LOCUS       NM_001358747            5207 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus G protein-coupled receptor 174 (Gpr174), transcript
            variant 4, mRNA.
ACCESSION   NM_001358747 XM_006527932
VERSION     NM_001358747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5207)
  AUTHORS   Yan,J., Zhang,C., Xu,Y., Huang,Z., Ye,Q., Qian,X., Zhu,L.,
            Huang,G., Wang,X., Jiang,W. and Zhou,R.
  TITLE     GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor
            immunity
  JOURNAL   Nat Immunol 25 (11), 2057-2067 (2024)
   PUBMED   39358444
  REMARK    Erratum:[Nat Immunol. 2024 Nov;25(11):2167. doi:
            10.1038/s41590-024-02001-w.. PMID: 39375551]
REFERENCE   2  (bases 1 to 5207)
  AUTHORS   Liu,J., Pan,L., Hong,W., Chen,S., Bai,P., Luo,W., Sun,X., He,F.,
            Jia,X., Cai,J., Chen,Y., Hu,K., Song,Z., Ge,J. and Sun,A.
  TITLE     GPR174 knockdown enhances blood flow recovery in hindlimb ischemia
            mice model by upregulating AREG expression
  JOURNAL   Nat Commun 13 (1), 7519 (2022)
   PUBMED   36473866
  REMARK    GeneRIF: GPR174 knockdown enhances blood flow recovery in hindlimb
            ischemia mice model by upregulating AREG expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5207)
  AUTHORS   Wolf,E.W., Howard,Z.P., Duan,L., Tam,H., Xu,Y. and Cyster,J.G.
  TITLE     GPR174 signals via Galphas to control a CD86-containing gene
            expression program in B cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (23), e2201794119 (2022)
   PUBMED   35639700
  REMARK    GeneRIF: GPR174 signals via Galphas to control a CD86-containing
            gene expression program in B cells.
REFERENCE   4  (bases 1 to 5207)
  AUTHORS   Wang,J., Hu,Y., Kuang,Z., Chen,Y., Xing,L., Wei,W., Xue,M., Mu,S.,
            Tong,C., Yang,Y. and Song,Z.
  TITLE     GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With
            Sepsis via Regulating the Inflammatory Response
  JOURNAL   Front Immunol 12, 789141 (2022)
   PUBMED   35173706
  REMARK    GeneRIF: GPR174 mRNA Acts as a Novel Prognostic Biomarker for
            Patients With Sepsis via Regulating the Inflammatory Response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5207)
  AUTHORS   Wang,X., Cai,J., Lin,B., Ma,M., Tao,Y., Zhou,Y., Bai,L., Jiang,W.
            and Zhou,R.
  TITLE     GPR34-mediated sensing of lysophosphatidylserine released by
            apoptotic neutrophils activates type 3 innate lymphoid cells to
            mediate tissue repair
  JOURNAL   Immunity 54 (6), 1123-1136 (2021)
   PUBMED   34107271
REFERENCE   6  (bases 1 to 5207)
  AUTHORS   Barnes,M.J. and Cyster,J.G.
  TITLE     Lysophosphatidylserine suppression of T-cell activation via GPR174
            requires Galphas proteins
  JOURNAL   Immunol Cell Biol 96 (4), 439-445 (2018)
   PUBMED   29457279
  REMARK    GeneRIF: Lysophosphatidyl serine acts via GPR174 and Galphas to
            suppress IL-2 production by activated T cells
REFERENCE   7  (bases 1 to 5207)
  AUTHORS   Barnes,M.J., Li,C.M., Xu,Y., An,J., Huang,Y. and Cyster,J.G.
  TITLE     The lysophosphatidylserine receptor GPR174 constrains regulatory T
            cell development and function
  JOURNAL   J Exp Med 212 (7), 1011-1020 (2015)
   PUBMED   26077720
  REMARK    GeneRIF: The lysophosphatidylserine receptor GPR174 constrains
            regulatory T cell development and function.
REFERENCE   8  (bases 1 to 5207)
  AUTHORS   Napier,C., Mitchell,A.L., Gan,E., Wilson,I. and Pearce,S.H.
