LOCUS       NM_008156               4659 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus glycosylphosphatidylinositol specific phospholipase D1
            (Gpld1), mRNA.
ACCESSION   NM_008156
VERSION     NM_008156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Ren,T., He,J., Zhang,T., Niu,A., Yuan,Y., Zuo,Y., Miao,Y.,
            Zhang,H., Zang,L., Qiao,C., Cao,X., Yang,X., Zheng,Z., Xu,Y., Wu,D.
            and Zheng,H.
  TITLE     Exercise activates interferon response of the liver via Gpld1 to
            enhance antiviral innate immunity
  JOURNAL   Sci Adv 10 (22), eadk5011 (2024)
   PUBMED   38809975
  REMARK    GeneRIF: Exercise activates interferon response of the liver via
            Gpld1 to enhance antiviral innate immunity.
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Li,X., Shi,X., McPherson,M., Hager,M., Garcia,G.G. and Miller,R.A.
  TITLE     Cap-independent translation of GPLD1 enhances markers of brain
            health in long-lived mutant and drug-treated mice
  JOURNAL   Aging Cell 21 (9), e13685 (2022)
   PUBMED   35930768
  REMARK    GeneRIF: Cap-independent translation of GPLD1 enhances markers of
            brain health in long-lived mutant and drug-treated mice.
            Erratum:[Aging Cell. 2023 Aug;22(8):e13901. doi:
            10.1111/acel.13901.. PMID: 37307144]
REFERENCE   4  (bases 1 to 4659)
  AUTHORS   Masuda,S., Fujishima,Y., Maeda,N., Tsugawa-Shimizu,Y., Nakamura,Y.,
            Tanaka,Y., Obata,Y., Fukuda,S., Nagao,H., Kita,S., Nishizawa,H. and
            Shimomura,I.
  TITLE     Impact of glycosylphosphatidylinositol-specific phospholipase D on
            hepatic diacylglycerol accumulation, steatosis, and insulin
            resistance in diet-induced obesity
  JOURNAL   Am J Physiol Endocrinol Metab 316 (2), E239-E250 (2019)
   PUBMED   30457913
  REMARK    GeneRIF: Mice lacking GPI-PLD exhibited the amelioration of glucose
            intolerance and hepatic steatosis under high-fat and high-sucrose
            diet. Furthermore, diacylglycerol (DAG) content was significantly
            decreased, and PKCepsilon activity was suppressed in the livers of
            GP-KO mice.
REFERENCE   5  (bases 1 to 4659)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4659)
  AUTHORS   Dai,G., Chapman,B.M., Wang,D., White,R.A., Preuett,B. and
            Soares,M.J.
  TITLE     Prolactin-like protein-A gene structure and chromosomal mapping
  JOURNAL   Mamm Genome 10 (1), 78-80 (1999)
   PUBMED   9892740
REFERENCE   7  (bases 1 to 4659)
  AUTHORS   Dai,G., Chapman,B.M., Liu,B., Orwig,K.E., Wang,D., White,R.A.,
            Preuett,B. and Soares,M.J.
  TITLE     A new member of the mouse prolactin (PRL)-like protein-C subfamily,
            PRL-like protein-C alpha: structure and expression
  JOURNAL   Endocrinology 139 (12), 5157-5163 (1998)
   PUBMED   9832456
REFERENCE   8  (bases 1 to 4659)
  AUTHORS   LeBoeuf,R.C., Caldwell,M., Guo,Y., Metz,C., Davitz,M.A., Olson,L.K.
            and Deeg,M.A.
  TITLE     Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1)
            characterization
  JOURNAL   Mamm Genome 9 (9), 710-714 (1998)
   PUBMED   9716655
REFERENCE   9  (bases 1 to 4659)
  AUTHORS   Sun,J., Ooms,L., Bird,C.H., Sutton,V.R., Trapani,J.A. and Bird,P.I.
  TITLE     A new family of 10 murine ovalbumin serpins includes two homologs
            of proteinase inhibitor 8 and two homologs of the granzyme B
            inhibitor (proteinase inhibitor 9)
  JOURNAL   J Biol Chem 272 (24), 15434-15441 (1997)
   PUBMED   9182575
REFERENCE   10 (bases 1 to 4659)
  AUTHORS   Metz,C.N., Zhang,Y.Y., Guo,Y., Tsang,T.C., Kochan,J.P.,
            Altszuler,N. and Davitz,M.A.
