LOCUS       NM_030258               4099 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus G protein-coupled receptor 146 (Gpr146), transcript
            variant 1, mRNA.
ACCESSION   NM_030258
VERSION     NM_030258.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Huang,J., Xie,Y., Chen,B., Xia,Y., Jiang,Y., Sun,Z. and Liu,Y.
  TITLE     GPR146 regulates pulmonary vascular remodeling by promoting
            pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase
  JOURNAL   Eur J Pharmacol 961, 176123 (2023)
   PUBMED   37926274
  REMARK    GeneRIF: GPR146 regulates pulmonary vascular remodeling by
            promoting pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase.
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   Han,F., Liu,X., Chen,C., Liu,Y., Du,M., Zhou,Y., Liu,Y., Song,B.L.,
            He,H.H. and Wang,Y.
  TITLE     Hypercholesterolemia risk-associated GPR146 is an orphan G-protein
            coupled receptor that regulates blood cholesterol levels in humans
            and mice
  JOURNAL   Cell Res 30 (4), 363-365 (2020)
   PUBMED   32203133
  REMARK    GeneRIF: Hypercholesterolemia risk-associated GPR146 is an orphan
            G-protein coupled receptor that regulates blood cholesterol levels
            in humans and mice.
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Yu,H., Rimbert,A., Palmer,A.E., Toyohara,T., Xia,Y., Xia,F.,
            Ferreira,L.M.R., Chen,Z., Chen,T., Loaiza,N., Horwitz,N.B.,
            Kacergis,M.C., Zhao,L., Soukas,A.A., Kuivenhoven,J.A.,
            Kathiresan,S. and Cowan,C.A.
  CONSRTM   BIOS Consortium
  TITLE     GPR146 Deficiency Protects against Hypercholesterolemia and
            Atherosclerosis
  JOURNAL   Cell 179 (6), 1276-1288 (2019)
   PUBMED   31778654
  REMARK    GeneRIF: these findings outline a regulatory role for the
            GPR146/ERK axis in systemic cholesterol metabolism.
REFERENCE   5  (bases 1 to 4099)
  AUTHORS   Martin,J.H., Aitken,R.J., Bromfield,E.G., Cafe,S.L.,
            Sutherland,J.M., Frost,E.R., Nixon,B. and Lord,T.
  TITLE     Investigation into the presence and functional significance of
            proinsulin C-peptide in the female germlinedagger
  JOURNAL   Biol Reprod 100 (5), 1275-1289 (2019)
   PUBMED   30715203
REFERENCE   6  (bases 1 to 4099)
  AUTHORS   Huang,H., Zhang,N., Xiong,Q., Chen,R., Zhang,C., Wang,N., Wang,L.,
            Ren,H., Liu,M., Qian,M. and Du,B.
  TITLE     Elimination of GPR146-mediated antiviral function through
            IRF3/HES1-signalling pathway
  JOURNAL   Immunology 152 (1), 102-114 (2017)
   PUBMED   28464285
  REMARK    GeneRIF: GPR146 has an antiviral role in fighting against viral
            infection, although the GPR146-mediated protection is eliminated by
            IRF3/HES1-signalling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161058.2, AK155876.1 and BB738958.1.
