LOCUS       NM_173747               3591 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus G patch domain and KOW motifs (Gpkow), mRNA.
ACCESSION   NM_173747
VERSION     NM_173747.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3591)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   2  (bases 1 to 3591)
  AUTHORS   Zhang,Y., Cheng,Y.T., Bi,D., Palma,K. and Li,X.
  TITLE     MOS2, a protein containing G-patch and KOW motifs, is essential for
            innate immunity in Arabidopsis thaliana
  JOURNAL   Curr Biol 15 (21), 1936-1942 (2005)
   PUBMED   16271871
REFERENCE   3  (bases 1 to 3591)
  AUTHORS   Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B.,
            Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and
            Ramsdell,F.
  TITLE     Disruption of a new forkhead/winged-helix protein, scurfin, results
            in the fatal lymphoproliferative disorder of the scurfy mouse
  JOURNAL   Nat Genet 27 (1), 68-73 (2001)
   PUBMED   11138001
REFERENCE   4  (bases 1 to 3591)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY074098.1, CK333382.1, BC092224.1, BC120679.1, AK028433.1 and
            BI076639.1.
            
            On Feb 17, 2007 this sequence version replaced NM_173747.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and homology data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144167.1, BC092224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY074098.1         4-28
            26-295              CK333382.1         1-270
            296-1971            BC092224.1         202-1877
            1972-2957           BC120679.1         1655-2640
            2958-3569           AK028433.1         2881-3492
            3570-3591           BI076639.1         11-32               c
FEATURES             Location/Qualifiers
     source          1..3591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.47 cM"
     gene            1..3591
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /note="G patch domain and KOW motifs"
                     /db_xref="GeneID:209416"
                     /db_xref="MGI:MGI:1859610"
     exon            1..262
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1559
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /note="g patch domain and KOW motifs-containing protein;
                     protein MOS2 homolog"
                     /codon_start=1
                     /product="G-patch domain and KOW motifs-containing
                     protein"
                     /protein_id="NP_776108.2"
                     /db_xref="CCDS:CCDS29969.2"
                     /db_xref="GeneID:209416"
                     /db_xref="MGI:MGI:1859610"
                     /translation="MAGRESPPPSAPSMAPISFGFTRTSVRRRLADLGDSERQAPEEK
                     DFLATVEGRKLQSVNPPEAPKELVIPLIQNGSRRQPLSKNPKPSSETSTVLMSDGVLS
                     QAVKELIEESKKSLEERENAGVDPTLTIPMIQKGCTPIEEGSDSEPQAETVPEEADYE
                     AVPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGANRMEAQDLASV
                     GSHHPPRPDGDRENDKEGQPQGLMHGRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLA
                     VGNRIVTVSEYCLRPVSQQEFDSHTSKPGHVSQTSTEQQNRATGTASSLKAAQNQEDS
                     KRRQKGSEKKRKHSPDRQDGPVPKTEKAAPRNKHWLHRDLRVRFIDKLHKSGRYYNTK
                     MTIEDVLSPDTCVCRTDEGRVLEDVREDMLETLIPKGEGHRVMVVLGPHAGKVGLLRS
                     RDRAQSHALVQLRRENQVVELHYNAICQYMGPGDSDED"
     exon            263..423
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            424..548
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            549..658
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            659..872
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1005
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1144
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1268
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1338
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1424
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3575
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /note="hexamer: AATAAA"
     polyA_site      3575
                     /gene="Gpkow"
                     /gene_synonym="4432411B18; DXErtd697e; DXImx41e; T54"
                     /note="major polyA site"
ORIGIN      
        1 ctgggattga ttcttacgtt tcccggccag cccctcacgg ctcgagctaa acttcccagc
       61 aagcggagcg ctcgcctgtg actcgagcga agatggcggg ccgtgagagt ccgccgccgt
