LOCUS       NM_001081220            9295 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 179 (Gpr179), mRNA.
ACCESSION   NM_001081220 XM_006533024 XM_484070
VERSION     NM_001081220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9295)
  AUTHORS   Wilmet,B., Callebert,J., Duvoisin,R., Goulet,R., Tourain,C.,
            Michiels,C., Frederiksen,H., Schaeffel,F., Marre,O., Sahel,J.A.,
            Audo,I., Picaud,S. and Zeitz,C.
  TITLE     Mice Lacking Gpr179 with Complete Congenital Stationary Night
            Blindness Are a Good Model for Myopia
  JOURNAL   Int J Mol Sci 24 (1), 219 (2022)
   PUBMED   36613663
  REMARK    GeneRIF: Mice Lacking Gpr179 with Complete Congenital Stationary
            Night Blindness Are a Good Model for Myopia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9295)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   3  (bases 1 to 9295)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9295)
  AUTHORS   Bachert,W., Klotz,L., Sticht,H. and Enz,R.
  TITLE     Homodimerization of a proximal region within the C-terminus of the
            orphan G-protein coupled receptor GPR179
  JOURNAL   Neurochem Int 149, 105150 (2021)
   PUBMED   34333057
  REMARK    GeneRIF: Homodimerization of a proximal region within the
            C-terminus of the orphan G-protein coupled receptor GPR179.
REFERENCE   5  (bases 1 to 9295)
  AUTHORS   Orhan,E., Neuille,M., de Sousa Dias,M., Pugliese,T., Michiels,C.,
            Condroyer,C., Antonio,A., Sahel,J.A., Audo,I. and Zeitz,C.
  TITLE     A New Mouse Model for Complete Congenital Stationary Night
            Blindness Due to Gpr179 Deficiency
  JOURNAL   Int J Mol Sci 22 (9), 4424 (2021)
   PUBMED   33922602
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9295)
  AUTHORS   Peachey,N.S. and Sturgill-Short,G.M.
  TITLE     Response properties of slow PIII in the Large (vls) mutant
  JOURNAL   Doc Ophthalmol 125 (3), 203-209 (2012)
   PUBMED   22865473
REFERENCE   7  (bases 1 to 9295)
  AUTHORS   Peachey,N.S., Pearring,J.N., Bojang,P. Jr., Hirschtritt,M.E.,
            Sturgill-Short,G., Ray,T.A., Furukawa,T., Koike,C., Goldberg,A.F.,
            Shen,Y., McCall,M.A., Nawy,S., Nishina,P.M. and Gregg,R.G.
  TITLE     Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation
  JOURNAL   J Neurophysiol 108 (9), 2442-2451 (2012)
   PUBMED   22896717
REFERENCE   8  (bases 1 to 9295)
  AUTHORS   Orlandi,C., Posokhova,E., Masuho,I., Ray,T.A., Hasan,N., Gregg,R.G.
            and Martemyanov,K.A.
  TITLE     GPR158/179 regulate G protein signaling by controlling localization
            and activity of the RGS7 complexes
  JOURNAL   J Cell Biol 197 (6), 711-719 (2012)
   PUBMED   22689652
  REMARK    GeneRIF: The loss of GPR179 in a mouse model of night blindness
            prevented targeting of RGS to the postsynaptic compartment of
            bipolar neurons in the retina, illuminating the role of GPR179 in
            night vision.
REFERENCE   9  (bases 1 to 9295)
  AUTHORS   Peachey,N.S., Ray,T.A., Florijn,R., Rowe,L.B., Sjoerdsma,T.,
            Contreras-Alcantara,S., Baba,K., Tosini,G., Pozdeyev,N.,
            Iuvone,P.M., Bojang,P. Jr., Pearring,J.N., Simonsz,H.J., van
            Genderen,M., Birch,D.G., Traboulsi,E.I., Dorfman,A., Lopez,I.,
            Ren,H., Goldberg,A.F., Nishina,P.M., Lachapelle,P., McCall,M.A.,
            Koenekoop,R.K., Bergen,A.A., Kamermans,M. and Gregg,R.G.
