LOCUS       NM_181751               2278 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G-protein coupled receptor 119 (Gpr119), mRNA.
ACCESSION   NM_181751
VERSION     NM_181751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2278)
  AUTHORS   Igarashi,M., Hayakawa,T., Tanabe,H., Watanabe,K., Nishida,A. and
            Kimura,I.
  TITLE     Intestinal GPR119 activation by microbiota-derived metabolites
            impacts feeding behavior and energy metabolism
  JOURNAL   Mol Metab 67, 101649 (2023)
   PUBMED   36462626
REFERENCE   3  (bases 1 to 2278)
  AUTHORS   Grevengoed,T.J., Trammell,S.A.J., McKinney,M.K., Petersen,N.,
            Cardone,R.L., Svenningsen,J.S., Ogasawara,D., Nexoe-Larsen,C.C.,
            Knop,F.K., Schwartz,T.W., Kibbey,R.G., Cravatt,B.F. and Gillum,M.P.
  TITLE     N-acyl taurines are endogenous lipid messengers that improve
            glucose homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (49), 24770-24778 (2019)
   PUBMED   31740614
REFERENCE   4  (bases 1 to 2278)
  AUTHORS   Arifin,S.A., Paternoster,S., Carlessi,R., Casari,I., Ekberg,J.H.,
            Maffucci,T., Newsholme,P., Rosenkilde,M.M. and Falasca,M.
  TITLE     Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1
            secretion from enteroendocrine L-cells through GPR119
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (9), 1132-1141
            (2018)
   PUBMED   29883799
  REMARK    GeneRIF: GPR119 is the oleoyl-lysophosphatidylinositol receptor
            that is required for GLP-1 secretion in enteroendocrine cells.
REFERENCE   5  (bases 1 to 2278)
  AUTHORS   Li,N.X., Brown,S., Kowalski,T., Wu,M., Yang,L., Dai,G., Petrov,A.,
            Ding,Y., Dlugos,T., Wood,H.B., Wang,L., Erion,M., Sherwin,R. and
            Kelley,D.E.
  TITLE     GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced
            Hypoglycemia
  JOURNAL   Diabetes 67 (7), 1401-1413 (2018)
   PUBMED   29669745
REFERENCE   6  (bases 1 to 2278)
  AUTHORS   Chu,Z.L., Jones,R.M., He,H., Carroll,C., Gutierrez,V., Lucman,A.,
            Moloney,M., Gao,H., Mondala,H., Bagnol,D., Unett,D., Liang,Y.,
            Demarest,K., Semple,G., Behan,D.P. and Leonard,J.
  TITLE     A role for beta-cell-expressed G protein-coupled receptor 119 in
            glycemic control by enhancing glucose-dependent insulin release
  JOURNAL   Endocrinology 148 (6), 2601-2609 (2007)
   PUBMED   17289847
  REMARK    GeneRIF: AR231453 also enhanced glucose-dependent insulin release
            in vivo and improved oral glucose tolerance in wild-type mice but
            not in GPR119-deficient mice.
            Erratum:[Endocrinology. 2007 Oct;148(10):4753]
REFERENCE   7  (bases 1 to 2278)
  AUTHORS   Sakamoto,Y., Inoue,H., Kawakami,S., Miyawaki,K., Miyamoto,T.,
            Mizuta,K. and Itakura,M.
  TITLE     Expression and distribution of Gpr119 in the pancreatic islets of
            mice and rats: predominant localization in pancreatic
            polypeptide-secreting PP-cells
  JOURNAL   Biochem Biophys Res Commun 351 (2), 474-480 (2006)
   PUBMED   17070774
  REMARK    GeneRIF: The Gpr119 mRNA levels were elevated in islets of obese
            hyperglycemic db/db mice as compared to control islets, suggesting
            a possible involvement of this receptor in the development of
            obesity and diabetes.
REFERENCE   8  (bases 1 to 2278)
  AUTHORS   Overton,H.A., Babbs,A.J., Doel,S.M., Fyfe,M.C., Gardner,L.S.,
            Griffin,G., Jackson,H.C., Procter,M.J., Rasamison,C.M.,
            Tang-Christensen,M., Widdowson,P.S., Williams,G.M. and Reynet,C.
  TITLE     Deorphanization of a G protein-coupled receptor for
            oleoylethanolamide and its use in the discovery of small-molecule
            hypophagic agents
  JOURNAL   Cell Metab 3 (3), 167-175 (2006)
   PUBMED   16517404
  REMARK    GeneRIF: GPR119 therefore represents a novel and attractive
            potential target for the therapy of obesity and related metabolic
            disorders.
REFERENCE   9  (bases 1 to 2278)
  AUTHORS   Soga,T., Ohishi,T., Matsui,T., Saito,T., Matsumoto,M., Takasaki,J.,
            Matsumoto,S., Kamohara,M., Hiyama,H., Yoshida,S., Momose,K.,
            Ueda,Y., Matsushime,H., Kobori,M. and Furuichi,K.
  TITLE     Lysophosphatidylcholine enhances glucose-dependent insulin
            secretion via an orphan G-protein-coupled receptor
  JOURNAL   Biochem Biophys Res Commun 326 (4), 744-751 (2005)
   PUBMED   15607732
  REMARK    Erratum:[Biochem Biophys Res Commun. 2005 Apr 1;329(1):417]
REFERENCE   10 (bases 1 to 2278)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB233291.1.