  TITLE     Production of the glycosylphosphatidylinositol-specific
            phospholipase D by the islets of Langerhans
  JOURNAL   J Biol Chem 266 (27), 17733-17736 (1991)
   PUBMED   1833386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY236833.1, AY081194.1 and AL645533.9.
            
            On Aug 8, 2006 this sequence version replaced NM_008156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF050666.1, SRR7974084.10908.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               BY236833.1         2-290
            290-2800            AY081194.1         17-2527
            2801-4659           AL645533.9         30111-31969
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.79 cM"
     gene            1..4659
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /note="glycosylphosphatidylinositol specific phospholipase
                     D1"
                     /db_xref="GeneID:14756"
                     /db_xref="MGI:MGI:106604"
     exon            1..98
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            99..413
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..2845
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /EC_number="3.1.4.50"
                     /note="phosphatidylinositol-glycan-specific phospholipase
                     D; glycosyl-phosphatidylinositol-specific phospholipase D;
                     GPI-PLD; PI-G PLD; GPI-specific phospholipase D;
                     glycoprotein phospholipase D"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan-specific
                     phospholipase D precursor"
                     /protein_id="NP_032182.2"
                     /db_xref="CCDS:CCDS26384.1"
                     /db_xref="GeneID:14756"
                     /db_xref="MGI:MGI:106604"
                     /translation="MSAGRLWSSLLLLLPLFCSKSSSCGLSTHVEIGHRALEFLRLQD
                     GRINYKELILEHQDAYQAGTVFPDAFYPSICKRGKYHDVSERTHWTPFLNASIHYIRE
                     NYPLPWEKDTEKLVAFLFGITSHMVADVSWHSLGIEQGFLRTMGAIDFYNSYSDAHSA
                     GDFGGDVLSQFEFNFNYLSRRWYVPVRDLLRIYDNLYGRKVITKDVLVDCTYLQFLEM
                     HGEMFAVSKLYSTYSTKSPFLVEQFQDYFLGGLDDMAFWSTNIYRLTSFMLENGTSDC
                     NLPENPLFISCDGRNHTLSGSKVQKNDFHRNLTMFISRDIRKNLNYTERGVFYSTGSW
                     APESVTFMYQTLERNLRLMLAGSSQKNLNHVSSPSASYTLSVPYARLGWVMTSADLNQ
                     DGHGDLVVGAPGYSHPGRFQIGRVYIIYGNDLGLPPIDLDLDKEAHGILEGFQPSGRF
                     GSALAVLDFNQDGLPDLAVGAPSVGSGQLTYNGSVYVYYGSQQGRLSSSPNVTISCKD
                     TYCNLGWTLLATDADGDGRHDLVISSPFAPGGGKQRGIVATFYSHPRRNDKELLTLEE
                     ADWKVNGEEDFSWFGYSLHGVTVANRSLLLIGSPTWKNVSRMARSSHKKNQEEKSLGK
                     VYGYFLPNRQSTITISGDKAMGKLGTSLSSGYVRVNGTLTQVLLVGAPTHDDVSKMAF
                     LTMTLHQGGATRMYELAPEKTQPALLSTFSGDRRFSRFGSVLHLTDLDDDGLDEIIMA
                     APLRITDVTSGLLGGEDGRVYIYNGMYTTLGDMTGKCKSWMTPCPEEKAQYVLTSPEA
                     SSRFGSSLVSVRSKGRNQVVVAAGRSSWGARLSGALHVYSFSSD"
     exon            414..469
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            470..548
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            549..646
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..757
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..806
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            807..861
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..969
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            970..997
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1137