  TITLE     GPR179 is required for depolarizing bipolar cell function and is
            mutated in autosomal-recessive complete congenital stationary night
            blindness
  JOURNAL   Am J Hum Genet 90 (2), 331-339 (2012)
   PUBMED   22325362
REFERENCE   10 (bases 1 to 9295)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R. and Schioth,H.B.
  TITLE     The gene repertoire and the common evolutionary history of
            glutamate, pheromone (V2R), taste(1) and other related G
            protein-coupled receptors
  JOURNAL   Gene 362, 70-84 (2005)
   PUBMED   16229975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596088.14.
            
            On or before Jul 6, 2018 this sequence version replaced
            XM_006533024.1, NM_001081220.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN02415123
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL596088.14        25225-25272         c
            49-871              AL596088.14        24139-24961         c
            872-980             AL596088.14        22609-22717         c
            981-1068            AL596088.14        20322-20409         c
            1069-1304           AL596088.14        19383-19618         c
            1305-1373           AL596088.14        18624-18692         c
            1374-1483           AL596088.14        17013-17122         c
            1484-1722           AL596088.14        16525-16763         c
            1723-1861           AL596088.14        16154-16292         c
            1862-1967           AL596088.14        15503-15608         c
            1968-2114           AL596088.14        14256-14402         c
            2115-9295           AL596088.14        5026-12206          c
FEATURES             Location/Qualifiers
     source          1..9295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.95 cM"
     gene            1..9295
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /note="G protein-coupled receptor 179"
                     /db_xref="GeneID:217143"
                     /db_xref="MGI:MGI:2443409"
     exon            1..48
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            49..871
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..6959
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /note="GPR158-like 1 receptor; probable G-protein coupled
                     receptor 179"
                     /codon_start=1
                     /product="G-protein coupled receptor 179 precursor"
                     /protein_id="NP_001074689.1"
                     /db_xref="CCDS:CCDS36292.1"
                     /db_xref="GeneID:217143"
                     /db_xref="MGI:MGI:2443409"
                     /translation="MGARAVVISSLAWGLLSCCFLCSGALGSQRPLRSLPPLPSQAKP
                     RSEPMWMPPKGAEAALAFLYSGDVQRLSGANCSEKYEVRGAEGKAGVPPVLQRAAGTL
                     AQAANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPKAYRALLTFNPAPGASHL
                     QLALQATRMGDETVLQDLSGNKVQEETPGEDLDRPVLQKRVLTNDLRSLDSPKWPRGD
