LOCUS       NM_019925               2439 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus G protein-coupled receptor 132 (Gpr132), mRNA.
ACCESSION   NM_019925
VERSION     NM_019925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2439)
  AUTHORS   Wang,J.L., Dou,X.D., Cheng,J., Gao,M.X., Xu,G.F., Ding,W.,
            Ding,J.H., Li,Y., Wang,S.H., Ji,Z.W., Zhao,X.Y., Huo,T.Y.,
            Zhang,C.F., Liu,Y.M., Sha,X.Y., Gao,J.R., Zhang,W.H., Hao,Y.,
            Zhang,C., Sun,J.P., Jiao,N. and Yu,X.
  TITLE     Functional screening and rational design of compounds targeting
            GPR132 to treat diabetes
  JOURNAL   Nat Metab 5 (10), 1726-1746 (2023)
   PUBMED   37770763
REFERENCE   2  (bases 1 to 2439)
  AUTHORS   Steffan,B.N., Calise,D., Park,S.C., Niu,M., Yang,J., Hammock,B.D.,
            Jones,M., Steele,C. and Keller,N.P.
  TITLE     Loss of the mammalian G-protein coupled receptor, G2A, modulates
            severity of invasive pulmonary aspergillosis
  JOURNAL   Front Immunol 14, 1173544 (2023)
   PUBMED   37435068
  REMARK    GeneRIF: Loss of the mammalian G-protein coupled receptor, G2A,
            modulates severity of invasive pulmonary aspergillosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2439)
  AUTHORS   Yi,C., He,J., Huang,D., Zhao,Y., Zhang,C., Ye,X., Huang,Y.,
            Nussinov,R., Zheng,J., Liu,M. and Lu,W.
  TITLE     Activation of orphan receptor GPR132 induces cell differentiation
            in acute myeloid leukemia
  JOURNAL   Cell Death Dis 13 (11), 1004 (2022)
   PUBMED   36437247
  REMARK    GeneRIF: Activation of orphan receptor GPR132 induces cell
            differentiation in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2439)
  AUTHORS   Wedel,S., Osthues,T., Zimmer,B., Angioni,C., Geisslinger,G. and
            Sisignano,M.
  TITLE     Oxidized linoleic acid metabolites maintain mechanical and thermal
            hypersensitivity during sub-chronic inflammatory pain
  JOURNAL   Biochem Pharmacol 198, 114953 (2022)
   PUBMED   35149052
REFERENCE   5  (bases 1 to 2439)
  AUTHORS   Vadevoo,S.M.P., Gunassekaran,G.R., Lee,C., Lee,N., Lee,J., Chae,S.,
            Park,J.Y., Koo,J. and Lee,B.
  TITLE     The macrophage odorant receptor Olfr78 mediates the lactate-induced
            M2 phenotype of tumor-associated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (37) (2021)
   PUBMED   34504016
  REMARK    GeneRIF: The macrophage odorant receptor Olfr78 mediates the
            lactate-induced M2 phenotype of tumor-associated macrophages.
REFERENCE   6  (bases 1 to 2439)
  AUTHORS   Radu,C.G., Yang,L.V., Riedinger,M., Au,M. and Witte,O.N.
  TITLE     T cell chemotaxis to lysophosphatidylcholine through the G2A
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 101 (1), 245-250 (2004)
   PUBMED   14681556
  REMARK    GeneRIF: role of G2A in lysophosphatidylcholine-mediated T-cell
            migration
REFERENCE   7  (bases 1 to 2439)
  AUTHORS   Rikitake,Y., Hirata,K., Yamashita,T., Iwai,K., Kobayashi,S.,
            Itoh,H., Ozaki,M., Ejiri,J., Shiomi,M., Inoue,N., Kawashima,S. and
            Yokoyama,M.
  TITLE     Expression of G2A, a receptor for lysophosphatidylcholine, by
            macrophages in murine, rabbit, and human atherosclerotic plaques
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (12), 2049-2053 (2002)
   PUBMED   12482833
  REMARK    GeneRIF: G2A is expressed predominantly by macrophages within
            atherosclerotic lesions at the aortic root of apolipoprotein
            E-deficient mice.
REFERENCE   8  (bases 1 to 2439)
  AUTHORS   Le,L.Q., Kabarowski,J.H., Wong,S., Nguyen,K., Gambhir,S.S. and
            Witte,O.N.
  TITLE     Positron emission tomography imaging analysis of G2A as a negative
            modifier of lymphoid leukemogenesis initiated by the BCR-ABL
            oncogene
  JOURNAL   Cancer Cell 1 (4), 381-391 (2002)
   PUBMED   12086852
REFERENCE   9  (bases 1 to 2439)
  AUTHORS   Le,L.Q., Kabarowski,J.H., Weng,Z., Satterthwaite,A.B.,
            Harvill,E.T., Jensen,E.R., Miller,J.F. and Witte,O.N.
  TITLE     Mice lacking the orphan G protein-coupled receptor G2A develop a
            late-onset autoimmune syndrome
  JOURNAL   Immunity 14 (5), 561-571 (2001)
   PUBMED   11371358
REFERENCE   10 (bases 1 to 2439)
  AUTHORS   Weng,Z., Fluckiger,A.C., Nisitani,S., Wahl,M.I., Le,L.Q.,
            Hunter,C.A., Fernal,A.A., Le Beau,M.M. and Witte,O.N.
