LOCUS       NM_201367               3911 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 176 (Gpr176), mRNA.
ACCESSION   NM_201367 XM_355375
VERSION     NM_201367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3911)
  AUTHORS   Tang,J., Peng,W., Ji,J., Peng,C., Wang,T., Yang,P., Gu,J., Feng,Y.,
            Jin,K., Wang,X. and Sun,Y.
  TITLE     GPR176 Promotes Cancer Progression by Interacting with G Protein
            GNAS to Restrain Cell Mitophagy in Colorectal Cancer
  JOURNAL   Adv Sci (Weinh) 10 (12), e2205627 (2023)
   PUBMED   36905238
  REMARK    GeneRIF: GPR176 Promotes Cancer Progression by Interacting with G
            Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
REFERENCE   3  (bases 1 to 3911)
  AUTHORS   Yamaguchi,Y., Murai,I., Takeda,M., Doi,S., Seta,T., Hanada,R.,
            Kangawa,K., Okamura,H., Miyake,T. and Doi,M.
  TITLE     Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting
            of Circadian Locomotor Activity
  JOURNAL   Biol Pharm Bull 45 (8), 1172-1179 (2022)
   PUBMED   35908898
  REMARK    GeneRIF: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced
            Light-Resetting of Circadian Locomotor Activity.
REFERENCE   4  (bases 1 to 3911)
  AUTHORS   Wang,T., Nakagawa,S., Miyake,T., Setsu,G., Kunisue,S., Goto,K.,
            Hirasawa,A., Okamura,H., Yamaguchi,Y. and Doi,M.
  TITLE     Identification and functional characterisation of N-linked
            glycosylation of the orphan G protein-coupled receptor Gpr176
  JOURNAL   Sci Rep 10 (1), 4429 (2020)
   PUBMED   32157140
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3911)
  AUTHORS   Doi,M., Murai,I., Kunisue,S., Setsu,G., Uchio,N., Tanaka,R.,
            Kobayashi,S., Shimatani,H., Hayashi,H., Chao,H.W., Nakagawa,Y.,
            Takahashi,Y., Hotta,Y., Yasunaga,J., Matsuoka,M., Hastings,M.H.,
            Kiyonari,H. and Okamura,H.
  TITLE     Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets
            the pace of circadian behaviour
  JOURNAL   Nat Commun 7, 10583 (2016)
   PUBMED   26882873
  REMARK    GeneRIF: Gpr176 is an suprachiasmatic nucleus-enriched orphan
            G-protein-coupled receptors that sets the pace of circadian
            behavior.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3911)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3911)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 3911)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929163.5 and AL845495.9.
            
            On Apr 28, 2010 this sequence version replaced NM_201367.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052037.1, CB527064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AL929163.5         49516-49916         c
            402-654             AL845495.9         159881-160133       c
            655-3911            AL845495.9         153073-156329       c
FEATURES             Location/Qualifiers
     source          1..3911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.4 cM"
     gene            1..3911
                     /gene="Gpr176"
                     /gene_synonym="Gm1012"
                     /note="G protein-coupled receptor 176"
                     /db_xref="GeneID:381413"
                     /db_xref="MGI:MGI:2685858"
     exon            1..401
                     /gene="Gpr176"
