LOCUS       NM_001025381            5209 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus G protein-coupled receptor 17 (Gpr17), mRNA.
ACCESSION   NM_001025381
VERSION     NM_001025381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5209)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   2  (bases 1 to 5209)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5209)
  AUTHORS   Liang,Y., Kang,X., Zhang,H., Xu,H. and Wu,X.
  TITLE     Knockdown and inhibition of hippocampal GPR17 attenuates
            lipopolysaccharide-induced cognitive impairment in mice
  JOURNAL   J Neuroinflammation 20 (1), 271 (2023)
   PUBMED   37990234
  REMARK    GeneRIF: Knockdown and inhibition of hippocampal GPR17 attenuates
            lipopolysaccharide-induced cognitive impairment in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5209)
  AUTHORS   Boccazzi,M., Macchiarulo,G., Lebon,S., Janowska,J., Le
            Charpentier,T., Faivre,V., Hua,J., Marangon,D., Lecca,D.,
            Fumagalli,M., Mani,S., Abbracchio,M.P., Gressens,P., Schang,A.L.
            and Van Steenwinckel,J.
  TITLE     G protein-coupled receptor 17 is regulated by WNT pathway during
            oligodendrocyte precursor cell differentiation
  JOURNAL   Neurobiol Dis 187, 106315 (2023)
   PUBMED   37783234
  REMARK    GeneRIF: G protein-coupled receptor 17 is regulated by WNT pathway
            during oligodendrocyte precursor cell differentiation.
REFERENCE   5  (bases 1 to 5209)
  AUTHORS   Miralles,A.J., Unger,N., Kannaiyan,N., Rossner,M.J. and Dimou,L.
  TITLE     Analysis of the GPR17 receptor in NG2-glia under physiological
            conditions unravels a new subset of oligodendrocyte progenitor
            cells with distinct functions
  JOURNAL   Glia 71 (6), 1536-1552 (2023)
   PUBMED   36815579
  REMARK    GeneRIF: Analysis of the GPR17 receptor in NG2-glia under
            physiological conditions unravels a new subset of oligodendrocyte
            progenitor cells with distinct functions.
REFERENCE   6  (bases 1 to 5209)
  AUTHORS   Maekawa,A., Xing,W., Austen,K.F. and Kanaoka,Y.
  TITLE     GPR17 regulates immune pulmonary inflammation induced by house dust
            mites
  JOURNAL   J Immunol 185 (3), 1846-1854 (2010)
   PUBMED   20574000
  REMARK    GeneRIF: GPR17 negatively regulates type 1 cysteinyl leukotriene
            receptor (CysLT1R)-mediated inflammatory cell accumulation in the
            bronchoalveolar lavage fluid and lung, in both the antigen
            presentation and downstream phases of allergic pulmonary
            inflammation.
            Erratum:[J Immunol. 2010 Oct 1;185(7):4506]
REFERENCE   7  (bases 1 to 5209)
  AUTHORS   Chen,Y., Wu,H., Wang,S., Koito,H., Li,J., Ye,F., Hoang,J.,
            Escobar,S.S., Gow,A., Arnett,H.A., Trapp,B.D., Karandikar,N.J.,
            Hsieh,J. and Lu,Q.R.
  TITLE     The oligodendrocyte-specific G protein-coupled receptor GPR17 is a
            cell-intrinsic timer of myelination
  JOURNAL   Nat Neurosci 12 (11), 1398-1406 (2009)
   PUBMED   19838178
  REMARK    GeneRIF: GPR17 orchestrates the transition between immature and
            myelinating oligodendrocytes via an ID protein-mediated negative
            regulation and may serve as a potential therapeutic target for CNS
            myelin repair.
REFERENCE   8  (bases 1 to 5209)
  AUTHORS   Maekawa,A., Balestrieri,B., Austen,K.F. and Kanaoka,Y.
  TITLE     GPR17 is a negative regulator of the cysteinyl leukotriene 1
            receptor response to leukotriene D4
  JOURNAL   Proc Natl Acad Sci U S A 106 (28), 11685-11690 (2009)
   PUBMED   19561298
  REMARK    GeneRIF: GPR17 is a negative regulator of the cysteinyl leukotriene
            1 receptor response to leukotriene D4.
