LOCUS       NM_001190297            4969 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 155 (Gpr155), transcript
            variant 1, mRNA.
ACCESSION   NM_001190297
VERSION     NM_001190297.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4969)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4969)
  AUTHORS   Kobayashi,M., Ohno,T., Ihara,K., Murai,A., Kumazawa,M., Hoshino,H.,
            Iwanaga,K., Iwai,H., Hamana,Y., Ito,M., Ohno,K. and Horio,F.
  TITLE     Searching for genomic region of high-fat diet-induced type 2
            diabetes in mouse chromosome 2 by analysis of congenic strains
  JOURNAL   PLoS One 9 (5), e96271 (2014)
   PUBMED   24789282
  REMARK    GeneRIF: Exome sequencing analysis between SM/J and A/J mice
            identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with
            nonsynonymous coding SNPs. These four genes might be candidate
            genes for type 2 diabetes caused by gene-gene interactions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4969)
  AUTHORS   Trifonov,S., Houtani,T., Shimizu,J., Hamada,S., Kase,M.,
            Maruyama,M. and Sugimoto,T.
  TITLE     GPR155: Gene organization, multiple mRNA splice variants and
            expression in mouse central nervous system
  JOURNAL   Biochem Biophys Res Commun 398 (1), 19-25 (2010)
   PUBMED   20537985
  REMARK    GeneRIF: This study reports the structural organization of mouse
            GPR155 gene and the generation of five variants (Variants 1-5) of
            GPR155 mRNA, including so far unknown four variants.
REFERENCE   4  (bases 1 to 4969)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954713.11, HM161763.2 and AV115983.1.
            
            On Feb 13, 2013 this sequence version replaced NM_001190297.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM161763.2, SRR7974084.26265.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL954713.11        128467-128489       c
            24-4968             HM161763.2         1-4945
            4969-4969           AV115983.1         246-246
FEATURES             Location/Qualifiers
     source          1..4969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.59 cM"
     gene            1..4969
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /note="G protein-coupled receptor 155"
                     /db_xref="GeneID:68526"
                     /db_xref="MGI:MGI:1915776"
     exon            1..216
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            217..380
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            381..865
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..3018
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integral membrane protein GPR155; lysosomal cholesterol
                     signaling protein"
                     /codon_start=1
                     /product="lysosomal cholesterol signaling protein isoform
                     1"
                     /protein_id="NP_001177226.1"
                     /db_xref="CCDS:CCDS50606.1"
                     /db_xref="GeneID:68526"
                     /db_xref="MGI:MGI:1915776"
                     /translation="MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPAL
                     LECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLY
                     SVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTY
                     PEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIV
                     FMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVV
                     LTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQF
                     NMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSL
                     IWSLSILLLSKKYKQLPHMLTANLLIAQTIVCAGMMIWNFVKEKNFVGQILVFVLLYS
                     SLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSI
                     DSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGST
                     AFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKT
                     DHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHE
                     TGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESP
                     VSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRG
                     EAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEI
                     GHSSPPSVSPKT"
     exon            866..1265
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1431
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1587
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1671
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1789
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1874
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1965
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2176
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2281
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2418
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2514
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2579
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2717
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..4969
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4945..4950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /note="hexamer: AATAAA"
     polyA_site      4968
                     /gene="Gpr155"
                     /gene_synonym="1110017O10Rik; DEPDC3; F730029F15Rik;
                     LYCHOS; PGR22"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggagg aggcaccggg ctgcagacgc ctaaggtagc tgacaggacc gcagcggctc
       61 acccctccct ttctcggaac gtggttgggc atctgccgct ggcacacgcc gctacaagag
      121 ggttcggggc gggagatgac ggcggtgtgc tcgctgcttg gccctctgtg agcatcggct
      181 tccttctcct tgcagccgga gctgcagacc tagcagggct tcctcatact ccaccaaaag
      241 ttatattcag cttggataag tgattactat gtgccggctg tgattagact gcaaggactc
      301 tacttgaagt agacattgat attggcacct cacagatgat aaggtgaagc acaaaaactc
      361 aagtttgggg ttccaagttg aggccagttt ggaagtggag ggagagagaa aatggattct
      421 tatttctcag caaagaactc aacgcttgct ggtgatatga atgcgacttg gcctgcctct
      481 catggattta atgccaccgg cgatccacct tcgatgtcga taacccggct cttcccggcc
      541 ttactggagt gctttggcat agtcctttgt ggctacatag caggaagggc caatatcata
      601 acctcaacac aggccaaagg actggggaat ttcgtctcca gatttgccct tccagcctta
      661 ttattcaaaa acatggttgt gcttaatttt tccaacgtgg actgggcttt tctctacagc
      721 gtcttaattg gcaaagcctc cgtgtttttc attgtgtgtg tattaacctt attggtggcc
      781 agtcctgaga gccggtttag caaagctgga ctattcccta tttttgctac acagagtaat
      841 gactttgctt tgggataccc tatagttgaa gctctgtacc aatctacata tccagagtat
      901 ctgcagtaca tttatttggt ggcaccaata tctcttatga tgctaaaccc catagggttt
      961 atcttctgtg aaatccagaa gtcaaaagac actcaaaatg cttctcaaaa taaagcaaaa
     1021 attgtgggac ttggatttct acgcgtgtta cagaacccga tagtatttat ggtctttgtt
     1081 ggcattgcct tcaattttat tcttgataaa aagatcccag tatatatgga aaactttctg
     1141 gatgggcttg caaattcctt ctctggatca gccctgtttt atcttggtct gaccatggta
     1201 ggaaaaatca ggcgactgaa gaagtcggcg tttgtggttc ttactcttct catcacagcc
     1261 aaactcctgg tgctgcccct cctgtgcaga gaaatggtgg aactcctgga caagggggac
     1321 agcgtagtga accatacaag cctgtccaac tatgcgtttc tatatggtgt cttccctgtg
     1381 gctccaggag tggctatctt tgcaacacag ttcaacatgg aagtggagat tataacctca
     1441 ggcatggtaa taagtacatt tgtgtctgct ccaatcatgt atgtttctgc ctggttatta
     1501 acctttccta ccatggatgc caagccactg gcgtatgcca ttcagaatgt tagctttgat
     1561 ataagtatta tcagcctggt ctccttgatc tggtccctgt ctattcttct cttgagtaag
     1621 aaatataagc agctcccaca tatgctcaca gcgaacttac tcatcgctca gactattgtt
     1681 tgtgctggaa tgatgatatg gaattttgtt aaagaaaaaa attttgttgg acaaattttg
     1741 gtgtttgttt tattgtacag ctccctgtac agcacctatc tgtggacagg ccttctagca
     1801 gtttctttgt ttcttttaaa gaagcgcgag agcgttcagc tcccggtggg aatcatcatc
