LOCUS       NM_053110               3798 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus glycoprotein (transmembrane) nmb (Gpnmb), mRNA.
ACCESSION   NM_053110
VERSION     NM_053110.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Ramadoss,S., Qin,J., Tao,B., Thomas,N.E., Cao,E., Wu,R.,
            Sandoval,D.R., Piermatteo,A., Grunddal,K.V., Ma,F., Li,S., Sun,B.,
            Zhou,Y., Wan,J., Pellegrini,M., Holst,B., Lusis,A.J.,
            Gordts,P.L.S.M. and Deb,A.
  TITLE     Bone-marrow macrophage-derived GPNMB protein binds to orphan
            receptor GPR39 and plays a critical role in cardiac repair
  JOURNAL   Nat Cardiovasc Res 3 (11), 1356-1373 (2024)
   PUBMED   39455836
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Barsanele,P.S., de Assis,L.V.M., da Silva,J.J., Furtado,E.M.O.,
            Fernandes,P., Cipolla-Neto,J., Poletini,M.O. and Moraes,M.N.
  TITLE     Glaucoma-inducing retinal ganglion cell degeneration alters diurnal
            rhythm of key molecular components of the central clock and
            locomotor activity in mice
  JOURNAL   FASEB J 38 (20), e70109 (2024)
   PUBMED   39441606
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Van Hook,M.J. and McCool,S.
  TITLE     Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus
            in a Mouse Model of Glaucoma
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38937109
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Diemler,C.A., MacLean,M., Heuer,S.E., Hewes,A.A., Marola,O.J.,
            Libby,R.T. and Howell,G.R.
  TITLE     Microglia depletion leads to increased susceptibility to ocular
            hypertension-dependent glaucoma
  JOURNAL   Front Aging Neurosci 16, 1396443 (2024)
   PUBMED   39015474
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Wang,N., Cai,L., Pei,X., Lin,Z., Huang,L., Liang,C., Wei,M.,
            Shao,L., Guo,T., Huang,F., Luo,H., Zheng,H., Chen,X.F., Leng,L.,
            Zhang,Y.W., Wang,X., Zhang,J., Guo,K., Wang,Z., Zhang,H., Zhao,Y.
            and Xu,H.
  TITLE     Microglial apolipoprotein E particles contribute to neuronal
            senescence and synaptotoxicity
  JOURNAL   iScience 27 (6), 110006 (2024)
   PUBMED   38868202
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Anderson,M.G., Smith,R.S., Hawes,N.L., Zabaleta,A., Chang,B.,
            Wiggs,J.L. and John,S.W.
  TITLE     Mutations in genes encoding melanosomal proteins cause pigmentary
            glaucoma in DBA/2J mice
  JOURNAL   Nat Genet 30 (1), 81-85 (2002)
   PUBMED   11743578
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   Shikano,S., Bonkobara,M., Zukas,P.K. and Ariizumi,K.
  TITLE     Molecular cloning of a dendritic cell-associated transmembrane
            protein, DC-HIL, that promotes RGD-dependent adhesion of
            endothelial cells through recognition of heparan sulfate
            proteoglycans
  JOURNAL   J Biol Chem 276 (11), 8125-8134 (2001)
   PUBMED   11114299
REFERENCE   8  (bases 1 to 3798)
  AUTHORS   Anderson,M.G., Smith,R.S., Savinova,O.V., Hawes,N.L., Chang,B.,
            Zabaleta,A., Wilpan,R., Heckenlively,J.R., Davisson,M. and
            John,S.W.
  TITLE     Genetic modification of glaucoma associated phenotypes between
            AKXD-28/Ty and DBA/2J mice
  JOURNAL   BMC Genet 2, 1 (2001)
   PUBMED   11178107
REFERENCE   9  (bases 1 to 3798)
  AUTHORS   John,S.W., Anderson,M.G. and Smith,R.S.
  TITLE     Mouse genetics: a tool to help unlock the mechanisms of glaucoma
  JOURNAL   J Glaucoma 8 (6), 400-412 (1999)
   PUBMED   10604301
  REMARK    Review article
REFERENCE   10 (bases 1 to 3798)
  AUTHORS   Chang,B., Smith,R.S., Hawes,N.L., Anderson,M.G., Zabaleta,A.,
            Savinova,O., Roderick,T.H., Heckenlively,J.R., Davisson,M.T. and
            John,S.W.
  TITLE     Interacting loci cause severe iris atrophy and glaucoma in DBA/2J
            mice
  JOURNAL   Nat Genet 21 (4), 405-409 (1999)
   PUBMED   10192392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205729.1, AK171517.1, AK171465.1 and AC153620.4.
