LOCUS       NM_001024138            4778 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus G protein-coupled receptor 139 (Gpr139), mRNA.
ACCESSION   NM_001024138 XM_146103
VERSION     NM_001024138.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4778)
  AUTHORS   Nogueira,P.A.S., Moura-Assis,A., Zanesco,A.M., Bombassaro,B.,
            Gallo-Ferraz,A.L., Simoes,M.R., Engel,D.F., Razolli,D.S.,
            Gaspar,J.M., Junior,J.D. and Velloso,L.A.
  TITLE     The orphan G protein-coupled receptor, GPR139, is expressed in the
            hypothalamus and is involved in the regulation of body mass, blood
            glucose, and insulin
  JOURNAL   Neurosci Lett 792, 136955 (2023)
   PUBMED   36347339
  REMARK    GeneRIF: The orphan G protein-coupled receptor, GPR139, is
            expressed in the hypothalamus and is involved in the regulation of
            body mass, blood glucose, and insulin.
REFERENCE   3  (bases 1 to 4778)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   4  (bases 1 to 4778)
  AUTHORS   Dao,M., Stoveken,H.M., Cao,Y. and Martemyanov,K.A.
  TITLE     The role of orphan receptor GPR139 in neuropsychiatric behavior
  JOURNAL   Neuropsychopharmacology 47 (4), 902-913 (2022)
   PUBMED   33479510
  REMARK    GeneRIF: The role of orphan receptor GPR139 in neuropsychiatric
            behavior.
REFERENCE   5  (bases 1 to 4778)
  AUTHORS   Lee,B.R., Budzillo,A., Hadley,K., Miller,J.A., Jarsky,T., Baker,K.,
            Hill,D., Kim,L., Mann,R., Ng,L., Oldre,A., Rajanbabu,R., Trinh,J.,
            Vargas,S., Braun,T., Dalley,R.A., Gouwens,N.W., Kalmbach,B.E.,
            Kim,T.K., Smith,K.A., Soler-Llavina,G., Sorensen,S., Tasic,B.,
            Ting,J.T., Lein,E., Zeng,H., Murphy,G.J. and Berg,J.
  TITLE     Scaled, high fidelity electrophysiological, morphological, and
            transcriptomic cell characterization
  JOURNAL   Elife 10, e65482 (2021)
   PUBMED   34387544
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4778)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4778)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
  REMARK    GeneRIF: GPR139 mRNA was predominantly expressed in specific areas
            of mouse brain during pre- and postnatal development.
REFERENCE   8  (bases 1 to 4778)
  AUTHORS   Matsuo,A., Matsumoto,S., Nagano,M., Masumoto,K.H., Takasaki,J.,
            Matsumoto,M., Kobori,M., Katoh,M. and Shigeyoshi,Y.
  TITLE     Molecular cloning and characterization of a novel Gq-coupled orphan
            receptor GPRg1 exclusively expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 331 (1), 363-369 (2005)
   PUBMED   15845401
REFERENCE   9  (bases 1 to 4778)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   10 (bases 1 to 4778)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124438.4.
            
            On Feb 13, 2019 this sequence version replaced NM_001024138.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.13577.1,
                                           SRR9219381.313991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC124438.4         66470-66736
            268-4778            AC124438.4         105751-110261
FEATURES             Location/Qualifiers
     source          1..4778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.79 cM"
     gene            1..4778
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /note="G protein-coupled receptor 139"
                     /db_xref="GeneID:209776"
                     /db_xref="MGI:MGI:2685341"
     exon            1..267
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1202
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /note="G protein-coupled receptor PGR3; orphan G
