polyA site"
ORIGIN      
        1 gactggattg ggaggataca ggaaaaaccc cagccctctc ccacagagcc tcagcaagtg
       61 acagctactt cctgcaggca agcagagctg cctggagcca gcagcagcgc ctgctccgca
      121 aagctgcctc tgcagcctcc tggcactaac agccccatcc acaggctccc cgggacaggt
      181 gctcccaaga gaaatccaga cccaagttgg ccctcatgtc agtcataccc agccccaggc
      241 ccgtctccac cttggaaccg gacaatgatt ttagagacat ccacaactgg acagagctgc
      301 tccacctctt caaccagacc tttaccgatt gccacataga attcaacgag aacaccaaac
      361 acgtggtcct cttcgtcttc tacctggcca tcttcgtggt aggcttagta gagaacgtcc
      421 tggtgatatg tgtcaactgc cgccgttcag gccgggtggg gatgctgaac ctgtacatcc
      481 tcaacatggc catcgcagac ctgggcatca tcctgtctct gcctgtttgg atgctggagg
      541 tcatgctgga gtacacttgg ctctggggca gcttctcctg tcgcttcatt cattatttct
      601 accttgtcaa catgtacagc agcatcttct tcctgacgtg cctcagcatt gaccgctacg
      661 tcaccctcac caacacctct ccctcctggc agcgccacca gcaccgaata cggagggccg
      721 tgtgcgcagg cgtctgggtc ctctccgcca ttatcccact gccggaggtg gtgcacatcc
      781 agctgttgga tggctccgag cccatgtgcc tcttcctagc accttttgaa acgtacagcg
      841 cctgggccct ggcagtggcc ctgtcggcca ccatcctggg cttcctactg ccttttcttc
      901 tcatcgcagt gttcaatatc ctgacagcct gccggcttcg gaggcaaagg cagacggaga
      961 gcaggcgcca ctgcctgttg atgtgggctt acatagttgt ctttgccatc tgctggctgc
     1021 cctaccaagt gactatgctg ctgctcactc tgcacgggac ccacatcttc ctccactgtc
     1081 acctggttaa ccttctctac ttcttctacg aaatcatcga ctgcttttcc atgctgcact
     1141 gtgtggccaa ccccatcctc tacaactttc tcagcccgag cttccggggc cgactgctga
     1201 gccttgtggt ccgttacctt cccaaggagc aggccagggc agcaggtggt cgagcctcct
     1261 cttcttcttc cacccagcac tccatcatca ttaccaaaga gggcagcctg cccgctgcag
     1321 cggatctcca cacccacccc atccgaaacg ttcaggcgtc ctctccgcct ccaaacacct
     1381 cacctacact ctgcaattct gtagccagct aaggtagact ctagcttcct ccaccaacaa
     1441 gaaagttcag agggggatgc gagaggtctg tgggaggggg tgggaaggac tggcttgttc
     1501 agggccaatt taagtatatc aaaatgttgc tgtggggaga gggaaacggt tcgggaagga
     1561 cagagaatgg atctttcctt gatagtacac tatttgtttg ggtactgatg tctaagggag
     1621 ccacaccggt ggggcgtggg gggtggggaa gcgaaataaa taaatcatag agacacccgt
     1681 gctgggaatc tctg
//
