LOCUS       NM_001379097            1047 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 142 (Gpr142), transcript
            variant 3, mRNA.
ACCESSION   NM_001379097 XM_006533066
VERSION     NM_001379097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Al-Amily,I.M., Duner,P., Groop,L. and Salehi,A.
  TITLE     The functional impact of G protein-coupled receptor 142 (Gpr142) on
            pancreatic beta-cell in rodent
  JOURNAL   Pflugers Arch 471 (4), 633-645 (2019)
   PUBMED   30767071
  REMARK    GeneRIF: The importance of Gpr142 in the maintenance of pancreatic
            beta-cell function.
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Rudenko,O., Shang,J., Munk,A., Ekberg,J.P., Petersen,N.,
            Engelstoft,M.S., Egerod,K.L., Hjorth,S.A., Wu,M., Feng,Y.,
            Zhou,Y.P., Mokrosinski,J., Thams,P., Reimann,F., Gribble,F.,
            Rehfeld,J.F., Holst,J.J., Treebak,J.T., Howard,A.D. and
            Schwartz,T.W.
  TITLE     The aromatic amino acid sensor GPR142 controls metabolism through
            balanced regulation of pancreatic and gut hormones
  JOURNAL   Mol Metab 19, 49-64 (2019)
   PUBMED   30472415
  REMARK    GeneRIF: GPR142 functions as a sensor of aromatic amino acids,
            controlling GIP but also CCK and GLP-1 as well as insulin and
            glucagon in the pancreas.
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Lin,H.V., Efanov,A.M., Fang,X., Beavers,L.S., Wang,X., Wang,J.,
            Gonzalez Valcarcel,I.C. and Ma,T.
  TITLE     GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone
            Secretion to Improve Glucose Metabolism
  JOURNAL   PLoS One 11 (6), e0157298 (2016)
   PUBMED   27322810
  REMARK    GeneRIF: these findings demonstrate GPR142 is a Tryptophan receptor
            critically required for insulin and incretin hormone regulation and
            suggest GPR142 agonists may be effective therapies that leverage
            amino acid sensing pathways for the treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Takeshita,S., Moritani,M., Kunika,K., Inoue,H. and Itakura,M.
  TITLE     Diabetic modifier QTLs identified in F2 intercrosses between Akita
            and A/J mice
  JOURNAL   Mamm Genome 17 (9), 927-940 (2006)
   PUBMED   16964447
REFERENCE   8  (bases 1 to 1047)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
  REMARK    GeneRIF: GPR142 mRNA showed a ubiquitous expression both in the
            brain and in various peripheral glands and organs in pre- and
            postnatal development.
REFERENCE   9  (bases 1 to 1047)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   10 (bases 1 to 1047)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669969.14.
            
            On Mar 20, 2020 this sequence version replaced XM_006533066.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KT749970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL669969.14        4907-4931
            26-187              AL669969.14        5676-5837
            188-1047            AL669969.14        7257-8116
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.54 cM"
     gene            1..1047
                     /gene="Gpr142"
                     /gene_synonym="PGR2"
                     /note="G protein-coupled receptor 142"
                     /db_xref="GeneID:217302"
                     /db_xref="MGI:MGI:2668437"
     CDS             1..1047
                     /gene="Gpr142"
                     /gene_synonym="PGR2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     probable G-protein coupled receptor 142; G protein-coupled
                     receptor PGR2"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 142 isoform
                     3"
                     /protein_id="NP_001366026.1"
                     /db_xref="GeneID:217302"
                     /db_xref="MGI:MGI:2668437"
                     /translation="MGLEGAETAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCV
                     AGIIPVIYYSVLLSLGLPVNVLTSVALARLAARTRKPSYHYLLALTASDIVTQVIIVF
                     VGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATS
                     SPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNV
                     FLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPV
                     HRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQ
                     TVVELMLKSVGTEL"
     exon            1..25
                     /gene="Gpr142"
                     /gene_synonym="PGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            26..187
                     /gene="Gpr142"
                     /gene_synonym="PGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..1047
                     /gene="Gpr142"
                     /gene_synonym="PGR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggacttg agggagcaga gacagctgtg cagccacaag tgaccctgct gcctacagtc
       61 aatggtagta acccaagata cgatggtgtg gatggccact ggccagagag cccagagagg
      121 tcaccctgtg tggctggtat catacctgtc atctattaca gcgtcctgct gagcctgggg
      181 ctgcctgtca acgtcctgac ttcagtggca ctggcccgtc ttgctgccag gaccaggaaa
      241 ccctcctatc actatctcct ggcactcacg gcttcagata tcgtcaccca agtgatcatc
      301 gtcttcgtag gcttcctcct gcagggagct gtgctggccc gccaggtgcc ccaggccgtg
      361 gtgcgcacag ctaacatcct ggagtttgct gccaatcacg cctcagtctg gattgcagtc
      421 ttgttcacgg tggatcgcta caatgccctg tgccgccctc tacgccatcg ggccacctcg
      481 tccccaggcc ggacccaccg cgctattgct gctgtcattg gcgttaccct cctgaccggc
      541 atcccattct actggtggct ggatgtgtgg agggatgcag accctcctag cactatggac
      601 aaactcctca agtgggctca ctgcctcatc gtctacttca ttccctgcaa tgttttcctg
      661 gtcaccaact ctgccatcat ccttcggcta cggaagagag gccagagagg gctgcggcca
      721 ttggtgagca agagcacagc catcctcctg ggtgtcacct ccctcttcgc cctcctctgg
      781 gcaccacgta ttattgtcat gctgtaccat ctgtatgtgg cccctgttca ccgggattgg
      841 agggtccacc tggccttgga catagccaac atgttggcca tgctcaacac agaggtcaac
      901 tttggcctct attgcttcat cagcaagact ttcagagcca ctgtccgaca ggtcatctgt
      961 gatgtccata tggcttgcgc cttaaagtca cagccaaagc aaacggtggt ggaactcatg
     1021 ctgaagtccg tagggacaga gctgtag
//