  TITLE     A DNA damage and stress inducible G protein-coupled receptor blocks
            cells in G2/M
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12334-12339 (1998)
   PUBMED   9770487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK153765.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019925.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153765.1, AK154509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2439              AK153765.1         2-2440
FEATURES             Location/Qualifiers
     source          1..2439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.25 cM"
     gene            1..2439
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /note="G protein-coupled receptor 132"
                     /db_xref="GeneID:56696"
                     /db_xref="MGI:MGI:1890220"
     exon            1..47
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /inference="alignment:Splign:2.1.0"
     exon            48..138
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1259
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /note="G protein-coupled receptor G2A; G2 accumulation
                     protein"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 132"
                     /protein_id="NP_064309.1"
                     /db_xref="CCDS:CCDS26199.1"
                     /db_xref="GeneID:56696"
                     /db_xref="MGI:MGI:1890220"
                     /translation="MRSEPTNAAGNTTLGVTSVLQSTSVPSSETCHVSYEESRVVLVV
                     VYSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQ
                     HKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTIS
                     ACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNH
                     QIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDA
                     VCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEVSRIHTGWKKWSTKTYVT
                     CSKDSEETHLPTELSNTYTFPNPAHPPGSQPAKLGLLCSPERLPEELC"
     exon            139..2439
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2439
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /note="putative"
ORIGIN      
        1 cctgcctcag gacgggcctg ccctgtgctg cctcaggact ggcttgggtc attttaagct
       61 gccagagcca ccttcacaag ggggtccaca gaactcacat aggagccacc atgagatcag
      121 aacctaccaa tgcagcagga aacaccacac tgggggttac ctccgttctt cagagcacct
      181 cagtaccttc ttctgagacc tgccacgtct cctacgagga gagcagagtg gtcctggtgg
      241 tggtgtacag tgccgtgtgc ctgctgggcc taccagccaa ctgcctgact gcctggctga
      301 cgctgctgca agtcctgcag aggaacgtgc tagccgtcta cctgttctgc ctgtccctct
      361 gtgagctgct ctacatcagc acggtgccat tgtggatcat ctacatccag aatcagcaca
      421 aatggaacct gggtccgcag gcctgcaagg tgactgctta catcttcttc tgcaacatct
      481 acatcagcat cctcttgctc tgctgcattt cctgcgaccg ctacatggcc gtggtctatg
      541 cactggagag ccgaggccac cgccaccaga ggactgctgt caccatttct gcgtgtgtga
      601 ttcttcttgt tggacttgtt aactatccag tgtttgacat gaaggtggag aagagtttct
      661 gctttgagcc cctgaggatg aacagcaaga tagccggcta ccactacctg cgtttcacct
      721 ttggctttgc catccctctc ggcatcctgg cgttcaccaa tcaccagatc ttccggagca
      781 tcaaactcag tgacagcctg agcgctgcgc agaagaacaa ggtgaagcgc tccgccatcg
      841 cggtcgtcac catcttcctg gtctgctttg ctccctacca cgtggtactc ctcgtcaaag
      901 ctgccagctt ttccttctac caaggagaca tggatgccgt gtgtgccttt gaaagcagac
      961 tgtacacagt ctctatggtg tttctgtgcc tgtctacagt caacagtgtg gctgacccca
     1021 tcatctacgt gctgggtaca gaccactctc ggcaagaagt gtccagaatc cacacagggt
     1081 ggaaaaagtg gtccacaaag acatatgtta catgctcaaa ggactctgag gagacacact
     1141 tgcccacaga gctttcaaac acatacacct tccccaatcc cgcgcaccct ccaggatcac
     1201 agccagcgaa gctaggttta ctgtgctcgc cagagagact gcctgaggag ctctgctaag
     1261 tccactcttc ctcaaaacta gcaccagtca cacatacctg gtcctctgag tcaccgtctg
     1321 gggtgtccac agcactatag atgcctttgt tcgggcacac gctgctgatc tttccttcct
     1381 aaggccacca actctgaaag tatctgttcc ttagacgtcc tcaggctccc ctctatggaa
     1441 agcggggctt gctaaggagc ctgtggctct taggagagct ctttatcagc agtgtgctct
     1501 gcggggctcc cagcggccat cagctgagca cctggtagga cactttattc ccccattgtc
     1561 cagtggctaa cacagttagt tcatcttggg gctttccact gagatggaag tgaactgtgt
     1621 tcagagttac caccatggag ataggagtcc aaccctgcgg gctcccactg ggggttggtt
     1681 ctgagtggac ataattgtct tctggaggag ccatggagca cggtggccaa ttgatccagc
     1741 tcctagtagc ccaggatatc ctcccctggg acccctcaac catttacatt aggaagtgct
     1801 agtggacacc ccaggaatag gttggtatag ctgctaccag ataaggagtt atctgacatc
     1861 tggcatgtct ttctttgcct tgcaacttct ggctttgaca tcacagagga ggtaggctgg
     1921 ggctcttgaa agggcaagcc aggagcaagc cccactttgc cccgttttct ccaatgttga
     1981 ctctgagtca aatcccggct ctgctccaag agccttgtct tgctgagtca ttcctgtgct
     2041 acctcactgg gtcactcgct gctgggactg acgccgcccc ctcccccccc cccgacccca
     2101 ccccatccca gaggctcctg atgcacttgg agtgcaaggg ccaaggaccc tgagcttggt
     2161 gggcctcgga gctgatcctc ctgaagcaca cacatcacgg atgctgcact gagactgtga
     2221 cctcagagtt aacttcagct ctaccttgga agaagtacgg agaataagaa cacagacttc
     2281 ctttccttgc tacagggcat ttttgattgt tttttgagac gaggtttctc gcacctcaga
     2341 ctgatcttaa actcactaag taacatagga agacctgttt tctcctgatt ctgtctgttg
     2401 tccccatctc ttggggtgga attaaaagga tgcatcacc
//
