LOCUS       NM_008155               2887 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glucose-6-phosphate isomerase 1 (Gpi1), mRNA.
ACCESSION   NM_008155 XM_916465
VERSION     NM_008155.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Kawakami,H., Chen,K.Q., Zhang,R., Pappas,M.P., Bailey,A.,
            Reisz,J.A., Corcoran,D., Nishinakamura,R., D'Alessandro,A. and
            Kawakami,Y.
  TITLE     Sall4 restricts glycolytic metabolism in limb buds through
            transcriptional regulation of glycolytic enzyme genes
  JOURNAL   Dev Biol 501, 28-38 (2023)
   PUBMED   37301463
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Zhu,M., Wang,Q., Tian,P., Cheng,L., Sun,Z., Hong,Q., Lv,P., Ji,L.,
            Liu,Y., Tang,Q.Q. and Wen,B.
  TITLE     A long non-coding RNA specifically expressed in early embryos
            programs the metabolic balance in adult mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (1), 165988 (2021)
   PUBMED   33059001
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Lin,H., Zhu,L., Baker,S.S., Baker,R.D. and Lee,T.
  TITLE     Secreted phosphoglucose isomerase is a novel biomarker of
            nonalcoholic fatty liver in mice and humans
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1101-1105 (2020)
   PUBMED   32819571
  REMARK    GeneRIF: Secreted phosphoglucose isomerase is a novel biomarker of
            nonalcoholic fatty liver in mice and humans.
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Watanabe,H., Takehana,K., Date,M., Shinozaki,T. and Raz,A.
  TITLE     Tumor cell autocrine motility factor is the
            neuroleukin/phosphohexose isomerase polypeptide
  JOURNAL   Cancer Res 56 (13), 2960-2963 (1996)
   PUBMED   8674049
  REMARK    GeneRIF: PGI is a moonlighting protein that functions as a
            cytosolic enzyme involved in glycolysis and gluconeogenesis, and as
            cytokine through binding to its cell surface receptor.
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Faik,P., Walker,J.I., Redmill,A.A. and Morgan,M.J.
  TITLE     Mouse glucose-6-phosphate isomerase and neuroleukin have identical
            3' sequences
  JOURNAL   Nature 332 (6163), 455-457 (1988)
   PUBMED   3352745
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Soares,E.R.
  TITLE     TEM-induced gene mutations at enzyme loci in the mouse
  JOURNAL   Environ Mutagen 1 (1), 19-25 (1979)
   PUBMED   162283
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   Padua,R.A., Bulfield,G. and Peters,J.
  TITLE     Biochemical genetics of a new glucosephosphate isomerase allele
            (Gpi-1c) from wild mice
  JOURNAL   Biochem Genet 16 (1-2), 127-143 (1978)
   PUBMED   25645
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 2887)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY350616.1, AK147124.1 and
            AK031081.1.
            
            On Jan 25, 2014 this sequence version replaced NM_008155.3.
            
            Summary: This gene encodes a member of the glucose phosphate
            isomerase protein family. The encoded protein has been identified
            as a moonlighting protein based on its ability to perform
            mechanistically distinct functions. In the cytoplasm, the gene
            product functions as a glycolytic enzyme (glucose-6-phosphate
            isomerase) that interconverts glucose-6-phosphate and
            fructose-6-phosphate. Extracellularly, the encoded protein (also
            referred to as neuroleukin) functions as a neurotrophic factor that
            promotes survival of skeletal motor neurons and sensory neurons,
            and as a lymphokine that induces immunoglobulin secretion. The
            encoded protein is also referred to as autocrine motility factor
            based on an additional function as a tumor-secreted cytokine and
            angiogenic factor. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031081.1, BC086640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 3352745, 8674049
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY350616.1         1-38
            39-2084             AK147124.1         2-2047
            2085-2887           AK031081.1         1990-2792
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.46 cM"
     gene            1..2887
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /note="glucose-6-phosphate isomerase 1"
                     /db_xref="GeneID:14751"
                     /db_xref="MGI:MGI:95797"
     exon            1..245
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1800
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /EC_number="5.3.1.9"
                     /note="autocrine motility factor; neuroleukin;
                     phosphohexose isomerase; phosphoglucose isomerase; glucose
                     phosphate isomerase 1, temporal; glucose phosphate
                     isomerase 1, regulatory; glucose phosphate isomerase 1,
                     structural; maturation factor; glucose phosphate isomerase
                     1 complex"
                     /codon_start=1
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="NP_032181.2"
                     /db_xref="CCDS:CCDS21138.1"
                     /db_xref="GeneID:14751"
                     /db_xref="MGI:MGI:95797"
                     /translation="MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNL
                     NTNHGHILVDYSKNLVNKEVMQMLVELAKSRGVEAARDNMFSGSKINYTENRAVLHVA
                     LRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGS
                     DLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQET
                     ITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSL
                     WSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCE
                     THALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFY
                     QLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQ
                     AAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDIN
                     SFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKLE"
     exon            246..336
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            337..405
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            406..525
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            526..609
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            610..756
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            757..828
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            829..873
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            874..927
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            928..988
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1032
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1185
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1315
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1392
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1521
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1597
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1664
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2887
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /note="hexamer: AATAAA"
     polyA_site      2085
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /note="major polyA site"
     regulatory      2866..2871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /note="hexamer: AATAAA"
     polyA_site      2884
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
ORIGIN      
        1 ggtcggacgc ctgcgccata aagcccgctg cgcgcactgg taccgacttg ccgcgcgccg
       61 ccgctcctct ttccttcctc ttccgagcac gtcctgctcc gtgtacctct cgggtccctc
      121 gccatggctg cgctcacccg gaacccgcag ttccagaagc tcctggagtg gcaccgcgcg
      181 aactctgcca acctcaagct gcgcgaactt tttgaggcgg atccggagcg cttcaacaac
      241 ttcagcttga acctcaacac caaccatggg catattctgg tggactactc caagaacctt
      301 gtgaacaagg aggtgatgca gatgctggtg gagctggcca agtccagagg cgtggaggct
      361 gcacgggaca acatgttcag tggttccaag atcaactaca ccgagaatcg ggcggtgctg
      421 catgtggccc ttcggaaccg gtccaacaca cccatcaagg tggacggcaa agatgtgatg
      481 ccggaggtga acagggttct ggacaagatg aagtctttct gccagcgggt ccggagtggt
      541 gactggaaag ggtacactgg caaatccatc acggacatca tcaacatcgg catcgggggc
      601 tctgacctgg gacccctcat ggtgactgaa gctctcaagc cttactcgaa aggaggtccc
      661 cgtgtctggt ttgtctctaa cattgatggg acccacattg ccaaaacact ggccagcttg
      721 tcccctgaga cttccctctt tataatcgcc tccaagacct tcaccaccca ggagaccatc
      781 accaatgcag agacagcaaa ggagtggttt ctcgaagcgg ccaaggatcc atctgcagtt
      841 gcaaagcact ttgtcgccct gtctacgaac acggccaaag tgaaagagtt tggaattgac
      901 cctcaaaaca tgttcgagtt ctgggattgg gtaggtggcc gctattcgct gtggtcagcc
      961 attggacttt ccattgctct gcatgtaggt tttgaccact tcgagcagct gctgtccggg
     1021 gctcactgga tggaccagca cttcctcaag acgcccctgg agaagaatgc ccccgtcctg
     1081 ctggctctac tgggcatctg gtacatcaac tgctacggct gtgagaccca cgccttgctg
     1141 ccctatgacc agtacatgca ccgctttgct gcctatttcc agcagggtga catggagtcc
     1201 aacggaaagt acatcaccaa gtccggggcc cgtgtggacc accagacagg ccccatcgtg
     1261 tggggggaac cagggaccaa tggtcaacat gcattctacc agctcatcca ccaaggcacc
     1321 aagatgatac cctgtgactt tctcatccct gtccagaccc agcaccccat acggaaaggt
     1381 ctgcatcaca agatcctcct ggctaacttc ttggcccaga ctgaggccct gatgaagggg
     1441 aagttgcctg aagaggccag gaaggagctc caggctgccg gaaagagccc agaagacttg
     1501 gagaaactct tgccacacaa ggtctttgaa ggaaaccgcc cgaccaactc tattgtgttt
     1561 accaagctga cacccttcat tctgggggcc ttgattgcca tgtatgagca caagatcttt
     1621 gttcagggca tcatgtggga catcaacagc ttcgaccagt ggggagtgga gctggggaag
     1681 cagctggcca agaaaattga gccggagctg gagggcagct ctgctgtgac ctcccatgat
     1741 tcctccacta acggactgat cagcttcatc aagcaacagc gggacaccaa actagaataa
     1801 ctccagccgc ggccctactg actggtcctc cgtgtccctt ctcaccatat gcactgcatg
     1861 gtcctgcccc tccctgccca gagcgcacca ccggtagttg gcctggacta caaggctgtt
     1921 gggagaagct ggtctggaac tgccatccac ccactacgca ccctccctgt tgaagctgat
     1981 ggaagggctt tgacgtgtca tgttgttctg acctgtattt cacaccccag ctagaataaa
     2041 gacacctaga ggaggcatgg gggctcagcc tcttcagttt actgagtcag tacttttatc
     2101 tgttacttgt gggtgaccct gcttatgcct tgtttggttg gctctttact tggtggtggg
     2161 ctggtccaca gtctcggagg attgatcgtt atgaggggac agctgggtga taggggcact
     2221 tgggaggcac aggcaggtct atctgaattc aaggccagcc tggtccacaa aatgagttcc
     2281 cggatagcca gggctacaca gagaaaccct gtctacaaaa aaggggttgg gtagggtggg
     2341 gtcagggatc tgcagttagg tgggcaactt gctctccagt cacgtgttca cctccttccc
     2401 ctcctcacct tggtgacgtg gaaaaagtaa ttctgcttca ctaggtaggt ttttgcttgc
     2461 ttgtttgttt gtttaccttc gctttatttt tggtatcaaa acctaggaat ggggctggag
     2521 agatggctca acagttaaga gtactgactg ctcttccaga ggtcctgagt tcaattccca
     2581 gcaaccacat ggtggctcac aaccacctgt aatgagatcc gatgccctct tctggtgtgt
     2641 ctgaggacag ctacaatgta ctcacataca taaaataaat aagtcttaaa aacaaacaaa
     2701 agaacccagg gatgaactcg attataccct tcaaaagaca gttttagcag ggtgtcatta
     2761 ctgtcacatt catatcctgg ctatcagtga gtccttgtga gactgagtga cagccctgtc
     2821 attctacttt ccaccatgtt aattaggccc atttgatggc cagtcaataa aaagacttgg
     2881 tacatgt
//