REFERENCE   9  (bases 1 to 5209)
  AUTHORS   Lecca,D., Trincavelli,M.L., Gelosa,P., Sironi,L., Ciana,P.,
            Fumagalli,M., Villa,G., Verderio,C., Grumelli,C., Guerrini,U.,
            Tremoli,E., Rosa,P., Cuboni,S., Martini,C., Buffo,A., Cimino,M. and
            Abbracchio,M.P.
  TITLE     The recently identified P2Y-like receptor GPR17 is a sensor of
            brain damage and a new target for brain repair
  JOURNAL   PLoS One 3 (10), e3579 (2008)
   PUBMED   18974869
  REMARK    GeneRIF: GPR17 may act as a 'sensor' that is activated upon brain
            injury on several embryonically distinct cell types, and may play a
            key role in both inducing neuronal death inside the ischemic core
            and in orchestrating the local remodeling/repair response.
REFERENCE   10 (bases 1 to 5209)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070439.1 and AI853548.1.
            
            On Feb 5, 2010 this sequence version replaced NM_001025381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070439.1, CX241083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5159              BC070439.1         1-5159
            5160-5209           AI853548.1         1-50                c
FEATURES             Location/Qualifiers
     source          1..5209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.89 cM"
     gene            1..5209
                     /gene="Gpr17"
                     /note="G protein-coupled receptor 17"
                     /db_xref="GeneID:574402"
                     /db_xref="MGI:MGI:3584514"
     exon            1..176
                     /gene="Gpr17"
                     /inference="alignment:Splign:2.1.0"
     exon            177..5193
                     /gene="Gpr17"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1203
                     /gene="Gpr17"
                     /note="UDP/CysLT receptor"
                     /codon_start=1
                     /product="uracil nucleotide/cysteinyl leukotriene
                     receptor"
                     /protein_id="NP_001020552.1"
                     /db_xref="CCDS:CCDS29114.1"
                     /db_xref="GeneID:574402"
                     /db_xref="MGI:MGI:3584514"
                     /translation="MNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFIL
                     AFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEI
                     PCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVA
                     VAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRS
                     LRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALA
                     LGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLS
                     ARSEL"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr17"
                     /note="hexamer: AATAAA"
     polyA_site      5178
                     /gene="Gpr17"
                     /note="major polyA site"
ORIGIN      
        1 aggagctgtg gactctcctg ctctccttaa atagtcaagc cttcctccta cagctacgag
       61 gagtccacct ggagcaccat ctagagcacc ctctggagca ccacccacgg ccagctcaca
      121 gcttacctgc ttccccccag tctcctgtcc tttccttcct gggtcttctg caagagccac
