LOCUS       NM_001310429            6815 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor 161 (Gpr161), transcript
            variant 2, mRNA.
ACCESSION   NM_001310429
VERSION     NM_001310429.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6815)
  AUTHORS   Kim,S.E., Kim,H.Y., Wlodarczyk,B.J. and Finnell,R.H.
  TITLE     Linkage between Fuz and Gpr161 genes regulates sonic hedgehog
            signaling during mouse neural tube development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39369306
  REMARK    GeneRIF: Linkage between Fuz and Gpr161 genes regulates sonic
            hedgehog signaling during mouse neural tube development.
REFERENCE   2  (bases 1 to 6815)
  AUTHORS   Hwang,S.H., White,K.A., Somatilaka,B.N., Wang,B. and
            Mukhopadhyay,S.
  TITLE     Context-dependent ciliary regulation of hedgehog pathway repression
            in tissue morphogenesis
  JOURNAL   PLoS Genet 19 (11), e1011028 (2023)
   PUBMED   37943875
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6815)
  AUTHORS   Kim,S.E., Chothani,P.J., Shaik,R., Pollard,W. and Finnell,R.H.
  TITLE     Pax3 lineage-specific deletion of Gpr161 is associated with spinal
            neural tube and craniofacial malformations during embryonic
            development
  JOURNAL   Dis Model Mech 16 (11) (2023)
   PUBMED   37885410
REFERENCE   4  (bases 1 to 6815)
  AUTHORS   Kim,S.E., Robles-Lopez,K., Cao,X., Liu,K., Chothani,P.J.,
            Bhavani,N., Rahman,L., Mukhopadhyay,S., Wlodarczyk,B.J. and
            Finnell,R.H.
  TITLE     Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic
            Midbrain Malformation and Failure of Craniofacial Skeletal
            Development
  JOURNAL   Front Genet 12, 761418 (2021)
   PUBMED   34887903
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6815)
  AUTHORS   Hwang,S.H., Somatilaka,B.N., White,K. and Mukhopadhyay,S.
  TITLE     Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in
            a tissue-specific manner
  JOURNAL   Elife 10, e67121 (2021)
   PUBMED   34346313
  REMARK    GeneRIF: Ciliary and extraciliary Gpr161 pools repress hedgehog
            signaling in a tissue-specific manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6815)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     In vitro expression of neural tube pathology in the vl mutant mouse
  JOURNAL   J Neuropathol Exp Neurol 52 (3), 253-259 (1993)
   PUBMED   8492142
REFERENCE   7  (bases 1 to 6815)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Aberrant convergence of the neural folds in the mouse mutant vl
  JOURNAL   Teratology 45 (1), 105-112 (1992)
   PUBMED   1731393
REFERENCE   8  (bases 1 to 6815)
  AUTHORS   Swank,R.T., Reddington,M., Howlett,O. and Novak,E.K.
  TITLE     Platelet storage pool deficiency associated with inherited
            abnormalities of the inner ear in the mouse pigment mutants muted
            and mocha
  JOURNAL   Blood 78 (8), 2036-2044 (1991)
   PUBMED   1912584
REFERENCE   9  (bases 1 to 6815)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Ultrastructural defects in the apical neural folds in mutant
            embryos with spina bifida
  JOURNAL   Acta Neuropathol 79 (1), 94-100 (1989)
   PUBMED   2686337
REFERENCE   10 (bases 1 to 6815)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Closure of the posterior neuropore in the vl mutant mouse
