LOCUS       NP_853521                422 aa            linear   ROD 27-APR-2025
DEFINITION  G-protein coupled receptor 151 protein [Mus musculus].
ACCESSION   NP_853521
VERSION     NP_853521.1
DBSOURCE    REFSEQ: accession NM_181543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Bielczyk-Maczynska,E., Zhao,M., Zushin,P.H., Schnurr,T.M.,
            Kim,H.J., Li,J., Nallagatla,P., Sangwung,P., Park,C.Y., Cornn,C.,
            Stahl,A., Svensson,K.J. and Knowles,J.W.
  TITLE     G protein-coupled receptor 151 regulates glucose metabolism and
            hepatic gluconeogenesis
  JOURNAL   Nat Commun 13 (1), 7408 (2022)
   PUBMED   36456565
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Allain,F., Carter,M., Dumas,S., Darcq,E. and Kieffer,B.L.
  TITLE     The mu opioid receptor and the orphan receptor GPR151 contribute to
            social reward in the habenula
  JOURNAL   Sci Rep 12 (1), 20234 (2022)
   PUBMED   36424418
  REMARK    GeneRIF: The mu opioid receptor and the orphan receptor GPR151
            contribute to social reward in the habenula.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Gurtan,A., Dominy,J., Khalid,S., Vong,L., Caplan,S., Currie,T.,
            Richards,S., Lamarche,L., Denning,D., Shpektor,D., Gurinovich,A.,
            Rasheed,A., Hameed,S., Saeed,S., Saleem,I., Jalal,A., Abbas,S.,
            Sultana,R., Rasheed,S.Z., Memon,F.U., Shah,N., Ishaq,M.,
            Khera,A.V., Danesh,J., Frossard,P. and Saleheen,D.
  TITLE     Analyzing human knockouts to validate GPR151 as a therapeutic
            target for reduction of body mass index
  JOURNAL   PLoS Genet 18 (4), e1010093 (2022)
   PUBMED   35381001
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Jiang,B.C., Zhang,J., Wu,B., Jiang,M., Cao,H., Wu,H. and Gao,Y.J.
  TITLE     G protein-coupled receptor GPR151 is involved in trigeminal
            neuropathic pain through the induction of Gbetagamma/extracellular
            signal-regulated kinase-mediated neuroinflammation in the
            trigeminal ganglion
  JOURNAL   Pain 162 (5), 1434-1448 (2021)
   PUBMED   33239523
  REMARK    GeneRIF: G protein-coupled receptor GPR151 is involved in
            trigeminal neuropathic pain through the induction of
            Gbetagamma/extracellular signal-regulated kinase-mediated
            neuroinflammation in the trigeminal ganglion.
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Antolin-Fontes,B., Li,K., Ables,J.L., Riad,M.H., Gorlich,A.,
            Williams,M., Wang,C., Lipford,S.M., Dao,M., Liu,J., Molina,H.,
            Heintz,N., Kenny,P.J. and Ibanez-Tallon,I.
  TITLE     The habenular G-protein-coupled receptor 151 regulates synaptic
            plasticity and nicotine intake
  JOURNAL   Proc Natl Acad Sci U S A 117 (10), 5502-5509 (2020)
   PUBMED   32098843
  REMARK    GeneRIF: These data identify GPR151 as a critical modulator of
            habenular function that controls nicotine addiction vulnerability
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Lein,E.S., Hawrylycz,M.J., Ao,N., Ayres,M., Bensinger,A.,
            Bernard,A., Boe,A.F., Boguski,M.S., Brockway,K.S., Byrnes,E.J.,
            Chen,L., Chen,L., Chen,T.M., Chin,M.C., Chong,J., Crook,B.E.,
            Czaplinska,A., Dang,C.N., Datta,S., Dee,N.R., Desaki,A.L.,
            Desta,T., Diep,E., Dolbeare,T.A., Donelan,M.J., Dong,H.W.,
            Dougherty,J.G., Duncan,B.J., Ebbert,A.J., Eichele,G., Estin,L.K.,
            Faber,C., Facer,B.A., Fields,R., Fischer,S.R., Fliss,T.P.,
            Frensley,C., Gates,S.N., Glattfelder,K.J., Halverson,K.R.,
            Hart,M.R., Hohmann,J.G., Howell,M.P., Jeung,D.P., Johnson,R.A.,
            Karr,P.T., Kawal,R., Kidney,J.M., Knapik,R.H., Kuan,C.L.,
            Lake,J.H., Laramee,A.R., Larsen,K.D., Lau,C., Lemon,T.A.,
            Liang,A.J., Liu,Y., Luong,L.T., Michaels,J., Morgan,J.J.,
            Morgan,R.J., Mortrud,M.T., Mosqueda,N.F., Ng,L.L., Ng,R.,
            Orta,G.J., Overly,C.C., Pak,T.H., Parry,S.E., Pathak,S.D.,
            Pearson,O.C., Puchalski,R.B., Riley,Z.L., Rockett,H.R.,
            Rowland,S.A., Royall,J.J., Ruiz,M.J., Sarno,N.R., Schaffnit,K.,
            Shapovalova,N.V., Sivisay,T., Slaughterbeck,C.R., Smith,S.C.,
            Smith,K.A., Smith,B.I., Sodt,A.J., Stewart,N.N., Stumpf,K.R.,
            Sunkin,S.M., Sutram,M., Tam,A., Teemer,C.D., Thaller,C.,
            Thompson,C.L., Varnam,L.R., Visel,A., Whitlock,R.M.,
            Wohnoutka,P.E., Wolkey,C.K., Wong,V.Y., Wood,M., Yaylaoglu,M.B.,
            Young,R.C., Youngstrom,B.L., Yuan,X.F., Zhang,B., Zwingman,T.A. and
            Jones,A.R.
