LOCUS       NM_021434               2877 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 180 (Gpr180), mRNA.
ACCESSION   NM_021434
VERSION     NM_021434.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Zhang,Y., Zhu,Z., Sun,L., Yin,W., Liang,Y., Chen,H., Bi,Y.,
            Zhai,W., Yin,Y. and Zhang,W.
  TITLE     Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High
            Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway
  JOURNAL   Nutrients 15 (8), 1838 (2023)
   PUBMED   37111058
  REMARK    GeneRIF: Hepatic G Protein-Coupled Receptor 180 Deficiency
            Ameliorates High Fat Diet-Induced Lipid Accumulation via the
            Gi-PKA-SREBP Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Balazova,L., Balaz,M., Horvath,C., Horvath,A., Moser,C.,
            Kovanicova,Z., Ghosh,A., Ghoshdastider,U., Efthymiou,V.,
            Kiehlmann,E., Sun,W., Dong,H., Ding,L., Amri,E.Z., Nuutila,P.,
            Virtanen,K.A., Niemi,T., Ukropcova,B., Ukropec,J., Pelczar,P.,
            Lamla,T., Hamilton,B., Neubauer,H. and Wolfrum,C.
  TITLE     GPR180 is a component of TGFbeta signalling that promotes
            thermogenic adipocyte function and mediates the metabolic effects
            of the adipocyte-secreted factor CTHRC1
  JOURNAL   Nat Commun 12 (1), 7144 (2021)
   PUBMED   34880217
  REMARK    GeneRIF: GPR180 is a component of TGFbeta signalling that promotes
            thermogenic adipocyte function and mediates the metabolic effects
            of the adipocyte-secreted factor CTHRC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Tsukada,S., Iwai,M., Nishiu,J., Itoh,M., Tomoike,H., Horiuchi,M.,
            Nakamura,Y. and Tanaka,T.
  TITLE     Inhibition of experimental intimal thickening in mice lacking a
            novel G-protein-coupled receptor
  JOURNAL   Circulation 107 (2), 313-319 (2003)
   PUBMED   12538434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX210992.1, AK053422.1 and AC108833.10.
            
            On Mar 24, 2009 this sequence version replaced NM_021434.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053422.1, BC069981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CX210992.1         1-31
            32-1233             AK053422.1         2-1203
            1234-2877           AC108833.10        8868-10511          c
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 61.78 cM"
     gene            1..2877
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="G protein-coupled receptor 180"
                     /db_xref="GeneID:58245"
                     /db_xref="MGI:MGI:1930949"
     exon            1..214
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1392
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="intimal thickness-related receptor; integral
                     membrane protein GPR180"
                     /codon_start=1
                     /product="integral membrane protein GPR180 precursor"
                     /protein_id="NP_067409.2"
                     /db_xref="CCDS:CCDS27333.1"
                     /db_xref="GeneID:58245"
                     /db_xref="MGI:MGI:1930949"
                     /translation="MGGLRLLAVALTCSCWWPQGGQGKTLRGSFSSAAARDAQGQSIG
                     HFEFHGDHALLCVRINNVAVAVGKEAKLYLFQAQEWLKLLESSPGYSCSERLARAQLT
                     VTVTQTEHNLTVSQLPAPQTWRVFYADKFTCRDDSESPQGEEIPFEMVLLNPDAEGNP
                     LDHFSARESGLHEFFFLLVLVYFVTACIYAQSLWQAMKKGGPMHTILKVLTTALLLQA
                     ASALANYIHLSRYSRDGLGVPLIGSLAEVFDIASQIQMLYLLLSLCMGWTIVRMKKSQ
                     SRPLQWDSTPASTGIAVFIVITQSILLLWEQFEDTSHHSAHSHRSLAGLLLIVLRICL
                     ALSLGCGLYQVITVERSALKREFYITFAKGCILWFLCQPALACIAVAFNDYQRDKLIT
                     VGVILCQAVAMVILYRLFLSHSLYWEVSSLSSVTLPLTISSAHRGRPHF"
     exon            215..373
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            374..574
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            575..755
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            756..805
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            806..963
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1155
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1233
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..2877
