LOCUS       NP_001156427             360 aa            linear   ROD 29-APR-2025
DEFINITION  G-protein coupled receptor 15 [Mus musculus].
ACCESSION   NP_001156427 XP_156321 XP_921879
VERSION     NP_001156427.1
DBSOURCE    REFSEQ: accession NM_001162955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Schramm,S., Liu,L.J., Saad,M., Dietz,L., Dedden,M., Muller,T.M.,
            Atreya,I., Voskens,C.J., Atreya,R., Neurath,M.F. and Zundler,S.
  TITLE     Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in
            Vivo
  JOURNAL   J Crohns Colitis 18 (7), 1162-1172 (2024)
   PUBMED   38243565
  REMARK    GeneRIF: Blocking GPR15 Counteracts Integrin-dependent T Cell Gut
            Homing in Vivo.
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Liu,C., Lan,Q., Cao,S., Zheng,F., Liang,Y., Shen,J., Wang,Y.,
            Ikezoe,T., Xu,K. and Pan,B.
  TITLE     Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15
  JOURNAL   Leukemia 38 (6), 1390-1402 (2024)
   PUBMED   38459169
  REMARK    GeneRIF: Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15.
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Okamoto,Y. and Shikano,S.
  TITLE     Emerging roles of a chemoattractant receptor GPR15 and ligands in
            pathophysiology
  JOURNAL   Front Immunol 14, 1179456 (2023)
   PUBMED   37457732
  REMARK    GeneRIF: Emerging roles of a chemoattractant receptor GPR15 and
            ligands in pathophysiology.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Pan,B., Wang,X., Kojima,S., Nishioka,C., Yokoyama,A., Honda,G.,
            Xu,K. and Ikezoe,T.
  TITLE     The fifth epidermal growth factor like region of thrombomodulin
            alleviates LPS-induced sepsis through interacting with GPR15
  JOURNAL   Thromb Haemost 117 (3), 570-579 (2017)
   PUBMED   28078348
  REMARK    GeneRIF: The fifth epidermal growth factor like region of
            thrombomodulin exerts anti-inflammatory function by inhibiting
            NF-kappaB in a GPR15-dependent manner.
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Nguyen,L.P., Pan,J., Dinh,T.T., Hadeiba,H., O'Hara,E. 3rd,
            Ebtikar,A., Hertweck,A., Gokmen,M.R., Lord,G.M., Jenner,R.G.,
            Butcher,E.C. and Habtezion,A.
  TITLE     Role and species-specific expression of colon T cell homing
            receptor GPR15 in colitis
  JOURNAL   Nat Immunol 16 (2), 207-213 (2015)
   PUBMED   25531831
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Lahl,K., Sweere,J., Pan,J. and Butcher,E.
  TITLE     Orphan chemoattractant receptor GPR15 mediates dendritic epidermal
            T-cell recruitment to the skin
  JOURNAL   Eur J Immunol 44 (9), 2577-2581 (2014)
   PUBMED   24838826
  REMARK    GeneRIF: findings establish a role for GPR15 in skin lymphocyte
            homing and suggest that it may contribute to lymphocyte subset
            targeting to diverse epithelial sites.
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Kim,S.V., Xiang,W.V., Kwak,C., Yang,Y., Lin,X.W., Ota,M.,
            Sarpel,U., Rifkin,D.B., Xu,R. and Littman,D.R.
  TITLE     GPR15-mediated homing controls immune homeostasis in the large
            intestine mucosa
  JOURNAL   Science 340 (6139), 1456-1459 (2013)
   PUBMED   23661644
  REMARK    GeneRIF: findings describe a T cell-homing receptor for large
            intestine lamina propria and indicate that GPR15 plays a role in
            mucosal immune tolerance largely by regulating the influx of Tregs
REFERENCE   10 (residues 1 to 360)
  AUTHORS   Jandke,A., Da Costa,C., Sancho,R., Nye,E., Spencer-Dene,B. and
            Behrens,A.
  TITLE     The F-box protein Fbw7 is required for cerebellar development
  JOURNAL   Dev Biol 358 (1), 201-212 (2011)
   PUBMED   21827743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159200.2.
            
            On or before Jul 2, 2009 this sequence version replaced
            XP_921879.1, XP_156321.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC107281.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     Protein         1..360
                     /product="G-protein coupled receptor 15"
                     /calculated_mol_wt=40411
     Region          34..313
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Site            34..54
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Region          36..60
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          69..90
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            70..90
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Region          107..129
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            121..141
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Site            150..170
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Region          152..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          193..216
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            193..213
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Region          240..262
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            240..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     Region          281..306
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            285..305
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0VDU3.2)"
     CDS             1..360
                     /gene="Gpr15"
                     /gene_synonym="4933439K08Rik"
                     /coded_by="NM_001162955.2:149..1231"
                     /db_xref="CCDS:CCDS49879.1"
                     /db_xref="GeneID:71223"
                     /db_xref="MGI:MGI:1918473"
ORIGIN      
        1 mepatalliv dyydytspdp pfletpshls ytsvflpify tvvfltgvvg nfilmialhf
       61 krgnrrlidi fiinlaasdf iflvtvplwm dkeaslglwr tgsflckgss yvisvnmhcs
      121 vflltcmsmd rylaimhpal akrlrrrssa yavcavvwii scvlglptll srelthiegk
      181 pycaekkpts lklmwglval ittffvplls ivtcyccitr rlcahyqqsg khnkklkksi
      241 kiviiavaaf tvswvpfntf kllaivsgfq peglfhseal qlamnvtgpl afasscvnpl
      301 iyyvfdsyir raivrclcpc lkthnfgsst etsdshltka lsnfihaedf irrrkrsvsl
//
