LOCUS       NM_026730                854 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus GPI-anchored HDL-binding protein 1 (Gpihbp1),
            transcript variant 1, mRNA.
ACCESSION   NM_026730 XM_128001
VERSION     NM_026730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 854)
  AUTHORS   Yuan,C., Xu,Y., Lu,G., Hu,Y., Mao,W., Ke,L., Tong,Z., Xia,Y.,
            Ma,S., Dong,X., Xian,X., Wu,X., Liu,G., Li,B. and Li,W.
  TITLE     AAV-mediated hepatic LPL expression ameliorates severe
            hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient
            mice and rats
  JOURNAL   Mol Ther 32 (1), 59-73 (2024)
   PUBMED   37974401
  REMARK    GeneRIF: AAV-mediated hepatic LPL expression ameliorates severe
            hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient
            mice and rats.
REFERENCE   2  (bases 1 to 854)
  AUTHORS   Yang,Y., Beigneux,A.P., Song,W., Nguyen,L.P., Jung,H., Tu,Y.,
            Weston,T.A., Tran,C.M., Xie,K., Yu,R.G., Tran,A.P., Miyashita,K.,
            Nakajima,K., Murakami,M., Chen,Y.Q., Zhen,E.Y., Kim,J.R., Kim,P.H.,
            Birrane,G., Tontonoz,P., Ploug,M., Konrad,R.J., Fong,L.G. and
            Young,S.G.
  TITLE     Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts
            of lipoprotein lipase in the capillary lumen
  JOURNAL   J Clin Invest 133 (23), e172600 (2023)
   PUBMED   37824203
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 854)
  AUTHORS   Fan,R., An,X., Wang,Y., Zhang,J., Liu,S., Bai,J., Li,J., Lin,Q.,
            Xie,Y., Xia,Y. and Liao,J.
  TITLE     Severe hypertriglyceridemia caused by Gpihbp1 deficiency
            facilitates vascular remodeling through increasing endothelial
            activation and oxidative stress
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (7), 159330 (2023)
   PUBMED   37172802
  REMARK    GeneRIF: Severe hypertriglyceridemia caused by Gpihbp1 deficiency
            facilitates vascular remodeling through increasing endothelial
            activation and oxidative stress.
REFERENCE   4  (bases 1 to 854)
  AUTHORS   Chandrasekaran,P., Negretti,N.M., Sivakumar,A., Liberti,D.C.,
            Wen,H., Peers de Nieuwburgh,M., Wang,J.Y., Michki,N.S.,
            Chaudhry,F.N., Kaur,S., Lu,M., Jin,A., Zepp,J.A., Young,L.R.,
            Sucre,J.M.S. and Frank,D.B.
  TITLE     CXCL12 defines lung endothelial heterogeneity and promotes distal
            vascular growth
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36239312
REFERENCE   5  (bases 1 to 854)
  AUTHORS   Song,W., Beigneux,A.P., Winther,A.L., Kristensen,K.K.,
            Gronnemose,A.L., Yang,Y., Tu,Y., Munguia,P., Morales,J., Jung,H.,
            de Jong,P.J., Jung,C.J., Miyashita,K., Kimura,T., Nakajima,K.,
            Murakami,M., Birrane,G., Jiang,H., Tontonoz,P., Ploug,M., Fong,L.G.
            and Young,S.G.
  TITLE     Electrostatic sheathing of lipoprotein lipase is essential for its
            movement across capillary endothelial cells
  JOURNAL   J Clin Invest 132 (5) (2022)
   PUBMED   35229724
REFERENCE   6  (bases 1 to 854)
  AUTHORS   Davies,B.S., Waki,H., Beigneux,A.P., Farber,E., Weinstein,M.M.,
            Wilpitz,D.C., Tai,L.J., Evans,R.M., Fong,L.G., Tontonoz,P. and
            Young,S.G.
  TITLE     The expression of GPIHBP1, an endothelial cell binding site for
            lipoprotein lipase and chylomicrons, is induced by peroxisome
            proliferator-activated receptor-gamma
  JOURNAL   Mol Endocrinol 22 (11), 2496-2504 (2008)
   PUBMED   18787041
  REMARK    GeneRIF: Gpihbp1 transcript levels in brown and white adipose
            tissue were lower in endothelial cell PPARgamma knockout mice than
            in littermate control mice, suggesting that PPARgamma regulates
            Gpihbp1 expression in vivo. (GPIHBP1)
            Erratum:[Mol Endocrinol. 2008 Dec;22(12):2766]
REFERENCE   7  (bases 1 to 854)
  AUTHORS   Gin,P., Yin,L., Davies,B.S., Weinstein,M.M., Ryan,R.O.,
            Bensadoun,A., Fong,L.G., Young,S.G. and Beigneux,A.P.
