LOCUS       NM_001177955            3387 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus glycoprotein m6b (Gpm6b), transcript variant 1, mRNA.
ACCESSION   NM_001177955
VERSION     NM_001177955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Sanchez-Roige S, Barnes SA, Mallari J, Wood R, Polesskaya O and
            Palmer AA.
  TITLE     A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral
            flexibility but increases delay discounting
  JOURNAL   Genes Brain Behav 21 (4), e12800 (2022)
   PUBMED   35243767
  REMARK    GeneRIF: A mutant allele of glycoprotein M6-B (Gpm6b) facilitates
            behavioral flexibility but increases delay discounting.
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Shan K, Zhou RM, Xiang J, Sun YN, Liu C, Lv MW and Xu JJ.
  TITLE     FTO regulates ocular angiogenesis via m6A-YTHDF2-dependent
            mechanism
  JOURNAL   Exp Eye Res 197, 108107 (2020)
   PUBMED   32531187
  REMARK    GeneRIF: FTO regulates ocular angiogenesis via
            m(6)A-YTHDF2-dependent mechanism.
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Zhang X, Xie H, Chang P, Zhao H, Xia Y, Zhang L, Guo X, Huang C,
            Yan F, Hu L, Lin C, Li Y, Xiong Z, Wang X, Li G, Deng L, Wang S and
            Tao L.
  TITLE     Glycoprotein M6B Interacts with TbetaRI to Activate
            TGF-beta-Smad2/3 Signaling and Promote Smooth Muscle Cell
            Differentiation
  JOURNAL   Stem Cells 37 (2), 190-201 (2019)
   PUBMED   30372567
  REMARK    GeneRIF: Findings demonstrate that GPM6B plays a crucial role in
            SMC differentiation and regulates SMC differentiation through the
            activation of TGF-beta-Smad2/3 signaling via direct interactions
            with TbetaRI.
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Bang ML, Vainshtein A, Yang HJ, Eshed-Eisenbach Y, Devaux J, Werner
            HB and Peles E.
  TITLE     Glial M6B stabilizes the axonal membrane at peripheral nodes of
            Ranvier
  JOURNAL   Glia 66 (4), 801-812 (2018)
   PUBMED   29282769
  REMARK    GeneRIF: Study identified glycoprotein M6B as a Schwann cell
            microvilli component of peripheral nodes of Ranvier. Study detected
            Na(+) channel clusters at heminodes without any associated M6B,
            indicating that it is not required for initial channel clustering;
            showed that absence of M6B results in progressive appearance of
            nodal protrusions of the nodal axolemma, that are often accompanied
            by the presence of enlarged mitochondria.
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Heng X, Guo Q, Leung AW and Li JY.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Mi ZP, Weng W, Hankin MH, Narayanan V and Lagenaur CF.
  TITLE     Maturational changes in cell surface antigen expression in the
            mouse retina and optic pathway
  JOURNAL   Brain Res Dev Brain Res 106 (1-2), 145-154 (1998)
   PUBMED   9554989
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Yan Y, Narayanan V and Lagenaur C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   8  (bases 1 to 3387)
  AUTHORS   Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger
            SL, Yan Y, Lagenaur C and Narayanan V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   9  (bases 1 to 3387)
  AUTHORS   Yan Y, Lagenaur C and Narayanan V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
REFERENCE   10 (bases 1 to 3387)
  AUTHORS   Baumrind NL, Parkinson D, Wayne DB, Heuser JE and Pearlman AL.
  TITLE     EMA: a developmentally regulated cell-surface glycoprotein of CNS
            neurons that is concentrated at the leading edge of growth cones
  JOURNAL   Dev Dyn 194 (4), 311-325 (1992)
   PUBMED   1286213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671905.4, AF254870.1 and BQ745381.1.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_001177955.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF254870.1, SRR1660817.12187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL671905.4         84568-84706
            140-613             AF254870.1         1-474
            614-649             BQ745381.1         449-484
            650-1596            AF254870.1         511-1457
            1597-3387           AL671905.4         127258-129048
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.86 cM"
     gene            1..3387
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /note="glycoprotein m6b"
                     /db_xref="GeneID:14758"
                     /db_xref="MGI:MGI:107672"
     exon            1..529
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..1455
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal membrane glycoprotein M6-b"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-b isoform 1"
                     /protein_id="NP_001171426.1"
                     /db_xref="CCDS:CCDS53245.1"
                     /db_xref="GeneID:14758"
                     /db_xref="MGI:MGI:107672"
                     /translation="MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQY
                     RPVPTLGDRAGPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGT
                     VAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELH
                     GEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQSNG
                     TSGVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATV
                     IALIHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT"
     exon            530..649
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            650..836
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            837..993
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1165
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1239
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1305
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..3387
                     /gene="Gpm6b"
                     /gene_synonym="Gpm6; M6B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagagag agagagagag agagagagag agagagagag agagagagaa gacagcaggg
       61 agaaaaagga gcttggtgga gagagagaga gagagagaga gagagagaga gagagagaga
      121 gagagaagac agcagggagg aaaaggagct tggtgggaga gcaggagctt cccggggtgc
      181 actgggagtg ggggcacaga gtggctgttt tataactggg atcctcggtg acgtatggtc
      241 gcctgctcct tggcagctgt ctttatggac cagtaggcag agcgaaattg acgctgacaa
      301 gacttttgca tcttggaagg cactgtaatc tactgtagtg aagaacagag cctctcaatc
      361 aggcgggtgt aaagaagaga gacagagggg agtccaaaag aaaaggaaga ggagggggga
      421 aattgtgtgt tgtggggaag cagggaaaaa gcatttttgg tggatggtat gaagccagcc
      481 atggaaactg cagccgagga aaatactgaa caaagccaag agagaaaagt gaacagcaga
      541 gctgaaatgg aaattggcag gtaccactgg atgtacccag gctcaaagaa ccatcagtac
      601 cgtcctgtgc caaccctggg ggacagggct ggccccttga gcagtccagg ttgcttcgaa
      661 tgctgcatca agtgtctggg aggagttccc tatgcctccc tggtggccac catcctatgt
      721 ttctctggag tggccttgtt ctgtggctgt gggcatgtgg ctcttgcagg caccgtggca
      781 attcttgagc aacacttctc caccaacacc agtgaccatg ccttgctgag tgaagtgatc
      841 caactgatgc agtatgttat ctatggaatc gcctcctttt tcttcctgta tggcatcatt
      901 cttctggcag aaggcttcta caccacaagt gcagtgaaag agctgcacgg tgagtttaaa
      961 acaactgcct gtggccgatg catcagtgga atgttcgtgt tcctcaccta tgtgctggga
     1021 gtggcctggc tgggtgtgtt cggcttttcc gcagtgccag tgtttatgtt ctacaacatc
     1081 tggtcaacct gtgaagtcat caagtcccca caaagcaacg ggacctcggg tgtggagcag
     1141 atctgtgtgg atgtccggca atatggtatc attccttgga atgctttccc aggcaaaatc
     1201 tgtggctcgg ccttggagaa catctgcaac acgaatgagt tctacatgtc ctatcacctg
     1261 ttcattgtgg cttgtgctgg agctggtgcc accgtcattg ccctgatcca cttcctcatg
     1321 atactgtctt ctaactgggc ttacttaaag gatgcaagca aaatgcaggc ttaccaggat
     1381 atcaaagcaa aggaagagca ggaactgcaa gatatccagt ctcgctcaaa agaacaactc
     1441 aattcttaca cttaaaagtg tttgccagag cgtgtcagcc aatgaattca cagctctgac
     1501 acatcatcag acagctgctc tgcagtacag atgtgtatcc caccaaacta atgtagacgt
     1561 accaacattt cactgtctgt ctcaaactgc tggggtggat ctctaggaaa accttccagt
     1621 gggtaaatca gtttctttag aacaaatatt ggaggtttca ctttagccat tttaaaaggc
     1681 aacacttttg acagaatgac cgttcatcct ttgcaaagtc gtggcatgtc cagttaactg
     1741 ctagagcagt tttaacacgg gatagaatca catcacgttc cttactgggg acctatggca
     1801 tgccagaatc aaaggatatg accctagatt tacatatgcc acctgtcttc aagtgttatc
     1861 aaaatagaat cagtgtcaag ttcatttttg ataactgacc tttattaacc tttggctcat
     1921 caaagataat gtgattcttc caaacttaaa actcagcacc ctcacggtct cacacattcg
     1981 aatgtttccc aagccactga gaaacctatc ttctagtaat aggaaaatga gctgcaagtg
     2041 tgctaaatgt atcagtgcag aagctggatt ctgacccgag ctctgcaaaa tgagcttccc
     2101 agttgatcac atcggaacaa aatgggactg aggatttggt gatcactatt gtttggaaat
     2161 aaatgtcagc tctgccttaa tatttgcttt caatttctaa tcatttatat tgtaaccaga
     2221 aacccaaaat tcctacatag attattttgt tccatgaata tctttcttaa gaagtgttac
     2281 cttgttaaag tgactaccat tctaaaccat ttttaagtgg tctggacagt gagtttacag
     2341 tttcatatca actatctaaa acctaactgc aaattgacca cagacctctg accttctact
     2401 tttatagact ttaatacata agtaatttaa attagggttg gtatttattt cactgttttc
     2461 ctatctaaat cttaatttcc tggaataata atgtttgata ttcagcaaga aaactgcttg
     2521 agtttaagcc attttcaaaa gaaacttgcc ttctaactca ttgtgttcca gaacattaag
     2581 tgactaatag gtactgggta ttagtgatgg taagttttgt gttcttcttt ctggaatgat
     2641 ccatataact gtggggtgca tcagtgcttt tcaaaggggc tgcatactat agggttaact
     2701 atgtatattc atgttaagag ttaacttgtg gtttggctgt ttcctggatt ttaaaacata
     2761 tacatgtgca gagatgtatt caaatgaaag gaagcatatc tttatcaaga tgctagtaaa
     2821 actgaacatc aactataata tttcatttgg attttttttc ttttggataa tgccgagaaa
     2881 cgcctaattg gattcctttt aattgggaga cgctctcttc tgtgtagaac agttgttcca
     2941 agatagctta gtgttttgtt ttcctgttgc atgacagaat tattgtttcc agcagtggag
     3001 gtgctgttaa gagtccagtg ttctagaaga ggcggtgtct aaagcctaat tttacttttc
     3061 taattctggt agctattgcc aggaactttt gaaagttttg ttgaagtagt ctaatatttt
     3121 ttatgtaaag agcattaaat tttgctatgt ataaattttt gtaacctaac agtgaatcaa
     3181 tattttctat cagtgccaag ggcttcctgt agttctattc aagtgttaca ataaatattt
     3241 gtagataata gtcaatactt gtgtatgctt attttaaaga tctatttagg tggaaatagt
     3301 tgtggatgta ctaaagaata atgaaataaa attatagctt cattcgcttg cctttttacc
     3361 atacataaat cctatctttc tctgttc
//