  TITLE     Role of the X-linked gene GPR174 in autoimmune Addison's disease
  JOURNAL   J Clin Endocrinol Metab 100 (1), E187-E190 (2015)
   PUBMED   25295623
REFERENCE   9  (bases 1 to 5207)
  AUTHORS   Kihara,Y., Maceyka,M., Spiegel,S. and Chun,J.
  TITLE     Lysophospholipid receptor nomenclature review: IUPHAR Review 8
  JOURNAL   Br J Pharmacol 171 (15), 3575-3594 (2014)
   PUBMED   24602016
  REMARK    Review article
REFERENCE   10 (bases 1 to 5207)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663081.10.
            
            On Dec 7, 2017 this sequence version replaced XM_006527932.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An
            upstream AUG is present that would result in a 13 aa N-terminal
            extension, but it has a weak Kozak signal and is absent in other
            mammals, whereas the annotated dAUG has a stronger Kozak signal and
            is well-conserved among mammals.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AL663081.10        35463-35701
            240-343             AL663081.10        35981-36084
            344-425             AL663081.10        48467-48548
            426-496             AL663081.10        68051-68121
            497-5207            AL663081.10        71644-76354
FEATURES             Location/Qualifiers
     source          1..5207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.48 cM"
     gene            1..5207
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /note="G protein-coupled receptor 174"
                     /db_xref="GeneID:213439"
                     /db_xref="MGI:MGI:2685222"
     exon            1..239
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            240..343
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..425
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..496
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..5207
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1022..2029
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /note="putative purinergic receptor FKSG79"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 174"
                     /protein_id="NP_001345676.1"
                     /db_xref="CCDS:CCDS30348.1"
                     /db_xref="GeneID:213439"
                     /db_xref="MGI:MGI:2685222"
                     /translation="MTDNFTCNKTDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVF
                     YGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM
                     YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIIGWLIICLACLLFPLLRTNDD
                     TPGNRTKCFVDLPIRNVNLAQSVAMITIGEVVGFVTPLMIVLYCTWKTALSLQNKYPI
                     SQHLGEKKKALKMILTCAGVFLVCFVPYHFSFPLDFLVKSNEIKSCFARRVILIFHSV
                     ALCLASLNSCLDPVIYYFTTNEFRRRLSRQDLPDNIQLHTKSYKIASNHATSTVAAEL
                     C"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /note="hexamer: AATAAG"
     polyA_site      3751
                     /gene="Gpr174"
                     /gene_synonym="Gm376; Lypsr3"
                     /note="major polyA site"
ORIGIN      
        1 attaatgaga aaggagagag agagagagag agagagagag agggagagag agagagagag
       61 agagagagag agagagagag agagagagag agagagagag aggagggagg aaaggggaag
