LOCUS       NM_001359449            4895 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus G-protein coupled receptor 173 (Gpr173), transcript
            variant 4, mRNA.
ACCESSION   NM_001359449 XM_006528981
VERSION     NM_001359449.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   He,L., Shi,H., Zhang,G., Peng,Y., Ghosh,A., Zhang,M., Hu,X.,
            Liu,C., Shao,Y., Wang,S., Chen,L., Sun,W., Su,J., Chen,X.,
            Zhang,L., Chan,Y.S., Pei,D., Tortorella,M., Guo,Y., Yan,H. and
            He,J.
  TITLE     A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic
            Inhibition
  JOURNAL   J Neurosci 43 (13), 2305-2325 (2023)
   PUBMED   36813575
  REMARK    GeneRIF: A Novel CCK Receptor GPR173 Mediates Potentiation of
            GABAergic Inhibition.
REFERENCE   3  (bases 1 to 4895)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4895)
  AUTHORS   McIlwraith,E.K., Loganathan,N. and Belsham,D.D.
  TITLE     Regulation of Gpr173 expression, a putative phoenixin receptor, by
            saturated fatty acid palmitate and endocrine-disrupting chemical
            bisphenol A through a p38-mediated mechanism in immortalized
            hypothalamic neurons
  JOURNAL   Mol Cell Endocrinol 485, 54-60 (2019)
   PUBMED   30716364
  REMARK    GeneRIF: Study reports that Gpr173 is downregulated by palmitate
            and BPA in hypothalamic neuronal cell lines and primary culture,
            both partially mediated by MAPK p38 pathway. Also, palmitate
            impairs the capacity of the GPR173 putative ligand, PNX, to
            activate signaling in hypothalamic neurons. These findings
            contribute to the understanding of how fats and endocrine
            disruptors affect reproductive function.
REFERENCE   5  (bases 1 to 4895)
  AUTHORS   Larco,D.O., Cho-Clark,M., Mani,S.K. and Wu,T.J.
  TITLE     The metabolite GnRH-(1-5) inhibits the migration of immortalized
            GnRH neurons
  JOURNAL   Endocrinology 154 (2), 783-795 (2013)
   PUBMED   23321696
REFERENCE   6  (bases 1 to 4895)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731727.18 and CK627285.1.
            
            On Jan 4, 2018 this sequence version replaced XM_006528981.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.86491.1,
                                           SRR1660825.138951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               AL731727.18        59578-60245         c
            669-758             AL731727.18        58948-59037         c
            759-907             AL731727.18        58648-58796         c
            908-4881            AL731727.18        35126-39099         c
            4882-4895           CK627285.1         325-338
FEATURES             Location/Qualifiers
     source          1..4895
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..4895
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /note="G-protein coupled receptor 173"
                     /db_xref="GeneID:70771"
                     /db_xref="MGI:MGI:1918021"
     exon            1..668
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..758
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..907
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..4882
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1005..2126
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /note="super conserved receptor expressed in brain 3; G
                     protein-coupled receptor SREB3"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 173"
                     /protein_id="NP_001346378.1"
