LOCUS       NM_001033360            5425 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus G protein-coupled receptor 101 (Gpr101), mRNA.
ACCESSION   NM_001033360 XM_141764 XM_905194
VERSION     NM_001033360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5425)
  AUTHORS   Wells,J.R., Padua,M.B., Haaning,A.M., Smith,A.M., Morris,S.A.,
            Tariq,M. and Ware,S.M.
  TITLE     Non-coding cause of congenital heart defects: Abnormal RNA splicing
            with multiple isoforms as a mechanism for heterotaxy
  JOURNAL   HGG Adv 5 (4), 100353 (2024)
   PUBMED   39275801
REFERENCE   2  (bases 1 to 5425)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5425)
  AUTHORS   Flak,M.B., Koenis,D.S., Gonzalez-Nunez,M., Chopo-Pizarro,A. and
            Dalli,J.
  TITLE     Deletion of macrophage Gpr101 disrupts their phenotype and function
            dysregulating host immune responses in sterile and infectious
            inflammation
  JOURNAL   Biochem Pharmacol 207, 115348 (2023)
   PUBMED   36400250
  REMARK    GeneRIF: Deletion of macrophage Gpr101 disrupts their phenotype and
            function dysregulating host immune responses in sterile and
            infectious inflammation.
REFERENCE   4  (bases 1 to 5425)
  AUTHORS   Flak,M.B., Koenis,D.S., Sobrino,A., Smith,J., Pistorius,K.,
            Palmas,F. and Dalli,J.
  TITLE     GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in
            arthritis and infections
  JOURNAL   J Clin Invest 130 (1), 359-373 (2020)
   PUBMED   31793912
  REMARK    GeneRIF: findings demonstrate a fundamental role for GPR101 in
            mediating the leukocyte-directed actions of RvD5n-3 DPA.
REFERENCE   5  (bases 1 to 5425)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5425)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   7  (bases 1 to 5425)
  AUTHORS   Larco,D.O., Cho-Clark,M., Mani,S.K. and Wu,T.J.
  TITLE     The metabolite GnRH-(1-5) inhibits the migration of immortalized
            GnRH neurons
  JOURNAL   Endocrinology 154 (2), 783-795 (2013)
   PUBMED   23321696
REFERENCE   8  (bases 1 to 5425)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   9  (bases 1 to 5425)
  AUTHORS   Bates,B., Zhang,L., Nawoschik,S., Kodangattil,S., Tseng,E.,
            Kopsco,D., Kramer,A., Shan,Q., Taylor,N., Johnson,J., Sun,Y.,
            Chen,H.M., Blatcher,M., Paulsen,J.E. and Pausch,M.H.
  TITLE     Characterization of Gpr101 expression and G-protein coupling
            selectivity
  JOURNAL   Brain Res 1087 (1), 1-14 (2006)
   PUBMED   16647048
  REMARK    GeneRIF: murine Gpr101 mRNA was detected predominantly in the brain
            within discrete nuclei and that GPR101 participates in a
            potentially wide range of activities in the CNS via modulation of
            cAMP levels.
REFERENCE   10 (bases 1 to 5425)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138370.1, BC139013.1 and DQ198079.1.