      181 aagatgaacg gtctggaggc agccctaccg agtctgactg acaactcctc cctggcttac
      241 tctgagcaat gcggacaaga gacccccctg gagaacatgc tcttcgcctg cttctacctt
      301 ctggacttca tcctcgcttt tgtgggcaat gctctggccc tgtggctttt catatgggac
      361 cacaagtcag gcactccggc caatgtcttc ctcatgcacc tggctgtggc cgacctgtcc
      421 tgcgtgttgg tcctgcctac ccggttggtt tatcacttct ctgggaatca ctggccattt
      481 ggggagatcc catgccgact cactggcttc ctcttctatc tgaacatgta tgccagcatc
      541 tactttctca cctgcatcag cgctgaccgg ttcctggcca ttgtgcaccc tgtcaagtcc
      601 ctcaagcttc gaagacctct ctatgctcac ctggcctgcg ccttcctgtg gatcgtggtg
      661 gctgtggcta tggccccact gctagtcagc ccacagacag tgcagaccaa ccacacagtt
      721 gtctgcctgc aactgtaccg ggagaaggcc tcccatcacg ccctggcatc cctggctgtg
      781 gcttttacct tcccattcat caccacggtc acctgctacc tgctgatcat tcgcagcctg
      841 cgccagggtc cccggataga gaagcacctc aagaataaag ccgtccgcat gattgctatg
      901 gttctggcca tcttcctgat ttgttttgtg ccctaccaca tccaccgttc agtctatgtg
      961 cttcactacc gtggtggtgg gacttcgtgc gctgctcagc gtgccctggc cctggggaac
     1021 cggatcacct cctgcctcac cagcctcaac ggggccctgg atcctgtcat gtacttcttt
     1081 gtggctgaga agttccgcca cgccttgtgc aacttgctct gcagcaaacg gctcacaggt
     1141 ccacctccca gcttcgaagg gaaaaccaac gagagctccc tgagtgcccg atccgagctg
     1201 tgagcctctg ggaggtccta caccaggcca gctgtagact ggtgcaggaa gaccagctat
     1261 caactggggc acatgctacc agagccagct aaagaagtct atcttccttc actattcctg
     1321 agcaaacaaa cggaaacatc gggagttctc accctgcttc aaggcctcaa ctgcaaggcc
     1381 atccagtctc agcgaatcca tcaagaggca ggactaacca cagggatgcc ctgcccaccc
     1441 ctccacagga ctgggttggc ctggcttctg tacagctccc agacactcag tgacttcact
     1501 cgtgctaaat agggaagaga gccacaggga catttctgga acaatgggaa tctttcttct
     1561 ctaataaatt tctagcttct ttcatactac agatgcccac agaaacaaag ccctacagaa
     1621 taacccagaa agcaagctgc ccaaggtccg ggagaagagg cagcacaaat gtcaatggaa
     1681 ctagatggat atttaatatt tcctttgaag tgtatggtat atcgaatatt gcttaagatg
     1741 cctttgcctc ataatctctg cctgagttta ggggacacag actctagtga tagctacatg
     1801 tgagtataat tcagactggt tgcttgtgaa cccagcgaat atagttctgg gctcagctcc
     1861 tcctgttgac agagggggca aagacccaga caggaaggtt agtctcgtga gaagctggag
     1921 ggtctctgga agtcagcacg ccatgtcccc acaccagcct caagcctggc actgttcaga
     1981 gcttgtcatt agaatgtggc ctagtcaggc atatggcatg gacggacaga cattagagcc
     2041 caggcagaga gcctgatgcg agaacttgtc tccaactgcg cccagaaggg acatcctgag
     2101 ccccactccc tcccaagagg cttctgccac cctggctgcc tggctctgag ctgttgaatg
     2161 tgccagcatg tggtgaccgc tctaatgtac ttgatagcaa tactcttaaa cataactgag
     2221 tcttaagatg aaggaaatta tcatgctggt ccaacatgac acatgatgtt ctccccctga
     2281 aatcctcgtc ctttccaccc aagaatgacc aagtagggca acatcttcct ggttgtggtt
     2341 ctggtggcct tgtgacatgt ctgtccaggc atgtgcgtta agggagctct caaacggatc
     2401 cctccagctg catcctgcct ttcaccagag aaaccctaag atggccctga tgctcagcac
     2461 tgcttctatc tggtgctgat ctgtccaccc ccatggccac aacaacctgc ggagtacaag
     2521 actgtgccag ccaggaccag cacgggacca tgtgtctctt cgacagaaga gcaaagggac
     2581 aagagtaccg cagtctgtga caggagggac agagggggca aagacccaga caggaaggac
     2641 agtctcctgg gaaactggag ggtctctgga aattagcact gcctttcctg acacaggggt