  JOURNAL   Anat Embryol (Berl) 178 (6), 559-563 (1988)
   PUBMED   3223614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN721893.1, BY731738.1, BC137659.1, AC116374.10 and BE991962.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            5' coding region compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CN721893.1         1-1
            2-23                BY731738.1         1-22
            24-1850             BC137659.1         1-1827
            1851-6564           AC116374.10        73465-78178
            6565-6815           BE991962.1         1-251               c
FEATURES             Location/Qualifiers
     source          1..6815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.64 cM"
     gene            1..6815
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /note="G protein-coupled receptor 161"
                     /db_xref="GeneID:240888"
                     /db_xref="MGI:MGI:2685054"
     exon            1..123
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     exon            124..538
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     exon            539..1263
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1368
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1488
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..6798
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2984
                     /gene="Gpr161"
                     /gene_synonym="Gm208; Gm208Gpr; vl"
ORIGIN      
        1 ctggaagaag gaagactgac tctctccttt gcctgcttgc cttgtgagac tggaaaattg
       61 ctatatcctt ggacttccat tcacagctgc tgctgaccat tgttgggagt tggactatgg
      121 acttcgtcca gcatgctctg ctcaccgcat cccgaggggc actgaccatg agcctcaact
      181 cctccctcag ctacaggaag gaactgagca acctcactgc aacagagggt ggtgaagggg
      241 gtgccgtctc tgagttcatc gccatcatca tcatcactgt cctcgtctgc ctgggcaacc
      301 tggtcattgt agtcaccttg tacaagaagt cctacctcct caccctcagc aacaagttcg
      361 tcttcagcct gaccttgtcc aacttcctgt tgtcggtgct ggtgctgccg ttcgtggtga
      421 ctagctccat ccggagggaa tggattttcg gcgtggtttg gtgcaacttc tctgccctcc
      481 tctacctgct gatcagctca gccagcatgc tcacgcttgg ggtcattgcc atcgatcgct
      541 actacgccgt cctgtatcca atggtgtacc ccatgaagat cacagggaac cgagctgtga
      601 tggctctcgt ctacatctgg ctccactctc tcattggctg tctgccgccc ctatttggtt
      661 ggtcatcggt ggagtttgat gagttcaagt ggatgtgtgt ggccgcgtgg caccaggaac
      721 ccggctacac cattttctgg cagatctggt gtgccctgtt cccctttctc atcatgctag
      781 tgtgctacgg tttcatcttc cgggtggcca gggtcaaggc ccgaaaggtg cactgtggca
      841 cggtggtcac tgtggaggag gactctcaga ggagcgggag gaagaattct agtacctcca
      901 cttcctcctc cggcagtagg aggaatgccc ttcaaggagt ggtctattca gctaaccagt
      961 gcaaagccct catcaccatc ctggtggtca ttggcgcctt catggtcacc tggggcccct
     1021 acatggttgt cattacctca gaggcactct gggggaagaa ctgtgtctcc ccaaccctgg
     1081 agacttgggc cacatggctg tcctttacca gtgccatctg ccaccctctg atctacggac
     1141 tctggaacaa gactgtgcgc aaggagctcc tgggcatgtg ctttggggac cgttattacc
     1201 gggaatcctt tgtgcagcga cagaggacct ccaggctctt cagcatttcc aacaggatca
     1261 cagacttggg tctgtcccca catctcacgg cgctcatggc aggcggacag tccctgggac
     1321 acagcagcag caccggtgac acaggcttca gctactctca ggattcaggg acggatgtga
     1381 tgctgttgga agatggcact tctgaggaca accctcccca gcactgcact tgcccaccca
     1441 agaggaggag ctccgtgaca tttgaggacg aagtggaaca gatcaaagag gccgccaaga