      121 ggagggagag agagatctgc tcacccactt gaaaacggaa atcttcaatg tattcagaac
      181 agcttgcata tttcactctg acaactcact accatatttt ccaacatggt agtggtttga
      241 aaacggagct ggatcaatgc acagatcagt agcatcctca ttggagtggc tgtcacatga
      301 attctttgga gacttctgga gaaaagagaa agaaactgaa acggcatgaa tgaaataatc
      361 agccctgtta tcacagtatc tgcaggggac ccgaataaga acttctatca gcgctggata
      421 aaacaatttt aatattcaag aagagaaagg ccacacacct ttttcccact gtctgttcta
      481 tggcaatatt attaagatct gaaaaagtct tgggaaaaaa aagaaccatc aaaataagtc
      541 atcttcaaac agtggctgag ccagcctgca ctgaagcaaa cctttcttct ctgtgtgcca
      601 gatgtctctc cccaaaagaa catgaaacgt ccttccaaac acctgtaaag tgataaccat
      661 catatgggaa tttgagaagt tgatgtatga catagttatg aatcaaatga gaaatatcct
      721 ctttccatga tgtcctggcc tggaagacct taccacaaaa taaacaagag aagaacattt
      781 taacaacttt tcatgtgtgc ttgcacaatg gatttctgtg gttatgtata caaagctgag
      841 gcataaatac agccaggttt ttttagactt cccaaatcat gtgtagaggc taacaattgt
      901 ggcaaaagtt tgttttatac tctgtctctc tgagccactg acttgtggac agtacagaag
      961 ttacttgtgg atttaaattt gaatgaccag taggcaaaga aaatttctct tggaaataat
     1021 catgactgat aattttacat gtaacaagac agatggagac aatacagatt tccggtactt
     1081 catttatgca gtgacataca ctgttattct tgtgccaggt cttataggga acatattagc
     1141 cttatgggta ttttacggct atatgaaaga aaccaaaagg gctgtggtat ttatgataaa
     1201 cctagccatt gctgacttat tacagattct ctctctgcca ctgaggatct tttactactt
     1261 gaaccatgac tggccatttg gtcctggtct ctgcatgttt tgtttctacc tgaaatatgt
     1321 aaacatgtat gccagcatct acttcttggt ctgcatcagt gtgcgaagat tttggtttct
     1381 catgtacccc tttcgtttca atgactgcaa acagaaatat gacttgtata tcagcattat
     1441 tggctggctg atcatctgcc ttgcctgcct gctctttcct ctcctcagaa ccaatgatga
     1501 tactccaggt aacagaacca aatgctttgt ggatcttcct atcaggaatg ttaatctggc
     1561 ccaatctgtt gccatgataa ctatcggaga ggtggttggg tttgttactc ctcttatgat
     1621 tgttttatac tgtacctgga agacagcttt gtcattacaa aataaatatc ccatttctca
     1681 acatcttgga gagaaaaaga aagccctgaa gatgattctg acctgtgcag gggtgtttct
     1741 agtttgcttt gtaccttatc acttcagctt tcctttagat ttcctggtta agtccaatga
     1801 aattaagagt tgctttgcca gaagagtgat tctaatattt cattctgtgg ccctgtgtct
     1861 ggcaagcctg aactcctgtc ttgacccagt tatatattat tttaccacta atgagttcag
     1921 aagacgcctt tcaagacaag atttgcctga taacatccaa ctccatacaa aatcatacaa
     1981 aattgcaagt aaccatgcca cttctaccgt ggcagctgaa ctatgttaaa taaaacccag
     2041 aactgaacat ggcctggaat gcaaatacca gaacacattt gcagtacctc atcaagacag
     2101 tattcacagg aagtattcat aacctttcag tgtggtctat attacttaca tggggaatgc
     2161 acatatttat gacaatacct gtttagaata ttgcatttca atatcattgc tggtgacatg
     2221 tccatgcggt aatgttggac caactcttta agacgtaaat ggtgaaattt tgataatact
     2281 gcgcacatat tctctcagct agagtcatca gctttatctg tgaacctaag tcacaaaatc
     2341 aattactaac tcaagcccat tttaagcact gagttttctt accacagttg ctgaatctat
     2401 gttcaaaagg tgtgcaattg tccatttgta gtagtgatca cagtttgcat tccaacaaca
     2461 tatttggttg tttttaaagt ggggtgggca aaactttatg tgtacatagt gttacaaaaa
     2521 cagggtaatt gttatttccc aagtgtgatt ccattcaagg atttgaaact ccaatgcttt
     2581 atttcttcag ttagttttaa tatgaaacat catctgtcac attacttgtt gaatgaattt
