LOCUS       NM_178760               3926 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor 107 (Gpr107), mRNA.
ACCESSION   NM_178760
VERSION     NM_178760.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3926)
  AUTHORS   Elrick,M.M., Samson,W.K., Corbett,J.A., Salvatori,A.S., Stein,L.M.,
            Kolar,G.R., Naatz,A. and Yosten,G.L.
  TITLE     Neuronostatin acts via GPR107 to increase cAMP-independent PKA
            phosphorylation and proglucagon mRNA accumulation in pancreatic
            alpha-cells
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (2), R143-R155 (2016)
   PUBMED   26561648
  REMARK    GeneRIF: Neuronostatin acts via GPR107 to increase cAMP-independent
            PKA phosphorylation and proglucagon mRNA accumulation in pancreatic
            alpha-cells.
REFERENCE   4  (bases 1 to 3926)
  AUTHORS   Zhou,G.L., Na,S.Y., Niedra,R. and Seed,B.
  TITLE     Deficits in receptor-mediated endocytosis and recycling in cells
            from mice with Gpr107 locus disruption
  JOURNAL   J Cell Sci 127 (Pt 18), 3916-3927 (2014)
   PUBMED   24849652
  REMARK    GeneRIF: GPR107 interacts directly or indirectly with a limited
            subset of surface receptors.
REFERENCE   5  (bases 1 to 3926)
  AUTHORS   Yosten,G.L., Redlinger,L.J. and Samson,W.K.
  TITLE     Evidence for an interaction of neuronostatin with the orphan G
            protein-coupled receptor, GPR107
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 303 (9), R941-R949 (2012)
   PUBMED   22933024
  REMARK    GeneRIF: GPR107 is a promising candidate receptor for
            neuronostatin, and neuronostatin, interacting with GPR107, may play
            an important role in the central control of cardiovascular
            function.
REFERENCE   6  (bases 1 to 3926)
  AUTHORS   Edgar,A.J.
  TITLE     Human GPR107 and murine Gpr108 are members of the LUSTR family of
            proteins found in both plants and animals, having similar topology
            to G-protein coupled receptors
  JOURNAL   DNA Seq 18 (3), 235-241 (2007)
   PUBMED   17454009
REFERENCE   7  (bases 1 to 3926)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 3926)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286814.1, AK034815.1 and AK030433.1.
            
            On Jul 25, 2009 this sequence version replaced NM_178760.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034815.1, AK030433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY286814.1         1-18
            19-1637             AK034815.1         2-1620
            1638-1987           AK030433.1         1634-1983
            1988-3926           AK034815.1         1971-3909
FEATURES             Location/Qualifiers
     source          1..3926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.8 cM"
     gene            1..3926
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="G protein-coupled receptor 107"
                     /db_xref="GeneID:277463"
                     /db_xref="MGI:MGI:2139054"
     exon            1..166
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1699
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="protein GPR107"
                     /codon_start=1
                     /product="protein GPR107 precursor"
                     /protein_id="NP_848875.2"
                     /db_xref="CCDS:CCDS15895.1"
                     /db_xref="GeneID:277463"
                     /db_xref="MGI:MGI:2139054"
                     /translation="MAVPVPLGRFGSFCLRLLRLLALLELLVHPVLGRVHHLALKDDV
                     RHKVHLNTFGFFKDGYMVVNVSSLSVNEPEGATDKDAEIGFSLDRTKNDGFSSYLDED