     1501 actctcttct tcatgtgaaa gctgaagtac acaaatcctt ggacagttac gcagccagct
     1561 tggctaaagc cattgaggct gaagccaaaa tcaacttatt tggggaggag gctctgccag
     1621 gggtcttgtt cacagcacgg accgtcccag gggctggctt tgggggccgt cgaggcagca
     1681 gaactcttgt gaatcagagg ctgcagctac agagcatcaa agaaggcaat gtcttagctg
     1741 cagaacagag atgaaagctt cagaggggag cggggccgca gcggagctac cgggactggt
     1801 gcctgtgcca agaccctgga acatgtcacc actcagagag ggccagacgc cgggaaggaa
     1861 acatctggta tgcagccagg aggattgaaa atactgtctc cagtctctga cttcagttgt
     1921 cttctgtaaa gcacatgtgg gctgcttcag ggctcctggg atggaacgag gcttcgaaag
     1981 cacacgttag aagcagatgg agatgtggct ggggcatcag gaggactaga gatggtggat
     2041 gtgaaaggga agccaccatg tggctcttgt cttcaatggt atccagctgc tttagctgtc
     2101 cctggtctca gtgaggcctc tagaggcaat ccctactccg tgcccctcat ggggacagaa
     2161 cggctcaccc tagcactgtc agaccatctg ggggctctgt gtagttgatc caggaagcgt
     2221 gggaccacaa gtactagact aaatgcaaaa acagtccaga gagcatccga gtagagcacc
     2281 ccacatagac accccatatc tattgcccta gttaggactt gctcttgggt agcacctgct
     2341 gctggccaat agaaacagcc cacaggccac ccaagatgtg gccaccccac ccacttcctt
     2401 gttgacagat ttttattatt actattatta tttgaaaaga agggagaaac cactatgaaa
     2461 gacaagggcg aataccaagc acttcatttc cagaataata aaaccaggag gttagggcat
     2521 atcactaagc ctgggacttg aggtcatacg cagatgaggg gaacttgggg ggaaatccct
     2581 cacacgggag atataggaga tgctagagtg actggcaaac atagctggcc tcactttcca
     2641 gaggcaattg tgactgtcat agcaagtttg ggggctggca caaaggtaga aagggcactg
     2701 gacccgagtt catagcctgg gttcttgacc cagcttggct tttgtctgca catcatctgg
     2761 gacatcctgt cccatcacta ggccatttgg agaaaagaaa ggtgtgggga gttggaacaa
     2821 gtagcctcca aggtaattcc agctctgact tttgatggct tctgaatctg caatttaaga
     2881 gatggggaca aactgaacat gactggtggg tgacctagga tctgtatact tttgagggtg
     2941 tgcccagtga gtacaggaag agcacctgca tgctctggcc ctcacgtctg tctttgtgtt
     3001 atttgtttgg ccgtctaggg cagtcctaac tgccgactac tgagccgtgg gtatgaagag
     3061 ggtgccacag ctgaggcaga tgtgggacag tgggtggggt ttgttgcctt ggactcctct
     3121 tgctctttga gctagaacaa gtttgggctt tgagtgcttg ctgtgggggt tctgtaagat
     3181 gatcttttct gctgctctta agcctgggtg ctttagataa gcgaagcgat gagcagggct
     3241 gtccaccaca cagagcagag gaagtctaag acctcgccat atctgccacg aggcagctaa
     3301 ttgagtggtt tacttttcaa atgtttcctg tgggctgccc agttcctgga gtgaccagtg
     3361 cctgtggttc ctgaggcttg gcttgagcct ttgggtgctt gattttgtca cctactccag
     3421 gtcaccggtg caggggagtg gcagggagga cgggtcctgc attccttgcg gcgcctgtct
     3481 tctctgtgta ttctgttttc cttttctagt actcacccgg tgtcttgagg gacccttttc
     3541 ccaattacct agtatgcacc gaagtggagc acgctcccta ggtgcgggtt gtcagttagt
     3601 acaatggatt ggcttaagac tcaaagggta gagagcgctt ttcttactgc cctgggctag
     3661 cctttatgga aaggatgctg aggcctctga accctattgg ctgaccccag gagtctccag
     3721 tattccagaa gtgatgtgac ctccctttta aaggatttga agcctactca tctgcctaac
     3781 actgtggatc tgccggcacc tcaccaagca ccagtgttga ccacaaagga gagcgcgggt
     3841 gtccagacgc tgatgctgtg gggaatgtag agcgttagca gtggtggcag agctgtggct
     3901 actcggggtc tgagtattcc ggctagggtg ctatggttga gccagtgaag caggtgacca
     3961 tctggactgc gtcttggggg gatttggggg ccagagccat tggttttgca tattcagggt
     4021 ttgcccaagt gagctagaga gaagtggggt ggggtgggga gagggggaga ggtctttcca
     4081 tatagcctct tgtgtcctct ctggaagacg cttgcctttt gtgcagaagc ctaccatccc