     2641 ctgaaaccag gctctggtac acttaaacta agaacaacaa acattcatga cacatagtaa
     2701 tcctctgtaa ttgtataaaa tgatacattg aatagtccca gggcaggtag ttttctacag
     2761 ttaaggcaac atgagtcaga tggcctttat gctttagaga aaggaaagag gtgacaacca
     2821 caattctggc tctctgaaac taggtccaaa gaataccttc aggtatatat gtatgaacat
     2881 gcctaggaga gggatagctt ttcatcataa tttagaatta cattgaagca atctgatagg
     2941 ttattactgc atttactgag cctatggaag aaacagtgca ccaattagtc gctaagcttg
     3001 ggcagagtga aaatatgaac caaagtgaag tataagtctt aaaaatcact attatccttt
     3061 aagtattctc caaggtaagt ggtgcctatt aagacatcta cacaagccag agtgtgacat
     3121 aaagacactg gtcatgtgga cttttaaatc tgcacttttc cagttaagtt atatgattat
     3181 aaagcctaca aagattacct ctcagaaact gttggaagca attctttcac cttttgagaa
     3241 aagtgtggat cattccagca gccatataca tccttacaaa agctatgtct actatctgtt
     3301 tagtactatt gagcaggaaa aactcgggta tgtggttgta agcactggaa tattctgaag
     3361 catgatatac attgtaaata agattacttt cagaaatcgt tgaataagag aatggggaga
     3421 aaacactctc ctttacattg agaaaataaa gaaatcaagc aagacatgca gttttaggga
     3481 tatagttaat gatactatat gttttaggaa aaactcatta aatggacatg aattttagct
     3541 tctaatacta gtgggaaacc tctaaagttt tgtttgagta agtaacaaaa atgtagtgct
     3601 tatgtttgaa cagtttatga aaataataat gtattagaaa aaatgagttt gtgctgctag
     3661 caacagtata tttatatata tcctaatcat tccttgtgat gtacatatgt tttgatgtat
     3721 taaataagtg ttaaattttg ttttcaaaaa agaaactata aatgtgtgtg gtctatttgt
     3781 tttaaagtga tttctgtttg attgtaagtt tgtatcataa tgagattaca agtaatcatt
     3841 tgtgaaacta tgaaacaact gtgggtgctt gaaatagtgc tcacacttaa aatatctatg
     3901 cctactattt ttttgtagca tgtgttacac tttttaaagt cactttggga gatcactgtt
     3961 ggaacgtttt tctaactttg atttcgttat actcatacca tttttcaagg gagaagaaat
     4021 acttctagga cattattgac cactgtagag tagttgagat tacagctcat ttgttagata
     4081 ttacttctcc atcatttagt gataagtcaa atgtctaatg attttatgct atttatctac
     4141 ccagatctgt ctatctgggt ttatattcag catctgaata ctgaatcaga gcaatttttc
     4201 tgattcttca acttcctcat cagtacattt caattttgct ccatcccctt ctccttctga
     4261 tcaacttatt cataataagg tgctaattat aatgttaact tcatattaat ttaccaagaa
     4321 atatctgaag ttcatacctt acaaataggc attaacacga agtacagaaa tccaaatgga
     4381 gcaatttcag acacagggag atgtggtaga ggggaagaca ctataaagaa attgagtctt
     4441 aaagcaatcc tttcaaataa tgcattacaa atggccatct actctggttg ccattgtgag
     4501 gatgctaaat tccaagaaat agctctataa acatgggtgt acattttcca gattgttgct
     4561 tgagattttt cttctaccct atctctcttc taacactgga cctagttttc agaaaaaaaa
     4621 acaaaaaaca aaaaactaat gctggagaaa atagtgcttc ggccaccaag caggcgcctc
     4681 tttactgagg ttccactctt cttggaaagt cttttcctca gatctcttat ttatcatttt
     4741 gagttctata agattgaata caaagacaat ctgaatgatg gcaatatata agtaaaggta
     4801 aatcatctca tatttctttt ataaacttgt taaaatttta gtcttaaaat taagcaaatt
     4861 atttaataag aaaatttgaa tatatatcat ttaatgctaa taaattgtct ttattgttgc
     4921 tcttattatt ttaatggcat ggtttatatg ttatatgtta tcattgacat gtaataaaac
     4981 agcaaatcct attaatcagt agtttatgaa gaggagccat ttgccctaca aataacaaac
     5041 cgagttgcca tgctctatag ggattcatca gaggaactct gcacagttta atttttatgc
     5101 aatcttttgg gttaacttcc aagatactgt gaaatgttgt tactgaagtt tatttgcagc
     5161 tcttatttat catatgaatt ttaataataa agtttatctc tgtatgt
//