  TITLE     Genome-wide atlas of gene expression in the adult mouse brain
  JOURNAL   Nature 445 (7124), 168-176 (2007)
   PUBMED   17151600
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Ignatov,A., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     Cloning and characterization of a novel G-protein-coupled receptor
            with homology to galanin receptors
  JOURNAL   Neuropharmacology 46 (8), 1114-1120 (2004)
   PUBMED   15111018
  REMARK    GeneRIF: Galanin-receptor like (GalRL) expression is found in the
            dorsal thalamus; hybridization signals are detected in the
            striatum, the locus coeruleus, and several hindbrain nuclei.
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Berthold,M., Collin,M., Sejlitz,T., Meister,B. and Lind,P.
  TITLE     Cloning of a novel orphan G protein-coupled receptor (GPCR-2037):
            in situ hybridization reveals high mRNA expression in rat brain
            restricted to neurons of the habenular complex
  JOURNAL   Brain Res Mol Brain Res 120 (1), 22-29 (2003)
   PUBMED   14667573
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121603.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ564167.1, BC120520.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.71 cM"
     Protein         1..422
                     /product="G-protein coupled receptor 151 protein"
                     /note="putative G protein-coupled receptor nGPCR-2037;
                     probable G-protein coupled receptor 151 protein;
                     GPCR-2037; G-protein coupled receptor PGR7"
                     /calculated_mol_wt=46695
     Site            14
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Site            19
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          42..321
                     /region_name="7tmA_GPR151"
                     /note="G protein-coupled receptor 151, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15002"
                     /db_xref="CDD:320133"
     Region          42..68
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320133"
     Site            46..66
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          77..102
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320133"
     Site            77..97
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Site            order(99,102..103,115..120,122..123,126,170,172..176,203,
                     206..208,210..212,214..215,267,270..271,273..274,277,
                     288..289,291..293,296,299..300)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320133"
     Region          114..144
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320133"
     Site            124..144
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          157..178
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320133"
     Site            158..178
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          203..232
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320133"
     Site            206..226
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          247..277
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320133"
     Site            260..280
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          289..314
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320133"
     Site            291..311
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     Region          339..422
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSN6.1)"
     CDS             1..422
                     /gene="Gpr151"
                     /gene_synonym="C130082O03Rik; GalRL; nGPCR-2037; PGR7"
                     /coded_by="NM_181543.2:42..1310"
                     /db_xref="CCDS:CCDS29215.1"
                     /db_xref="GeneID:240239"
                     /db_xref="MGI:MGI:2441887"
ORIGIN      
        1 mgkamlragf adtnssnmne sfarlhfagg ylpsdskdwr tiipsllmav clvglvgnlc
       61 vigillhgvw krkpstihsl ilnlsladfs lllfsapvra aayskgvwdl gwfickssdw
      121 fthvcmaaks ltfvvvakac fayasdpakq esihsrtiws vlagiwvvas llplpewlfs
      181 ttrrhagvem clvdvpavae efmsmfgkly pllvfclpll lagvyfwray dqcktrctkt
      241 rnlrdqmrsk qltvmllsta iisallwlpe wiawlwvwhv kaggpmppqg fialsqvlmf
      301 ftstanplif lvmseefkag lkglwkwmit rkpavtsevq eapagnteal pgkapspetq
      361 tcildtdgrg spddskeksg kvvapilpdv eqfwherdav psaqdndpip wehegqeteg
      421 cn
//
