LOCUS       NM_153581               3351 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus glycoprotein m6a (Gpm6a), transcript variant 1, mRNA.
ACCESSION   NM_153581
VERSION     NM_153581.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3351)
  AUTHORS   Honda,A., Nozumi,M., Ito,Y., Natsume,R., Kawasaki,A., Nakatsu,F.,
            Abe,M., Uchino,H., Matsushita,N., Ikeda,K., Arita,M., Sakimura,K.
            and Igarashi,M.
  TITLE     Very-long-chain fatty acids are crucial to neuronal polarity by
            providing sphingolipids to lipid rafts
  JOURNAL   Cell Rep 42 (10), 113195 (2023)
   PUBMED   37816355
REFERENCE   2  (bases 1 to 3351)
  AUTHORS   Zhang,J., Xiong,Y.W., Tan,L.L., Zheng,X.M., Zhang,Y.F., Ling,Q.,
            Zhang,C., Zhu,H.L., Chang,W. and Wang,H.
  TITLE     Sperm Rhoa m6A modification mediates intergenerational transmission
            of paternally acquired hippocampal neuronal senescence and
            cognitive deficits after combined exposure to environmental cadmium
            and high-fat diet in mice
  JOURNAL   J Hazard Mater 458, 131891 (2023)
   PUBMED   37354721
  REMARK    GeneRIF: Sperm Rhoa m6A modification mediates intergenerational
            transmission of paternally acquired hippocampal neuronal senescence
            and cognitive deficits after combined exposure to environmental
            cadmium and high-fat diet in mice.
REFERENCE   3  (bases 1 to 3351)
  AUTHORS   Li,L., Sun,Y., Davis,A.E., Shah,S.H., Hamed,L.K., Wu,M.R.,
            Lin,C.H., Ding,J.B. and Wang,S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
  REMARK    GeneRIF: Mettl14-mediated m[6]A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells.
REFERENCE   4  (bases 1 to 3351)
  AUTHORS   Xie,W., Zhang,A., Huang,X., Zhou,H., Ying,H., Ye,C., Ren,M.,
            Qian,M., Liu,X. and Mo,Y.
  TITLE     SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN
            SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION
  JOURNAL   Shock 59 (5), 791-802 (2023)
   PUBMED   36877222
  REMARK    GeneRIF: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY
            RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N
            EXPRESSION.
REFERENCE   5  (bases 1 to 3351)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3351)
  AUTHORS   Yan,Y., Narayanan,V. and Lagenaur,C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   7  (bases 1 to 3351)
  AUTHORS   Olinsky,S., Loop,B.T., DeKosky,A., Ripepi,B., Weng,W., Cummins,J.,
            Wenger,S.L., Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   8  (bases 1 to 3351)
  AUTHORS   Shimizu,F., Watanabe,T.K., Fujiwara,T., Takahashi,E., Nakamura,Y.
            and Maekawa,H.
  TITLE     Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to
            4q33-->q34
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 138-139 (1996)
   PUBMED   8893821
REFERENCE   9  (bases 1 to 3351)
  AUTHORS   Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
REFERENCE   10 (bases 1 to 3351)
  AUTHORS   Baumrind,N.L., Parkinson,D., Wayne,D.B., Heuser,J.E. and
            Pearlman,A.L.
  TITLE     EMA: a developmentally regulated cell-surface glycoprotein of CNS
            neurons that is concentrated at the leading edge of growth cones
  JOURNAL   Dev Dyn 194 (4), 311-325 (1992)
   PUBMED   1286213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247392.1, AK081877.1 and BC033357.1.
            
            On Dec 2, 2011 this sequence version replaced NM_153581.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.29214.1,
                                           SRR1660817.260648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BY247392.1         2-116
            116-3328            AK081877.1         2-3214
            3329-3351           BC033357.1         2898-2920
FEATURES             Location/Qualifiers
     source          1..3351
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.33 cM"
     gene            1..3351
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /note="glycoprotein m6a"
                     /db_xref="GeneID:234267"
                     /db_xref="MGI:MGI:107671"
     exon            1..588
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..1388
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal membrane glycoprotein M6-a"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-a isoform 1"
                     /protein_id="NP_705809.1"
                     /db_xref="CCDS:CCDS22310.1"
                     /db_xref="GeneID:234267"
                     /db_xref="MGI:MGI:107671"
                     /translation="MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFC
                     GCGHEALSGTVNILQTYFELARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVE
                     GFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWT
                     ICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTASENFLRMCESTELNMTFHLFIVAL
                     AGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNA