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1200
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1324
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1464
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1651
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1762
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1837
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1994
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2136
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2245
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2339
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2519
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2680
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2707
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2758
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..4659
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3457..3462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3478
                     /gene="Gpld1"
                     /gene_synonym="6330541J12Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaggatga ggaaactctg ataagtgtga ggtgaggata ttggagatgc cgctcgtgga
       61 cagcaaggta gtatcggagt gaccatcaac tggcataggt ggacagtttg tttgctgttc
      121 tggaaaaact aaacagtggg cgatccccgt cgacttcatt ggaaaacagt gttattttga
      181 aacgaggctt ggtttcctgt gtcagtgacc tgtgtagagg gaacacaccg agtccgtgcc
      241 tggatttggg agtcatagtt tggctacagc taagattgtc cccacgttag cagagcagct
      301 gaggaggaat gacaacatgt ctgcaggcag gctgtggtct agcctgctgc ttctgctgcc
      361 tcttttctgc tctaaaagct catcttgtgg tctctcaaca catgtagaaa taggacacag
      421 ggctctggag tttcttcggc ttcaagatgg acgcattaac tacaaagagc tgatcttaga
      481 gcaccaggac gcatatcagg ctgggaccgt gtttcctgat gccttttatc ctagcatctg
      541 caaaagagga aaatatcatg acgtttctga gaggactcac tggactccat ttcttaacgc
      601 cagcatccat tatattcgag agaactaccc tctgccctgg gagaaggaca cagagaagtt
      661 ggtggctttc ttgtttggaa tcacctccca catggtcgct gacgtgagct ggcatagcct
      721 gggtattgaa caagggttcc tcaggacaat gggagctatc gatttttaca actcttactc
      781 tgacgctcac tcggctggtg attttggagg agatgtgttg agccagtttg aatttaattt
      841 taattacctc tcacggcgct ggtacgtgcc cgtcagggat cttctgagaa tttatgataa
      901 tctctatggt cggaaagtca tcaccaaaga cgtccttgtt gattgcacct accttcagtt
      961 cctggaaatg cacggggaga tgtttgctgt ttccaagctc tattccacgt actctacaaa
     1021 gtccccattt ctggtggagc agttccaaga ctatttcctc ggaggtctgg atgacatggc
     1081 attctggtcc acgaacattt accgtttgac cagctttatg ctggagaacg ggaccagtga
     1141 ctgcaacctg cctgagaacc ccctgttcat ctcctgtgat ggcaggaacc acaccctcag
     1201 tggctcaaaa gtgcagaaaa atgattttca caggaatttg accatgttca taagtagaga
     1261 catcaggaaa aacctcaatt acacagaaag aggcgtgttc tacagcacag gctcctgggc
     1321 cccggaatct gtcaccttta tgtaccagac tctggagagg aacctgaggc tgatgcttgc
     1381 tggcagctct cagaaaaatc tgaatcatgt ctccagcccc tctgcctcct acaccctgtc
     1441 tgtcccctat gccaggctcg gctgggtcat gacctcagct gacctcaacc aggatgggca
     1501 cggagacctc gtggtgggtg caccaggcta cagccaccct ggccgcttcc agattgggcg
     1561 ggtgtacatc atctatggca acgatctggg cctgcctccc atcgacctgg acttagacaa
     1621 ggaggcccat gggatcctgg agggcttcca gccttcaggt cgctttggct cagctttggc
     1681 cgtgctggac ttcaaccagg atgggctgcc tgacctggct gtgggcgctc cctccgtggg
     1741 ctcagggcag ctcacctaca atggctcggt gtatgtctac tatggttccc agcaagggag
     1801 gctgtcttct tcccctaacg tcaccatctc ctgcaaggac acctactgta acttgggctg