            
            On Aug 6, 2006 this sequence version replaced NM_181751.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB233291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.69 cM"
     gene            1..2278
                     /gene="Gpr119"
                     /note="G-protein coupled receptor 119"
                     /db_xref="GeneID:236781"
                     /db_xref="MGI:MGI:2668412"
     exon            1..1232
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1228
                     /gene="Gpr119"
                     /codon_start=1
                     /product="glucose-dependent insulinotropic receptor"
                     /protein_id="NP_861416.1"
                     /db_xref="CCDS:CCDS30113.1"
                     /db_xref="GeneID:236781"
                     /db_xref="MGI:MGI:2668412"
                     /translation="MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFT
                     LNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFD
                     RYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAV
                     FHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSV
                     NDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNP
                     LIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELD
                     G"
     exon            1233..2269
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagctag aaaagccgga ggctgaggac tgaaaaggag aggatgagta agctttaatg
       61 acatcaggaa accaaagatg gcaagctgcc agactggcct gccagtaatg gccagaacgg
      121 tgctgtgact ctgagcctat agcacatcta atcctgtccc atgagaatct gagctcgcca
      181 tccagcatgc ctttgtaagt ggaagtgctg ctacctcacc atggagtcat ccttctcatt
      241 tggagtgatc cttgctgtcc taaccatcct catcattgct gttaatgcac tggtagttgt
      301 ggctatgctg ctatcaatct acaagaatga tggtgttggc ctttgcttca ccttgaatct
      361 ggccgtggct gataccttga ttggcgtggc tatttctggt ctagttacag accagctctc
      421 cagctctgct cagcatacac agaagacctt gtgtagcctt cggatggcat ttgtcacttc
      481 ttctgcagct gcctctgtcc tcaccgtcat gctgattgcc tttgacagat accttgccat
      541 taagcagccc ctccgttact tccagatcat gaatgggctt gtggctggag catgcattgc
      601 aggactgtgg ttggtatctt accttatcgg cttcctccca ctcggagtct ccatattcca
      661 gcagaccacc taccatggac cctgcagctt ctttgctgtg tttcacccaa ggtttgtgct
      721 gaccctctcc tgtgctggct tcttcccagc tgtgctcctc tttgtcttct tctactgtga
      781 catgctcaag attgcctctg tgcacagcca gcagatccgg aagatggaac atgcaggagc
      841 catggccgga gcttatcggc ccccacggtc tgtcaatgac ttcaaggctg ttcgtactat
      901 agctgttctt attgggagct tcactctgtc ctggtctccc tttctcataa ctagcattgt
      961 gcaggtggcc tgccacaaat gctgccttta ccaagtgctg gaaaagtacc tgtggctcct
     1021 tggagttggc aactccctac tcaacccact catctatgcc tattggcaga gggaggttcg
     1081 gcagcagctc taccacatgg ccctgggagt gaaaaagttc ttcacttcaa tcctcctcct
     1141 tctcccagcc aggaatcgtg gtccagagag gaccagagaa agcgcctatc acatcgtcac
     1201 tatcagccat ccggagctcg atggctaaga cgctgcagga cttctctcaa gaacatgcaa
     1261 tcacatatcc ttctgtatga tgtgttttga gtgttttaca actggtaaag gcaggttgtc
     1321 ctgacctgcc gacactctta catgaccttt cagttcatct ctagaagtcg gccagccaga
     1381 gctggccttg ggatagcttc tccctagatg aagtattaac tgactcaaag gagaattgat
     1441 gtcatgagct tgatttcatt tgcagcaagt ttggtaactg gccaatctga agactactga
     1501 aatgagcaag catgagagat actctgaaaa catcagaagg aataagatgt caacacctgg
     1561 gcaagatcaa cagcaatgta ctccaggaca gactacaatt cctggagata acatctgtca
     1621 ctcaacactg agtgataact tcagtacctt cctggctatt tcttcaaagg ctacagagca
     1681 gtctggaatc acctcttcca tgaattctca tttgctattt cttcaatctt accaactcag
     1741 aggtggtacc tacaaatgtt aactctcatt aatcgtatat ctctccaccc gtctatcccc
     1801 aaaacattta agagggaggt gctataagat tgcatctttg ctgggacttc ttttagaggt
     1861 acacactgat ttgtggaaga tatttattaa ccctttctta ttaaaacttt tactcatttt
     1921 agaaatcttt gaacatagtt caggtactta taattatacc ctccagagat gaccactttt
     1981 attctccatt gttttttata ctttatatta tattatacat attttcctat gtcattgtgt
     2041 cttcttcaag agcataacag ctgtatgtat atgtgttttc aacaaatgaa tatgtagtgt
     2101 tttaattact tcctacagtt gtgtttgaat ctagtatttg tcattatcat atcagtataa
     2161 gtaacctgtg cataaatctc taatgtgcct ctgttcaatt actgaatttt atacagtctt
     2221 caaagcagca ttaataaatc aacaagtatt atgtcttgat aagaatttaa aaaaaaaa
//
