LOCUS       NM_001162955            2230 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus G protein-coupled receptor 15 (Gpr15), mRNA.
ACCESSION   NM_001162955 XM_156321 XM_916786
VERSION     NM_001162955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Schramm,S., Liu,L.J., Saad,M., Dietz,L., Dedden,M., Muller,T.M.,
            Atreya,I., Voskens,C.J., Atreya,R., Neurath,M.F. and Zundler,S.
  TITLE     Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in
            Vivo
  JOURNAL   J Crohns Colitis 18 (7), 1162-1172 (2024)
   PUBMED   38243565
  REMARK    GeneRIF: Blocking GPR15 Counteracts Integrin-dependent T Cell Gut
            Homing in Vivo.
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Liu,C., Lan,Q., Cao,S., Zheng,F., Liang,Y., Shen,J., Wang,Y.,
            Ikezoe,T., Xu,K. and Pan,B.
  TITLE     Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15
  JOURNAL   Leukemia 38 (6), 1390-1402 (2024)
   PUBMED   38459169
  REMARK    GeneRIF: Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15.
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Okamoto,Y. and Shikano,S.
  TITLE     Emerging roles of a chemoattractant receptor GPR15 and ligands in
            pathophysiology
  JOURNAL   Front Immunol 14, 1179456 (2023)
   PUBMED   37457732
  REMARK    GeneRIF: Emerging roles of a chemoattractant receptor GPR15 and
            ligands in pathophysiology.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Pan,B., Wang,X., Kojima,S., Nishioka,C., Yokoyama,A., Honda,G.,
            Xu,K. and Ikezoe,T.
  TITLE     The fifth epidermal growth factor like region of thrombomodulin
            alleviates LPS-induced sepsis through interacting with GPR15
  JOURNAL   Thromb Haemost 117 (3), 570-579 (2017)
   PUBMED   28078348
  REMARK    GeneRIF: The fifth epidermal growth factor like region of
            thrombomodulin exerts anti-inflammatory function by inhibiting
            NF-kappaB in a GPR15-dependent manner.
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Nguyen,L.P., Pan,J., Dinh,T.T., Hadeiba,H., O'Hara,E. 3rd,
            Ebtikar,A., Hertweck,A., Gokmen,M.R., Lord,G.M., Jenner,R.G.,
            Butcher,E.C. and Habtezion,A.
  TITLE     Role and species-specific expression of colon T cell homing
            receptor GPR15 in colitis
  JOURNAL   Nat Immunol 16 (2), 207-213 (2015)
   PUBMED   25531831
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Lahl,K., Sweere,J., Pan,J. and Butcher,E.
  TITLE     Orphan chemoattractant receptor GPR15 mediates dendritic epidermal
            T-cell recruitment to the skin
  JOURNAL   Eur J Immunol 44 (9), 2577-2581 (2014)
   PUBMED   24838826
  REMARK    GeneRIF: findings establish a role for GPR15 in skin lymphocyte
            homing and suggest that it may contribute to lymphocyte subset
            targeting to diverse epithelial sites.
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Kim,S.V., Xiang,W.V., Kwak,C., Yang,Y., Lin,X.W., Ota,M.,
            Sarpel,U., Rifkin,D.B., Xu,R. and Littman,D.R.
  TITLE     GPR15-mediated homing controls immune homeostasis in the large
            intestine mucosa
  JOURNAL   Science 340 (6139), 1456-1459 (2013)
   PUBMED   23661644
  REMARK    GeneRIF: findings describe a T cell-homing receptor for large
            intestine lamina propria and indicate that GPR15 plays a role in
            mucosal immune tolerance largely by regulating the influx of Tregs
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Jandke,A., Da Costa,C., Sancho,R., Nye,E., Spencer-Dene,B. and
            Behrens,A.
  TITLE     The F-box protein Fbw7 is required for cerebellar development
  JOURNAL   Dev Biol 358 (1), 201-212 (2011)
   PUBMED   21827743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159200.2.