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="hexamer: AATAGA"
     polyA_site      1906
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="major polyA site"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="hexamer: AATAAT"
     polyA_site      2333
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="hexamer: ATTAAA"
     polyA_site      2562
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
                     /note="hexamer: AATACA"
     polyA_site      2865
                     /gene="Gpr180"
                     /gene_synonym="E130016I23Rik; Itr"
ORIGIN      
        1 ctgctgccga cgtgggctgc aggccgcagg cggttgccgg gcgagcaaac ggagcgggcg
       61 gcgggcatgg gcggcctgcg gctgctggcg gtagccctca cgtgcagctg ctggtggccg
      121 cagggcggcc agggcaagac cctgcgtggc agcttcagca gcgccgcggc ccgcgacgcc
      181 cagggccaga gcatcggcca tttcgagttc cacggtgacc atgctcttct gtgtgtcaga
      241 atcaacaacg tagcagtggc tgttggaaaa gaagctaaac tctacctgtt ccaagcccag
      301 gaatggctga agctgctgga gagcagcccc ggctacagct gcagtgagcg gctagcccga
      361 gctcagctga cagtgacagt gacccagacg gagcacaacc tcacagtgtc ccagctgccc
      421 gctccccaga catggcgagt gttctatgcc gacaagttca cctgcaggga tgactcagag
      481 agcccccagg gggaggagat cccctttgaa atggtgctcc tcaacccgga cgccgaggga
      541 aacccactgg atcattttag cgccagagag tccgggctcc acgagttctt tttcctcctc
      601 gtcctagtgt actttgtgac tgcgtgcatc tatgcgcagt ctctgtggca ggctatgaag
      661 aagggaggac ccatgcacac catcttaaag gtcctcacca ctgcactgct gcttcaagct
      721 gcttcagcct tagctaatta catccacttg tccaggtact ccagagatgg gctaggagtg
      781 cctctcatag gaagcctggc agaagttttt gacattgcct cccaaattca gatgctgtac
      841 ctgcttctga gcctgtgtat gggctggaca atagtgcgga tgaagaagtc gcagagcaga
      901 ccgctccagt gggactcgac acccgcgtcc acgggcatcg cagtcttcat cgtcatcaca
      961 cagagcattt tgctactctg ggagcagttt gaagacacca gtcaccacag cgcacattca
     1021 caccgcagct tagccgggct cttgctgatt gtcttacgga tctgcctggc gctgtcgctg
     1081 ggctgcggac tctaccaggt catcacagtg gagaggagcg cgctcaagag agagttctac
     1141 atcacgtttg ccaagggctg catcctgtgg ttcttgtgcc agccagcgct cgcatgcatt
     1201 gctgtcgctt ttaatgacta ccaaagagat aagcttatca cagtaggtgt catcctgtgt
     1261 caggccgtgg ccatggtcat tctgtacaga cttttcctgt cccacagtct ttactgggag
     1321 gtctcctcgc tctcctcagt aacgctacca ctgaccatct cgtctgcaca cagagggcgc
     1381 cctcatttct gatgcttgag ttttgtggag agaaccagtg aatggagaag tgcaatagga
     1441 tccaacgcag caccgtcttg ctgtgccttt gtgtgacagc tgagcggtgg aagcagggcg
     1501 tcttatttat agaactgaac gtcagcgggc tcagcagaaa ggaatagaag ctccggagtg
     1561 aactcaaaca gtgaacttcc cagaaagaat gttgtttcaa ggtgactgaa acagtttcca
     1621 cgtggaaata aatgtgaaaa ggactgctta gagtacacgt gggccaggtg gtcacacctg
     1681 cgatgcctcg tcactagcaa actcaggcct gatagtccta cagtattcac ctagacaata
     1741 cttgcctgtg cgtgcccagc tcgcccagtt atgaaatcag cgggatgtgc tgattttaaa
     1801 actacttctt tttatccttt aaagaacgtg catttcaaat tataatttaa aggacttgaa
     1861 agtgaaatta cttaggaaat aaatagaaaa tatgttaaca gttaaacgaa ttagcatttg
     1921 tttattcacg tgtggagtta ttctgcaatt tctccttgta ttgttggccc tgcttcaggt
     1981 cttatcttga ttgaggaagg atcttggata aagtgtggaa aatcatgggt acattacatt
     2041 ggttggaaga acagagagct taagtgtgag gacgtgggta agggacaagc agggttttgt
     2101 gtttaaaaag aaagaaggaa gaggtagtat gtggtatggc cctgaaattt taatcctgtg
     2161 ataattcatt tctcttgcgc ggaatcccca gtcctaatga agctgtagac acagattaaa
     2221 ttaacaggag catttcacag gactgttagt ttccgtcatc aacctaccca cgaattcctg
     2281 cccaaggata cttaatcagg attaaatttt ctatgaataa ttgaaaaaca aaatactcac
     2341 tggatttgtt ctaatccatg ttggcactgg atggtaagga gttgccatct tgaatccttt
     2401 gtaataaagc tgtgtgtgtg tgtgtttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2461 tgtgtgtgtt tgtgtgtgtg tgtgtgtgtg ttgctcccca aattaagtat gctagtcctc
     2521 taaaaggttc ctcattaaag aaccactctg tagctgtcag gacttgctgt gtgctggtat
     2581 ctgtgaagtc gcttggacct tattgtttac ttttaactaa ttttaaatat ttaatctgct
     2641 tgccatattt ttaaacagga aatggtgcaa taatctggta attgcgtttt ttaatggaag
     2701 ggttcagtta atgtagcaga atggaaaagg actgtggctt tgtctttatt ttttccttgt
     2761 ctatagtttc attgaaaatg aaaatatcct gcttcatttt aagacaaaat gtgtttgcag
     2821 tcagcaaaat ggcaaagtaa tacagtctag cccgtgatta aaacatttct ataggtt
//