                     GYVGDIQQVKLSPPFLECHEGQLRPGWLVTVSATFYGLKPDLTPEVRGQVQMDIDLQS
                     VDINQCASGPGWYSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASGSGGLEE
                     SATQAAGQFGSPQDSLGKLLRCQPCPEGCTSCLDATPCLVEEALALRTAVLACQACCM
                     LAVFLSMLVAYRCRGSKRIRASGIVLLETILFGSLLLYFPVFILYFKPSVFRCVALRW
                     VRLLGFAVVYGTIILKLYRVLQLFLSRTAQRVPHPSSGQLLRRLGQLLLLVLGFLVVW
                     TAGALEPGTQHTALVTRGHTPTGRHFYLCHHDHWDYIMVVAEMLLLCWGSFLCYATRA
                     VPSAFHEPRYMSIALHNELLLSTAFHTARFVLVPSLHPDWTLLLFFLHTHSTVTATLA
                     LIFIPKFWKPGAPPREEILDEVYEDELDLQRSGSYLNSSIASAWSERSLEPGDIRDEL
                     KKLYAQLEIRKTKEMAANNPHLPKKRGSSHQGLGRSFMRYLAEFPEALARQHSRDSGS
                     LGLGSLPGSSRRRLLSSSLQETEKPPALRKTRSTYDHHREHNTLPFDSTLRRTLSKKA
                     SPTDGRESLADGPPALGFRSASAHNLTVGERLPRARPISLQKSLSVAAGSREKALLVA
                     SQAYLEETYRQAKEREERKKAEAAMVSPVRRPSTRRLEWPLRAPLSAPPSPGKSSSMD
                     SSQTTARPHEEAGRRLPHPPIRHQVSTPVLALSGICLGEPRMLSPTPASTLAPILLPA
                     PAPAPAPVLAPVSKPPQSPTLLTFICPWENAELPGKKENVVQEDPAGPERSGHSPASA
                     RTKIWRALSVAVEKRGTGESEALTEGGHVQGEADDTDEEKPKVFSKSHSLKTPLQQGS
                     VRSLGLAIKALTRSRSTYKEKDGGEGTPETEKGKPTEVSTGAPLRSPRLGRPKAVSKQ
                     VALAPCEDEESLQNQQNAHTSRMLHVCQKEGSREQEDRNKRVAPGPGERKVERTGKIT
                     MTTLRQVFGEKNAEQAKESPAGYQEVPNPALQSLGSADHRVAEVCPWEVTEPESGMDP
                     PESVNKAKVYSWERTEGGSLEKKPSRQVLSRSWEEREKVLAESETEGVGAIPRKKPER
                     LVRSQEAVCPWESPDSGGLSPQLVHQESDRTGGRFVVVSKGDAHPEALPSHAAKAELC
                     LWEMSDVGEGTSTQRVQELPEERQKSPKKATFWGERNLGGDLVSLCPWESTDFRGPSA
                     VSLQAPGSSGSLGSGIAEVCPWEAENIANDKKAEVCPWELGEELAGSDGLNPGADGKS
                     LPGKETPSRKGCLAESGEQTVRAKPTVPQGQESVCPWEDEAPERSSPQPDKASSKAGE
                     KLLSHGGSQVLQVCPWEAVKPEEKQATLSTAEICPWEVDGQPETRTSEHPSKGEVHKD
                     EEKMPGRARIKAQEEAEGRIQKQEAICPWESMAPGSTPQRDTEKAQASLQRQGSVAGR
                     AAEICPWEVGTEVGEERTIGAEASEARPNDAGHASTDSGSRQVAASAPKKSERLGSEK
                     EVVCPWDSLSPGDSSQQPDTPNTEKLKDELQEHGSSRPIEVCPWEAEEVPTGEKAKIC
                     PWELNEGTVGKGLEREPGCEPERQRRQNLEEAGLPFQEEGTSKGDTKLCREQEGEAIC
                     PWKPPAQVPKVSDLPLSTVGQGVEGQSLEASDRASEKGELRQDLKMGSLPEYITQVVP
                     VDGGGASSELQPISLQEGMVLAGSSSHPHIQCPDQPRVSSQPLVSTGDGTAEVCPWDA
                     PDSDSDTKVEPCAQKVTGRVTETEMSRQDEKEKSQEEKERAPETRDHEGVAVQKMPQT
                     SNFGKQEAVCPRESQDFGVQAATDASDGSKGGSEKVCPWEVEEVPSIKEAEICPWEAS
                     PGAVGEGALDLGQDGESQGEGRAERHLLKAAETVCPLEGTMSSGLFTQEDVVDTDLPK
                     VGLHGASSPGKGLAELCVWEVTDPEGNKIKGTMADICPWEETRAQSDESGPLALPVTQ
                     AGVPAAPEKSVCLSVHGPLESFLPESKSVRPDISKPPGSSRPEGVREQEPLELETGAK
                     SVPKPSPTETEAPESFTLTDDQGLMASEGEAGELSPPPDYPWDCE"
     exon            872..980
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1068
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1304
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1373