     1861 gaccctcttg gcaacagatg cagacggaga tggccggcac gatctggtca tcagctcccc
     1921 tttcgcacca ggtggaggga agcagagagg aattgtggcc accttttatt ctcaccccag
     1981 acggaatgac aaagaattac tgactttgga ggaagctgac tggaaggtga atggggagga
     2041 ggacttctcg tggtttggat actcccttca cggggtcaca gtggcaaaca gaagcctgct
     2101 gctgattggg agcccgacct ggaagaatgt cagcaggatg gcacgctcaa gccacaaaaa
     2161 gaaccaagag gaaaagagcc tgggaaaggt gtacggctac tttctcccga accgccagag
     2221 cacaatcact atctcgggag ataaggcgat gggaaagctg ggtacctccc tgtccagtgg
     2281 ttatgtgaga gtgaatggga ccctaaccca agtcctgctg gttggagccc ctactcatga
     2341 tgacgtgtct aaaatggcat tcctaaccat gaccctgcac cagggtggag ccactcggat
     2401 gtacgaacta gctcccgaga agacacagcc tgctctgctc agcacattca gtggagaccg
     2461 acgcttttct cgatttggta gtgttctgca cctgactgac ctggatgatg atggcttaga
     2521 tgaaatcatc atggctgccc cactgaggat aacagatgtc acttccggac tgctaggggg
     2581 agaagatggg cgagtgtaca tttataatgg catgtatacc accttaggtg acatgaccgg
     2641 caaatgcaag tcctggatga ctccatgtcc ggaggagaag gcacagtatg tactaacttc
     2701 tccagaggca agttcaaggt ttgggagctc gctggtgtcc gtgcggtcta agggaaggaa
     2761 ccaagtggtt gttgctgctg gaaggagttc ttggggagcc cggctctctg gggcacttca
     2821 tgtctacagc ttcagctcag actaaagacg gcactcttct attcagcccc gctttcttga
     2881 gccaagtcat ctccaggatg gacaaagtag ttctccggtg gagcgaaacc tgggacagcc
     2941 aggctgccta gaaatatggt cagctatgtg tggacgccgt gtgataggag cagcaggctg
     3001 tgaggtcccc tctcaagctc tttcttctgc atcctctgag tttgctgccg gtgcttggga
     3061 ctttatcaac ccacctcctt ttctgtggga atacctggct ctcttgccta gaaagggtgt
     3121 agttagctct taacactctc catataattg ctcctataaa aaatccttgg tagtggtggc
     3181 tggtcctatt tggatcttaa atgtacccca aatctcctat gttgaaggct tgatccttag
     3241 cttaaagaag gtaggaactg tggagtagga ctctgttgag gagagttacg tactgggttg
     3301 tatcaggacc cctgggcctt ccttgcctct ctgttgccag ctgagctgcc atgacctggg
     3361 cagctcccct ctgccacagc accctgcttc ttccccagcc ccaaagcaac agggccaagc
     3421 accctggcgc tgacatggcc gaaaactgtg agcccaaata aacatttcct ctttttaagc
     3481 tgtttatctt gggtattttg tcatatgtct ggtgaaaaca gtgggaggag gagagagggg
     3541 cgtggggaag gggccacact ggccctcctc actgctgatc tctgtgctcc cattctaaac
     3601 agtcaagtac aactacagac actaaggaag gaaggcacag ctgctgtgag tacacactct
     3661 gactcctaag gcacagcagg aagcacaatg ggacatttgg tttaagtagt ggtccaacct
     3721 atctaaagag cacagccagc agaagggcca tcgttttggt acacggacag caattagcaa
     3781 atgtaaatgg caaggcgaac cccagagcct tgtgcacagc aggcaggggc tccctcaacc
     3841 cagccacaca gtgccagtga ttttgctctg taatggatgg acaaaagcct gtctaaacat
     3901 ggccagagga tttgtctttt gttcagtgcc tgagcatagc atgtaacagg catcagataa
     3961 agaaaactta aagcttacag aaatccaaac atcttcaagt cgacaggata ctgactgtat
     4021 tgagtcctct gtgagaaagt acatgataca cccacgtttg gatcctccca ttagaacctc
     4081 tttggccatt acttaagtta tcacactgaa gctcaaatgt agcttcactg cagccaatca
     4141 cagaaatgaa gctgagcgca gctcctggat cccagcaccc agcagcctgt cagtgagctg
     4201 tttagcctat tccagtctgc tgtcaggaat cacttcacag gatgacctct gctctgccca
     4261 catgggctca gaggctctga acgttaagga cagaccggat cccacctctt tgctcacacc
     4321 tgatgtgtga ctgctttctc aatcactaaa ctcagtattt gctatttaca gtccctttaa
     4381 ggagcactgt cactcaaaaa ccctacctga cctagccacc tttaaaaact ttaaactgcc
     4441 ggttctgtcc ttttatgtga ggtgaattaa ttacattttg gggtggaagc acttcattat
     4501 tccttccctg taggctaagc gttgctctgg cctcactata gtcttacaag tgcattactt
     4561 tgggaagcac actttttggt attgtaatgt tctagcacac aactgtatga aacctcctga
     4621 gaacacacaa gggcaggctg aatggttatt agaacaaca
//
