LOCUS       NM_010951               1651 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus G protein-coupled receptor 143 (Gpr143), mRNA.
ACCESSION   NM_010951
VERSION     NM_010951.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Arai,M., Suzuki,E., Kitamura,S., Otaki,M., Kanai,K., Yamasaki,M.,
            Watanabe,M., Kambe,Y., Murata,K., Takada,Y., Arisawa,T.,
            Kobayashi,K., Tajika,R., Miyazaki,T., Yamaguchi,M., Lazarus,M.,
            Hayashi,Y., Itohara,S., de Kerchove d'Exaerde,A., Nawa,H., Kim,R.,
            Bito,H., Momiyama,T., Masukawa,D. and Goshima,Y.
  TITLE     Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa
            Receptor, in Striatal Cholinergic Interneurons
  JOURNAL   J Neurosci 44 (11), e1504232024 (2024)
   PUBMED   38286627
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Masukawa,D., Kitamura,S., Tajika,R., Uchimura,H., Arai,M.,
            Takada,Y., Arisawa,T., Otaki,M., Kanai,K., Kobayashi,K.,
            Miyazaki,T. and Goshima,Y.
  TITLE     Coupling between GPR143 and dopamine D2 receptor is required for
            selective potentiation of dopamine D2 receptor function by
            L-3,4-dihydroxyphenylalanine in the dorsal striatum
  JOURNAL   J Neurochem 165 (2), 177-195 (2023)
   PUBMED   36807226
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Fukuda,N., Naito,S., Masukawa,D., Kaneda,M., Miyamoto,H., Abe,T.,
            Yamashita,Y., Endo,I., Nakamura,F. and Goshima,Y.
  TITLE     Expression of ocular albinism 1 (OA1), 3, 4- dihydroxy-
            L-phenylalanine (DOPA) receptor, in both neuronal and non-neuronal
            organs
  JOURNAL   Brain Res 1602, 62-74 (2015)
   PUBMED   25601010
  REMARK    GeneRIF: OA1 expression in both neuronal and non-neuronal tissues
            was examined by immunohistochemical analyses, results suggested
            that OA1 may modulate the monoaminergic functions in both
            peripheral and central nervous systems
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Falletta,P., Bagnato,P., Bono,M., Monticone,M., Schiaffino,M.V.,
            Bennett,D.C., Goding,C.R., Tacchetti,C. and Valetti,C.
  TITLE     Melanosome-autonomous regulation of size and number: the OA1
            receptor sustains PMEL expression
  JOURNAL   Pigment Cell Melanoma Res 27 (4), 565-579 (2014)
   PUBMED   24650003
  REMARK    GeneRIF: Melanosome-autonomous regulation of size and number: the
            OA1 receptor sustains PMEL expression.
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Young,A., Wang,Y., Ahmedli,N.B., Jiang,M. and Farber,D.B.
  TITLE     A constitutively active Galphai3 protein corrects the abnormal
            retinal pigment epithelium phenotype of Oa1-/- mice
  JOURNAL   PLoS One 8 (9), e76240 (2013)
   PUBMED   24098784
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Blair,H.J., Uwechue,I.C., Barsh,G.S., Rowe,P.S. and Boyd,Y.
  TITLE     An integrated genetic and man-mouse comparative map of the
            DXHXS674-Pdha1 region of the mouse X chromosome
  JOURNAL   Genomics 48 (1), 128-131 (1998)
   PUBMED   9503026
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Montini,E., Rugarli,E.I., Van de Vosse,E., Andolfi,G., Mariani,M.,
            Puca,A.A., Consalez,G.G., den Dunnen,J.T., Ballabio,A. and
            Franco,B.
  TITLE     A novel human serine-threonine phosphatase related to the
            Drosophila retinal degeneration C (rdgC) gene is selectively
            expressed in sensory neurons of neural crest origin
  JOURNAL   Hum Mol Genet 6 (7), 1137-1145 (1997)
   PUBMED   9215685
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Newton,J.M., Orlow,S.J. and Barsh,G.S.
  TITLE     Isolation and characterization of a mouse homolog of the X-linked
            ocular albinism (OA1) gene
  JOURNAL   Genomics 37 (2), 219-225 (1996)
   PUBMED   8921399
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Bassi,M.T., Incerti,B., Easty,D.J., Sviderskaya,E.V. and
            Ballabio,A.
  TITLE     Cloning of the murine homolog of the ocular albinism type 1 (OA1)
            gene: sequence, genomic structure, and expression analysis in
            pigment cells
  JOURNAL   Genome Res 6 (9), 880-885 (1996)
   PUBMED   8889556
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Dinulos,M.B., Bassi,M.T., Rugarli,E.I., Chapman,V., Ballabio,A. and
            Disteche,C.M.
  TITLE     A new region of conservation is defined between human and mouse X
            chromosomes
  JOURNAL   Genomics 35 (1), 244-247 (1996)
   PUBMED   8661129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ131873.1, BC119384.1 and BB762363.1.