     1861 atctctggct gggggatccc tgctctcctt gtgggcgtgc ttctgataac tggaaaacac
     1921 aacggagaca gcattgactc agccttcttt tatggaaaag agcagatgat caccacggca
     1981 gtcaccctgt tctgcagcat tctcatagct ggggtgtcac tcatgtgcat gaaccgcacc
     2041 acccaagctg gtcactacga aggtttcggc cagtctcaga accacaaacc agtagagcct
     2101 ggaagcactg cgtttgagga gaacccagca ccaacaaatg aaccagaact cttcccaagt
     2161 tctatcccag aaacaagttg ctgttcttgc tccttgggaa atggtgaatt acgctgccca
     2221 tccatagagc cagtaacgaa ctcaagtgct agtgggccta tgccttcttc ctttgagaaa
     2281 accgaccact gtgtgagccg ttgtgactcc cagagctgca tcctcgccca ggaagaagag
     2341 cagtacctgc agagcggaga cccacagctg acccggcacg tcctgttgtg cttgctgctt
     2401 atcatcggcc tctttgctaa tctctccagc tgcctgtggt ggttgttcaa ccacgagacg
     2461 ggacggctct atgttgaatt acagtttttc tgtgccgtgt ttaactttgg ccagggattt
     2521 atttcctttg gaatctttgg gctggacaaa catctaatca tcctaccttt caaaagaagg
     2581 cttgaattcc tgtggaacaa caaagaagca gcagcagaca gagaatcccc cgtttccgag
     2641 gaaataaaaa tgacctgtca acagtttgtg cattatcacc gcgacctgtg catccgaaac
     2701 atcgtcagag aaaggaggtg tggtgccaag acttctgccg ggaccttctg tggctgtgac
     2761 ctggtgaact ggctcatcga agtcggcctt gcttctgacc gcggcgaagc tgtgatctac
     2821 ggagacagac tggtgcaagg gggggtcatc caacacatca ccaatgaata cgagttccgg
     2881 gacgagtatc tcttttaccg attccttcag aagagtcctg agcagagtcc tcctgcccgt
     2941 actctaagag accaccagga ggaaagctat aaagaaatcg gtcactcatc tccaccctca
     3001 gtctccccta agacttaagt gccagagaga gccccacagg aatcataccc tctagcctcc
     3061 tatctgatcc ttttagctgg gtgaccttgg gcaggtcatc tcttctgtaa aatgacaaaa
     3121 ggcattccta ctctgtactg acatgctata actttatgtg tatataaagc acataggaaa
     3181 ctgacaagag aaaccatgag gttaaaaggt atgataacga atacaatagt tgctatagag
     3241 aaccactatt gtcacaatat tttaaaatca tttctttctg aaactgttca ttataattac
     3301 aaggtcagca tccaactggc tgtaatttta aattgccaaa cttggcaggt ttgctgctct
     3361 caaaatgaac tttaagacaa cattacattt atcaataaca cctccccaac agattttact
     3421 tattctagta aaaggtttta ttttccttcc cacttcttta atacatacta cccattcaaa
     3481 aattacaact actgttttgt ttttgagaca aggtctcatg tagcccaggc tggcctatgt
     3541 agccaaggat ggcttttaac tcctgatctt cctgcctctg cctcctgagt tctgggctca
     3601 ttggtatgtg ccaacatgcc tggctaatcc cagtattttt ttaaagtaat ttttaaattt
     3661 atttttgata aaacaccaat tttaaaggtt tgtcttgtct tctatctaaa ctactaatgt
     3721 gtaccaatac caagagaata agaacattaa tattattatg tctgtaatct ttcaagttaa
     3781 cattttaagt aatttgaaca tattcattta aatgttatat aagaaataat gccatgagat
     3841 gtactgtttc tggtagtttc aaagtatatt gtagaagaaa aatctacttt gttccctgca
     3901 ttgagaaagt atatagtcag gaacttgaaa ttctaaacct agcatcctac ctttagattt
     3961 tagtcttttt tgggtccatg tctaaaaaat ttgtaagttt aaaaatgagt aactgttgcc
     4021 tagttcacta agattttaaa acaaaatgac atgagcacag atagctccta agcaccagga
     4081 aggctgtctt acaggtctgc aggctggcag tgtaagagta ggcagctgag cactcggact
     4141 ctggcaaggc cccatttcag gtccaccgat ggagccgcca tggtgggagg ggaggctctg
     4201 gaagagcaaa acgcatgctg aacctcttct ctcatgagcc acacttctcc aggctacctc
     4261 actggggcag ggttttgaag agacaggtcc agaccatagc agcctcaggt aaagctttac
     4321 tctctgataa tttgcacatc ctttgaacag ctatttaatt atttgctatc agcgatagtt
     4381 taacctattt taaatgttat ttatcttatt ttagtgtttg atatataaaa gccatttagg
     4441 aaattattta tggggttagt gccctgaccc ctttaatgta gcaaatacat atcaaaatga
     4501 aaccttgcat ggaagcctag tgtctataaa aagaaatgat gtttattttc tgttgtgatc
     4561 atggaattgg gatgttttag gcagaactat atcgccataa aacttagggg gaaaaaagag
     4621 acatgtccac actgtacttc taatgcccag gggtacgagt aagcctcagc agcctgagtg
     4681 acaagacaga attcacacat attcgggcaa ctcaaattca ggtgagggca tttgttttgt
     4741 ttatgagtag ccatattaac gatgctcttt catttgcaca aatggaatct gaaacattat
     4801 tgtccatggg agactctaaa agaaaaccat aggtcagagt gacttgcagt ttcagatgat
     4861 agaggttttt taggattaag gataagctaa ttttattaaa tgaaaatatt tctatgttac
     4921 tttctcactg acagcatgtt tctcaataaa atacctattt taacttgcc
//