                     /gene_synonym="Gm1012"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1780
                     /gene="Gpr176"
                     /gene_synonym="Gm1012"
                     /note="probable G-protein coupled receptor 176; G-protein
                     coupled receptor AGR9"
                     /codon_start=1
                     /product="G-protein coupled receptor 176"
                     /protein_id="NP_958755.1"
                     /db_xref="CCDS:CCDS16575.1"
                     /db_xref="GeneID:381413"
                     /db_xref="MGI:MGI:2685858"
                     /translation="MGHNSSWVSPNTSHPRNTSGAEAGANLSAFGELSEAQLYRQFTT
                     TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASVVCVPFDIILSS
                     SPHCCWWIYTMLFCKVLKFLHKVFCSVTVLSFPAIALDRYYSVLYPLERKISDAKSRE
                     LVMYIWAHAVVASVPVFAVTNVADIYAMSTCTEVWSNSLGHLVYVLIYNVTTVIVPVA
                     VVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVTVFIL
                     CSVPYATLVVYQTVLNVPNTSVFLLLTAIWLPKVSLLANPVLFLTVNKSVRKCLVGTL
                     VQLHHRYSRRNVVSTGSGVAEPSLEPSMRSGSQLLEMFHIGQQQIFKPSEDEEESEAK
                     YLGSADFQAKEVLTSCPEGEQEPPQLAPSVPPPGTVDSEPRVSPVAPMESGIFPDKYS
                     LQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPRVNRVERKMSRNNKVS
                     IFPKVDS"
     exon            402..654
                     /gene="Gpr176"
                     /gene_synonym="Gm1012"
                     /inference="alignment:Splign:2.1.0"
     exon            655..3911
                     /gene="Gpr176"
                     /gene_synonym="Gm1012"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgctgac gggcccaggg gggagcaggc atggggcgcg gccgcacctc cctcccaccc
       61 ctcctcgcgg atggctggct aggcgatgag cagacgtgag gggctagccg gctggccggc
      121 tctgcaggac gctgcctggc tcccgagcgt cggtccctcc acgcccgggg caggagcggc
      181 tgtgcgctgg gctcagaggc caggcggacg agcgcaaacc ccgggcttcg ctatggggca
      241 caacagcagc tgggtgtcac cgaacaccag ccacccgcgc aacacgtcgg gcgccgaggc
      301 tggcgccaac ctcagcgcgt tcggggagct gagcgaggct cagctgtacc gccagttcac
      361 caccaccgtg caggtcgtca tcttcattgg ctcgctactg ggaaacttca tggtgttatg
      421 gtcaacttgc cgcacaacag tgttcaaatc tgtcaccaac aggttcatta aaaacctggc
      481 ctgctccggg atttgtgcca gtgtggtctg tgtgcccttc gacatcatcc tgagcagcag
      541 ccctcactgt tgctggtgga tctatacgat gctcttctgc aaggtgctca aattcctaca
      601 caaggtgttc tgctctgtga ctgtcctcag ttttcctgct attgccctgg acaggtacta
      661 ttcagtcctt tatcctctgg agagaaaaat atctgatgcc aagtctcggg agctagtgat
      721 gtacatctgg gctcatgcag tggtggccag tgtccctgtg tttgctgtga ccaatgtcgc
      781 tgacatctat gctatgtcca cctgcacgga agtctggagc aactccttgg gccacctggt
      841 gtatgttctg atctacaatg tcaccacagt cattgtgccc gtggctgtgg tatttctctt
      901 tctcatcctg atccggaggg ccctgagtgc cagccagaag aagaaagtca taattgctgc
      961 actgaggacc ccacagaaca ccatctctat cccctatgct tcccagcgag aggcagagct
     1021 acatgccacc ctgctctcca tggtgacagt tttcattctc tgcagtgtac cctatgccac
     1081 cctggttgtc taccagactg tgctcaatgt acctaacacc tctgtcttct tgcttctcac
     1141 ggccatttgg ctgcccaaag tctctctgtt ggccaaccct gtgctcttct taactgtgaa
     1201 caaatcggta cgcaagtgct tggtggggac cctggtgcag ttgcaccacc ggtacagtcg
     1261 ccgcaatgtg gttagtacag ggagtggggt ggctgagccc agccttgagc ccagcatgcg