            
            On Nov 3, 2009 this sequence version replaced NM_001033360.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ198079.1, AK138185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1975              AK138370.1         3-1977
            1976-5165           BC139013.1         1768-4957
            5166-5425           DQ198079.1         5125-5384
FEATURES             Location/Qualifiers
     source          1..5425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.93 cM"
     gene            1..5425
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /note="G protein-coupled receptor 101"
                     /db_xref="GeneID:245424"
                     /db_xref="MGI:MGI:2685211"
     exon            1..216
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            217..5410
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1825
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /note="G protein-coupled receptor GPR101"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 101"
                     /protein_id="NP_001028532.1"
                     /db_xref="CCDS:CCDS30154.1"
                     /db_xref="GeneID:245424"
                     /db_xref="MGI:MGI:2685211"
                     /translation="MPPSCTNSTQENNGSRVCLPLSKMPISVAHGIIRSVVLLVILGV
                     AFLGNVVLGYVLHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIH
                     FCTALVSLTHLFAFASVNTIVVVSVDRYLTIIHPLSYPSKMTNRRSYILLYGTWIAAF
                     LQSTPPLYGWGHATFDDRNAFCSMIWGASPAYTVVSVVSFLVIPLGVMIACYSVVFGA
                     ARRQQALLYKAKSHRLEVRVEDSVVHENEEGAKKRDEFQDKNEFQGQDGGGQAEAKGS
                     SSMEESPMVAEGSSQKTGKGSLDFSAGIMEGKDSDEVSNGSMEGLEVITEFQASSAKA
                     DTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIPESSPPSRRNSTSDPPLPPCY
                     ECKAARVIFVIISTYVLSLGPYCFLAVLAVWVDIDTRVPQWVITIIIWLFFLQCCIHP
                     YVYGYMHKSIKKEIQEVLKKLICKKSPPVEDSHPDLHETEAGTEGGIEGKAVPSHDSA
                     TSP"
     regulatory      5386..5391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /note="hexamer: AATAAA"
     polyA_site      5410
                     /gene="Gpr101"
                     /gene_synonym="Gm365; GPCR6"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcgcccc cgccacagct cagagcttgt ggcgctgtgc gctggctgga cgtacgggca
       61 tatactcggt gtcccgctcc cgctgagcac cgctgctcct accactcggt gcgagctctc
      121 agccgcctgt gccccgaaag gtggtcagag gaaacgcggc gagccccgag ggatcggtct
      181 ccggttcctg tggcgcgaag ccttcagcag caacagatcg tgtgcggtat cattgcccac
      241 cactccaaac acaaagctgg accttctgtc gtgcctgtct gacttcacca tgccacccag
      301 ctgcactaac agtactcaag agaacaatgg cagtcgagtg tgcctccccc tctccaagat
      361 gcctattagt gtagctcacg gcatcatccg ctcagttgtg ctgctcgtca tccttggtgt
      421 agcctttctg ggtaacgtag tgctgggtta tgtattgcac cgtaagccaa acttgctgca
      481 ggtgaccaac cggttcatat ttaacctgct tgtcactgac ctgctgcagg ttgctctcgt
      541 ggccccctgg gtggtgtcca ctgccattcc tttcttctgg cctctcaaca tccacttctg