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1483
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1722
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1861
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1967
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2114
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..9295
                     /gene="Gpr179"
                     /gene_synonym="5330439C02Rik; Gpr158l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctctgg agcagatgtg gactgtgtgt cagtgtactg gatcagagga ctccagggat
       61 ctgaaaactg ctgaaggatg ggggccagag cagtggtcat ttcttctctt gcttgggggc
      121 tcctgagttg ctgtttcctc tgtagtgggg ctctagggag ccaaaggccc ttgcgctctc
      181 tgcctccact accgtcccaa gccaagccaa gatctgagcc catgtggatg cccccaaagg
      241 gggctgaagc agccctggcc tttctctact ctggagatgt tcaacggctg tcaggagcaa
      301 actgcagtga gaaatatgaa gtccgtgggg cggaaggcaa agccggggtc cccccagtcc
      361 tacagagagc agcgggcacc ctggcccagg ctgccaactt tctcaacatg ctcctacaag
      421 ccaacgacat ccgggagtcg agcgtggagg aggacgtgga gtggtatcag gcgcttgttc
      481 gcagtgtggc agagggagac ccgaaagcct acagggctct gctgaccttt aaccctgcac
      541 cgggggccag ccaccttcag ctggccctgc aggccactcg gatgggggat gagaccgtcc
      601 ttcaggacct ctctgggaac aaggtacagg aagagactcc aggagaggat ctggatcgtc
      661 ctgtcctcca gaagcgagta ctgaccaatg acctaaggag ccttgacagt cccaagtggc
      721 cacgggggga tggatacgtg ggggacatac agcaggtgaa gctatctccc cctttcctgg
      781 aatgtcatga gggccagctc cgtcctggct ggctagtcac agtctctgcc acgttctatg
      841 gactcaagcc agacctcacc ccagaggtca ggggacaggt gcagatggac atcgacctcc
      901 aaagtgtgga catcaaccag tgtgcaagcg gcccgggctg gtactcaaac acacacctgt
      961 gcgacctcaa cagcacccag tgtgtccctc tggagagtca gggttttgtc cttggccgct
     1021 atctctgccg ctgccgacct ggattctatg gagctagtgg ttctgggggc ttagaagaga
     1081 gtgcaacaca agctgccggg caatttgggt ccccacaaga cagcttaggg aagctgctac
     1141 ggtgccagcc gtgtcctgag ggctgcacca gctgtctgga tgccacacca tgcctggtgg
     1201 aagaggccct ggcactgagg acggcagtgc tggcatgcca ggcctgttgc atgctggcgg
     1261 tcttcctgag tatgctggtg gcctaccgtt gccgagggag caagaggatc cgggcatctg
     1321 gaatcgtcct gctggaaacc atcctttttg gatccttact tctctacttc ccggtgttca
     1381 ttctgtactt caagcccagc gtattccgct gcgttgctct ccgttgggtc cggctgctgg
     1441 gttttgccgt cgtctatggg accattatcc tgaagcttta tagggtgctc cagctgtttc
     1501 tgtctcgaac tgcccagcgg gtgccacacc caagtagcgg gcagctgctg cggcgtctgg
     1561 ggcagctcct gctgctggta ttgggcttcc tggttgtgtg gacagcgggc gccctggagc
     1621 caggcaccca gcacacagct ctggtgaccc ggggtcacac tcccactggc cgccacttct
     1681 acctctgtca ccatgaccac tgggactaca tcatggttgt ggcggaaatg ctgctgcttt
     1741 gttggggcag cttcctctgc tatgccaccc gggctgtccc ctcagccttc cacgaaccac
     1801 gctacatgag cattgccctg cacaatgagc tactgctctc tactgccttc cacactgcca
     1861 ggtttgtgct ggttccttcc ctgcacccag actggacact tctcctcttc ttcctccata
     1921 cccacagtac agtcacagcc acacttgctc tgatcttcat ccctaagttc tggaagccag
     1981 gggcacctcc ccgggaagaa atcttggatg aagtgtatga ggatgagctg gacctgcaac
