LOCUS       NM_030084               2157 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 108 (Gpr108), transcript
            variant 1, mRNA.
ACCESSION   NM_030084
VERSION     NM_030084.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Zhao,M., Zhang,Y., Qiang,L., Lu,Z., Zhao,Z., Fu,Y., Wu,B., Chai,Q.,
            Ge,P., Lei,Z., Zhang,X., Li,B., Wang,J., Zhang,L. and Liu,C.H.
  TITLE     A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1
            to suppress antiviral innate immunity
  JOURNAL   Cell Rep 42 (6), 112655 (2023)
   PUBMED   37330913
  REMARK    GeneRIF: A Golgi-resident GPR108 cooperates with E3 ubiquitin
            ligase Smurf1 to suppress antiviral innate immunity.
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Dong,D., Zhou,H., Na,S.Y., Niedra,R., Peng,Y., Wang,H., Seed,B. and
            Zhou,G.L.
  TITLE     GPR108, an NF-kappaB activator suppressed by TIRAP, negatively
            regulates TLR-triggered immune responses
  JOURNAL   PLoS One 13 (10), e0205303 (2018)
   PUBMED   30332431
  REMARK    GeneRIF: GPR108, an NF-kappaB activator suppressed by TIRAP,
            negatively regulates TLR-triggered immune responses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Edgar,A.J.
  TITLE     Human GPR107 and murine Gpr108 are members of the LUSTR family of
            proteins found in both plants and animals, having similar topology
            to G-protein coupled receptors
  JOURNAL   DNA Seq 18 (3), 235-241 (2007)
   PUBMED   17454009
  REMARK    GeneRIF: Murine Gpr108 gene is located at 17C-D and spans 12.8 kb;
            Gpr108 cDNA encodes a 562 residue protein that has 49% identity to
            human GPR107.[Gpr108 protein]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611826.1, AK159313.1 and BE981210.1.
            
            On Apr 22, 2015 this sequence version replaced NM_030084.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016104.1, AK159313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB611826.1         2-31
            31-2139             AK159313.1         2-2110
            2140-2157           BE981210.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.74 cM"
     gene            1..2157
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /note="G protein-coupled receptor 108"
                     /db_xref="GeneID:78308"
                     /db_xref="MGI:MGI:1925558"
     exon            1..179
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1763
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein GPR108; lung seven transmembrane
                     receptor 2"
                     /codon_start=1
                     /product="protein GPR108 isoform 1 precursor"
                     /protein_id="NP_084360.2"
                     /db_xref="CCDS:CCDS28929.1"
                     /db_xref="GeneID:78308"
                     /db_xref="MGI:MGI:1925558"
                     /translation="MAVSERRGLSGESPTQCRWGYLSLLVLTLSGCSGRIHRLTLTGE
                     KRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKKLPKVGFSLSRVRSGSVRSYSRRN
                     SHECPLDRNSSNFLVLFLINIKDLQVQVRKYGEQKLFISPGLLPEAPTQSGPPKPDPA
                     GTPKDNHVIHPSPTEMSAVKENQTAPQVSGDKTTPGEHRHSSERQPPTQDPSGKEKDQ
                     VLGLGHLNDSYNFSFHIVISSRAEEGQYSLNFHNCHNSIPGQEQPFDLTVMIREKNPE
                     GFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFKIHWLMAALAFTKSVSLL
                     FHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFVKYMLSDKEKK
                     IFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHL
                     QDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVE
                     SSTLAFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGR
                     ELL"
     exon            180..299