            
            On Feb 8, 2007 this sequence version replaced NM_010951.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63918.1, BC119384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                CJ131873.1         2-85
            85-1366             BC119384.1         1-1282
            1367-1651           BB762363.1         255-539
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..1651
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /note="G protein-coupled receptor 143"
                     /db_xref="GeneID:18241"
                     /db_xref="MGI:MGI:107193"
     exon            1..372
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1340
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /note="MOA1; ocular albinism type 1 protein homolog;
                     homolog of human ocular albinism 1 (Nettleship-Falls)"
                     /codon_start=1
                     /product="G-protein coupled receptor 143"
                     /protein_id="NP_035081.3"
                     /db_xref="CCDS:CCDS30476.1"
                     /db_xref="GeneID:18241"
                     /db_xref="MGI:MGI:107193"
                     /translation="MASPRLGIFCCPTWDAATQLVLSFQPRVFHALCLGSGTLRLVLG
                     LLQLLSGRRSVGHRAPATSPAASVHILRAATACDLLGCLGIVIRSTVWIAYPEFIENI
                     SNVNATDIWPATFCVGSAMWIQLLYSACFWWLFCYAVDVYLVIRRSAGRSTILLYHIM
                     AWGLAVLLCVEGAVMLYYPSVSRCERGLDHAIPHYVTTYLPLLLVLVANPILFHKTVT
                     SVASLLKGRKGVYTENERLMGAVIKTRFFKIMLVLIACWLSNIINESLLFYLEMQPDI
                     HGGSLKRIQNAARTTWFIMGILNPAQGLLLSLAFYGWTGCSLDVHPPKMVIQWETMTA
                     SAAEGTYQTPVRSCVPHQNPRKVVCVGGHTSDEVLSILSEDSDASTVEIHTATGSCNI
                     KEVDSISQAQGEL"
     exon            373..482
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..577
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..670
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..780
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..889
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1007
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1245
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1651
                     /gene="Gpr143"
                     /gene_synonym="Oa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggttcggg aagaggcaca gggcacatga cgcccaatct ccctcaccag cccagcacct
       61 gatcaggaaa agctgaaagc tgtgggttcc gcaaaccaga gaccggtccc tgagcaagac
      121 gaatggcctc cccgcgcctg ggaattttct gctgccctac gtgggacgca gccacacagc
      181 tggtgctaag cttccaaccg cgggtgttcc atgccctgtg cctgggaagc ggcactctcc
      241 gcctggtgct tggcctcctt cagctcctat cagggcgtcg atctgttggt cacagggcgc
      301 ctgcgacatc cccagccgcc tcagtccaca tcctccgtgc tgccactgcc tgtgacttgc
      361 ttggctgcct gggaatcgtt atcaggtcca cagtgtggat agcctaccca gagttcattg
      421 aaaacatttc caatgtgaat gcaacagaca tttggcctgc tactttctgt gtggggagcg
      481 caatgtggat ccagctgttg tacagtgcct gcttctggtg gctcttttgc tatgcagttg
      541 atgtatactt ggtgatcagg agatcggcgg gacggagcac catcctgctg taccacatca
      601 tggcctgggg cctggctgtg ctgctctgtg tggagggagc agtcatgctc tactaccctt
      661 ctgtgtccag gtgtgagagg ggcctggacc atgccatccc ccattatgtc accacatact
      721 tgccacttct gcttgtcctg gtggccaacc caatcctgtt tcacaagaca gtgacttcag
      781 tggcctcttt actgaaagga agaaaaggtg tttacacaga gaatgagaga ctgatggggg
      841 ctgtgatcaa gacccgtttt ttcaaaataa tgctggtgtt aattgcatgt tggttgtcca
      901 atatcatcaa tgaaagtctt ttgttctacc ttgaaatgca accagatatc catggaggct
      961 ctctgaaacg catccagaat gcagctagga ccacatggtt tataatggga atactgaatc
     1021 cagcccaagg acttctcttg tctctggcct tctatggctg gacaggatgc agcctggatg
     1081 tccatcctcc caagatggtg attcagtggg aaacaatgac tgcctctgct gctgagggca
     1141 cgtaccagac ccctgtgcgt tcctgtgtgc cccatcaaaa ccccaggaag gttgtatgtg
     1201 tcgggggaca tacttctgat gaggtgctga gcattttgtc tgaagattca gatgccagta
     1261 ctgttgaaat ccatactgca actgggtcct gcaacataaa ggaagttgac tccatttccc
     1321 aagcccaggg ggaactctga aggaatggga taggggtcag acacccctat ttttcaggtt
     1381 ctgtgtcttg ttgttttgga ttgtgttctt gctgccacaa tgtatgtatg atctttcaaa
     1441 ttccactctg gtcaccatag tggagttcac tgaatatgtc ctttatactg ggagaaacaa
     1501 cacatcagaa cttgaagatg gaaagttccc tctagaacag tcagtatcac ctcttgactc
     1561 ttaattaccc cttggacttt ttctaaggcc agctgtaatg ctaagtgcca gatccaaatc
     1621 catgagaaaa tagttaaata aagtcattgt g
//