                     VNYCILKKKSMSSVTLVILDISGSIVKVRSPPEAGKQLPEIVFSKDEKILSQSQEPAV
                     SSNPKDSEARRTLDGFKAGRSTVDSKAITERSFSIHKNDGVVSFQFFFNISTDDQEGL
                     YSLYFHKCSGNNVKPGEQASFSLNIAITEKNPNSYLSAGEIPLPKLYVSMALFFFLSG
                     TIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYI
                     THLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEG
                     TTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKAAINLAKLRLFRHYYV
                     LIVCYIYFTRIIAFLLKFAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQL
                     SQEDDDLEMESVVTTSGVMENMKKVKKVSNGAVEPQGSWEGTA"
     exon            167..289
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            290..340
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            341..423
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            424..563
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            564..601
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            602..658
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            659..769
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            770..903
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            904..979
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1053
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1171
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1302
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1346
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1396
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1480
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1602
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3926
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="hexamer: AGTAAA"
     polyA_site      1970
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="major polyA site"
     regulatory      3872..3877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="hexamer: AATAAA"
     polyA_site      3908
                     /gene="Gpr107"
                     /gene_synonym="9930033D15Rik; C530034M11; mKIAA1624"
                     /note="major polyA site"
ORIGIN      
        1 gaagtgggtg ggagaggaag cagctggtga tgctggaaca aacatggccg tcccggtacc
       61 cctcggccgc ttcggctcct tctgcctgcg gctgctacga ctgctggcgt tgctggagct
      121 gctggtccac cccgtcttgg gccgcgtcca tcacctggcg ctcaaagatg atgtgcggca
      181 taaagtccat ctcaacacct tcgggttctt caaggatggg tacatggtgg tcaacgtcag
      241 cagcctctct gtgaacgagc ctgagggagc cacggacaag gatgctgaga tcggattcag
      301 tctggatcgg actaagaacg atggcttttc ttcttacctg gatgaagatg tgaattactg
      361 tattttaaaa aagaagtcca tgtcttctgt cactcttgtc atcttagaca tctctggaag
      421 catagtcaag gtcagatccc caccagaagc tggtaagcag ttaccagaga ttgtcttcag
      481 caaggatgag aaaatcctga gtcagagcca ggagcctgct gtcagctcca accccaaaga
      541 cagtgaggct cggagaaccc tcgatggttt caaggctgga cgaagtacag tggactcaaa
      601 ggctatcaca gagcgatcct tctcaattca caagaatgac ggggtggtct catttcagtt
      661 cttctttaac atcagcaccg atgaccagga aggcctctac agcctttact tccacaagtg
      721 ctcaggcaac aacgtgaagc ctggtgaaca ggcctcattc agcctgaata ttgctatcac
      781 agagaagaac cctaacagct acctctctgc cggggaaatc cctctcccca agttatatgt
      841 ttccatggcc ttgttcttct ttctgtctgg gaccatttgg attcacatcc ttcgtaagag
      901 aaggaatgat gtatttaaaa ttcactggtt gatggccgcc cttcctttca ccaagtctct
      961 ctcgttggtg ttccatgcaa tcgactacca ctacatctcc tcgcagggct ttccgattga
     1021 aggctgggct gttgtatact acataactca cctgctaaag ggcgcactcc tgttcatcac