      601 cactgccctg gttagcctca cccacttatt tgcctttgct agtgtcaata ccattgtggt
      661 ggtgtcagtt gatcgttacc tgaccatcat ccaccctctt tcctacccat ccaagatgac
      721 caaccgacgt agttatattc tcctctatgg cacctggatt gcagccttcc tgcagagcac
      781 acctccactc tatggctggg gccacgctac ttttgatgac cgtaatgcct tctgttccat
      841 gatctgggga gccagccctg cctatacggt tgtcagtgtg gtatccttcc tcgttattcc
      901 actgggtgtt atgattgcct gctattctgt ggtgttcggt gcagcccgga ggcagcaagc
      961 tctcctgtat aaggccaaga gccaccgctt ggaggtgaga gtcgaggact ctgtggtgca
     1021 tgagaatgaa gagggagcaa agaagaggga tgagttccag gacaagaatg agttccaggg
     1081 ccaagatgga ggtggtcagg ccgaggctaa gggaagcagc tccatggaag agagtcccat
     1141 ggtagccgag ggcagcagcc agaagaccgg aaaaggaagc ctggatttca gtgcaggtat
     1201 catggagggc aaggacagtg acgaggtcag taatggcagc atggaggggc tggaagtcat
     1261 cactgaattt caggctagca gcgcaaaggc agacaccggc cgcatagatg ccaatcagtg
     1321 caacattgac gtgggcgaag atgatgtaga gtttggcatg gatgaaattc atttcaacga
     1381 cgatgttgag gcgatgcgca ttccagagag cagtccaccc agtcgtcgaa acagcaccag
     1441 cgacccacct ttgcctccat gctatgagtg caaagctgct agagtgatct tcgtcatcat
     1501 ttccacttat gtgctatctc tggggcccta ctgctttcta gcagtgctgg ctgtgtgggt
     1561 ggatatcgat accagggtac cccagtgggt gatcaccata ataatctggc tttttttcct
     1621 gcagtgttgc atccacccat atgtctatgg ctatatgcac aagagcatca agaaggaaat
     1681 ccaggaggta ctgaagaagt taatctgtaa gaaaagcccc cctgtagaag atagccaccc
     1741 tgaccttcat gaaacggaag ctggtacaga gggaggtatt gaaggcaagg ctgtcccctc
     1801 ccatgattca gctacttcac cttaaagtta acagtaaggc aaactttaat tgtacacaaa
     1861 aacagaacac aagagcagct ttcttttcag cgctccgctc acaatctcat tagtgccagt
     1921 gcttaccatt tcaggcaaag gggttgcgcg cacatccttt cccaccacac ggcagataaa
     1981 taaaaggaag aagtagggac ttggatcttt cctgaaaagt ataagcctgt caaagcacgg
     2041 actttaggat ccccaccaaa tatatataca gatgtacaca tattaggctc taaatttccc
     2101 aaagcaagga ctatctggtt tggagctgtt cttggtattc tgcctgtctc cccagaacta
     2161 tgacatgtca gctttagctc tgaataaaag gaaaagcaat gcctacggac ataaggacta
     2221 tttggccttc aggtcaggaa ctcatgggct agggctacat attgtgtgca gctgaaagaa
     2281 aagaaattga ccaaatcaag caaagctagg tggatggatc accaaatgag cagatttctg
     2341 taccagagag taccacagta tggtgcaaag actgtactgc aagctgcaac aaaggtggat
     2401 tacgcagata gactgtaaag aaagcttcta ggtcttcaaa agggatccag aaaagggcaa
     2461 gcctgaaatg aggagctagg gcaaaagaag aaatggagaa ataaggcata tccacggagc
     2521 taaacaactg tatgtttctt tctctttctc tctcttctct ccttctccac cttcccctac
     2581 cctgctacat gggcagggac tgaccactgt gcaaatggaa aaaaggacaa ttgacacaaa
     2641 tgttttctgt ctcctatttg aataacagca ggaaagaaat caggccacta ttttactatt
     2701 tcccttctgc ctctagacct ctgaaagcca ctattttatt ttcttttatt tctaactgat
     2761 ttttttatta aaaagtattt ccaggtttca agaagaaagg aagaaagaag aaagacagag
     2821 agatagaagg aaaaaaaatc aagtatgaat ggccaaagtt ctagaaaact cacactgcca
     2881 ataaatttta tatcaagaaa atatctttta tctctgtacc gtaataaaca tgaagtaggt
     2941 tttccatatg aggatagata tgtacatgca tagatatctt ttcaacctgt ggctctctct