     2041 gctcaggctc ctacctcaac agcagcatcg cctcggcatg gagtgagcgc agcctggagc
     2101 caggggatat tcgggatgag ctgaagaaac tctacgccca gttagagatc cgaaagacca
     2161 aggagatggc tgctaacaac ccccacctgc ccaagaagcg gggcagctcg caccagggat
     2221 tgggccgctc tttcatgaga tacctggccg agttcccaga ggccctggct cggcagcact
     2281 ctcgggactc gggctctctc ggcctcggca gcctgccagg ctcttcccga cgaaggctcc
     2341 tcagctccag ccttcaagaa acggagaagc caccggccct ccgcaagacc cgcagcactt
     2401 atgaccacca cagggaacat aacactctcc ccttcgactc cacgctgaga cggaccctgt
     2461 ccaagaaggc ttcccccaca gacggccgag agtcgttggc agacgggccc ccagccctgg
     2521 gcttcaggtc tgccagtgct cacaacctga cagtgggaga aagactccct cgagccaggc
     2581 ccatctccct gcagaagtca ctcagtgtgg cggctggctc cagggaaaag gcgctgctgg
     2641 tggccagtca agcctacctg gaggaaacct atcggcaggc aaaagagaga gaggaaagaa
     2701 agaaggctga ggcagccatg gtgagcccgg tgcggaggcc atcgaccagg aggctggaat
     2761 ggcctctaag ggctcctctg tcagccccac cttctcctgg caagagcagc agcatggaca
     2821 gctctcaaac cactgcgagg cctcatgaag aggctgggag aaggctgcct cacccaccca
     2881 tcaggcacca ggtctccaca ccggtcttgg ctctgtccgg gatctgcctg ggagagccaa
     2941 gaatgttgtc tcccactccg gcctccacat tggctcctat tctgttgccg gctccggccc
     3001 cagcccccgc ccctgttctg gcaccagtct caaaaccccc tcaaagcccc acccttctca
     3061 ctttcatctg cccctgggag aatgcagaac ttccaggcaa gaaagaaaat gtggtccagg
     3121 aagacccggc agggccagag cgaagcggcc actcacctgc ctctgctcgt accaagatct
     3181 ggagggccct gtctgtggca gtggagaaaa gggggactgg agagagtgag gcactcacag
     3241 agggtgggca tgtccagggg gaagccgatg atacagatga ggaaaagccc aaggtcttct
     3301 caaaatccca cagcctcaag acccctctgc agcagggttc cgtgcgcagc ctgggcctgg
     3361 ccattaaagc tctgacccgg tctaggagca cctacaaaga gaaggatggt ggggagggca
     3421 cccctgagac tgagaaggga aagcctaccg aggtgagcac aggggctcca ctccgatctc
     3481 ccaggctagg ccggcccaag gcagtgagca aacaggttgc cctcgccccc tgcgaagatg
     3541 aagagtccct ccagaaccaa cagaacgctc acaccagccg catgctccac gtttgtcaaa
     3601 aggagggcag ccgagagcaa gaagatagga acaagagagt ggccccgggt ccaggggagc
     3661 ggaaagttga gagaactggt aaaataacga tgaccacact gaggcaagtt tttggggaga
     3721 aaaatgctga acaagcgaag gaatcccccg cgggatacca agaggtgccc aaccctgccc
     3781 tccagtccct gggcagtgct gaccacaggg tggcagaggt gtgcccctgg gaagtaactg
     3841 aacccgaatc aggaatggac ccgccagaga gtgtcaacaa ggccaaagtc tactcctggg
     3901 agaggactga gggaggaagc cttgagaaga agccatcaag acaagtccta agtaggtcct
     3961 gggaagagag agagaaagtc ctagcggagt cagagaccga aggtgtgggt gccattcctc
     4021 ggaagaagcc ggagaggctg gtccggagcc aggaggctgt gtgtccctgg gagagcccgg
     4081 actctggagg tctgtctcct caattagtgc atcaggagtc tgacagaact gggggcaggt
     4141 ttgtggtagt gagcaaagga gacgcacacc cagaggctct tccgtcccat gctgccaagg
     4201 cagaactgtg cctgtgggag atgagtgatg tgggggaggg gacatctact cagagggtac
     4261 aggaactccc tgaagaaagg cagaaatccc ccaagaaggc aaccttctgg ggagaacgga
     4321 atctgggcgg agacctggtg tctctctgtc cgtgggaaag tactgatttt cggggccctt
     4381 cagccgtctc acttcaagcc ccaggaagct caggtagttt gggcagtggt attgcggagg