                     protein-coupled receptor TRHRL2; g(q)-coupled orphan
                     receptor GPRg1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 139"
                     /protein_id="NP_001019309.1"
                     /db_xref="CCDS:CCDS21778.1"
                     /db_xref="GeneID:209776"
                     /db_xref="MGI:MGI:2685341"
                     /translation="MEHTHAHLAANSSACGLGFVPVVYYSFLLCLGLPANILTVIILS
                     QLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILTMQMPLIPDKIIEVLEFS
                     SIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSVYITCFLTSIPYYWWPN
                     IWTEDYISTSMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKT
                     TAILFTITSIFATLWAPRIIMILYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFL
                     YCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQY
                     DKHGKPIKVSP"
     exon            268..4778
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /note="hexamer: ATTAAA"
     polyA_site      4778
                     /gene="Gpr139"
                     /gene_synonym="Gm495; GPRg1; PGR3"
                     /note="major polyA site"
ORIGIN      
        1 gccagagaac cgagctgcct atctaggagg gcaggtgcgg agccacccga ggacaccagc
       61 cagtagtgga agcgggtccc gcggtgcggc gatcctccct agggctgcct ggtccccagc
      121 cgcttggcag ctgcgccgag cccagcccgg cgaggggcgc gctcatggag cacacgcacg
      181 cccacctcgc tgcgaatagc tcggcttgcg gcttaggctt cgtgccggtg gtctactaca
      241 gcttcttgct gtgcctcggg ttaccagcaa atatcttgac agtcattatc ctctctcaac
      301 tggtagccag aagacagaag tcctcctaca actatcttct ggcacttgct gctgctgaca
      361 tcttggtcct ctttttcatt gtctttgtgg atttcttgtt agaagatttc attttgacca
      421 tgcagatgcc tctgatccct gacaagatca tagaagttct agagttctcc tccatccaca
      481 cttctatttg gattacggtc cccttaacgg ttgacaggta tatcgctgtc tgtcacccac
      541 tcaaatacca cacagtttcc tacccagcca ggacccggaa agtcattctg agtgtttaca
      601 taacttgctt cctgaccagt atcccctact actggtggcc taacatctgg accgaagact
      661 acatcagcac ctccatgcat catgtccttg tctggatcca ctgtttcacc gtgtacctgg
      721 tgccctgctc catcttcttc atcttgaact ccatcattgt gtacaagctt aggagaaaga
      781 gcaatttccg cctccgtggc tattccacag ggaagaccac tgccatcttg tttaccatta
      841 cctccatctt cgccaccctc tgggcccccc gcatcatcat gattctctac cacctctacg
      901 gagcacccat ccagaaccct tggctggtcc acatcatgtt ggatgttgcc aacatgctag
      961 cccttctgaa cacagccatc aacttctttc tctactgctt catcagcaag cgcttccgta
     1021 ccatggcagc tgccacactc aaggccttgt tcaagtgtca gaagcagcct gtacagttct
     1081 ataccaacca taacttttcc ataacaagta gtccctggat ctcaccagca aactcacact
     1141 gcatcaagat gctggtgtac cagtatgaca aacatggaaa gcctataaaa gtatccccgt
     1201 gaccccacag ggctggcact tgtgcctctg tgtaatgttt ccagatgaga gggtatccca
     1261 tcctctggct gaacagctct ccttaagagt gctaacctga tttccaatct ccacagactg
     1321 agcagctctc aggctgccag atgagaagag atggaagaga aaagaggaga gcatgaatct
     1381 tggtgtttga gggtttttct tttttaatgc acgtattttc acaaaatcat actgacagcc
     1441 aaaggtcctg ctggcttgaa gacgccactg gcacttataa atgccatcat attgtgacca
     1501 ataaagacca cagtagagaa gtagttagtg ctggtaccat ccacagccac taggaactaa
     1561 ccactcatgt gtgtgatcca ccaagtcacc gtggtgtgta gctgagccac actcttcttc
     1621 caagagtcag gtcatccctc atttccttgt gccattgcca gcagctaaca gggctgactg
     1681 atttggattt ttttttccaa aggtgccctt tgtcccaggc aaagctgtgg tctccaagtg
     1741 gcactggcga ctctggctgc agcatgacaa catggggaaa cggacgtgtc acatcccatc
     1801 caaactgttg ctggaatgtc tacagggagg ttccaaaccc acatgactat gtcccttaga
     1861 cttgggggtc taaggtgcag ttttctattt gccataatgt atagatttta tgtctcctct