     3001 aaaacttgta aattctctgt acaaatgcag gggagaatat aaatgtcagg aatgatgttt
     3061 tattttttcc ttctcacaga ttccagcttg agcttctcaa gggaggagag gtaaacggtt
     3121 gtgaattgtg agggtgtggg attaccatat tcagaatgca ggagagttga tacaaccaaa
     3181 tagtattgaa atggcctgtc agattagtat attcacgaga agtttatcga cttccacttc
     3241 actaatttag gacttgtgat aacctcagac aaggcactgt atctaaagtt aactctcaca
     3301 cttcccttca ttttaacact ctcactactt aactgtgttt ctattttttt tcttattact
     3361 ctaggcctct aaaggcccca tgttactccc aaggttaggc atctgaggag gcagaaacgt
     3421 gctggaaaca acaaactgta gcctaagacc catgaagaac aggcaccgtg ccaattatat
     3481 atggcttctt cctccatggc aaatgtttaa tgtgcacact agcacagtta gtctataagc
     3541 cacaaaacag gttagagaaa gatacaggaa aagtaaatat actgaacttg gctactgcca
     3601 atcactggca agttcattgc tttttggtaa atagggtaag aatcctcaaa gaacatgaag
     3661 gctgccaata gaagttaggt ttccatcatt gcctccctaa gcctccatat cttagcagta
     3721 tacacactaa ggggaaacca cagcaatgtg tacacttaag aaggtctgct gtgtgaagat
     3781 taatatctgt ctttctttga ctctaaaaga gacaaaaaca agattggttt tagtttgctg
     3841 tttcagacat gagtggattt cccccttttc attagttata actttattga aaattgagta
     3901 cttttgtctt gtgtcagtga tgtgttctct tgtggtattt cttctactgt aagttctaac
     3961 tgtatataaa attcgttctt ggagataagg tgctagagat tagattgtgt gtgtttgtgg
     4021 ctagtgtcat cagtaaaatg agtgatgtgt gtgtgtacat gtaaagttag ttaacaaaat
     4081 gcatgcagta tcctatatgt gacccacaat ttggtcactt tttgaagtag aacatagtac
     4141 attaatttac ctttaaaagt gtatactaca ggatatgtaa catggctcca cagtggtatt
     4201 cgggaagagg tgcctttcat tccttacatc cctggtacgt gacaagcaag aacttattct
     4261 ggtacagctg ggaatagatg tgaactaaat tatcatcttg gctgaagtcc tcacctgcag
     4321 ttctccaccc cactggcact ggtatgcctg ttttcttcaa tacatagata gatctcaaaa
     4381 tcaaagaaga caagtccttt ccccataaaa gggtaagaac cccagggcag gctattggag
     4441 tcctgatagc aggaggattt taaaagagta ctgcagtttc aagacctaaa caggaaccag
     4501 tacctgactg gaaagttaat cagacttaca tttagctgat ccatagttgg tgatccctgc
     4561 cctcctagag aagtgccaag acccagaaga aggctgctct gttttgtttt tgttgttttc
     4621 ctctttggct gtctcagatg agatgcagca ttaataaaga aacagtgaga attggggggt
     4681 gggtgggggg agggcaggga ttgaagctca ggtgtttgaa gagttacagt tgtagattaa
     4741 atatatttgc agaagaactc agattatttt attatatttt gaaaacaaaa gtattacaag
     4801 aggatatata tttatatata ttctcattaa atcatttcta aaactgcctt taataccaaa
     4861 tttcacgtgc tattttgaga ctgagaacaa taggacgagt gcactcagtc aataagacag
     4921 ttctctttaa tactttccat tttaaatcta aaactttcct tttaaaacaa aagatttgta
     4981 atttaaaagt gccttttcaa aggattttca aaactatagt cctggggcca tgttcccatt
     5041 ggcacaactt accttcaggt gcacaaatgg gtcggaattt attgtccacc tgtcagcgag
     5101 aagagaaatc cctcacactc aaatcaaatt tatgaattga tactgttaca tgggcaggtc
     5161 gtcccagaga ctctgcccaa agtcacggtt tcatatattg gttgatttta agtgaatgca
     5221 ttctaaactg gttgtgatac ctttagtgcc agacaggaac aacagactcc tgcttgggga
     5281 atgaagagag attaacattt gtggtttaag tattattaat atttttcgtg tttcttaaat
     5341 aggtgctgta aatctgttct tggtacattc ttctgaaata tgctaaataa agtctcattt
     5401 tatgtgtgaa aaaaaaaaaa aaaaa
//