     4441 tatgcccatg ggaggcggag aacatagcta atgacaagaa agctgaggtc tgtccctggg
     4501 agctggggga ggagctagca ggttcagacg ggctgaatcc gggggcagat gggaagtctc
     4561 tcccaggaaa ggagactccc tccagaaagg gatgcttagc agagtcgggg gagcaaaccg
     4621 tgagggcaaa acccacagtc cctcaaggac aggagtcagt atgcccttgg gaggatgaag
     4681 cccctgagcg gtccagccca cagccagaca aagcttcctc caaggccggt gagaaactcc
     4741 taagccatgg gggtagccag gtactgcaag tgtgtccttg ggaagcagtc aagccagagg
     4801 aaaagcaagc aacactttca acagcagaaa tctgtccctg ggaagtagat ggacaaccag
     4861 agaccaggac atcagaacac ccatcaaaag gagaagttca caaagatgag gagaaaatgc
     4921 cggggagagc aaggatcaaa gcacaggaag aggctgaggg gcggatccaa aagcaggaag
     4981 caatctgccc ctgggagagc atggccccgg gtagcacccc acaaagagac acagagaaag
     5041 cccaagcctc tctccagagg caaggcagcg tggcaggcag agctgctgag atctgtccct
     5101 gggaagtggg gactgaggtt ggagaggaaa ggactattgg agctgaagcc tctgaggccc
     5161 gtccgaacga tgcaggccac gcgtctacag attctggatc caggcaggta gctgccagtg
     5221 ctccaaaaaa gtcagagagg cttggttcgg agaaggaggt ggtctgtccc tgggatagct
     5281 tgagtccagg ggactcctct cagcagccag acactccgaa cactgagaaa ctaaaagatg
     5341 aactccagga acacgggagc tccaggccca tagaggtgtg tccctgggaa gccgaggaag
     5401 ttcctactgg tgaaaaagcc aagatctgtc cctgggaatt gaatgaaggg acggtgggaa
     5461 aaggactgga gcgagagccg ggatgcgagc cagaacggca aaggagacag aatctagaag
     5521 aggcaggact ccccttccaa gaagaaggca cgtcaaaggg ggacacaaaa ctctgccggg
     5581 aacaggaagg ggaagctatc tgtccttgga aaccacctgc ccaggtcccc aaggtctcag
     5641 acttgcccct cagcactgtt ggtcagggag tagaaggaca gtccttggaa gcaagtgaca
     5701 gggcatcaga gaagggagag ctgagacaag acctgaagat gggttctctc ccagaataca
     5761 taacccaagt ggttcctgtc gatgggggag gagcaagctc ggaacttcag cctataagcc
     5821 tgcaggaagg catggtactg gcaggctctt cctcccatcc acacatccag tgccctgacc
     5881 aacctagagt tagctcccag cccttggtca gcaccgggga tgggactgct gaggtgtgcc
     5941 catgggatgc tcctgactcg gacagtgaca ccaaggttga gccctgtgcc cagaaggtga
     6001 ctgggagagt tacagagaca gagatgtcaa gacaagatga aaaggagaaa tctcaagagg
     6061 agaaagagcg agcccctgaa acacgagatc acgaaggtgt ggccgttcag aaaatgccac
     6121 agaccagcaa ctttgggaag caggaagctg tgtgtcccag ggagagtcag gactttgggg
     6181 tgcaagcagc tacagatgct tctgatggaa gcaaaggcgg ttctgagaaa gtgtgtcctt
     6241 gggaagtaga agaggtccct tctatcaagg aagctgagat ctgcccctgg gaggcaagtc
     6301 caggagctgt gggggagggg gcgctggacc tggggcagga tggagagtca cagggggagg
     6361 gaagggctga aagacatctc ttgaaggcag cagagacagt ctgcccctta gaaggcacaa
     6421 tgtcatcagg gctcttcacc caggaagacg tggtggacac agacctcccc aaggttggtc
     6481 ttcatggagc aagcagccca gggaaagggc tagcagaact gtgtgtgtgg gaagtcacag
     6541 acccggaagg aaataaaatc aagggtacca tggcagacat ctgtccctgg gaggagacta
     6601 gagcccaatc tgatgaatct ggccccctgg ctttaccagt aacccaggca ggtgtgccag
     6661 ctgcccctga gaaatcagtc tgtctctcgg tacacggacc gttggagagc tttctcccag
     6721 agagcaagag tgtccgccca gacatcagca agccacctgg ctcttcccgc ccggaaggcg
     6781 tcagagaaca agaacctttg gagcttgaga ctggagccaa gtcagttcca aagccaagcc
     6841 ccacagaaac ggaggctcca gagtctttca ccttaactga cgaccaagga ctaatggctt
