LOCUS       NP_064309                382 aa            linear   ROD 27-APR-2025
DEFINITION  probable G-protein coupled receptor 132 [Mus musculus].
ACCESSION   NP_064309
VERSION     NP_064309.1
DBSOURCE    REFSEQ: accession NM_019925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Wang,J.L., Dou,X.D., Cheng,J., Gao,M.X., Xu,G.F., Ding,W.,
            Ding,J.H., Li,Y., Wang,S.H., Ji,Z.W., Zhao,X.Y., Huo,T.Y.,
            Zhang,C.F., Liu,Y.M., Sha,X.Y., Gao,J.R., Zhang,W.H., Hao,Y.,
            Zhang,C., Sun,J.P., Jiao,N. and Yu,X.
  TITLE     Functional screening and rational design of compounds targeting
            GPR132 to treat diabetes
  JOURNAL   Nat Metab 5 (10), 1726-1746 (2023)
   PUBMED   37770763
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Steffan,B.N., Calise,D., Park,S.C., Niu,M., Yang,J., Hammock,B.D.,
            Jones,M., Steele,C. and Keller,N.P.
  TITLE     Loss of the mammalian G-protein coupled receptor, G2A, modulates
            severity of invasive pulmonary aspergillosis
  JOURNAL   Front Immunol 14, 1173544 (2023)
   PUBMED   37435068
  REMARK    GeneRIF: Loss of the mammalian G-protein coupled receptor, G2A,
            modulates severity of invasive pulmonary aspergillosis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Yi,C., He,J., Huang,D., Zhao,Y., Zhang,C., Ye,X., Huang,Y.,
            Nussinov,R., Zheng,J., Liu,M. and Lu,W.
  TITLE     Activation of orphan receptor GPR132 induces cell differentiation
            in acute myeloid leukemia
  JOURNAL   Cell Death Dis 13 (11), 1004 (2022)
   PUBMED   36437247
  REMARK    GeneRIF: Activation of orphan receptor GPR132 induces cell
            differentiation in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Wedel,S., Osthues,T., Zimmer,B., Angioni,C., Geisslinger,G. and
            Sisignano,M.
  TITLE     Oxidized linoleic acid metabolites maintain mechanical and thermal
            hypersensitivity during sub-chronic inflammatory pain
  JOURNAL   Biochem Pharmacol 198, 114953 (2022)
   PUBMED   35149052
REFERENCE   5  (residues 1 to 382)
  AUTHORS   Vadevoo,S.M.P., Gunassekaran,G.R., Lee,C., Lee,N., Lee,J., Chae,S.,
            Park,J.Y., Koo,J. and Lee,B.
  TITLE     The macrophage odorant receptor Olfr78 mediates the lactate-induced
            M2 phenotype of tumor-associated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (37) (2021)
   PUBMED   34504016
  REMARK    GeneRIF: The macrophage odorant receptor Olfr78 mediates the
            lactate-induced M2 phenotype of tumor-associated macrophages.
REFERENCE   6  (residues 1 to 382)
  AUTHORS   Radu,C.G., Yang,L.V., Riedinger,M., Au,M. and Witte,O.N.
  TITLE     T cell chemotaxis to lysophosphatidylcholine through the G2A
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 101 (1), 245-250 (2004)
   PUBMED   14681556
  REMARK    GeneRIF: role of G2A in lysophosphatidylcholine-mediated T-cell
            migration
REFERENCE   7  (residues 1 to 382)
  AUTHORS   Rikitake,Y., Hirata,K., Yamashita,T., Iwai,K., Kobayashi,S.,
            Itoh,H., Ozaki,M., Ejiri,J., Shiomi,M., Inoue,N., Kawashima,S. and
            Yokoyama,M.
  TITLE     Expression of G2A, a receptor for lysophosphatidylcholine, by
            macrophages in murine, rabbit, and human atherosclerotic plaques
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (12), 2049-2053 (2002)
   PUBMED   12482833
  REMARK    GeneRIF: G2A is expressed predominantly by macrophages within
            atherosclerotic lesions at the aortic root of apolipoprotein
            E-deficient mice.
REFERENCE   8  (residues 1 to 382)
  AUTHORS   Le,L.Q., Kabarowski,J.H., Wong,S., Nguyen,K., Gambhir,S.S. and
            Witte,O.N.
  TITLE     Positron emission tomography imaging analysis of G2A as a negative
            modifier of lymphoid leukemogenesis initiated by the BCR-ABL
            oncogene
  JOURNAL   Cancer Cell 1 (4), 381-391 (2002)
   PUBMED   12086852
REFERENCE   9  (residues 1 to 382)
  AUTHORS   Le,L.Q., Kabarowski,J.H., Weng,Z., Satterthwaite,A.B.,
            Harvill,E.T., Jensen,E.R., Miller,J.F. and Witte,O.N.
  TITLE     Mice lacking the orphan G protein-coupled receptor G2A develop a
            late-onset autoimmune syndrome
  JOURNAL   Immunity 14 (5), 561-571 (2001)
   PUBMED   11371358
REFERENCE   10 (residues 1 to 382)
  AUTHORS   Weng,Z., Fluckiger,A.C., Nisitani,S., Wahl,M.I., Le,L.Q.,
            Hunter,C.A., Fernal,A.A., Le Beau,M.M. and Witte,O.N.
  TITLE     A DNA damage and stress inducible G protein-coupled receptor blocks
            cells in G2/M
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12334-12339 (1998)
   PUBMED   9770487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK153765.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153765.1, AK154509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.25 cM"
     Protein         1..382
                     /product="probable G-protein coupled receptor 132"
                     /note="G protein-coupled receptor G2A; G2 accumulation
                     protein"
                     /calculated_mol_wt=42522
     Site            11
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z282.1)"
     Site            43..65
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Region          46..317
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          46..66
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          75..96
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            77..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Region          113..135
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            114..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Site            156..175
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Region          158..174
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          195..218
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            199..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Region          239..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            242..261
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     Region          285..310
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            287..309
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z282.1)"
     CDS             1..382
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /coded_by="NM_019925.4:111..1259"
                     /db_xref="CCDS:CCDS26199.1"
                     /db_xref="GeneID:56696"
                     /db_xref="MGI:MGI:1890220"
ORIGIN      
        1 mrseptnaag nttlgvtsvl qstsvpsset chvsyeesrv vlvvvysavc llglpanclt
       61 awltllqvlq rnvlavylfc lslcellyis tvplwiiyiq nqhkwnlgpq ackvtayiff
      121 cniyisilll cciscdryma vvyalesrgh rhqrtavtis acvillvglv nypvfdmkve
      181 ksfcfeplrm nskiagyhyl rftfgfaipl gilaftnhqi frsiklsdsl saaqknkvkr
      241 saiavvtifl vcfapyhvvl lvkaasfsfy qgdmdavcaf esrlytvsmv flclstvnsv
      301 adpiiyvlgt dhsrqevsri htgwkkwstk tyvtcskdse ethlptelsn tytfpnpahp
      361 pgsqpaklgl lcsperlpee lc
//
