LOCUS       NM_133756               3125 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus GPN-loop GTPase 1 (Gpn1), mRNA.
ACCESSION   NM_133756
VERSION     NM_133756.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Lembo,F., Pero,R., Angrisano,T., Vitiello,C., Iuliano,R.,
            Bruni,C.B. and Chiariotti,L.
  TITLE     MBDin, a novel MBD2-interacting protein, relieves MBD2 repression
            potential and reactivates transcription from methylated promoters
  JOURNAL   Mol Cell Biol 23 (5), 1656-1665 (2003)
   PUBMED   12588985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113276.9.
            
            On Jan 10, 2023 this sequence version replaced NM_133756.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146686.1, AK145957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC113276.9         46268-46389         c
            123-216             AC113276.9         45540-45633         c
            217-256             AC113276.9         43801-43840         c
            257-323             AC113276.9         42745-42811         c
            324-361             AC113276.9         41847-41884         c
            362-440             AC113276.9         40219-40297         c
            441-535             AC113276.9         39945-40039         c
            536-581             AC113276.9         37715-37760         c
            582-728             AC113276.9         37093-37239         c
            729-811             AC113276.9         36116-36198         c
            812-851             AC113276.9         34919-34958         c
            852-942             AC113276.9         33587-33677         c
            943-1050            AC113276.9         31745-31852         c
            1051-3125           AC113276.9         28245-30319         c
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..3125
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="GPN-loop GTPase 1"
                     /db_xref="GeneID:74254"
                     /db_xref="MGI:MGI:1921504"
     exon            1..122
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1130
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="XPA binding protein 1; methyl-CpG binding domain
                     protein 2 interacting protein; MBD2-interacting protein"
                     /codon_start=1
                     /product="GPN-loop GTPase 1"
                     /protein_id="NP_598517.1"
                     /db_xref="CCDS:CCDS19185.1"
                     /db_xref="GeneID:74254"
                     /db_xref="MGI:MGI:1921504"
                     /translation="MAAPVAPSEPQASRAPQPPVCLLVLGMAGSGKTTFVQRLTGHLH
                     NKGCPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRF
                     DQVMKFIEKAQNTFRYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRS
                     TNPVTFMSNMLYACSILYKTKLPFIVVMNKTDIIDHSFAVEWMQDFEAFQDALNQETT
                     YVSNLTRSMSLVLDEFYSSLRVVGVSAVVGTGFDELCTQVTSAAEEYEREYRPEYERL
                     KKSLANAQSNQQKEQLERLRKDMGSVALDPEAGKGNASPVLDPSDLILTRGTLDEEDE
                     EADSDTDDIDHRVTEESREEPAFQNFMEESMAHWKRNK"
     exon            123..216
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..256
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..323
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..361
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..440
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..581
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..728
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..811
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..851
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..942
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1050
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..3125
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="hexamer: GATAAA"
     polyA_site      1636
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="major polyA site"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="hexamer: AATACA"
     polyA_site      1850
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
     regulatory      3093..3098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