                     /db_xref="CCDS:CCDS30475.1"
                     /db_xref="GeneID:70771"
                     /db_xref="MGI:MGI:1918021"
                     /translation="MANTTGEPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILS
                     LLVLKERALHKAPYYFLLDLCLADGIRSAICFPFVLASVRHGSSWTFSALSCKIVAFM
                     AVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVF
                     DVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMK
                     PVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMD
                     EVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAA
                     VNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM"
     regulatory      4860..4865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /note="hexamer: CATAAA"
     polyA_site      4882
                     /gene="Gpr173"
                     /gene_synonym="3230401K02Rik; Sreb3"
                     /note="major polyA site"
ORIGIN      
        1 cgtccatccc ctccccaaca ccacctctgc tactgcctct ggctgtggac ctgcacctct
       61 tctccatcct cgccaggccc ggagagtggg gttagcctgg atgagagtgt gcccctaacc
      121 tggggccctc ccaagccatg gctcctgtgt tcccagggag gagtccagga ccctgagcat
      181 ctgctagaag cttggcagag gccccgctgg gaccgtgtct tctgaggaca aaaggctgcg
      241 gccagcaggc agactgggtg gggggtgggg gggaaccggt agctaggcag gcagaacagt
      301 agcggagcca acactggccc cctcccagac cggcggtggc atgaagatgg gggtgggagt
      361 gtgtagtggg agaagcacct accaggaccc ccatctgccc gctacttggg caccccaaag
      421 ctgtgtgctg cccacctggt gttccccaac atctccagct ctaccaagtg cacccctctg
      481 gcacctgctt cccttgctgc cagtgattta gatcaaccag gctgtatcca cggcaacaga
      541 agcaggagtg tcactggctg ccagatcagt gagggtccca caatgtggcc tgggctgtgg
      601 tttatcctgg atgagacaga gtgagtctcc ttcctgaatt ccaagacagt cctgctaaga
      661 gaacccagtc tctacctaca ggtaacatac ctttgctcac tcaccctgga agatgtgtcc
      721 cagctagtgg gaggaagctg ctataggaat agaggaagat acccatattg tgtttgggac
      781 ctccagatct atgacacagt aagccagagg tccctgtatc tggaggtgca ggaaaacctg
      841 gtatatggag aacatggatt ctactaggga cacggctcct aactactagt tcgcaacttt
      901 agtggaggtg tagctcagca agaaaactga tggagtccgc cagggcccat caaatactga
      961 actggccaat cccctagggt tgggggtagc ctttgcccct cagtatggcc aacaccaccg
     1021 gagagcccga agaggtgagc ggcgcactgt ctctgccatc agcatcggct tatgtgaagc
     1081 tggtgctgct gggactgatc atgtgtgtaa gcctggcagg caatgccatc ttgtccctgc
     1141 tggtgctcaa ggagcgtgcc ctgcacaagg ctccttacta ctttctgctg gacctgtgcc
     1201 tagccgatgg catacgctct gccatctgct tcccctttgt actggcttct gtgcgccatg
     1261 gctcctcatg gaccttcagt gcactcagct gtaagattgt ggcctttatg gctgtgctct
     1321 tttgcttcca tgcggccttc atgctgttct gcatcagcgt cacccgctac atggccatcg
     1381 cccaccaccg cttctatgcc aagcgcatga cactctggac atgcgcagct gtcatctgca
     1441 tggcctggac cttgtctgtg gccatggctt tcccacctgt ctttgatgtg ggcacctaca
     1501 agtttatccg agaggaggac cagtgcatct ttgagcatcg ctacttcaaa gcaaatgaca
     1561 cactgggctt tatgcttatg ttggctgtgc tcatggcagc cacacatgct gtctatggca
     1621 agctgctact cttcgagtat cgtcaccgca agatgaagcc agtgcagatg gtgccagcca
     1681 tcagccaaaa ctggacattc catggccctg gggctaccgg ccaggctgct gccaactgga
     1741 tcgctggttt tggccgtggg cccatgccac caactctgct gggtatccgg cagaatgggc
     1801 atgcagctag ccggcggcta ctgggcatgg acgaggtcaa gggtgaaaag cagctgggcc
     1861 gaatgttcta cgcgattaca ctgctcttcc tgctcctctg gtcaccatac attgtggcct
     1921 gctactggcg agtgtttgtg aaagcctgcg ctgtgcccca ccgctacttg gccactgctg
     1981 tttggatgag cttcgcccag gctgccgtca acccaatcgt ctgcttcctg cttaacaagg
