LOCUS       NM_175688               2773 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 141B (Gpr141b), mRNA.
ACCESSION   NM_175688
VERSION     NM_175688.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Ghilas,S., Ambrosini,M., Cancel,J.C., Brousse,C., Masse,M.,
            Lelouard,H., Dalod,M. and Crozat,K.
  TITLE     Natural killer cells and dendritic epidermal gammadelta T cells
            orchestrate type 1 conventional DC spatiotemporal repositioning
            toward CD8+ T cells
  JOURNAL   iScience 24 (9), 103059 (2021)
   PUBMED   34568787
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Mattiuz,R., Wohn,C., Ghilas,S., Ambrosini,M., Alexandre,Y.O.,
            Sanchez,C., Fries,A., Vu Manh,T.P., Malissen,B., Dalod,M. and
            Crozat,K.
  TITLE     Novel Cre-Expressing Mouse Strains Permitting to Selectively Track
            and Edit Type 1 Conventional Dendritic Cells Facilitate
            Disentangling Their Complexity in vivo
  JOURNAL   Front Immunol 9, 2805 (2018)
   PUBMED   30564233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Draheim,M., Wlodarczyk,M.F., Crozat,K., Saliou,J.M., Alayi,T.D.,
            Tomavo,S., Hassan,A., Salvioni,A., Demarta-Gatsi,C., Sidney,J.,
            Sette,A., Dalod,M., Berry,A., Silvie,O. and Blanchard,N.
  TITLE     Profiling MHC II immunopeptidome of blood-stage malaria reveals
            that cDC1 control the functionality of parasite-specific CD4 T
            cells
  JOURNAL   EMBO Mol Med 9 (11), 1605-1621 (2017)
   PUBMED   28935714
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Taleb,K., Auffray,C., Villefroy,P., Pereira,A., Hosmalin,A.,
            Gaudry,M. and Le Bon,A.
  TITLE     Chronic Type I IFN Is Sufficient To Promote Immunosuppression
            through Accumulation of Myeloid-Derived Suppressor Cells
  JOURNAL   J Immunol 198 (3), 1156-1163 (2017)
   PUBMED   28003378
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Alexandre,Y.O., Ghilas,S., Sanchez,C., Le Bon,A., Crozat,K. and
            Dalod,M.
  TITLE     XCR1+ dendritic cells promote memory CD8+ T cell recall upon
            secondary infections with Listeria monocytogenes or certain viruses
  JOURNAL   J Exp Med 213 (1), 75-92 (2016)
   PUBMED   26694969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153016.2.
            
            On Jul 25, 2009 this sequence version replaced NM_175688.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041317.1, BC150909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AC153016.2         192616-192895       c
            281-2773            AC153016.2         187361-189853       c
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.03 cM"
     gene            1..2773
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /note="G protein-coupled receptor 141B"
                     /db_xref="GeneID:319293"
                     /db_xref="MGI:MGI:2441809"
     exon            1..280
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /inference="alignment:Splign:2.1.0"
     exon            281..2773
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1209
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /codon_start=1
                     /product="G protein-coupled receptor-like"
                     /protein_id="NP_783619.2"
                     /db_xref="GeneID:319293"
                     /db_xref="MGI:MGI:2441809"
                     /translation="MDVMDVDLVSNGSSVVMPMAEQVCDAHCRAILTTAYSVVFFGGT
                     VGTVMMSHMMFKRNCQSMIATIIINIIVLHSLLLISLPFRLSYYLSAVWKLGSFTCRM
                     VSGVIYGHMYLTFIFYVAIVTLRLLIYFKKLQMQQLQKFHAVALSIIIWVTGSFIFLP
                     IFFLQYGTDPSYTEQQRCFEFHKSLNSRDIIIINYSIIVIMMTTVLLLFLIQMAVILH
                     LIKAYWPDMWAHQEYRAQIKSFFFLLVIVVCFIPHHAFRVYFIQNFPEQENSKLILYN