     1921 aaaacaaaga ccctgcctgt tgtgtggggg aaaaggagga actcttgagc ccagaaaaac
     1981 aaaaaaaatc aagcccactc ttgccactgt tttgattcat ccctgtgtgt gctgtataca
     2041 atccttgcat tcaaatcatc ttcctgcggc accccacgtg cttgctagag aagccttttc
     2101 tgtgtcaagc tgttagtcct gccccttgcc tgctcaagcc ctcaccaatg ttgctttact
     2161 tgaagtgact tcttaactgg agatactaat tggggggtca gaaactgaag ctcttctggt
     2221 gggaaggaag tgtgtagatc ccaccacagc ccagctagca ttgctgtata ggaccctaaa
     2281 cacaaacaca gaggggtggc tgtgacatag aggagtggct atgccaacca ctgttctggc
     2341 ctttgatgta agtggctcag ttgggggagg ggtgccagct atcagtaaag ctgtttaact
     2401 cagatgtttc aaagatgcta aattttattt attattttcc ccttacctgt tcaaggtaag
     2461 aagaaaccta ggatgtggat aggggcatct ctgaggatta ccacgtgtat gtgcagacat
     2521 gtagcacata tatatagaca tgactacatt aaactgttgt gtggtgtgct ttaaaaggga
     2581 tgttcacact agagttaccc ttatttgtgc attttatttg tgcccctttt ccagatcctc
     2641 agcatttgaa accatccctg gtttggaaga aatcttccaa aatggttttg gaaactgcat
     2701 gatatttttg atgtccaaac taaacagagt cacctgaaac acttagcccc atagacttga
     2761 tttatactgc attttctctc tcaattgaaa ggtctgtccc tatcacctta aggggttcta
     2821 tagcaaaaga gtgggatgga aaggcccctg gagcaacaca agtaccaaat ttccaccaag
     2881 gctattctat actaacccaa tgcaatttga agttgtattg tttctatccc tgttaaatgg
     2941 cttatgggag agtctcacca aacccaatag ttagattctg aagtcagtgc aaaagtggat
     3001 gaactcatgg ggctgtggtt cctgcacaca gtcctcagga aaaaaagacc tctgaacacc
     3061 caagaagctt cattttgatc cagcattgag acgggccaat gatactttgg ttgaagataa
     3121 tacagagtca gctggtgttt agggggtgtg tcctactatt gtgatgtatc tgagaaaatc
     3181 aggattacct ggatacagca agccacaccc accaaaaagt ctgcagaagt tactcacgtg
     3241 agggatgaac tgagtcctag cttccatctt gcttgctccc tagagcatac actcaatgag
     3301 tgaaatgtga gcaaatcccc cacatctctt gaattgcatt tctttcattt ttcccccaag
     3361 catgtacaat cgaatgtatg ttcattagct gtgtgtatga cacaattcca ttgcccttcc
     3421 cccgtatgta aacattaacc aaaggttacc tatgctgagt atatattata tatgtgtgtg
     3481 tttatttatt tttaagacac atatctctaa aaatgttacc ttgagctata cataaatgat
     3541 tcaaagtgca atatctataa aggttaagca attccttttt gagaatgtac acaggatgag
     3601 aagttagtct ttgactctca gtgctgcctg ctctgtgttt taaattgtgt gtaaaacaat
     3661 taattattta aaggctgggt gtgcactggg aatgctcccc agacactcat ttatgacttt
     3721 tcttaatagt acaggttcta ttaggtaggt atggcagcat ctctttcttc tgactacatt
     3781 tctatttctc taagcaattt ttcaaactaa tccataaaag caccccagag agctgctata
     3841 tcttctgttt aatatataca tggataccct tttggttagt tgctatatat catagcctat
     3901 atatgtatgt atatatacat atatatgtat accttttagt atgtatatgt atatatatat
     3961 gtatatgcat gtatatacat atatatatac atatcctaaa gtttaagtat ttaagatttc
     4021 agattgaata ttcatttatt tactatttat attaataata acaaacaatg atgaagatgt
     4081 tttcttttta actttaaaga ttataagcct tttctttcag gccaggtttg aaagacgaag
     4141 cttgtcacat aaacagctgc tgctaaggac aaacacctta gcctgggttt ttgtggtgct
     4201 tctttcaaag actgttgttc actatcacct ccattgctgt atgatttgtg tccttggaca
     4261 tggtgacagt gccacacatg tacatgctga gtctctttct taacaactgg aagcctgggg
     4321 aaagagataa gggggacagc agacaaacca taaaagataa gccatgcgaa tgaatgaaca
     4381 tccctgctcc aaccaccttg caataggaaa gggttatttt gcacagctgg tgcctacttg
     4441 tccagcgtgg ggaaccctta ggaagtgcat taatgactct aatgttgacg actactactg
     4501 ctcaaaaagg gaacacgagg ttactacaga taaacagtaa atgctcatat tttcttaact
     4561 agataatata ttgtgtttgg actagtttgt attctaattc taatatggtg cacacttggt
     4621 gtttgctatt tgcatatatg ttcaaccacc tgcagtatgc tgggttttag ttatattatt
     4681 tttaattgat aaatcataat tgtatacagt tatggggtgc cgtgtgatgt tttgatatgt
     4741 gtattaaatg tgcaatgatt aaatcgagca aatcaaaa
//