            
            On Apr 7, 2018 this sequence version replaced NM_030258.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154478.1, AK155876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC161058.2         6514-6541           c
            29-4093             AK155876.1         4-4068
            4094-4099           BB738958.1         405-410
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.49 cM"
     gene            1..4099
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /note="G protein-coupled receptor 146"
                     /db_xref="GeneID:80290"
                     /db_xref="MGI:MGI:1933113"
     exon            1..105
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /inference="alignment:Splign:2.1.0"
     exon            106..4099
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1130
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 146"
                     /protein_id="NP_084534.2"
                     /db_xref="CCDS:CCDS19809.1"
                     /db_xref="GeneID:80290"
                     /db_xref="MGI:MGI:1933113"
                     /translation="MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLLYLGAGVPVSLGYN
                     ALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHV
                     TLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFS
                     SLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTP
                     LDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAK
                     DLAKFLAFSSSSVTPLLYRYINKAFPGKLRRLMKKMHCGRRHCSPDPSGIQQVMAQA"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /note="hexamer: AATGAA"
     polyA_site      1490
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
     regulatory      4077..4082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /note="hexamer: ATTAAA"
     polyA_site      4099
                     /gene="Gpr146"
                     /gene_synonym="D830046C22Rik; PGR8"
                     /note="major polyA site"
ORIGIN      
        1 acgtgtgtac acagccccca cggcgtgcgc gccgtgagct ccgctgcctc ctgcaagccc
       61 agctgcccgc ccgcggccgg tgcgcgggcc gccgcccagc gagcgctgcg aagctggggt
      121 gagctgccat gtggagctgt ggcccactca acagcacagc gtgggctgag gagccgctgt
      181 gccggaacct gcgcctgggg ctgtgggtcc tctcgctgct ctacctgggg gcaggggtcc
      241 ctgtgagctt aggctataat gctcttctgg tgctggccaa cctggccagc aagaacacca
      301 tgaccatgcc cgacgtgtac ttcgtgaaca tggccgtggc ggggctggtg ctcacggcac
      361 tggcacctgc gtacctgttg ggccctgccc actccaggtg ggccctgtgg agcctcagca
      421 gtgaggccca tgtgacactg ctcatcctgt tcaacgtggc ttccctggtg accatgtact
      481 ccactgcact gctgagcctt gactactaca tcgagcgtgc cctgccacgc acctacatgg
      541 ccagtgtgta caacacccgg cacgtgtgtg gcttcgtctg gggaggggcg gtgctcacca
      601 gcttctcctc cctgctcttc tacatctgca gtcacgtgtc ttctagaatc gctgagtgtg
      661 cccggatgca gaacacggag gcagccgatg ctatccttgt gctcatcggc tacgtggtgc
      721 caggtctggc tgtgttgtat gccctggcac tcatctcgag aatcgggaag gaagacacac
      781 ccctggacca ggacaccagc aggctggacc cctcggtgca caggctgctg gtggccaccg
      841 tgtgcactca gtttggcctc tggacacctt actacttgag cctggggcac acagtgctga
      901 cgtcacgggg gaggaccgtg gaggggcatt atctgggcat cctacaggtt gctaaggacc
      961 tggccaagtt cctggccttc tcaagcagtt ctgtgacacc actgctctac cgttacatca
     1021 acaaagcctt ccccggcaag ctccggcggc tgatgaagaa gatgcactgc gggcgccgcc
     1081 actgctcccc cgacccctcg gggatacagc aggtgatggc acaggcgtag ctaaccctcc
     1141 ctgggctgac cacgaggaac actaaaactc aactggacac atagcacttt gttccccagg
     1201 cacatggagc ttccagccca ggagacacgc tgaagccaga gatgcacagc ggggcatttc