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..350
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..433
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..555
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..749
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..854
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..988
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1064
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1138
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1256
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1387
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1431
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1481
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1565
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1690
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2143
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2143
                     /gene="Gpr108"
                     /gene_synonym="1810015L19Rik; Lustr2"
                     /note="major polyA site"
ORIGIN      
        1 aggccttatc aggcgtcaga ggctgtgttc ggggggcagt cgcagcccca gagatggcag
       61 tgagcgagag gagggggctc agcggcgaga gcccaacgca gtgccgatgg ggatacttgt
      121 cgctgctggt gctgacgctg agcggctgct caggccgtat ccaccggctg actctcacag
      181 gggagaagcg agctgacatc caactgaaca gcttcggatt ctacaccaat ggttccctgg
      241 aagtagagct gagcttactg cgactcagcc tccaggagac agaaaagaag ttgccaaagg
      301 tggggttcag cttgagcaga gttcggtctg gcagtgtccg ctcctactcg agacggaact
      361 cccatgaatg ccctctggat agaaacagca gcaacttcct ggtcctgttc ctcatcaata
      421 tcaaggacct gcaggtccaa gtccgaaaat atggggagca gaagttgttc atctcccctg
      481 gccttctccc tgaagctccc acccagtcag gtcccccgaa accagaccca gcaggcaccc
      541 ccaaggacaa ccacgtcatt cacccatctc ctacagagat gtctgcagtc aaggagaatc
      601 agacagcgcc ccaggtttca ggggataaaa ctaccccagg ggaacacagg cactcatccg
      661 agagacagcc acccacgcag gaccccagtg ggaaggagaa ggatcaggtg ttgggactgg
      721 gccacctcaa tgactcctac aacttcagtt tccacattgt gatcagctcc agggctgagg
      781 aaggccagta cagcctcaac ttccacaact gtcacaactc catcccaggc caggagcagc
      841 cattcgacct cactgtgatg atccgggaga agaatccaga aggcttcttg tcagcagccg
      901 aaatccccct cttcaaactc tacctgatca tgtctgcctg ctttctggcc gcagacatct
      961 tctgggtgtc cgtgctctgc aagaacacat acagtgtctt caagatccac tggctcatgg
     1021 cagccctggc gttcaccaag agtgtctccc tactcttcca cagcatcaac tactacttca
     1081 tcaacagcca gggccacccc atcgaaggcc tcgcggtcat gcactatatc acacacctgc
     1141 tgaagggcgc ccttctcttc atcaccatcg ccttgatcgg ctcaggctgg gcctttgtga
     1201 agtatatgct gtcggacaag gagaagaaga tttttggcat tgtgattccc ctgcaggtcc
     1261 tggctaatgt agcatacatt gttattgagt cccgtgagga gggtgccagc gactatggac
     1321 tctggaagga gatcttgttc ctggtggatc tcatctgctg tggtgccatc cttttcccgg
     1381 tggtctggtc cattcggcat ctgcaggatg catccggcac tgatgggaag gtggcagtga
     1441 acctggccag gctgaagctg ttccgacatt actacgtcat ggtcatctgc tatatctact
     1501 ttacacgtat catcgccatt ctgctgcaag tagcagtgcc cttccagtgg cagtggctgt
     1561 accagctctt ggtggagagt tccacactgg ccttcttcgt gctcactggc tacaagttcc
     1621 agccggctgg ggacaaccca tacctgcagc tgccacagga ggatgaggag gacgtacaga
     1681 tggagcaagt gatgacagac tctgggtttc gggaaggcct gtccaaagtt aacaagacag
     1741 ccagtggccg ggagctgttg tgacttccct gtgtccagtg agccgccctc agacctcctg
     1801 cacctcgcac ccctacactt gtcccaagtg tgcagggagc tggaggggat gctgcggaca
     1861 aggcatccag gatgtggatc cccaaggagc cttcagaaaa gatgccctct cctcaccagg
     1921 gagcaagcag ttcagcctct tgtggtacaa taaggaccag tctcttgact tggagggttc
     1981 tgagtatcta cggcaggctg catttatgat ctcagttcac ggggtggcac gtgcctgtca
     2041 tcccattgct ctggagagcc cgggcttcat aaaaccttga ttagtaaaca aataaagaaa
     2101 aagtggaatt cccagtgagg ggaggaccac ctgttgagct aaaaaaaaaa aaaaaaa
//
