LOCUS       NM_173398               2225 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor 171 (Gpr171), mRNA.
ACCESSION   NM_173398
VERSION     NM_173398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   McDermott,M.V., Ram,A., Mattoon,M.T., Haderlie,E.E., Raddatz,M.C.,
            Thomason,M.K. and Bobeck,E.N.
  TITLE     A small molecule ligand for the novel pain target, GPR171, produces
            minimal reward in mice
  JOURNAL   Pharmacol Biochem Behav 224, 173543 (2023)
   PUBMED   36933620
  REMARK    GeneRIF: A small molecule ligand for the novel pain target, GPR171,
            produces minimal reward in mice.
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Afrose,L., McDermott,M.V., Bhuiyan,A.I., Pathak,S.K. and
            Bobeck,E.N.
  TITLE     GPR171 activation regulates morphine tolerance but not withdrawal
            in a test-dependent manner in mice
  JOURNAL   Behav Pharmacol 33 (7), 442-451 (2022)
   PUBMED   35942845
  REMARK    GeneRIF: GPR171 activation regulates morphine tolerance but not
            withdrawal in a test-dependent manner in mice.
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Smith,N.K., Plotkin,J.M. and Grueter,B.A.
  TITLE     Hunger dampens a nucleus accumbens circuit to drive persistent food
            seeking
  JOURNAL   Curr Biol 32 (8), 1689-1702 (2022)
   PUBMED   35259342
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Fujiwara,Y., Torphy,R.J., Sun,Y., Miller,E.N., Ho,F.,
            Borcherding,N., Wu,T., Torres,R.M., Zhang,W., Schulick,R.D. and
            Zhu,Y.
  TITLE     The GPR171 pathway suppresses T cell activation and limits
            antitumor immunity
  JOURNAL   Nat Commun 12 (1), 5857 (2021)
   PUBMED   34615877
  REMARK    GeneRIF: The GPR171 pathway suppresses T cell activation and limits
            antitumor immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2225)
  AUTHORS   McDermott,M.V., Afrose,L., Gomes,I., Devi,L.A. and Bobeck,E.N.
  TITLE     Opioid-Induced Signaling and Antinociception Are Modulated by the
            Recently Deorphanized Receptor, GPR171
  JOURNAL   J Pharmacol Exp Ther 371 (1), 56-62 (2019)
   PUBMED   31308196
REFERENCE   6  (bases 1 to 2225)
  AUTHORS   Gomes,I., Bobeck,E.N., Margolis,E.B., Gupta,A., Sierra,S.,
            Fakira,A.K., Fujita,W., Muller,T.D., Muller,A., Tschop,M.H.,
            Kleinau,G., Fricker,L.D. and Devi,L.A.
  TITLE     Identification of GPR83 as the receptor for the neuroendocrine
            peptide PEN
  JOURNAL   Sci Signal 9 (425), ra43 (2016)
   PUBMED   27117253
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2225)
  AUTHORS   Gomes,I., Aryal,D.K., Wardman,J.H., Gupta,A., Gagnidze,K.,
            Rodriguiz,R.M., Kumar,S., Wetsel,W.C., Pintar,J.E., Fricker,L.D.
            and Devi,L.A.
  TITLE     GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a
            neuropeptide involved in feeding
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16211-16216 (2013)
   PUBMED   24043826
  REMARK    GeneRIF: GPR171 is a hypothalamic G protein-coupled receptor for
            BigLEN, a neuropeptide involved in feeding.
REFERENCE   8  (bases 1 to 2225)
  AUTHORS   Rossi,L., Lemoli,R.M. and Goodell,M.A.
  TITLE     Gpr171, a putative P2Y-like receptor, negatively regulates myeloid
            differentiation in murine hematopoietic progenitors
  JOURNAL   Exp Hematol 41 (1), 102-112 (2013)
   PUBMED   23022127
  REMARK    GeneRIF: findings indicate that the orphan receptor Gpr171
            negatively regulates myeloid differentiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115919.14.