     6901 ctgaaggaga ggctggagaa ctcagccctc cccctgacta cccttgggac tgtgaatgac
     6961 agcaccctcc ccctgactac ccttgggact gtaaatgaca gcaccccccc ctggctaccc
     7021 ttgggactgt gaatgacagc accctacccc tgactaccct tgagactgtg aatgacagca
     7081 ccctccccct gactaccctt gggactgtga atgacagcac cctggtgggg gtcagaactc
     7141 cttcaggaca cttcctgtgt tccagtgttc ccaaagagct gactcaaaga tagcttgggt
     7201 acttcctggg cccaggaggc cagatggcaa cccattcaga aggaactgta gaagaagggt
     7261 tggagcccag gggacattct gttctcccca cttctctccc tgcttcagga aacagaaact
     7321 agaccttcat cttctaaaga gttctgccat tcgtccagag taccctacac agctgttcaa
     7381 actggaattc tcccaaagtt tacccaaggt agcaaaacaa ctagagcact taagggagta
     7441 gcaactgggg actgtgggca agagaaggct ataaggccat gtagttcagg atgaaagatg
     7501 agatggctct gtgattgaga gcgcatgctg ctcttgcaca ggacccaggt ttggatctca
     7561 acggccaaga caaatcggct tataaccact tgtgactcca gcttggggag gggggtgtcc
     7621 tccaatttct tctcctggtc tctgaggcta cctacactca tgtgcacata tccccacaga
     7681 gacagacata tagagagaca cacacacata tacacacaaa attaaaataa atatttaaaa
     7741 gatgaaaact aaaccagagg aaaacaaaga caaaaataat gtgtctggaa aaaagcctca
     7801 caggcctaga ccttgcccct ctccccaccc ctttccctga cacgtggtcc catagaggac
     7861 gggctgggac atctaaaaat caggatgtag ctaaggctga acttttatct tccggtcctc
     7921 ctgcctccac ttcctggggt ccaggatcac aggtgtacaa cgccatggcc agtttacaca
     7981 gaggccatag agtaaacttc ctgtgtgcta ggcaagcact ctgtcacctg aactacatcc
     8041 ccagccagcc tttgtctttc tgtgggtacc tgtggtgctg ggacccgaac cctcaggaat
     8101 actaatcgag caccctccca ctaagccaca ccctcagggc aaggggcgtg tcttttgacc
     8161 tgactcttcc gtttctgctt cactacttct catgtgtacc ctgaccgttg gctgacgtag
     8221 caacagtcag acactctgac atttatgtca cggctggtat ccaaagtgac aacagagaac
     8281 agagaaggag agacgctctc tcagggccct cccacactgg acaaggtgtt cttcccgatg
     8341 tctccaggaa gcctcttccc atattcctgc cccagctctt gccacgtcca ggccccacct
     8401 cactgcctcc tcctccttgt ctttctgtag tcagcaagcg gaccctcttt ttagtaaatg
     8461 taactggtgc caaggaggaa tctctggttc tcaagcaaga acttgactct aactcactca
     8521 gatctcttcc cagaggagcc tgggaaagaa tagagggcct gttcaatccg aatcccaacc
     8581 actatcagaa agagtagcgc tccccagggc cgggaaaggc acctcgtgag tacaaagcct
     8641 ctttctcagc cgtccacccg cagcttggct ctcctctcca caatcagttt aggccacctt
     8701 gcttaagcag tgcgagatga cagggttggt gtcatgtgat gggaaactaa gaaggagaaa
     8761 aacttataca gaggttccag cttgagagag ggagatgggg gtgaagacaa gcaggctaat
     8821 gtggcagagc cagcaggcag gggcattaaa gacaacggtg taagtcccac cctctaaccg
     8881 gagtgataca ggtgctgttt aagaggtaga aaacctcaaa tgagaccaaa tgcctggtgg
     8941 gagaaccagg agtccacatg caaaatcgct gaacagactc agagcctcag agaaaagcaa
     9001 ccgaatgctc cacttctgaa agagagtcgc ctggtctcct ttgggggcca gtggccctca
     9061 ttcccacact aagccctcct acctacccag ctctcctgcg ctgggtttct acagctgtat
     9121 tgttctgcgg ctgtggttac ttaaccccac agcttctgag ctatggtaga cttcactaac
     9181 tgtgcaccct agagcaatcc cactgggtct gttctagctg ggacgagcat cgttatcccc
     9241 gtattactgt tataaatagc cacctaggaa aataataaag aatgcttgtt ctcgg
//