     1081 catcgccctc atcggcactg gctgggcctt catcaagcac atcctgtctg ataaagacaa
     1141 gaagatcttc atgattgtca tcccgctcca ggtcctggcg aatgtggcct acatcatcat
     1201 agagtccact gaggagggca caactgagta tggcctatgg aaggactctc tgttcctggt
     1261 tgacttgctt tgctgtggcg ccatcctctt cccagtggtg tggtcaatca ggcatttaca
     1321 agaagcctcc gccacagatg gaaaagctgc cattaactta gcgaagctga ggcttttcag
     1381 acattactac gtcttgattg tgtgctacat ctactttacc aggatcatcg ccttccttct
     1441 caagtttgct gttccattcc agtggaagtg gctctaccag ctgctggatg aaacagccac
     1501 gctggtgttc tttgtcctga cggggtataa atttcgccca gcttcagata acccctacct
     1561 gcagctctct caggaagatg atgacctgga gatggagtcc gtagtgacga catcgggtgt
     1621 gatggagaat atgaagaagg tgaagaaagt gagcaacggt gctgtggagc cccagggcag
     1681 ctgggaaggc accgcgtgac agcagggctg aggactgctg tcaatgaaac tagcttattc
     1741 atagccaagc agtgagcaag cgcgttcctg acagaacgat ggcatctccc agcggtgaca
     1801 ctccagccag cgctcagcgc tcatgctgag caagtgccac ggacacacat ttttgtactc
     1861 ttaggatctg gattgtggtg tgggctacag gcagctagga ctgccctcag tgagggcggg
     1921 aaggggctta gaggaggagt aaaggactgg agtctgattt accttgctaa ttgggagcct
     1981 gggtctgtgc caaggagccc tgtggctgct actcagaaag gctatggggt gggggagcgg
     2041 gtctgcgctg gtcagtgctg tggaggctgg ggagggtgtg actcgctgct cagcctagca
     2101 gtttataagg ctttgggttc aattcctagc accagggtgg gggagaagga tttactttgg
     2161 gaactagaca gatatctacc aagggcatag gagaaaggga ttgtcagcct ttggggacaa
     2221 gaaccacaga aatgaatgaa attctttcag atagccaaat agacacccta ggtggcatga
     2281 cacctgtcca gggagggcca ctggtcccca agcaccactc taaatgtcct cgccctgatg
     2341 tgacctacac cagtggtgct agaggccagc agggaggacc cagtacacag ctggctgaag
     2401 ggagaaaggc cttggagctc cagaagtgcg ctccagctgg ctctcctgac tccattcccc
     2461 tgcctgccca gagcagccgc ctggcttcct ctccttccac ctgtgtcttc tgatccgaat
     2521 ccgagaaaac agaactttcc tgaaggagca gctgaggaca gaaagggtag tgtctaaacg
     2581 aacgcttagg taagcatcct tccacagatt gcatgggcca ggcaggacct ctgagcctca
     2641 actacgtagt ccaagtatgc atgaagggag tgagtgtgtt tgagccactc atgctcagag
     2701 acctgaaaca gccagatctg ctcagagatt gggcaggaac accagcggct gcctgcagaa
     2761 ggcatgtgac aaagtcacag gagaccagtt cggcacctca gagccgctta gtgcccagga
     2821 cttgcaggtg agtcgcacct tcaaggaaca ggcgcttcct ggggtgagtt actctacctc
     2881 ccagtgcaga agatctctgt cctgaagaca gtgtgtctgt ctccacaccc ccagcccaag
     2941 tccatgtcct aagccatcag tgagaagccg ctgcttgtgc tgccctggca ggtccgtccc
     3001 taccacaggt gttccgacag gcctgaagga tctatttaag ggactctttc tcctcgttcc
     3061 gtttgtttgt ttgtttgttt gtttgttgtg tttatacttg tttaaagtgt gtggtgggga
     3121 aggagttgtt gaggagatgg ggcattagtg ctttgttttc tgcacgtaag cactgcagaa
     3181 gtgtgttcct ctggtgacat ctaagccaca gcctgcctct cagagggcag ggtctttttg
     3241 gaaggggcct cgtttcactt gctgggtttt aggagagcca gaggggagaa gttgtaccac
     3301 ccagcccaca gagctgtctg ggtgcacagc cgagcgggtg gagggacagc ctgctccttc
     3361 cagggcatgg gtgcacgggc tgggaggtgt gctacagcag tatcctccca agtcttgccc
     3421 tggaactgct gtaggtggga agccaggcat ggcgggggaa tgggaagcct aacctggggc
     3481 tgggaagact ggcctggtgc ccaggctgtg gaaaggaaag cttctagccc tttatcctgc
     3541 actgtaagcg tatctcgtat ctcgtctcca tcacttgaga gctgtgagcc agcattccgc
     3601 ggtgtccttg ggtagaggag tctgattgga gtccagccgc cccagctcac gagctgtcct
     3661 ctgcagcctt gagtcttagc ccacctggct tcacacagcc ctgtttcagt ggtaaagccc
     3721 atgtgttgga ggggctgagc aaaaatgggg tgtgcattgc actgccactc tggtattaac
     3781 agctctgctc tgtgtctctc ccccttctgc ctgtgtgagg tatccatact ttgagagtgc
     3841 tgtggactgg aagctgtggg ctgtgacatt taataaagtg tggtagataa ttatttcttg
     3901 gacaacaaga gcaagtgttc aactct
//