      121 ctgccccgtc aatggctcca atttctttcg ggttcactcg cacgtctgtc cggaggcgac
      181 tggcagacct cggagatagc gaaagacagg ccccagagga gaaagatttc ttggcgaccg
      241 tggaagggag gaagctgcag agtgtgaacc ctccagaagc ccccaaggag ctggttatcc
      301 cgttgatcca gaatggctct cgcaggcaac ctctgtccaa gaaccctaag ccatcctcag
      361 aaactagcac cgtgttgatg tcagacggtg tgttgtccca ggctgtgaag gaactcattg
      421 aggaatccaa gaagtctctg gaggagaggg agaatgcagg tgttgacccc acgctcacta
      481 tccccatgat ccagaaagga tgtactccca ttgaggaagg atcagacagc gaacctcagg
      541 ctgagacagt gccggaggaa gccgactatg aggcagtccc tgtggaggcc tatgggctgg
      601 ccatgttgcg gggcatggga tggaaacctg gcaagggcat cggcaatacc ttcagtcagg
      661 tagtgaagcc ccgagtcaac tctataaggc cgaagggctt agggctaggt gccaaccgga
      721 tggaggctca ggacttggcc tccgtaggct ctcaccaccc accaagacca gatggggatc
      781 gagagaatga taaggaaggc caacctcaag ggctgatgca tggaagagct gtggttgtcc
      841 tttctggccc ctaccggggc ctctatggca aggtagaagg cctagatcct gacaacgtac
      901 gggccatggt tcgcttggca gtgggcaacc gcattgtgac tgttagtgag tattgcctgc
      961 ggcctgtttc ccagcaggag tttgatagcc acacctcgaa gccaggccat gtgagccaaa
     1021 cttccacaga acaacaaaac agagcaactg gaacagcctc gtcattgaag gctgcacaga
     1081 atcaggaaga ctcaaagagg aggcaaaagg gttcggagaa gaagcggaaa cactctcccg
     1141 accgacagga tggacctgtg cccaagactg agaaagcagc ccctagaaac aagcactggt
     1201 tgcacaggga cctacgtgtg cggttcattg acaaactaca caagagtggc cgctattata
     1261 acaccaagat gacaattgaa gatgtcctga gcccagacac atgtgtgtgt cggacggatg
     1321 aaggccgagt tctggaagat gtgagagaag atatgctgga gaccctgatt cccaagggag
     1381 aaggccaccg tgtgatggtg gtgctcggac cacatgctgg aaaggtggga cttcttagga
     1441 gtcgggacag agcgcagagt catgctttgg tccaacttag gagagagaac caggtggtgg
     1501 agctccacta taacgccatc tgccagtaca tgggccccgg tgactcagat gaagactgac
     1561 acatggacca ctgcccgtcg ctcagatgcc agggagaaga cagatgttct gtcctccttt
     1621 gagatgcaag gatggggatg tgactagata gagcagaact gtttaccaaa ctttagagtg
     1681 tgataaaaac cattttaaat agtggaaaga tgaaatcaaa accagtatgt aaactgtaaa
     1741 tttgggtgga agctgagata atcaaagtgg aaacacttca tttcttagcc tcatttccct
     1801 gctgagggtt caggacaagt taaattcccc attcagtaca tagtttaccc ttggaacatg
     1861 aaatctatga agtctgtccc cagacaaaca caatagaatc tgcaatgttg catctcagaa
     1921 caacttcctg agtttggatc ttgaatggtc ttcaaaggct cttttttttt taagatttat
     1981 tgtattttgt tgttgtttta tgtgtgtaag agagaacgag tatgtgattg tgaatacaaa
     2041 tgcttccaga gagagagaaa atatgtgaat gctcagagac cattaatgtt gagttcccca
     2101 ggagttgaag ttacagacaa ttgtaagctg ccctgcatgg gagccctgca tgggagcaga
     2161 cttggatcct ttggaagtac agtaagcact cttaagcact gagccacctc tccagctcct
     2221 gtgcccatat ggtaaaggac tcttgctcgg gattatgcta gtagcacata cgtttgacct
     2281 ctaggaatgt ctctgggctg ataatgcact gaagagaaag gggaacttct gcccatgaac
     2341 agcacgggtt ggctccagtt tccaaaggac tagtcacttc tagtccccga acatggctta
     2401 ggttaaaagg tatttctgac tcgtgcactt tctttgcttg ccatgggtga ttagattctt
     2461 tttaaaaaaa ggttattgtt gagaatcctg aacctttttc ctgcttgatg gttggagaag
     2521 aaaagtcaga gccttagaca caattgtttc tagataatcc ctaatatata tagtatttaa
     2581 gttaggcctg tgccacaggt taaaataccc aacttgtcag cccgccacac acactgaaaa
     2641 gaatcaaaac atcccagaac acaatgagac tggtaaatgt ggctagaact gggctgaact
     2701 ctctggccaa aataaacaga caaaaggaca tgagtcacac agagtgtggt ggcccatatc
     2761 tgtaatctag cacttgagag gctgaggcag gaaaatttcc acgagttcca agacagtctg
     2821 aggagcttca ctgaaaaacc tagcaggaaa tgtgctaggt gaagtagcac accctttgag
     2881 cttcgcaggc aggagagaga agtaggcaga tctccatgag tgcgaagcca gcctggtcta
     2941 caaaacaggc cccaggccag ccagaactcc taataagaac ctatctcaaa taggaaagga
     3001 tactgtggtt ttctcccttc ctattgtccc ttttatgtct tctcttatct aattgctata
     3061 tctaagactt tgatactgta ggggacaatg gacatctcat tcctgatttc cgaggaaatg
     3121 ctcagtgtgt ctatttaata taatgttggc tatagattta ttgtatatag ccattattat
     3181 tttgacatat ttccatgtat ttctacagtc tcacagcttt tatcactgtc aaatggattt
     3241 tcagcactta ctttaataat tcatgttttt ctgtccttga gtttgtttat atgctgtatt
     3301 ccatttgctg tatatgtatg ttgaaacacc tttgcctttt gggaatgaag cctacttggt
     3361 cataatgtgt aatcttctca atgtgttcct agattcagtt tctaagcatt ttgttaggat
     3421 attttaacat aacattttta ttgactctct gagaatttca catcatacat cctcgtcaca
     3481 cttcccagtc cttccatgtc tgtcccccac actactttgt gacctcccta ccaaaacaag
     3541 ttaaaataaa aataaataaa aattagaaaa taaaaaaaaa aaaaaaaaaa a
//
