LOCUS       NM_177346               3869 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 149 (Gpr149), transcript
            variant 1, mRNA.
ACCESSION   NM_177346
VERSION     NM_177346.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3869)
  AUTHORS   Wyler,S., Surbhi, Cao,N., Merchant,W., Bookout,A. and Gautron,L.
  TITLE     Gpr149 is involved in energy homeostasis in the male mouse
  JOURNAL   PeerJ 12, e16739 (2024)
   PUBMED   38282864
  REMARK    GeneRIF: Gpr149 is involved in energy homeostasis in the male
            mouse.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3869)
  AUTHORS   Suo,N., He,B., Cui,S., Yang,Y., Wang,M., Yuan,Q. and Xie,X.
  TITLE     The orphan G protein-coupled receptor GPR149 is a negative
            regulator of myelination and remyelination
  JOURNAL   Glia 70 (10), 1992-2008 (2022)
   PUBMED   35758525
  REMARK    GeneRIF: The orphan G protein-coupled receptor GPR149 is a negative
            regulator of myelination and remyelination.
REFERENCE   3  (bases 1 to 3869)
  AUTHORS   Tenney,A.P., Livet,J., Belton,T., Prochazkova,M., Pearson,E.M.,
            Whitman,M.C., Kulkarni,A.B., Engle,E.C. and Henderson,C.E.
  TITLE     Etv1 Controls the Establishment of Non-overlapping Motor
            Innervation of Neighboring Facial Muscles during Development
  JOURNAL   Cell Rep 29 (2), 437-452 (2019)
   PUBMED   31597102
REFERENCE   4  (bases 1 to 3869)
  AUTHORS   Edson,M.A., Lin,Y.N. and Matzuk,M.M.
  TITLE     Deletion of the novel oocyte-enriched gene, Gpr149, leads to
            increased fertility in mice
  JOURNAL   Endocrinology 151 (1), 358-368 (2010)
   PUBMED   19887567
  REMARK    GeneRIF: Gpr149 null mice are one of the few models with enhanced
            fertility.
REFERENCE   5  (bases 1 to 3869)
  AUTHORS   Kurrasch,D.M., Cheung,C.C., Lee,F.Y., Tran,P.V., Hata,K. and
            Ingraham,H.A.
  TITLE     The neonatal ventromedial hypothalamus transcriptome reveals novel
            markers with spatially distinct patterning
  JOURNAL   J Neurosci 27 (50), 13624-13634 (2007)
   PUBMED   18077674
REFERENCE   6  (bases 1 to 3869)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115721.11 and AC114424.10.
            
            On Oct 7, 2017 this sequence version replaced NM_177346.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136826.1, AK166029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1548              AC115721.11        85970-87517         c
            1549-1741           AC115721.11        84893-85085         c
            1742-2190           AC115721.11        77185-77633         c
            2191-3869           AC114424.10        53847-55525
FEATURES             Location/Qualifiers
     source          1..3869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     gene            1..3869
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /note="G protein-coupled receptor 149"
                     /db_xref="GeneID:229357"
                     /db_xref="MGI:MGI:2443628"
     exon            1..1548
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..2763
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor PGR10; probable G-protein coupled
                     receptor 149"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 149 isoform