            
            On Jun 19, 2019 this sequence version replaced NM_001162955.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC107281.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2230              AC159200.2         64716-66945
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..2230
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /note="G protein-coupled receptor 15"
                     /db_xref="GeneID:71223"
                     /db_xref="MGI:MGI:1918473"
     exon            1..2230
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1231
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /codon_start=1
                     /product="G-protein coupled receptor 15"
                     /protein_id="NP_001156427.1"
                     /db_xref="CCDS:CCDS49879.1"
                     /db_xref="GeneID:71223"
                     /db_xref="MGI:MGI:1918473"
                     /translation="MEPATALLIVDYYDYTSPDPPFLETPSHLSYTSVFLPIFYTVVF
                     LTGVVGNFILMIALHFKRGNRRLIDIFIINLAASDFIFLVTVPLWMDKEASLGLWRTG
                     SFLCKGSSYVISVNMHCSVFLLTCMSMDRYLAIMHPALAKRLRRRSSAYAVCAVVWII
                     SCVLGLPTLLSRELTHIEGKPYCAEKKPTSLKLMWGLVALITTFFVPLLSIVTCYCCI
                     TRRLCAHYQQSGKHNKKLKKSIKIVIIAVAAFTVSWVPFNTFKLLAIVSGFQPEGLFH
                     SEALQLAMNVTGPLAFASSCVNPLIYYVFDSYIRRAIVRCLCPCLKTHNFGSSTETSD
                     SHLTKALSNFIHAEDFIRRRKRSVSL"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2137
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /note="major polyA site"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2230
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgttcatcc aagatcttga aagagagggg gtgacggaaa gaacagtgaa cagcaagaaa
       61 gggtgtacat caagacgctc ccttggtttc tcaagttcgt aagacgcaag gtaaggcact
      121 taccagattc agcgtcgaac ctccagtgat ggaaccagca acagccctgc tgattgtgga
      181 ttactatgac tacacaagcc cagatcctcc tttcctggag actccctccc acctgtccta
      241 cacatctgtc ttcctcccta tcttttacac agttgtattc ttgactggag tggtggggaa
      301 tttcatcctc atgatagctc tgcatttcaa acgcggcaac cgaagattga tcgacatctt
      361 tatcatcaac ctggctgcct ctgacttcat tttccttgtc acagtgcctc tttggatgga
      421 taaggaagcc tctctaggac tatggaggac tggctctttc ctgtgcaaag gcagctccta
      481 tgtgatctcc gtgaacatgc actgtagtgt cttcttgctc acatgcatga gcatggaccg
      541 ttacctggct atcatgcacc cagccttagc caagagatta cgaaggagaa gctctgcata
      601 tgcagtgtgt gccgtcgtct ggatcatctc atgcgtcctg gggttgccca ctcttctgtc
      661 cagggagctc actcacattg aaggcaaacc atactgtgca gagaagaaac ccacgtcctt
      721 aaaactgatg tggggcctgg tagccttgat taccaccttt ttcgtccccc tcctgagcat
      781 tgtgacctgc tactgttgca tcacaaggag gctgtgtgct cattaccagc agtcgggaaa
      841 gcataacaag aaactaaaga agtccataaa gatcgttatt attgcggtgg cggccttcac
      901 cgtctcctgg gtacccttta acactttcaa gctcctagcc attgtttcag ggttccagcc
      961 agaaggcctt tttcactccg aggctttgca gctggccatg aatgtgactg ggcccttggc
     1021 ctttgccagc agctgtgtca accctctcat ttactatgtc tttgacagct atatccgccg
     1081 ggccattgta cgttgtctgt gcccttgtct gaagacccac aactttggga gcagcactga
     1141 gacatcggac agtcacctca ctaaggctct ttccaacttc attcatgcag aggatttcat
     1201 ccggcggagg aagagatctg tgtcactcta aaaggaactg tgacatgtca agctctgttg
     1261 gcactctttg gaagctgggg tttgtcagca gcagagaaag agaagagcat taaagatgac
     1321 attcattttg attcataaat ccaaggaagt gttggctttt tttaaaaagc ctccctgaag
     1381 agctcttgtg ctgtgggtct aatcagaaca tatgcagtgt gttcacctta aaggtcttct
     1441 tacttggtaa tccagccaac cagacaacat acaaactcca ctgtctttga actcaaaggc
     1501 tgttttcttc atgcatgcat tgggaccttt ctgaaccatc cgctgtttgt actgggctat
     1561 gtttggacga gacattttga tctggtaaga agtgtagtgg gatgctggat aacaaaagca
     1621 aaaatacttg tactctgtaa ctcactgtcc ccgagttact gagattgact ctggtcccaa
     1681 ttaagaatct gtctggttag tcttcctctc tgtcctgcat tggctttcag accatagctt
     1741 tggactggga aaaacaaaag aaagaaaatc catatgagga aaaagacact gtgcattgtg
     1801 tttatgaatc gagagtcacg tcatcacctg atctgaaatg tgctagcagg tattcattgc
     1861 gtaaggcttg atctttgcct tgtaagaaac actggtaaca acaattcagc ttatcatatg
     1921 cgatggtaac tgctttttaa aaagattttt aatatgctgt ttgttttcat tgcctttata
     1981 aattggaatt tgactttgtt gtaattacat gttttgaatt acctatcatc ttgttatcaa
     2041 atgaaaatgt tactactaat gtaattggag ccgggaggct tgggccaacc cccatgcaga
     2101 tgatcactta aggttctaat taaaatgtta ctgtgcacat tctttgaaca attcctttgc
     2161 ttggtgtata taatttcaag atgatgtggg atgctctgta tccagctgaa ataaaagacc
     2221 tatcagagaa
//