                     YT"
     exon            589..781
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            782..938
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1092
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1169
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1235
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..3337
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2824..2829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /note="hexamer: AATAAA"
     polyA_site      2847
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /note="major polyA site"
     regulatory      3301..3306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /note="hexamer: AATAAA"
     polyA_site      3331
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
ORIGIN      
        1 gaaaaaacta ctgcagcaga aagacacgac gagaattcgg gctttcccac tgtggtggca
       61 aaggggggaa ttatgggttg gtggtccgct tcatgctagg aggacacccc tctgtctgtt
      121 cacagttcag cctgcttcca gtttaaagcc gagatttcag cacaaacctc aatttctttc
      181 ccccatttta aatgcaaagc gaggcttgtg aatcacagtg tctctgctcc tagaatccag
      241 acccctttcc actccccctc ccaaaattat ccggctgttt gtttgagtac ctgcttactg
      301 tggcacacac aatgggcagc tttgagaaga aaaattgata atcttcacgg aagagtaatt
      361 tgaatgaaat tacacttgac agccagtctc taagcaaaca agaggcgcga gggagcctca
      421 gctaagctcc aaggacttgc ccaagccact gctgctggag ctgcccaggg aaaaaaggca
      481 cacgcttttt tgacatctaa ttgagctttt gactaatacc gtgcgccaga ttctcctgaa
      541 gaaaggtagc catggaagag aatatggaag aaggacagac acagaaaggg tgcttcgagt
      601 gctgcattaa atgcctggga ggtattccct atgcttctct gattgcaacc atcctgctgt
      661 atgcaggcgt tgccctgttc tgtggctgtg gccatgaagc cctttctgga acagtcaaca
      721 ttctgcagac ctactttgag ttggcaagga ctgctggaga cacactggat gttttcacta
      781 tgattgacat ctttaagtat gtgatctatg gcattgcggc tgctttcttt gtctatggca
      841 ttttactgat ggtagaaggt ttcttcacaa ctggggctat caaagatctc tatggagact
      901 tcaaaatcac cacctgtggc agatgtgtga gcgcttggtt tatcatgctg acatacctct
      961 tcatgttggc ctggctggga gtcacagctt tcacctcact gcccgtgtac atgtatttca
     1021 atgtgtggac catctgccgg aacaccactc tagtggaggg agcaaatctc tgcttggatc
     1081 tgcgtcagtt tgggattgtg acaattggag aggaaaagaa aatttgtact gcctctgaga
     1141 acttcctgag gatgtgtgaa tctactgagc tgaatatgac cttccacttg ttcattgtgg
     1201 cacttgctgg agctggagca gcagttattg ctatggtcca ctacctgatg gttctgtctg
     1261 ccaactgggc ctatgtgaaa gatgcctgcc gcatgcagaa gtacgaagac atcaagtcaa
     1321 aggaagagca ggagctgcac gacatccatt ctactcgctc caaagagcgg ctcaatgcgt
     1381 acacataaat acgcttctct gttccttacc actcgaaggc attggtgttt cattaagggc
     1441 catccaacca tccaacctgt gaagagcaaa acgagaatgc tactcatcaa agatgcgcag
     1501 ggtgactaat gaatcacctg agtataactc tttgctgttg agcattccat cttctaattt
     1561 gttaaattgg aatgaccaaa tctcctctac aagctcctat tcagtctttt tttttaacct
     1621 ctcaaattga tttagttctt ctgtatgatc aaagatatta acattgtcca acgcaaatct
     1681 ttgtttgatt tttaatcacc tcccacatat cacacataac actttttgca ttgtttctta
     1741 tgttttggaa gagaaaatag ctttttttat actttttagt tttgatttca gtaactagtt
     1801 taactacagg taaccttcaa agggaccgtt gtacattatg aaagagagac agagatggta
     1861 tcatgatgac tccgcttgat atgggaatca gtctggagag atcagtggcc acacggctat
     1921 cggccatggt taatgttttc atccatctaa ggtgcaattt caaaatttct aagggtaggt
     1981 taaaaaaaag tgcttcttat ctttgttaac attgtattct tttttcttga tgttcgtaaa
     2041 aggtatttct ctgattactc atgtttatgt tgtgagcatg tagaaacagt aatgctaatg
     2101 catggccagt tgccttccta agattgtgac accaggctta ccttttcaag tttagtatag
     2161 aaacaattat catggaaata actactgtgg actgttggag agtgatcttt ttttgtgatt
     2221 tatgcagtgg ctggattgga tcttttaata tgctaatgtg gaaaattaat tacctttatg
     2281 aaggtggtat cttaaacata agcacactaa accctcaaga cttgttttac ccacttaaaa
     2341 cttttaacgg attgcacctc tgtaagctat ttcttaaaat gtgtatgata tatttgaaaa
     2401 gacttccatt aatataatag ctttgcttgc agccttccaa tctatgttgg tttacctgta
     2461 gtgtttctaa agggtggtca gaggccacta gagaatgtat tgtttgggag tgtagtgata
     2521 tatattttgt gtttttattt caagtaagtc attttaacca aatgttcatt cacattcatt
     2581 tataagaagt acctatatca gacaaatttt aaaagaaaaa caatcagtat taatggacca
     2641 aatttcgtgt ttgttttaac cttgactctc ttttgattct ttctaatgct acaagaatgc
     2701 tgtgaaatgt catttaaaat aatgatgtag cctgacaaga aattttgtca gtgtataaac
     2761 ctaggtagta ttgtgcactg atttgaccat tgtgaattcc tccttcagtg taagtgcatt
     2821 cccaataaaa tttattgagt gaaacaatct ttgtacaact actagtcatg catcatcagt
     2881 aattttacaa gttcttgtag taggtagggg gtattactag cgtttctgtg gcatgattat
     2941 gcattctgta atattaattt gggggtcctt ttgcttttta acacttagat tatcttaatg
     3001 gttcaacatt tttctgatat atgcagtatt aaagatattg agcaaaagta ttaatgggct
     3061 tctttaaatt ctatattata gtgtttcagt tctgtgtcta cagtgtgtga tgatttttaa
     3121 aactgtcttt taaatttatg taatgatgtt gacattttga cttttatttc tggttttaga
     3181 gtttgtattt tcatggagtg ctttgtagca ggcattacaa gtaatctgtt ttgtacataa
     3241 atgtgccaac agcttgatgg tggcgttttt gaaatgtaga acaaagtgct tgcaaaatgt
     3301 aataaataca cttgtgtact ttgtgtactt attcttaaaa aaaaaaaaaa a
//
