LOCUS       NM_001206684             756 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus G protein coupled receptor 15 ligand (Gpr15lg), mRNA.
ACCESSION   NM_001206684 XR_105647 XR_106843
VERSION     NM_001206684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 756)
  AUTHORS   Chen,C., Cai,R., Zhou,J., Zhang,D. and Chen,L.
  TITLE     GPR15LG regulates psoriasis-like inflammation by down-regulating
            inflammatory factors on keratinocytes
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38393364
  REMARK    GeneRIF: GPR15LG regulates psoriasis-like inflammation by
            down-regulating inflammatory factors on keratinocytes.
REFERENCE   2  (bases 1 to 756)
  AUTHORS   Tseng,P.Y. and Hoon,M.A.
  TITLE     GPR15L is an epithelial inflammation-derived pruritogen
  JOURNAL   Sci Adv 8 (24), eabm7342 (2022)
   PUBMED   35704588
REFERENCE   3  (bases 1 to 756)
  AUTHORS   Dainichi,T., Nakano,Y., Doi,H., Nakamizo,S., Nakajima,S.,
            Matsumoto,R., Farkas,T., Wong,P.M., Narang,V., Moreno Traspas,R.,
            Kawakami,E., Guttman-Yassky,E., Dreesen,O., Litman,T., Reversade,B.
            and Kabashima,K.
  TITLE     C10orf99/GPR15L Regulates Proinflammatory Response of Keratinocytes
            and Barrier Formation of the Skin
  JOURNAL   Front Immunol 13, 825032 (2022)
   PUBMED   35273606
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 756)
  AUTHORS   Suply,T., Hannedouche,S., Carte,N., Li,J., Grosshans,B.,
            Schaefer,M., Raad,L., Beck,V., Vidal,S., Hiou-Feige,A., Beluch,N.,
            Barbieri,S., Wirsching,J., Lageyre,N., Hillger,F., Debon,C.,
            Dawson,J., Smith,P., Lannoy,V., Detheux,M., Bitsch,F.,
            Falchetto,R., Bouwmeester,T., Porter,J., Baumgarten,B.,
            Mansfield,K., Carballido,J.M., Seuwen,K. and Bassilana,F.
  TITLE     A natural ligand for the orphan receptor GPR15 modulates lymphocyte
            recruitment to epithelia
  JOURNAL   Sci Signal 10 (496) (2017)
   PUBMED   28900043
  REMARK    GeneRIF: Allotransplantation of skin from Gpr15l-deficient mice
            onto wild-type mice resulted in substantial graft protection,
            suggesting nonredundant roles for GPR15 and GPR15L in the
            generation of effector T cell responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 756)
  AUTHORS   Ocon,B., Pan,J., Dinh,T.T., Chen,W., Ballet,R., Bscheider,M.,
            Habtezion,A., Tu,H., Zabel,B.A. and Butcher,E.C.
  TITLE     A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte
            Chemoattractant Receptor GPR15
  JOURNAL   Front Immunol 8, 1111 (2017)
   PUBMED   28936214
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 756)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 756)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009495.13 and AK012157.1.
            
            On or before May 5, 2011 this sequence version replaced
            XR_105647.1, XR_106843.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB864020.1, AK012157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CT009495.13        155457-155460
            5-754               AK012157.1         8-757
            755-756             CT009495.13        163417-163418
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 21.29 cM"
     gene            1..756
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /note="G protein coupled receptor 15 ligand"
                     /db_xref="GeneID:70045"
                     /db_xref="MGI:MGI:1917295"
     exon            1..123
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..290
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /note="secreted protein C10orf99 homolog; protein GPR15L;
                     protein GPR15 ligand; protein GPR15LG"
                     /codon_start=1
                     /product="protein GPR15LG precursor"
                     /protein_id="NP_001193613.1"
                     /db_xref="CCDS:CCDS56949.1"
                     /db_xref="GeneID:70045"
                     /db_xref="MGI:MGI:1917295"
                     /translation="MRLLALSGLLCMLLLCFCIFSSEGRRHPAKSLKLRRCCHLSPRS
                     KLTTWKGNHTRPCRLCRNKLPVKSWVVPGALPQI"
     exon            124..204
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /inference="alignment:Splign:2.1.0"
     exon            205..756
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      729..734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /note="hexamer: AATAAA"
     polyA_site      751
                     /gene="Gpr15lg"
                     /gene_synonym="2610528A11Rik; Gpr15l"
                     /note="major polyA site"
ORIGIN      
        1 ggtctttcgt ggcacagctt cctccctagg cgtgagactc cggctccttc actatgagac
       61 ttctagccct ttccggtctg ctctgcatgc tgctcctctg tttctgcatt ttctcctcag
      121 aagggagaag acatcctgcc aagtccttga aactcaggcg ctgctgtcac ctatctccta
      181 gatccaagct gacaacctgg aaaggaaacc acacaaggcc ctgcagactc tgcagaaaca
      241 agctaccagt caagtcatgg gtggtgcctg gggctctccc acagatatag ggcctcctcc
      301 gcccagatga agcgttgatg cccagatgtg gagacaccag aagcatacac actatgttgc
      361 cttgcccctt gccaatgagc tgtgacactg gaatgcttca cttcagacat cagggcggat
      421 ggattgcaga attccaagtc ctcattccaa aggtgtcacc aaccttcaga gtcactaagg
      481 tccaggctca gcccacaagt caccatggct cctccagagt aaaagtccaa gattccacct
      541 gtgggagcta cagatccaga gactttcaag ctgactagag tgcagagaag caagacctca
      601 gtgtgatcag ccgagactac agcatcttgg gaaccctcag tcagccccaa acccctaaca
      661 cttaaccact ggtctccaaa ccaacacctg taacttccta atgaaatcat caggaggata
      721 ccaaaagaaa taaaccataa atcagcatac acacta
//