            
            On Jun 19, 2009 this sequence version replaced NM_173398.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079674.1, AK089287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC115919.14        81234-81468
            236-2225            AC115919.14        84618-86607
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.94 cM"
     gene            1..2225
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /note="G protein-coupled receptor 171"
                     /db_xref="GeneID:229323"
                     /db_xref="MGI:MGI:2442043"
     exon            1..235
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /inference="alignment:Splign:2.1.0"
     exon            236..2225
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1280
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /note="probable G-protein coupled receptor 171"
                     /codon_start=1
                     /product="G-protein coupled receptor 171"
                     /protein_id="NP_775574.1"
                     /db_xref="CCDS:CCDS17370.1"
                     /db_xref="GeneID:229323"
                     /db_xref="MGI:MGI:2442043"
                     /translation="MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKTT
                     NHRCVSIYLINLLTADFLLTLALPVKIIVDLGVAPWKLRIFHCQVTACLIYINMYLSI
                     IFLAFVSIDRCLQLIHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKDIKEK
                     SNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSVIILISNFLAIRQLYRNRDNTNYPSV
                     KSALLHILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVS
                     NLCFDPILYYHLSKAFRLKVTETFASPKKSKPLEERLRSENDV"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /note="hexamer: AATAAA"
     polyA_site      1700
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /note="hexamer: ATTAAA"
     polyA_site      1755
                     /gene="Gpr171"
                     /gene_synonym="A630006E05; F730001G15Rik; H963"
                     /note="major polyA site"
ORIGIN      
        1 cttagttcag caggcgaccc tgcaaaatgg aactgctgtc actgtgggta actaaatagc
       61 tcctgattct ctgaagacct ggacctgggc ctactcaggc cagagaagac agccaggacc
      121 caggccttct caggccagag acgacacagc caggtacaac ctggacccag gcctgcttag
      181 gccagaaaag acagccagga ccctggcctt ctcaggccag agaagacaca gccagagcct
      241 tgaggggttt ttttttgttt tgttttggtt ttgttgtttt tttttttttt taattattga
      301 acttgacctt ctccctgaag atgacaaaca gttcaacgtt ctgtccggtt tacagagatc
      361 tggaaccatt tacctatttt ttttatttag ttttcctcat tggaattatt ggaagttgtt
      421 ttgccacgtg ggcttttata cagaaaacca caaatcacag atgtgtcagc atatacttaa
      481 ttaatttgct tacagctgat ttcctgctca ccctggcatt accagtaaaa atcattgttg
      541 acttgggtgt ggcaccctgg aagctaagga tattccactg ccaagtgaca gcctgcctca
      601 tctacatcaa tatgtactta tctattatct tcttagcctt tgtcagcatc gatcgctgtc
      661 ttcagttaat acacagctgc aagatatacc gaatacaaga acctgggttt gccaaaatga
      721 tatcagctgt cgtgtggctc atggtcctgc tgatcatggt gccgaacatg gtgattccca
      781 tcaaggacat caaagaaaag tcaaatgtag gttgcatgga gtttaaaaag gagtttggaa
      841 gaaactggca tttgctaaca aacttcatct gtgtggcaat atttttaaat ttctcagtca
      901 tcattttgat atccaacttc cttgcaatca gacaactcta tagaaataga gacaacacaa
      961 actatccaag tgtgaaatca gctctgctcc acattctctt ggtgacagct agttacatca
     1021 tatgctttgt tccctaccac gctgtcagga tcccatacac cctcagccag acagaggtca
     1081 tatctgattg ctcaactagg atcgcactct tcaaagccaa agaggccaca ctgctgctgg
     1141 cggtgtctaa tttgtgtttt gatccaatcc tgtactatca tctgtcaaaa gcctttcgac
     1201 taaaggtcac cgagactttc gcctcaccta aaaagagcaa gcctctggaa gaaagattga
     1261 gaagtgagaa tgatgtgtaa aatgcaggct ttgcacgtta gtccttcttc ctgactggac
     1321 cataaagctg gtcacagttt tcaaaaataa aagaagatgc tgagatagaa gaagatgctt
     1381 aggaataaga gccaccaata gctagcaaac gggactggtt catgcagaaa gtcctttctt
     1441 caatccaagc caaccctgca ctctcacaga tgctgacatt ctttacctaa caaagcacat
     1501 tgaaccaagg tcaactggaa tgatcaaagt ggggaggaca gccatggcaa agactcagaa
     1561 attcacttca atttctggaa catttacttt ctggatgaaa atatatcaaa taatctacat
     1621 ctaagttgcc aggaagccct tcagcgatac cttaaaggtc ttctgtgacc tagaaaaata
     1681 aaagcatcaa aatacctgca tcatttttat ttataactat tgccttgaaa ggtattaaat
     1741 gctctctatt caacactcct atttttaata tctaattttt ggtaacataa taacaacttt
     1801 ttgttatgaa aggtttacag taaccaggac aggaggtcac actggttaat tccagcaccc
     1861 tgggggctga ggcagaaaga ttatgagttt gaggctagct ggggctacaa agtgaactgc
     1921 aggccaccca ggtctataaa gtgagacctt atccctaatt aattttaaga ggcgtttgca
     1981 aatacatggg aatttttttt aacaatataa ggaagctact aaattacttt aactactgaa
     2041 attgttttgg aagtaaaaaa tccacatcaa aagtataaaa aaaaatcagc ttaagaatct
     2101 taaaatagac acatggactc atacagtagg ccattctaga aacatgggtg actctcagat
     2161 ctagagacaa ggccaaccag aatgaatctg cagtacaaag tacaagtcac cccattgctg
     2221 accag
//