  TITLE     The acidic domain of GPIHBP1 is important for the binding of
            lipoprotein lipase and chylomicrons
  JOURNAL   J Biol Chem 283 (43), 29554-29562 (2008)
   PUBMED   18713736
  REMARK    GeneRIF: the acidic domain of GPIHBP1 is important and
            electrostatic interactions play a key role in ligand binding
REFERENCE   8  (bases 1 to 854)
  AUTHORS   Beigneux,A.P., Gin,P., Davies,B.S., Weinstein,M.M., Bensadoun,A.,
            Ryan,R.O., Fong,L.G. and Young,S.G.
  TITLE     Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its
            appearance on the cell surface and the binding of chylomicrons and
            lipoprotein lipase
  JOURNAL   J Lipid Res 49 (6), 1312-1321 (2008)
   PUBMED   18340083
  REMARK    GeneRIF: Eliminating the N-glycosylation site in a truncated
            soluble version of GPIHBP1 causes a modest reduction in the
            secretion of the protein. These studies demonstrate that
            N-glycosylation of GPIHBP1 is important for the trafficking of
            GPIHBP1 to cell surface
REFERENCE   9  (bases 1 to 854)
  AUTHORS   Beigneux,A.P., Davies,B.S., Gin,P., Weinstein,M.M., Farber,E.,
            Qiao,X., Peale,F., Bunting,S., Walzem,R.L., Wong,J.S., Blaner,W.S.,
            Ding,Z.M., Melford,K., Wongsiriroj,N., Shu,X., de Sauvage,F.,
            Ryan,R.O., Fong,L.G., Bensadoun,A. and Young,S.G.
  TITLE     Glycosylphosphatidylinositol-anchored high-density
            lipoprotein-binding protein 1 plays a critical role in the
            lipolytic processing of chylomicrons
  JOURNAL   Cell Metab 5 (4), 279-291 (2007)
   PUBMED   17403372
  REMARK    GeneRIF: GPIHBP1 is an important platform for the LpL-mediated
            processing of chylomicrons in capillaries.
REFERENCE   10 (bases 1 to 854)
  AUTHORS   Ioka,R.X., Kang,M.J., Kamiyama,S., Kim,D.H., Magoori,K.,
            Kamataki,A., Ito,Y., Takei,Y.A., Sasaki,M., Suzuki,T., Sasano,H.,
            Takahashi,S., Sakai,J., Fujino,T. and Yamamoto,T.T.
  TITLE     Expression cloning and characterization of a novel
            glycosylphosphatidylinositol-anchored high density
            lipoprotein-binding protein, GPI-HBP1
  JOURNAL   J Biol Chem 278 (9), 7344-7349 (2003)
   PUBMED   12496272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119264.8 and BC061225.1.
            
            On Mar 19, 2018 this sequence version replaced NM_026730.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061225.1, AB095543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC119264.8         58892-58919         c
            29-854              BC061225.1         1-826
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.59 cM"
     gene            1..854
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /note="GPI-anchored HDL-binding protein 1"
                     /db_xref="GeneID:68453"
                     /db_xref="MGI:MGI:1915703"
     exon            1..101
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..224
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..341
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..825
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /note="hexamer: AATAAA"
     polyA_site      825
                     /gene="Gpihbp1"
                     /gene_synonym="1110002J19Rik; GPI-HBP1"
                     /note="major polyA site"
ORIGIN      
        1 agaaccccga gtgaggactg cgccagtaga cagaacagcc tgagccagga tgaaggctct
       61 cagggctgtc ctcctgatct tgctactaag tggacagcca gggagtggct gggcacaaga
      121 agatggtgat gcggacccgg agccagagaa ctacaactac gatgatgacg atgatgaaga
      181 ggaagaggag gagaccaaca tgatccctgg aagcagggac agagcacctc tacaatgcta
      241 cttctgtcaa gtgcttcaca gcggggagag ctgcaatcag acacagagct gctccagcag
      301 caaacccttc tgcatcacgc tcgtctccca cagcggaacc gacaaaggtt acctgactac
      361 ctactccatg tggtgtactg atacctgcca gcccatcatc aagacagtgg gaggcaccca
      421 gatgactcag acctgttgcc agtccacact gtgcaatatt ccaccctggc agaaccccca
      481 agtccagaac cctctgggtg gccgggcaga cagccccctg gaaagtggga ctagacatcc
      541 tcagggtggc aagtttagcc acccccaggt tgtcaaggct gctcatcctc agagcgatgg
      601 ggctaacttg cctaagagtg gcaaggctaa ccagccccag ggaagtgggg caggataccc
      661 ttcaggctgg accaaatttg gtaatatagc cctcctgctc agcttcttca cttgtctgtg
      721 ggcgtcaggg gcctgaagac ccgttctcct ccaaccagga cgccctggcc tctccttcct
      781 gacaaccagc ttcagagaat aaacttgaat gtcgtttgcc atctaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aaaa
//