     1321 ctctggtagc cagctcttgg agatgttcca cattgggcag caacagatct ttaagccctc
     1381 ggaggatgag gaagaaagtg aggccaagta tctcggctca gccgatttcc aggcaaagga
     1441 ggtgctcact tcctgcccag agggcgagca ggagccacca cagcttgcac cgtctgtgcc
     1501 acctccaggc acagtggact ctgaacctcg ggtgtcccca gtagctccca tggaatctgg
     1561 gatatttcct gataagtatt ccctgcagtt tggctttggg ccttttgagt taccccctca
     1621 gtggctctct gagacccgaa atagcaagaa gaggctgctt cccccactgg gcaatacccc
     1681 agaagagctg atccagacaa aggtgcccag agtgaacagg gtggaacgga agatgagcag
     1741 aaacaataaa gtgagcattt ttccaaaggt agactcctag caaggcctgt gagggcccgg
     1801 aagccacagg gagcttgtgt agtcctgttc ccccctcact ctggctgcaa gccaccgtgg
     1861 ggcgacaact cctctatggg gcagatgctt ctgagtgaaa gggaagtcta cataaatcca
     1921 atgtcctctt tattgaggga gtatatatta tctatcttag tggtctgtgt ccttcgtcac
     1981 attcagtgta aactgggcag atcggaacat ttttttctgg gagattcctc ctttccctgt
     2041 gtacaacaga gaactcaaag ggagtaggca ctctgagagg cccaggataa ttatgggcat
     2101 cattggccac aaagaggaag ctgatttggt tttatttatt ttttatttta ttttattttt
     2161 tttgagactg gatctctcta tatagcccca ccatatagac cgggctggct ttgaactcag
     2221 agatccactt gcctctgcct tctgagagct gggattaaag gccttgcccg catgcccact
     2281 taagaaacat atttggatag ctaaataaga ataacaaaca gaaagatatc tgtactgaga
     2341 agacagagcc atggtgtcca atgctgttcg ctagattttg caaccacctg gatcctgttt
     2401 gccgataccc ctcatccgga tttctgggtc ataaaggggg gatgactggt cctaccttgt
     2461 ggcagacagg gcagtatcgg agggagcctt tttgtccttg attatctttc catcctgttg
     2521 gtatcaccaa ggcctcccac aaatgtccct tctgtcacca gtcaccactg ctgccaggaa
     2581 accactgcca acccttcctt cgctgtatgt ccgtttaaac tgcacttgat cagcaacaag
     2641 gagagaagct ttgtggcagt gaaggcaggt tgagaaatgc ccacgatgca tagcttttct
     2701 ttctttgacg tgatctagaa caaaagacta gagtcagtat agtgggatat attgagtgac
     2761 gtataggcac aaagtaaaac gtcatagttg gcaaatgttt ggagttaaaa ggtgctgaag
     2821 aaatgtaggt gacatgcact gggtcctttg acacctttaa ggtaaacttc ctttattagc
     2881 acaagtgatt ctgccccagg acttgttagt ctgacctata gaatgggccc gcctgacagt
     2941 ctcattttca atatgttcaa tgattctggt ccccagagaa ggtgagcaga gcaaggagaa
     3001 ataatgattg caaaatgcta aagcaatacc caccctgatt tagcacctca ccccctactt
     3061 cccagtgaag gttcagtctg agccatggtg gatgggagaa cgtgttcttt cagcagccca
     3121 atgtcctggt tctcacgtgt gagccactct gggactgatg taccaggcct aattccaacc
     3181 aaaccctccc ctcatacgtc aagtctgcag ctctgctctt ctttagggtg ctttgttctt
     3241 gttcgtggta cttagtggag ccagccggct ggcttgaatg gatgggtgtt ccttactggc
     3301 aaacctctac atctcaaagg cagtggtcct agcagcctgt ttagtcatgc tggcccatct
     3361 cccctaggca gaagttcagt ccatgtgtgg ggagactcct tttctttcct tctgttgtgt
     3421 tatgtcttgt gaacctcaaa atcttctcct tgaagaggga gcaccttcct ttctgtgcac
     3481 cacctcacag acttgtttgc ttgccataga gacagggcac tgcacccctc ttgaggctct
     3541 gtggccctcc gggccccgtg tacatgccat ctgtagccct tggtcctgac tctgtgttaa
     3601 tgctgtggcc cttcaagctc atctttcaaa gccttcttaa ttgatacagc ttttactaag
     3661 gggaaaaaac aatctgtcag aatattgtat gtacctgaga agaacctgtg aaataaacct
     3721 gtgttgctgt caccgtcctg acatgtgtat gtatgacttt agtacattct caacaacaga
     3781 gtttcgttca ccaaattctc atgtaagctt gaaagagaag gctgacgcct aacaggctgt
     3841 caccgagtgt atttctatac tctttgaaga ataacatttt aataaaaatt acaaagctgt
     3901 ttctgagctc g
//