     2701 tcagaagcag acttgggtca gaggaggaga aatttgcagc tcgatttggg acctgttaca
     2761 ttagaatctt aaacagagat gccacactgg taggagactt gagcaaagga gagatctgga
     2821 ggggatacct ggattgtcca gatgtatcat tgagaggccc aagacttcat cctcaaaggc
     2881 tgacatggat atggggccca aagaacatct ctgtgccaag gaagaagctg agggaagcta
     2941 gcacaacaca gaaatctcac tgaaagagga gggctctgct gtgagggcac tcggaggtca
     3001 aggggaggac ctggtgatac ccaggcttga cctgagtcgt tgagaagctg tgctggggag
     3061 ggcttcgggg cacaaaggcg ttgctgggtg ctccccccaa agctttccca cccaggaggg
     3121 agataagctc acggctgctg gggaggtata gagcccacag tgagggaggc aggggtaaga
     3181 agaaagagta aggccttctg gaaggggaac tggcagagta ccagtgaggc ttacagtcct
     3241 gaatttggag taaattgggc aacctggtcc agccatgtga atgctgggag gaaggcagac
     3301 agatggggtc agcgtggtgc agcagtggtg ggtgggatgt catgagtaat tgggattcgc
     3361 caacttaaaa ctcctcatct attcattgcc acttaaagcc cttcaagcct tctgtccccc
     3421 aaagaccacc ctatgcccag agggagctgt ctgtccttac tctcctgcct ccacccttat
     3481 ccatcccctg ggggctgtgt tctccatcta gcaggggtag gacaaagccc acaaccagat
     3541 cagttgagat gccacagagc ctactgggca ggaccacagc tcttagagta gggacaaggg
     3601 gtcctcctct ctgcccatga ctgcagctgg ctcacctgcc tgcgttcttc acaaagccca
     3661 ggtcagccag ctccacatca cacaattcac agcggaagca gccaggatgc cagttggcgt
     3721 tcatggcctt gatcacgcgg ccaatgacaa attcacctgc aagaggagag acctcagctg
     3781 tcagggcgca caccccaccc ttcagctccc acggtctttg taaccagtgt tcttccgggt
     3841 ccacccttgt ccaagtaccc ctcttttagg ggcctgaaga caatgctcag gaagccagga
     3901 aaagtcccca ggctaaggaa cttcagtact ggctgttacc ccacttgtcc ccgtcctgct
     3961 tgctaagtgc tgtcaccagc tcttaccaca gaatccgcag catggagcaa atagcatttg
     4021 gaagtcatgt tcacagtact tccggccctc aaactgcaaa tgggggccac agaagaaaag
     4081 atacatgagt cattcaactt ctctgtaagt cttggccccc caataaatag caggggtctg
     4141 aggtcctgag aaggggggct tccaaagctg tagtgggggt ctagcccatg tgacttagca
     4201 gagtgcaaag tggggggttc acagagatac tgagggtccg agacagcttt tggggattct
     4261 gctgtctgct gagggagagg ggacctgtgg atcctgacaa caggccacgc agaggtggga
     4321 gccggggctg ggaaaggatg ggtcaaatct tgagttatct gactggcttt gtcctctgtg
     4381 tctgaccagc tcagtccctc cagagactac aaaagaccca aagagggaag acggaagaca
     4441 gaattcctca gggaggggaa ttgggagtga cagcagcgct tcagtcagcc accatctgaa
     4501 gcttgctttt ccctccctta aagatttgct ttcttaagca aagtctgggc ggtagctcag
     4561 tttgtagagt gcttgcctac cattcacaga agtcctggtt gggttcacag aactgtgtga
     4621 atagggtaca gcagtgcaca tctgtaacct cagcaccgga ggatggaggc aggatgcgcc
     4681 ggaagttcgt catctttgat aacttccttc ccctaaagcc acatgcagct ctccactgtg
     4741 agccagaggg gagggggcaa catctcccaa acacctcctg tgctaggctt ggttgtgctc
     4801 taaaagccct cgcagagctc tgcccaaccc tctgatgcct cccagccagc atctctcagg
     4861 agcctggaac gtgacaggag atcctcatct aactccattt ctgcatcaat caatcaatga
     4921 tgcaaacagc tcacaggaga gcccagtccc cttgagctct ggtccccccc ctccactgca
     4981 gcccagtgga atggcagcca gtgtttaacc agtccttgcc tctgggtctg ccagatgctg
     5041 gggtgtaaat cttactgcta gactgatgtc accacacaga caaataatct ctgatgcata
     5101 aacgtgaaag tctaacaaat aatgggaagt tggatgtctt atatacttgt tatcattttt
     5161 aataaagtat tatatgtata ttggtatggt ttaaaaaaaa aaaaaaaaa
//
