LOCUS       NM_182806               1424 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus G protein-coupled receptor 18 (Gpr18), mRNA.
ACCESSION   NM_182806
VERSION     NM_182806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Lipscomb,M., Walis,S., Marinello,M., Mena,H.A., MacNamara,K.C.,
            Spite,M. and Fredman,G.
  TITLE     Resolvin D2 limits atherosclerosis progression via myeloid
            cell-GPR18
  JOURNAL   FASEB J 38 (6), e23555 (2024)
   PUBMED   38498346
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Fitzgerald,H., Bonin,J.L., Khan,S., Eid,M., Sadhu,S., Rahtes,A.,
            Lipscomb,M., Biswas,N., Decker,C., Nabage,M., Ramos,R.B.,
            Duarte,G.A., Marinello,M., Chen,A., Aydin,H.B., Mena,H.A.,
            Gilliard,K., Spite,M., DiPersio,C.M., Adam,A.P., MacNamara,K.C. and
            Fredman,G.
  TITLE     Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow
            Function and Limits Steatosis and Hepatic Collagen Accumulation in
            Aging
  JOURNAL   Am J Pathol 193 (12), 1953-1968 (2023)
   PUBMED   37717941
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Dicker,M., Li,Y., Giles,D.A., Verstichel,G., Castelan,V.C.,
            Ascui-Gac,G., Chou,T.F., Perez-Jeldres,T., Cheroutre,H. and
            Kronenberg,M.
  TITLE     CD4+-mediated colitis in mice is independent of the GPR183 and
            GPR18 pathways
  JOURNAL   Front Immunol 13, 1034648 (2022)
   PUBMED   36389671
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Bardin,M., Pawelzik,S.C., Lagrange,J., Mahdi,A., Arnardottir,H.,
            Regnault,V., Feve,B., Lacolley,P., Michel,J.B., Mercier,N. and
            Back,M.
  TITLE     The resolvin D2 - GPR18 axis is expressed in human coronary
            atherosclerosis and transduces atheroprotection in apolipoprotein E
            deficient mice
  JOURNAL   Biochem Pharmacol 201, 115075 (2022)
   PUBMED   35525326
  REMARK    GeneRIF: The resolvin D2 - GPR18 axis is expressed in human
            coronary atherosclerosis and transduces atheroprotection in
            apolipoprotein E deficient mice.
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Dort,J., Orfi,Z., Fabre,P., Molina,T., Conte,T.C., Greffard,K.,
            Pellerito,O., Bilodeau,J.F. and Dumont,N.A.
  TITLE     Resolvin-D2 targets myogenic cells and improves muscle regeneration
            in Duchenne muscular dystrophy
  JOURNAL   Nat Commun 12 (1), 6264 (2021)
   PUBMED   34716330
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Chiang,N., Dalli,J., Colas,R.A. and Serhan,C.N.
  TITLE     Identification of resolvin D2 receptor mediating resolution of
            infections and organ protection
  JOURNAL   J Exp Med 212 (8), 1203-1217 (2015)
   PUBMED   26195725
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Becker,A.M., Callahan,D.J., Richner,J.M., Choi,J., DiPersio,J.F.,
            Diamond,M.S. and Bhattacharya,D.
  TITLE     GPR18 Controls Reconstitution of Mouse Small Intestine
            Intraepithelial Lymphocytes following Bone Marrow Transplantation
  JOURNAL   PLoS One 10 (7), e0133854 (2015)
   PUBMED   26197390
  REMARK    GeneRIF: GPR18 has a role in the development and reconstitution of
            thymus-derived intestinal IEL subsets in the steady-state and after
            bone marrow transplantation
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
  REMARK    GeneRIF: Data indicate that orphan G-protein-coupled receptor GPR18
            is required for the normal homeostasis of CD8alphaalpha gammadeltaT
            and alphabetaT and CD8alphabeta intestinal intraepithelial
            lymphocyte compartment.
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Caldwell,M.D., Hu,S.S., Viswanathan,S., Bradshaw,H., Kelly,M.E. and
            Straiker,A.
  TITLE     A GPR18-based signalling system regulates IOP in murine eye
  JOURNAL   Br J Pharmacol 169 (4), 834-843 (2013)
   PUBMED   23461720
  REMARK    GeneRIF: Data (including data from knockout mice) suggest that
            signal transduction involving GPR18 in corneal epithelium and
            ciliary epithelium is required for regulation of intraocular
            pressure.