                     EICVALTAFCCLDMLCFIGGVIH"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /note="hexamer: AAGAAA"
     polyA_site      2407
                     /gene="Gpr141b"
                     /gene_synonym="A530099J19Rik; Karma"
                     /note="major polyA site"
ORIGIN      
        1 ctctgttttg aatctgcccc actgtggaga caatgtccgt ttgagctcac aggcttaact
       61 tatcaggact ctgcatcttg gctgatgggc ttcttgagcc ctcagtgcaa ggcttgaact
      121 tgtccctcca ctcatgaccc cactcatgac tgtgttgacg gttgggctag gatagttctg
      181 gtttcagcaa ctgcgtttac tgcctgcttt gatgtagaac aacagatgac cacggtacgt
      241 taagttttcc accaggatcg atcacaacta gaaggagcag tttgtggtct aatttctcca
      301 cgatcaacca tggatgtgat ggatgtagac ctcgtgtcaa atggctcaag tgtggtgatg
      361 cctatggcag agcaagtctg tgatgctcac tgcagagcaa ttctgacaac agcctatagt
      421 gtggtcttct ttggaggcac cgttggaaca gttatgatgt cacacatgat gttcaagagg
      481 aattgccaat caatgattgc cactatcatc attaatatca ttgtgttgca ctcccttctc
      541 ctgattagtc tgccattccg cctcagttac tatctctcag cagtctggaa gcttgggtct
      601 tttacctgcc gaatggttag tggcgtcata tatggtcata tgtaccttac cttcattttt
      661 tatgtggcca ttgttaccct tcggctgctc atctatttta agaaactgca aatgcaacag
      721 ttacaaaagt tccatgccgt ggctctaagt attattattt gggtgacagg aagcttcatc
      781 tttttaccaa tatttttttt acaatatggc acagatccaa gttatacaga gcaacagcgg
      841 tgctttgagt ttcataaatc tctcaactcc agggacatca tcatcataaa ctattctata
      901 attgttatta tgatgacaac agttctgctc ctctttctga tacagatggc tgtcattctt
      961 catttgataa aagcctattg gcctgatatg tgggcccatc aagagtacag agctcaaatc
     1021 aagagttttt tcttcctgtt ggtcatagtt gtctgcttta taccccacca tgcattcagg
     1081 gtatatttta ttcaaaattt tccagagcaa gaaaattcta agttaattct gtacaatgaa
     1141 atctgtgttg ctttaacagc tttctgctgc ctggatatgt tatgtttcat aggtggtgtc
     1201 atccattaga ccttcccgtg ctctttctgt gattggttta taggccatca tgatgaaaaa
     1261 tacttcagtt gaatggatgg agtgctatta ttgtatttaa aattttgaag ctctctgctc
     1321 ccgaacatca gactttttta tttctcttag ccacaattgt tttctttcaa aaacttaatc
     1381 aaccctagtc atctactttt cctttgagaa tgcttgtagg ccccaaatgt atcccagaat
     1441 atgttgggtt tcttagctgt accaaacaca ctattccttc ctctttgcgt ttcattcagt
     1501 attcacttca accacgcata cctgtgagtt ctccccatac tcctgaggct tctagccaac
     1561 catgttttcc tctgaatatg tttgctcccc cctccattct tatccaccaa aatttagata
     1621 acctatagtt ataaatgagg ctctaaaata gccttaagct attaaaatta agatttcctg
     1681 ccaataattg cattgggagt agagtattac tttgagcaga gatgtcaaga aagttagaag
     1741 aaactcttcc aagagactgg gcatctacat gctccatcct gttgaaggca cagaaaggac
     1801 ttggaagcca gaggttacct cctgatctac cttcagtaca aaacagtaaa agacattgga
     1861 aatgacaaaa aatatgacca aaccaaacca accccccacc ttgctaccac caccaccacc
     1921 accaacaaca acaacaacaa caaaaaactg gacctgggct gagcttgcca acaaactctt
     1981 tggccacaaa ccttgaggcc atatagctcc ttttataatt tttcaggaca ccctatgctt
     2041 tcaagaacca tcatataatt aaaagcagta ctcattctgt cacactcaac aaaaataatc
     2101 aagataacta acttggattc tgtttatatc atatagaaat cgacatgtac ttattctttg
     2161 attataatag tgcatccttg aagaatgtat ctaattaatt caacaatcag acaattctct
     2221 ggtgattagt agcatagtta atacaaatga attttgaagt tatgtggaga gctaacaaca
     2281 gacggtggag aactaactgt acttaatgat cattgaactt tgggtcaaat atttgcaatc
     2341 ctctccatgg ccctgtgaaa aggtactaaa cactccaaaa taaagaaatg ggatgatacc
     2401 aatgggatgt aggactgaga gttagttctt tgctcccata cttcagggac atcttataca
     2461 atacaatttt aagacagtgt tataatggct tggaatggag tataccctaa caaggtattg
     2521 aaagtttggt ccttgtgttg atgttctaga aattttagga agcaagacct acccaagagg
     2581 aggtaggtca atggttcttc ctctctcatt ttctgcttct tgtttcccat agaggaaggc
     2641 agctctttgc tacacccctt ctacactgat attttactca agtgcataaa atctaactga
     2701 tataaaaaaa tccttcatta acttgctctg ttagtaattt ggttataata ttataaaatg
     2761 attgataaaa atg
//