                     /note="hexamer: AATAAA"
     polyA_site      3125
                     /gene="Gpn1"
                     /gene_synonym="2410004J02Rik; MBDIN; NTPBP; Xab1"
ORIGIN      
        1 gctgaggaaa gatggcggcg cccgtggctc catccgaacc ccaggcttcc cgggctcctc
       61 agccccccgt gtgtctgttg gtgttgggaa tggcgggatc cgggaaaact acctttgtac
      121 agaggctcac aggacacctg cacaacaaag gctgtccacc gtatgtaatc aacctggacc
      181 cagctgtgca tgaagtcccc tttcccgcca atattgatat ccgagacaca gtgaaatata
      241 aagaagtcat gaagcaatat ggacttgggc caaacggagg tatagtgacc tcactcaacc
      301 tctttgctac cagatttgat caggtgatga aatttattga gaaggcccag aacacattca
      361 gatatgtctt gattgacaca cctggacaga ttgaagtatt tacctggtca gcttcaggga
      421 caatcatcac tgaggccctg gcttcctcat ttccaacagt agtcatctat gtcatggata
      481 catcacggag cactaaccca gtgaccttca tgtccaatat gctttacgca tgcagcatct
      541 tgtacaaaac caagctgcct ttcattgtgg tcatgaacaa aaccgacatc attgaccaca
      601 gctttgccgt ggagtggatg caggattttg aggctttcca ggatgccttg aaccaagaga
      661 ctacctacgt cagtaacctg actcgttcca tgagcctggt gttggatgag ttctacagct
      721 cactcagggt ggtgggtgtg tctgctgtgg tgggcaccgg cttcgatgaa ctctgtactc
      781 aggtcaccag tgctgcagag gagtacgaaa gggaatatcg tcctgaatac gagcgtctga
      841 agaaatcact ggcaaatgcc cagagtaatc agcagaagga gcaactggag cgtcttcgga
      901 aggatatggg ctccgtagcc ctggatccag aggccggcaa aggcaacgca tctcctgtgc
      961 tggatccttc tgacttgatc ctgactcgag gaaccttgga tgaggaggat gaagaagctg
     1021 acagtgacac ggatgacatt gaccacagag ttacagagga aagccgtgaa gagccagcat
     1081 ttcagaactt catggaggag tcaatggcac actggaagag gaacaagtag gccctcccac
     1141 ctgctgtaca gctctgatgt gctgagtctc catgcagagg acatccttcc tgtgaaccag
     1201 ggctgcagtc aagagcagtt ttctcccaaa tggtgacttc tctgagggaa actgggctta
     1261 gatgaagtct ggttgaaggc ggagctggca ggtggatgcc cattcttggg tagctcctcc
     1321 cgatatttat gcaaggatgt attctcaccg ctctggaagc tgagagatag ctgctgagcc
     1381 tataacttca agtatcatcg tttgaactca agtatttctg ctgctgatgg acagagagga
     1441 cgtctgtccc agagacgctt tggaccttga ctagctgggt ctgtgggcac agcaggatgg
     1501 aaaggagagt gtgtgtgtac agagggcagc acagtgccct gggcagccag gtcggatgtg
     1561 atctgtgctc acacgaggta gcccattttc aagaatactg ttaggatggt gacttggata
     1621 aagattttga ctttaacttt gtggtaagct ttcctgtcat ggtttgatat tagaaagtat
     1681 gtgatcacta atagatttcc cactattagt tatgaccaag ccttaaagac atgtctggta
     1741 ggatataatg catagtaggt tagtttccca tgtctatcca cctaaccatg gccaaaatca
     1801 tgtccttata ttgtacttag aacaatacaa agcattgttt gtgaccagga tttggtccat
     1861 tccgtccatt cagagctagg atttgccctg gttctcagga gtgtagtaaa atcacgagcc
     1921 aggcagttct tatggataca cctccaaatc agctttccta gaaacggggt cgggggtggg
     1981 gacgcagcag gctggctcat aagccttcca ggtgactgct ttgctctttg cagaactgtt
     2041 tcaggtcagc ctgtgactga accccagggc aggtgactca gccacccagt cctcctaacg
     2101 cgccttctcc ggcttcttgc ccggcttcac atggtgcctt ctctccaggg ttacttcaaa
     2161 gcaacacaga attaaatctt accattaact atttaatatt ccatagctgg tgggaaatgc
     2221 tgatctaaag agcctcacct ttttcttttc ttttttaaag acctttctgc caggtttcat
     2281 ggtggctgtc tttaatccca gcatgtggga ggcagagaca ggtgagctcg agacctgtca
     2341 gggtgacata cagagtgaga ctatgtctta aaaaagaaga cacctctggc tgggcgtggt
     2401 ggcgcacgcc tttaatccca gtacttggga ggcagaggca ggtggatttc tgagttcaag
     2461 gccagcctgg tctacaaagt gagctccagg acagccaggg ctacacagag aaaccctgtc
     2521 tcggaaaacc aaaaaaaaaa aaaaatgaag acacctctgc ctcctgagtg tgggacctat
     2581 aggactgggc tatcatgctt gacctattct ttaaggggga accatacaca gagcggaact
     2641 gacatgctca gctcttttcc gtggtgccct ttccttttct ttcttaaaat gttacctctc
     2701 tctctcctgc tggcagctct ctaagggtct tgtctttaca tcacttgtac aagacctagt
     2761 atatgatgtg gggaaactaa ttaatgttgc agactagaat atctgggtag ctcttctgag
     2821 ctctgagcaa aatggagaac tccctttacc agcagcctgt ggagcccaac acccctaccc
     2881 cctctacttg ggaaaggcaa cttcctcttt ctggataaga acccgcccaa aagtacctgg
     2941 cattcatgga ctacttctcc atacaaatga ggcattcaca gtactttaaa ctctagccaa
     3001 tgattttaca atcaccctgg aaactccttc ccactctcca tggttcatat atatcccttg
     3061 tccttcctga ataaagtcca caagcccacc ccaataaagg tgtgtgcacc agctgtttca
     3121 ccgaa
//