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Samuelson,L.C., Swanberg,L.J. and Gantz,I.
  TITLE     Mapping of the novel G protein-coupled receptor Gpr18 to distal
            mouse chromosome 14
  JOURNAL   Mamm Genome 7 (12), 920-921 (1996)
   PUBMED   8995768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154180.2.
            
            On Jan 17, 2019 this sequence version replaced NM_182806.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034872.1, AK157029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC154180.2         43185-43396         c
            213-1424            AC154180.2         38942-40153         c
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.86 cM"
     gene            1..1424
                     /gene="Gpr18"
                     /note="G protein-coupled receptor 18"
                     /db_xref="GeneID:110168"
                     /db_xref="MGI:MGI:107859"
     exon            1..212
                     /gene="Gpr18"
                     /inference="alignment:Splign:2.1.0"
     exon            213..1424
                     /gene="Gpr18"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1242
                     /gene="Gpr18"
                     /note="NAGly receptor"
                     /codon_start=1
                     /product="N-arachidonyl glycine receptor"
                     /protein_id="NP_877958.1"
                     /db_xref="CCDS:CCDS27342.1"
                     /db_xref="GeneID:110168"
                     /db_xref="MGI:MGI:107859"
                     /translation="MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTAL
                     WVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVV
                     FYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLY
                     EDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQ
                     TSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMN
                     LSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr18"
                     /note="hexamer: AATAAT"
     polyA_site      1370
                     /gene="Gpr18"
                     /note="major polyA site"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr18"
                     /note="hexamer: ATTAAA"
     polyA_site      1424
                     /gene="Gpr18"
                     /note="major polyA site"
ORIGIN      
        1 gtctcatttc agagcgtttc ctgaaaacgg cagagcagtg ctcagagctc agcagaccaa
       61 ccccactatc ggtactacat ctcaacaacc ctccaacaag acacagcaca gagacaccac
      121 ctacctaaca caggcgactc tgagcactct ctctctggga ctgggcagag cggcaaacgg
      181 tcacctctca gacagccttt gacagacagg aggttctaca taccatggga gccagcctgc
      241 tgtaagatgg ccaccctgag caatcacaac cagcttgatc tttctaatgg ctcacaccca
      301 gaggaataca aaatcgcagc cctagtcttc tacagctgca tcttcctgat tgggctgttt
      361 gttaatgtca ctgcgttgtg ggttttcagc tgtacgacca agaaaagaac cacagtgacc
      421 atctacatga tgaacgttgc actactggac ctcgtattta tactcagtct gccctttcgg
      481 atgttttact atgcaaaagg cgagtggcca tttggagagt acttctgcca cattcttggg
      541 gccctggtgg tgttttaccc aagcctcgct ctgtggcttc ttgctttcat tagtgctgac
      601 agatacatgg ccatcgtaca gccaaaatat gccaaggagc tgaagaacac cggcaaggcc
      661 gtgcttgcgt gtgggggggt ctgggtaatg accctgacca ccactgtccc cctgctactg
      721 ctctacgaag acccagacaa ggcctcctcc ccagccacct gcctgaagat ctccgacatc
      781 acccacttaa aagctgtcaa cgtgctcaac ttcacgcgac tcatattttt cttcctgatc
      841 cctttgttca tcatgatcgg gtgctacgtg gtcatcattc acagtctcct ccgagggcag
      901 acgtctaagc tgaagcccaa ggtcaaggag aagtccatac ggatcatcat gaccctcctg
      961 ctgcaggtgc tcgtctgctt cgtgcccttc cacatctgct ttgccgtcct gatgctacaa
     1021 ggacaggaga acagctatag cccctgggga gccttcacca ccttcctcat gaacctcagc
     1081 acctgtctcg atgtagtcct ctactacatc gtttccaaac agttccaggc tcgagtcatc
     1141 agcgtcatgc tgtaccgcaa ttaccttcgc agtgttcgca gaaaaagtgt ccgatcgggc
     1201 agtttacggt cacttagcaa catgaacagt gagatgcttt gagtcagagc aagctgccag
     1261 tcttcagtct ctttaaaatt cttttcctat ctactttcgg gtgaaccagc attctacact
     1321 atccagtccc ttctctaaca aagagaaata ataatgatga actttaaaaa cttctgcggt
     1381 attctgtgta ttctagccac atgattaaaa actgagtatt ctga
//