     4141 aattaagccc tggcatgtaa tggcagaccc tgctgcaaat tcctgtgtag tggcaggccc
     4201 aaggccttcc caggggaacc ataggtggtg gtaggtggga catgtggcca cttgttttgc
     4261 tttaaatacc tcagtcctta ttctgacagg atcacttgta gggccgtggc ccatctctgc
     4321 tgctgcttta caagatttta cccttgtctt ggtacctgtg ctgtgttcca gatgccagcc
     4381 ctgtgacctg ttgcatccaa gaaggcactg ggtccagcac tgtagtgtac atagctcagc
     4441 accttgcttt tccctggcca gacaacccaa atgggaggtt caagacctta gacataagat
     4501 ggcagcagta ttgttgtgga gaggaaaaaa caaacacaaa aacaaaacat ggtggcttgt
     4561 tcctctgagc tctgccatga ctacaagtcc ctagccttgg agctgattct taccatatat
     4621 atatatatat atatatatat gcaacccctg ttggagttca caggaactat ctgtactggg
     4681 ctgggtgatc ttaaatcact gcaccatggc ccattggtgc taatgttcgt agatttctca
     4741 tttgtgtacc tgattccatc tttcaaccaa gaattaaacc ttcaccccca ggacaaactc
     4801 agtattagca acagaccact gtagtttggg aatagacaag aggcagaaaa tgttgatata
     4861 gtgagaatgc ttgctggtct gttgtgatgg agtgcttttt caaatggaca atgtgctcct
     4921 tagccttgca gattagagag acattcctca atggatcatg agatgaactc aggatacatg
     4981 tccagcctca tttcatacct cctgcctgtg tggaaggaac aagagggggc caagaacagg
     5041 catgtattag gtcccactgt gtgcctcact taaaaaatgg ctaagagccc attaggtgct
     5101 aggcactaat tgaagttttc aaatgcacca tctccctttg cagatgggat acagtaggga
     5161 tggtgctggt gtgtgatgac tgagttaaga tttcaggttg ccaattaact agctaggtgt
     5221 ccaggggcaa attattcttg catctgaaaa tgaagttttg taatctattt atatacaggg
     5281 acacagaatc caaggatacc gcctgcacag ggtgcttggc agactacaga aatgctcatg
     5341 gtacatccag cacaggacat aggtgcaggg agacctgaga cactggcctt gcttttcagt
     5401 gtatctgatg gggccaactc attcctgttt tacagggatc tctagtacgg ggaaccttca
     5461 aaagacatgt tatccaattc aggatactta atcatgttga gggttgttgc ttggggactt
     5521 atttcctatt cggtacaaaa gggcttaatg gaaatgaagg aattctgaca agaagcagac
     5581 aatagagagg atgttggaga agctgagtag gatctggaat gcaagaggtt agtaggaaca
     5641 gaaacaggca gtcttcattc cacacgaatg gcctgattgc acacaaaaca aatagttcta
     5701 cttagccctg aattaaagat gatctataga atcccaaagg acatcaattc aacattgacc
     5761 ttccttatac ccagaaagaa catcctgccc caccccaatg ccgttaggtg ctgaggactg
     5821 ctctgtccag cagtgacaag tgtctggctc ccagttccca gagctcttgt cttccaagcc
     5881 ctgatggaag atgtagagga gggataggtg tccatgccat tccccagagt gttcagaacc
     5941 agataaagcc tggggatgaa ggaagtgagt tataacatga actacaggac catggttgtg
     6001 accagctatg aacggctacg aggagggaca ggcgggcact gttctgtgag ttggggagag
     6061 agacaatgag gatccaggaa ggccatagaa aacctgtgtc tcaaaatgag atcagggcca
     6121 aatcactatg tcttggtcat gaggctgaga gaagatcaag cctgtagccc aaggagagtg
     6181 atgcacaggt aggttaaagg tcatccttag cagagtgggc cagctgggtt ttattagata
     6241 agaagaaact aggggctcca gaccctgccc cccaaaaagt cccaatgtca ggtgatcatc
     6301 tgttggaaag aattcaaagc acaaacactg atctgcacac gattaccaca agcacagttc
     6361 tgctcaatgt cagttgcatt tatttaaaga tgaattttta aaagcagtat tgatggctta
     6421 ggaggcagca gtcacttctg gttttccttt tgacactatt tgaaacacta caaatcacag
     6481 atgcaccagt tcttcccaaa gaccatgcca agtgtggtag aaagcctgca cgcctaggaa
     6541 tggatctgtt ggtggtatag gcatgcttac atgtgttctg ttctgatgat gatgtatacc
     6601 tgaaggaaga catggttaaa aaccaaactt caaaaataag aacccaacct aatcctgaaa
     6661 tatatctaac ttgaagtttt ggatggtgtt tttgaggata aaactgtctg gggtattata
     6721 tgtaaatcag tatttatgaa taagtaaaag tgtgtttaga ctagatttgt ttacctgatt
     6781 aaatgttttt ggaatgtgaa aaaaaaaaaa aaaaa
//
