LOCUS       NM_207220               1858 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus G protein-coupled receptor 137 (Gpr137), transcript
            variant 1, mRNA.
ACCESSION   NM_207220 XM_129075
VERSION     NM_207220.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Li,L., Tang,J., Cao,B., Xu,Q., Xu,S., Lin,C. and Tang,C.
  TITLE     GPR137 inactivates Hippo signaling to promote gastric cancer cell
            malignancy
  JOURNAL   Biol Direct 19 (1), 3 (2024)
   PUBMED   38163861
  REMARK    GeneRIF: GPR137 inactivates Hippo signaling to promote gastric
            cancer cell malignancy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Iwasa,K., Yamagishi,A., Yamamoto,S., Haruta,C., Maruyama,K. and
            Yoshikawa,K.
  TITLE     GPR137 Inhibits Cell Proliferation and Promotes Neuronal
            Differentiation in the Neuro2a Cells
  JOURNAL   Neurochem Res 48 (3), 996-1008 (2023)
   PUBMED   36436172
  REMARK    GeneRIF: GPR137 Inhibits Cell Proliferation and Promotes Neuronal
            Differentiation in the Neuro2a Cells.
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX200961.1, BC048078.1 and AC120557.12.
            
            On Apr 13, 2018 this sequence version replaced NM_207220.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039612.1, SRR7974084.30058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               CX200961.1         1-339
            340-1845            BC048078.1         212-1717
            1846-1858           AC120557.12        60909-60921
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.09 cM"
     gene            1..1858
                     /gene="Gpr137"
                     /note="G protein-coupled receptor 137"
                     /db_xref="GeneID:107173"
                     /db_xref="MGI:MGI:2147529"
     exon            1..711
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1545
                     /gene="Gpr137"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integral membrane protein GPR137; G protein-coupled
                     receptor TM7SF1L1; transmembrane 7 superfamily member
                     1-like 1 protein"
                     /codon_start=1
                     /product="integral membrane protein GPR137 isoform 1"
                     /protein_id="NP_997103.1"
                     /db_xref="CCDS:CCDS29512.1"
                     /db_xref="GeneID:107173"
                     /db_xref="MGI:MGI:2147529"
                     /translation="MESNLSGLVPAAGLVPALPPTVTLGLTAAYTALYALLFFSVYAQ
                     LWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCP
                     VCLQFFTLTLMNLYFVQVVFKAKAKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVL
                     SRQRQAQPWVLLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQA
                     AAIGGAMVLLYASRACYNLAALALAPRSRLDAFDYDWYNVSDQADLVNDLGNKGYLVF
                     GLILFVWELLPTTLLVGFFRVHRPPQDLSTSRILNGQVFGSRSYFFDRAGHCEDEGCS
                     WEHSRSESTSMSGSLGSGSWYGAIGREPGWGGASQTRTTPLLFSQVPGPGSHHHSLYS
                     TPQT"
     exon            712..761
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     exon            762..987
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1137
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1266
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1385
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1858
                     /gene="Gpr137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr137"
                     /note="hexamer: AATAAA"
     polyA_site      1845
                     /gene="Gpr137"
                     /note="major polyA site"
ORIGIN      
        1 gagcaaccaa ggccagggac tctgtgccac tgcatcctcg catcttggct ctggggctgg
       61 cccagggagg gacaccccca acccccattt catttgccct gggtaggaaa gaccacttta
      121 tacactccag agtgacgggt ctagggccca gggcccaggt tacccgtgcc cacccccacc
      181 cccaccccca cgcccgactc tgctgagaag gaaaggcctg acaacctcaa cttctttttt
      241 ccagagtttc caggtctcac cacctattgc aggtcccacc cctccgtatt tatttccctg
      301 gcttctggcc agccctctat ctctgtctcc gggtttcagg cctccctcct tgacatggag
      361 agtaacctgt ctggtctggt gcctgcagct gggctggtac ctgcactgcc gcctacagtg
      421 accctggggc tgaccgctgc ctacactgcc ctatatgctc tgctcttctt ctctgtctat
      481 gcccagctct ggctggtgct tctgtatggg cacaagcgcc tcagctatca gacagtattc
      541 ctggcgctct gtctgctctg ggcagccttg cgtaccacac ttttctcctt ctacttccga
      601 gatactccca gggccaaccg cctggggccc ttgccttttt ggcttctcta ttgctgccct
      661 gtctgcctgc agttcttcac actgacgctt atgaacctct actttgtgca ggtggtgttc
      721 aaggccaagg cgaagcgtcg gccagagatg agccgaggct tgctggctgt ccgaggggcc
      781 ttcgtgggtg cttcactgct ctttttgctg gtgaatgtac tgtgtgcagt gctgtctcgc
      841 cagcgccagg cacagccctg ggtccttctg ctggtacgtg tcctggtgag cgactctctc
      901 ttcgtcatct gtgccctctc gcttgctgcc tgcctctgcc ttgtggcccg tcgagcccct
      961 tccaccagca tctacttaga ggccaagggg accagcgtgt gtcaggcagc tgctataggg
     1021 ggtgccatgg tccttctcta tgccagccgg gcctgttaca acctggcagc tctggccttg
     1081 gcccctcgga gccggctaga tgccttcgat tacgactggt acaacgtatc tgaccaggca
     1141 gatctggtga atgacctagg gaacaaaggc tacctggtgt ttggtctcat cctcttcgtt
     1201 tgggaactgc tgcccaccac attgctggtg ggcttcttcc gggtacaccg gcccccacag
     1261 gatctgagca ccagtcgaat cctcaatggg caggtttttg gctcccgatc ctacttcttt
     1321 gaccgggctg gccactgtga ggatgagggc tgctcctggg agcatagccg gagtgagagc
     1381 accagcatgt ccggcagcct gggctctggc agttggtatg gtgccatcgg acgtgagcca
     1441 ggctggggag gggccagcca gacgaggacc actcctctgc tcttctccca ggtgccagga
     1501 cctggtagtc accaccacag cctctattct acaccacaga cgtgatctgc ttttactccc
     1561 cttagaatac ccaggcccca gctcccctga tccctggccc ctgtgccaag tacgtctgct
     1621 gcttcttgcc caggttgcca ggagactgtg gctgcttctc tcctctggcc ggctccttgc
     1681 cgctcctatt gtagtgagct tgtgccatcc ccctaaaatg gaaacaaggc cccaggatac
     1741 cagatgccca cagtgccctg gcatgacctg ccacctctgc ttccacactg gagccggcta
     1801 cctctcctgt gcctaccact caataaacag aggctgtgcc ctgtcctccc tcctgtca
//