                     1"
                     /protein_id="NP_796320.2"
                     /db_xref="CCDS:CCDS17380.1"
                     /db_xref="GeneID:229357"
                     /db_xref="MGI:MGI:2443628"
                     /translation="MSFFLSNLTNDSNLWKASHNSTETDLMNSPATLTLSLFCLICIM
                     TLAALVGSIFSLVSLLTMQYRTVLSILVTSWSVDDLLSVLSVAIFMVLQWPKEAQGYF
                     QSLCTTSALLYMCQGLSSNLKATLIVCYNFYTMNRTVESQSSSWRLGQVLGVTLTVWA
                     VSLLLASLPLCGWGVFVRTPWGCLTDCSSPYVLLLFAVYASAFGLLAVLSVPLTHQLL
                     CSEEPLRLHANYQEISRGASTPGTPAAAGRVLCLPPEDVEIPALRCTGGCSPSSDVVF
                     APGQPAASGAGAGRRENPGTPQGTNSFPLSLAQKRFSLILALTKVILWLPMMIHMVVK
                     HVVGFQSLPVDMLSFLLSLLASSVTPVFVLSKRWAHLPCGCIINCQPDTYSVAFDGKK
                     SKRKGFEFNLSFQQSYGLYKIPHADCYDDDENSISYHNPKNYECEATKEPWGDNRSVF
                     NTITVEISTTPPLDSATLTGVHKCTNTDIPESKQAMKEEKGAFSVKTESDINYGETTS
                     FEGPERRLSHEENQKPDLSDWEWCRSKSERTPRQRSGGGLAIPICAFQGTVSLQAPTG
                     KTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEESPSTFADTSVKIHLEVLE
                     ICDNDEALDTVSIISNISQSSTKVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSDP
                     DGDINISIPDTVEAHRQNSRRQHEERDGYQEEIQLLNKAYRKREAESKGD"
     exon            1549..1741
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2190
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..3869
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /note="hexamer: AATGAA"
     polyA_site      3869
                     /gene="Gpr149"
                     /gene_synonym="9630018L10Rik; Ieda; PGR10; R35"
                     /note="major polyA site"
ORIGIN      
        1 aaaggtttga tgggagcctg ttctcctcag gctcagcaga ctccctgtat atctcctctc
       61 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tccacccccc
      121 ccccctgagc tgagacctac ctgacaacct ctgcctttga atccagctct gagcacagat
      181 gcatcttttt atttattgtt ctcccaagtg attccatcaa actggagatc ctccttagga
      241 aaagacccgc acggcatcca cgcatgagca ctgtgcaatc tgcctgagaa gctcctgatt
      301 tcttgtctgg aatttggtgg gtggggagaa gttttttgtt ggatttattt acttaaaata
      361 ttgaaaagtt tcttattgct gcctgaaatg gagcacagct ttaaaacatg ggctgagaca
      421 gatctttcta ccggagacat gtctggacca acacatggaa catctagaaa aacttggcca
      481 gagaaatgac atctgctttg caactctcac gctcagagaa aatcatcaga ctcgttgaag
      541 agggaaatta aaatactaag gaaaatgtct ttctttctca gcaacttaac aaatgactct
      601 aacctgtgga aagcaagtca taattctacg gagacggacc ttatgaattc accagcaact
      661 ctgactcttt ctctcttttg cctgatctgt ataatgactc tcgcagctct ggtgggcagc
      721 attttctcac tggtttcgct gctgaccatg caatacagaa ctgttttgtc catacttgtg
      781 acatcttggt ctgtggatga tctcttgagc gtcttgtccg tggccatctt catggtttta
      841 cagtggccaa aagaggcaca gggctacttc cagtctctgt gcaccacctc tgccctactg
      901 tatatgtgcc agggcctctc cagcaacttg aaggcgactc tcatagtctg ctacaacttt
      961 tatacgatga acaggacggt ggagagtcag tcaagctcct ggcgattagg acaggtactt
     1021 ggtgtgactt taaccgtttg ggcagtcagc ctgctgctgg cttcgctccc gctctgtggc
     1081 tggggtgtct tcgtgcgcac gccttggggc tgcctgaccg actgctccag cccatacgtg
     1141 ctgctcctct tcgcggtata cgcttccgct ttcgggctcc tggcggttct ctctgtccct
     1201 ctcactcacc agctgctgtg ttcggaggaa ccgctgagac tccatgccaa ctaccaggaa