            
            On Apr 2, 2008 this sequence version replaced NM_053110.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171347.1, AK044764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY205729.1         1-16
            17-1777             AK171517.1         4-1764
            1778-2396           AK171465.1         1647-2265
            2397-3798           AC153620.4         138298-139699
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.82 cM"
     gene            1..3798
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /note="glycoprotein (transmembrane) nmb"
                     /db_xref="GeneID:93695"
                     /db_xref="MGI:MGI:1934765"
     exon            1..275
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1930
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /note="dendritic cell-associated heparin sulfate
                     proteoglycan-dependent integrin ligand; transmembrane
                     glycoprotein NMB; osteoactivin; dendritic cell-associated
                     transmembrane protein; iris pigment dispersion"
                     /codon_start=1
                     /product="transmembrane glycoprotein NMB precursor"
                     /protein_id="NP_444340.3"
                     /db_xref="CCDS:CCDS20122.1"
                     /db_xref="GeneID:93695"
                     /db_xref="MGI:MGI:1934765"
                     /translation="MESLCGVLGFLLLAAGLPLQAAKRFRDVLGHEQYPDHMREHNQL
                     RGWSSDENEWDEHLYPVWRRGDGRWKDSWEGGRVQAVLTSDSPALVGSNITFVVNLVF
                     PRCQKEDANGNIVYEKNCRNDLGLTSDLHVYNWTAGADDGDWEDGTSRSQHLRFPDRR
                     PFPRPHGWKKWSFVYVFHTLGQYFQKLGRCSARVSINTVNLTAGPQVMEVTVFRRYGR
                     AYIPISKVKDVYVITDQIPVFVTMSQKNDRNLSDEIFLRDLPIVFDVLIHDPSHFLND
                     SAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNLNLTVQTAVPGPCPPPSPSTPPPP
                     STPPSPPPSPLPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVEGIL
                     EVSIMQIADVPMPTPQPANSLMDFTVTCKGATPMEACTIISDPTCQIAQNRVCSPVAV
                     DGLCLLSVRRAFNGSGTYCVNFTLGDDASLALTSTLISIPGKDPDSPLRAVNGVLISI
                     GCLAVLVTMVTILLYKKHKAYKPIGNCPRNTVKGKGLSVLLSHAKAPFFRGDQEKDPL
                     LQDKPRTL"
     exon            276..428
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            429..572
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            573..746
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            747..905
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1271
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1370
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1473
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1682
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1776
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..3798
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /note="hexamer: ATTAAA"
     polyA_site      2401
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /note="major polyA site"
     regulatory      3709..3714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
                     /note="hexamer: ATTAAA"
     polyA_site      3728
                     /gene="Gpnmb"
                     /gene_synonym="DC-HIL; Dchil; ipd"
ORIGIN      
        1 ggggcaagtg actcatgagc acgagttgtt aagcgatgga atttgggaga tcaagccaca
       61 ctgcttaaaa catcacatga tctccctctg gccccgtatt tcataaaaca gagcggatcg
      121 caggaggccg acactgtgac tcctggtgga tgggactggg gagtcagagt caagccctga
      181 ctggttgcag gcgctcggag tcagcatgga aagtctctgc ggggtcctgg gatttctgct
      241 gctggctgca ggactgcctc tccaggctgc caagcgattt cgtgatgtgc tgggccatga
      301 acagtatccc gatcacatga gagagcacaa ccaattacgt ggctggtctt cggatgaaaa
      361 tgaatgggat gaacacctgt atccagtgtg gaggagggga gacggcaggt ggaaggactc
      421 ctgggaagga ggccgtgtgc aggcagtcct gaccagtgac tcaccggctc tggtgggttc
      481 caatatcact tttgtggtga acctggtgtt ccccagatgc cagaaggaag atgctaatgg
      541 caatatcgtc tatgagaaga actgcaggaa tgatttggga ctgacatctg acctgcatgt