     1261 tcttgatgtt tcctgttttc ccctaaaagg ccaaccttgg tcttatgctg catggtggaa
     1321 agcagaggtg ccctgtgtga acaggctgct tctgactaac cttcccacct tctccctcaa
     1381 ggtgtgtgcc tttctcccag ggacatcttc aaggtccatg tcctcacaag caggctgacc
     1441 ttcggcctcc ctggtatttg ggctttctaa atgaagcgat gaaatctaaa gccagtattt
     1501 atacttcata ttgacatgat acttgattct cctattatta tttttttaaa aatagaagtg
     1561 ttagaaagat acctagtatt aagaagaagg cacttcaggg gaatgtggct gtcgctgata
     1621 ccagtgttag agcttgagga caggacagtg ggcctgtcag gcctgcagca gctacacagc
     1681 cattgctgac agtgacagct atggagcact ggccctctcc tctactgaga gaggatcttt
     1741 ccagtgcttc aacatatgca tatacataaa tggaaaaaaa agaagtgtgt tctcttagtg
     1801 ccaaaggcct tctggagacc tggatatggt agagggttag ccaggcatag aaggaaaagg
     1861 caggatggta tgagaccacg gctccaagat gaccagggac tggcatcagg gaaagggccc
     1921 tgcttggcca gtttcacaca gctgtgggtg gcacatgagg aggctcacct cccacaggtg
     1981 cctggatcca ggcctcaccc acgtgcttct ggggtctttt accatcctca tgtttggtaa
     2041 ttatctactc taatgtgggc atgaaaagaa ttcccaccac ccgaattctc tcggctacat
     2101 ggcaagccca caagtccctg cccccagttc taaagctctc catgtgacca tctcacccct
     2161 gtctctacag aaggcgggtg tgtgacccac attcagtggc cttcttgcat ggccccacag
     2221 ctggtcctgg ctgtctggga actgctgctc tgagtcagta actttagtgt tatctattct
     2281 atgcaaactc catctccatg gacggtgacg gctccagtta atctgcctta aggagaaaca
     2341 cgaggcccgc agccctagct gtgacctact gggcatgctc tgtgggtctc agttcatgaa
     2401 taaaccaaag ggctgggtta gacaggcatc ttcagagttg cttacggctg tagaattttg
     2461 ttttgaggac tttaaattgg caaacctgac tttccctacc cccgccccag gtgcacagct
     2521 gagtgaaggc tctgaaaagc taatggcttc caggcttccc accctgatag ccacaatgaa
     2581 caccttaacg cttgctgagg aaacaagaac cctcaccatg aaggttctag ctagacctgg
     2641 cctgcaggcc acggtaattc tcctatgaga gcaagcccag ggaccaaggt cacatcaaac
     2701 aaaaggcaac ctatgctctg ggggtcatag aggaaacagg cttcaggtgg gcagggctgt
     2761 ttgtgatgtt ggcgccccag tttaacagtc tttgccctgg ggaccgtttt ataccactta
     2821 ctccaggcag aggtccagag aggggcagac ccccaggtcc aagtggggtt gtacgcccta
     2881 gaaccctcca ccccagtcac ccccaagcat gatagagaga ggcccaaacc atgttccttt
     2941 gttgcacttt ttcagtcaca ttaggtacaa actggcgagg ttctagggga cccttgaggg
     3001 gttggaagcc aggaccagga atgtgtgact gccatcaatt gtatagccaa tcactgccta
     3061 cctgggtctt ccttgtggag ccgcacatgg ccagggtagt ggccatctgc agtgctgacc
     3121 cctttgctgt agagacccct ggagcaatgc actctcctac ccggggcccc atttccacca
     3181 cctgcctcct tcttgcccca gctttccttt ccatcacaac cacccaagct cagcagccac
     3241 tggtgctcag acatctgctg tccctgatgc tgttcatcac gtgtccccag tgtctgcttc
     3301 ccaattctgc cctgcacctt gcacctccca aagtaggaaa gaacctaaac cacacaaaga
     3361 agaggttact gcaatggggt gtgtgtgtgt gtgtgtgcgt gcccatgtct atgtacgtgt
     3421 gtgtgtgccc atgtctatga acatgtgtgt gtgcccatgt ctatgaacat gtgtgtgtgc
     3481 ccatgtctat gaacatgtgt gtgtgcccat gtctatgtac gtgtgtgtgt gctcatgtct
     3541 atgaacatgt gtgtgtgccc atgtctatgt acatgtgtgt gtgtgtcact cagtgatgct
     3601 ttcttacatg agtttaagac tccaggcaag acacacattt ccccaaggct tcttaactta
     3661 gctgtcgaca cttcttggtg gttttaattt acaatgaatg ctcttatttt cattaactag
     3721 taagaaagct tgctatgtgt cattattcag gattccagaa ggtgaccttt tttcttgggt
     3781 ttccttctca atgccacatg acacgacata ggaaaccagg ccccttgctc actggggcag
     3841 atatactcag gaaccaacag acacctgttc tgtcagagaa agcattcggc aaaggtcagc
     3901 ccagagagaa ggtctgacgt tcatctgtgt gtctggttct tgggtttaag cccgtgggaa
     3961 gatgtgggtt ttctgactcc tttcctacag gatccacccc agaccctaga tccatttgcc
     4021 aaaattctgt gaatgtgaaa aagaaactac tgatgggatc cacacttctg aagactatta
     4081 aattatttaa cactcatca
//