     2041 acctcaagaa gtgcctgagg actcatgccc cttgctgggg cacaggaggt gccccagctc
     2101 ccagagaacc ctactgtgtc atgtgaagca agcccgtagg tgataggcag ggggaaagtc
     2161 agaatcacca tacgggggcc agcagcaggg gaagggtggg acccatacag aagccttctc
     2221 tttcaagctt cagtccaggc tctcaaacca tccataactg aggcaactcg ccaacacctc
     2281 cctagggttg gaaacggggt gaggaactgg aaaagaggca tttctagttt tgtggggatt
     2341 gtcccgcagc ctcctccact tcaacaatct ccttttccca tgccctccct gccttccctt
     2401 ccctctcccc tctcctatct ttctaaagta atgattcagt aaatgaaaac aaactgaaaa
     2461 tgcagggttt ttaataataa cagctgagga agtaggctct cttgcttaaa tgtcccccct
     2521 tttgacattg tcaagaaatg ggaagtttct cctgtaaaat agattcccag agatcgtatc
     2581 gtcccctggg ctcccattca ccctcccctt ccaaatcctt tagcaagact tggatgttta
     2641 ggaaatattg gcttaagtct tcagacaaga gggaccaaat ggggtgctat attccttggg
     2701 agcaaggatg tttaaattgc tatgtgctat gtgcaatgtt gtttttggct aaccttggtc
     2761 caaagcccaa tctccaatcc ctccctacca tgtccagact tcacaggtgt ttcttgaggc
     2821 tgtttgagaa gccaagagca tacaaagaag agcctccatg atgtgcccag gctagatgaa
     2881 gagcagaatg ggggatgggc tcctcaacca gaatatacca aacttagcta cgttcactca
     2941 agcttcctcc aggaatatat aactaacttt tcctcctagg aatatatatc cactttagtc
     3001 cccattaggg atgatgtggg tataagctga cagggaaagt cacccatggg gaaatagttg
     3061 aactctccag agtacctaga gcccagacca tggggtcaga gctaaattca accccacaat
     3121 tatcccttgg gttcacaata ctccccccta aaataaaatt ctttggagac cttgataatc
     3181 aaaagttata caaacttcaa ggcactgtgg aattgagtcc atttctgctt gacctctttt
     3241 tgtcccttcc aagcctcaca gtccttgagc tcctccttgg ttgggcccca aacatccttc
     3301 ccagaagttt tttctccatc cactcttaca ggtggatggt cccaagcctc ttttccatgg
     3361 acaaaaacca ctttgggctt acttcaaggc cagttctaca gactggtgag ccaagttgga
     3421 actctttgcc taagtctggg gcagtgatct ctccatctcc tttccttcct tataaactcc
     3481 tgtcctaaac tccacctcta ccccaagata ggccctgaac tgaggtagtc ttgacccaaa
     3541 agcaatgaag ggggcactct aggcagaaga gatattgatg accctggttg tggagtggcc
     3601 ctggaaaagc aagccagagg agctgagagg ctgggaatgt gtgtttgggg tggggctatt
     3661 ctctcagtga tgatgataga aatgcctttc tgagggctgg ggtgcaaaga ccaaggtggg
     3721 agggcaaata gggtaaactc gggagggttt tcctccgttt cctttttcta actgcctgga
     3781 ttcatcattg gattttgtaa atggaaaaag tgaaatgaac aatgttatat tggatgttct
     3841 ctctctctct ctctctctct ctctctctct ctctctgtgt gtgtgtgtgt gtgtgtgtgt
     3901 gtgtgtgtgt gtgtgtgtcc atgtctccta tctgtgtatg atcacatgag gaggtatgat
     3961 tgaatgagat agtgtgtgtc tgtgtgactt tgtgtgggta agaacctctg aggaaaactt
     4021 gcctggtaca catatgtgag caaatacata tatgtgaaga aatagagtat acacacacac
     4081 acatacacac aatggagagg agacaaaact tagtatgtgc ctgcagcagg aaatagagtg
     4141 cttaggagat ggaacctgaa atttttcatg tatgtatgtg tcaagagagt caactcccat
     4201 ctcataaagt tgtcttcctt tggcccagct tctgagcacc aggtaaggag agaatacttt
     4261 agaaccccat ctcttcccaa tgtctggaga ttcaatcctc accccaaatt tcaaacaagg
     4321 tatttcttat attagaccac catggaaata ggaactggga ataggggagg gatcaaacat
     4381 gaaggcaatg gggttaagaa atggccccct gcaatgtaat ggcttttaga ggaactgctc
     4441 agcctaaact gcaagtcctt cttacggttc cactgtatac agctgggact tggtttagct
     4501 ttgactaaat tcagaaggaa agataacata acgaaaaagc ccaagtctgg ggatctaccc
     4561 agctggccta ctccctaagc actcaattaa tttactattt atttacttat ttcttcaggt
     4621 gcacagaatt gagctgaccc tattactcag ttcttggcac actctatcat tggtccatgc
     4681 aaggtccttt tattattttg ctttgtcccc ttcatcaccc attcctgatc ccatccttcc
     4741 aaccccacat aggcaccgct cttcagtact taatgtgtgt ccttccaaac caccgttcat
     4801 gtgtttattt acttatgtgt atctgtggaa aatatatggt attgatgtgt tttaatttac
     4861 ataaacagta ttgtactata aaaaaaaaaa aaaaa
//