     1261 atttctcgtg gcgcctctac tcctgggacc cctgctgctg cgggaagagt gctctgtctg
     1321 ccgccagagg atgttgagat ccctgctctg cgatgcactg ggggatgctc cccgagctcc
     1381 gacgtggtgt ttgccccggg tcagccggct gcctccggcg ctggagccgg caggcgagag
     1441 aatcccggga ctccccaggg caccaacagc ttccccttga gcttggcaca gaagcgcttt
     1501 tctttgattc tagcgctgac gaaagtcatc ctttggctac ccatgatgat ccacatggtg
     1561 gtaaaacacg tggtggggtt tcagagcctt ccggtcgata tgctcagctt tctactaagc
     1621 ctgctggcca gcagtgtaac accagtgttt gtcttatcca aacgttgggc ccacttgcct
     1681 tgtggctgca tcatcaactg ccagccagac acctactccg ttgccttcga tgggaaaaag
     1741 tcgaagagga aaggctttga attcaatcta tcattccaac aaagttatgg actctataaa
     1801 ataccacatg cagattgcta tgatgatgat gaaaattcca tatcctatca caacccaaag
     1861 aattatgagt gtgaagctac aaaggagcct tggggagaca accgcagtgt cttcaatacc
     1921 atcacagtag aaatcagcac cacgccaccg ctggacagcg ccacactgac gggtgtccac
     1981 aagtgtacca atactgacat cccagaatcc aaacaggcca tgaaagagga aaagggtgct
     2041 ttttctgtta aaacagaaag cgatattaac tatggagaaa ccacctcttt tgaaggtcca
     2101 gagagacgac tgtcccatga ggagaatcag aaaccagatc tttcagactg ggaatggtgc
     2161 aggagtaagt ctgaacgaac gcctcgccag cgttccggtg gtgggctggc tattcccata
     2221 tgcgcgttcc aggggactgt gtctctccaa gcacctactg ggaaaacgct ctctctttct
     2281 acttatgagg tcagcgcaga agggcaaaag ataaccccag cctctaagaa aatagaagtc
     2341 tatcgatcta aaagtgttgg ccatgaaccg aactcagagg agtctccctc cacgtttgcg
     2401 gacaccagtg taaaaataca cttggaagtt cttgaaattt gtgacaacga tgaggctcta
     2461 gacactgtgt caattatcag caacatcagc caatcctcca caaaagtcag gtctccttct
     2521 ctgcgctact cacggaagga aaacagattc gtctcctgcg acttaggaga aactgcctca
     2581 tactcgctct ttttacccac aagtgatcct gatggtgata ttaacatctc tatccctgac
     2641 acggtggagg cccacagaca gaacagcagg cggcagcatg aagagaggga tggctaccag
     2701 gaagagatcc agttgttaaa caaagcctac aggaaaagag aggcagaaag caagggtgat
     2761 taggaagtgc tgagactagt agaggccaga attgctgcaa aacagacctt agactgcaaa
     2821 ccataatcct gagactaatc tcccactttc ttctagttat atgctctcat aaccttccct
     2881 ggttttctag ttactatttg tttggatgac ctgccatagt gcatacataa agtgcatttc
     2941 acatattact taaaaatcat acactgtggt aactgaccag ttttgtgtct gatttctaaa
     3001 atctttctaa acccaatctt gacctagttt gataatattt tgcctgtttg tctaatgaat
     3061 acactgttct cgtgcatgag tttttgtaca caggctgctt tttactgcaa aagagaaaag
     3121 agatgttctg gccatagggg ggaaaaatac accaaaattc ggagttgtat ttgaatatgg
     3181 atatgtatct ggccaaagga gcttattcta gtttctgctt taacctttct gtgatctagg
     3241 aagtatgttc ttagcttcga agtggaactt tggaaatatg tgtattccta gtctatgatt
     3301 atttcatttg ttgttataaa atacacgtag tttagtaagt ggttctgctt gtctttcttt
     3361 gaatggagat tccgagaaat cctgccacat taagtcctga gaggcgcact acaggagggc
     3421 aacaagcttc tggctaaacc agaggaaccc ccccccccca agtctaacga aacgttcctg
     3481 tcgaagattg gaaagacttg ctttgctctt ctggatgcat agaaagtttt acttcaaata
     3541 ttattctagg ttaagtactt taaggatttt ttttctttaa aacaatgtat tatatcaaac
     3601 aatgaaacaa ctcaacatgt atgtccctaa tggtgagaaa tatttggaaa gattaatttc
     3661 tcaaaacacc tgatcagcac acagctaatg tatatttcaa aagtcctggt cctttaaaat
     3721 tactctattc taatatttcc ataaacatta aatatgttac ctaaatattt gtttattaaa
     3781 gtcattgttt tacgtgctct tagattgtgc atacgtgcag ttcaggcaca tctgatgttt
     3841 acagattaaa tgaatcatat ttaaaaata
//