      601 ctacaactgg actgcagggg cagatgatgg tgactgggaa gatggcacca gccgaagcca
      661 gcatctcagg ttcccggaca ggaggccctt ccctcgcccc catggatgga agaaatggag
      721 ctttgtctac gtctttcaca cacttggcca gtatttccaa aaactgggtc ggtgttcagc
      781 acgggtttct ataaacacag tcaacttgac agctggccct caggtcatgg aagtgactgt
      841 ctttcgaaga tacggccggg catacattcc catctcgaag gtgaaagatg tgtatgtgat
      901 aacagatcag atccctgtat tcgtgaccat gtcccagaag aatgacagga acttgtctga
      961 tgagatcttc ctcagagacc tccccatcgt cttcgatgtc ctcattcatg atcccagcca
     1021 cttcctcaac gactctgcca tttcctacaa gtggaacttt ggggacaaca ctggcctgtt
     1081 tgtctccaac aatcacactt tgaatcacac ttatgtgctc aatggaacct tcaaccttaa
     1141 cctcaccgtg caaactgcag tgcccgggcc atgccctccc ccttcgcctt cgactccgcc
     1201 tccaccttca actccgccct cacctccgcc ctcacctctg cccacattat caacacctag
     1261 cccctcttta atgcctactg gttacaaatc catggagctg agtgacattt ccaatgaaaa
     1321 ctgccgaata aacagatatg gctacttcag agccaccatc acaattgtag aggggatcct
     1381 ggaagtcagc atcatgcaga tagcagatgt ccccatgccc acaccgcagc ctgccaactc
     1441 cctgatggac ttcactgtga cctgcaaagg ggccaccccc atggaagcct gtacgatcat
     1501 ctccgacccc acctgccaga tcgcccagaa ccgggtctgc agccctgtgg ctgtggatgg
     1561 gctgtgcctg ctgtctgtga gaagagcctt caatgggtct ggcacctact gtgtgaattt
     1621 cactctggga gatgatgcaa gcctggccct caccagcacc ctgatctcta tccctggcaa
     1681 agacccagac tcccctctga gagcagtgaa tggtgtcctg atctccatcg gctgcctggc
     1741 tgtgcttgtc accatggtta ccatcttgct gtacaaaaaa cacaaggcgt acaagccaat
     1801 aggaaactgc cccaggaaca cggtcaaggg caagggcctg agtgttctcc tcagtcacgc
     1861 gaaagccccg ttcttccgag gagaccagga gaaggatcca ttgctccagg acaagccaag
     1921 gacactctaa gtctttggcc ttccctctga ccaggaaccc actcttctgt gcatgtatgt
     1981 gagctgtgca gaagtatgtg gctgggaact gttgttctct aaggattatt gtaaaatgta
     2041 tatcgtggct tagggagtgt ggttaaatag cattttagag aagacatggg aagacttagt
     2101 gtttcttccc atctgtattg tggtttttac actgttcgtg gggtggacac gctgtgtctg
     2161 aaggggaggt ggggtcactg ctacttaagg tcctaggtta actgggggag ataccacaga
     2221 tgcctcagct ttccacataa catgggcatg aacccagcta atcaccacct gaaggccatg
     2281 cttcatctgc cttccaactc actgagcatg cctgagctcc tgacaaaatt ataatgggcc
     2341 cgggctttgt gtatggtgcg tgtgtgtaca tattctactc attaaaaagg cagtctaata
     2401 agctgtgtga ttattatatt ggggagaaaa ttttccctgt gtagttcagt gaactaccca
     2461 tccattcatt tatccatgga cacttataaa gcatgtggtg ggctgcactt gacctatgag
     2521 accttgtcta ttctatacca gcagaccctt aatagcaacc aagtgagatc tgagagtcca
     2581 gactgtatct accttgatga aggtagacaa ctggataaat atgatggtat tatagaatga
     2641 ctgctcattt ttgaggcatt gtggaggacc aacattcagt ctggtacttt gacacccccc
     2701 ccccccacta ggtggcctag aagcaaaaag aagctttttg tttggaaatt gtctccaaag
     2761 aatgtaaaaa ttgctgacca cttaggacag ggcctctcag ccaggagtgt ttggcaatgt
     2821 ttggagagat ttgtggttgt caaaactagg gtggggtgct actggcatct agtggggaga
     2881 gcccagggct gctgaacacc ctgtgcctgc gggacagccc cacagccaag gagcccagag
     2941 caactgaagg agtcctgggc acaggcatcc caacagcagc cttgtatctg aaccgagccc
     3001 tgacatctaa agctttgtga cctagtgaca tggcatgtta ggagtctttt ctgcctctgt
     3061 ctcagctgta gaaggggtat gctgtccctc tctgactcac ttcacatggc cgctactgct
     3121 cctgatggaa gaatgagtgc aggtacagcc ttgtgttaca gtctcagcct ggggacagaa
     3181 acacgtgaag aagcttgatt gattgattga ttgattgatt gattgattga ttgattgatt
     3241 gattgatttt tacatactaa ggagcccgtt cactagtacc caaaacagga cattgatttc
     3301 aggttgctgc agaatccaca gaccgcttag actccacccc atggttccaa acactgtctt
     3361 gtggaggtgg gaccccataa tttggatttc tgagaaacca acagagaatc cttattctgc
     3421 tggttccagg acaagaatga gcaaggctgg gcttgggatc acttccttgc tcaggtcaac
     3481 agggggcagc agagaacagc agatacagaa cagccaccaa agcggcaggt ccatgacttt
     3541 gtttatctag cttcatctaa acaaatttta atctagtagt aggaaagaag tctgaaatag
     3601 taaattgtgt cgatttatat tttccaagtg accctggtaa gggaactgtc tgcagaatgg
     3661 aagaaatagc ctaagagaca gggatggctt gattgatgtt ggctgagaat taaaacttct
     3721 cacgaaaagt acatgtgtat gtaacaaatt attccaggaa ttgcttattt ctagggcttt
     3781 tataaatgtc tgcatcct
//
