LOCUS       NP_032181                558 aa            linear   ROD 24-DEC-2024
DEFINITION  glucose-6-phosphate isomerase [Mus musculus].
ACCESSION   NP_032181 XP_921558
VERSION     NP_032181.2
DBSOURCE    REFSEQ: accession NM_008155.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 558)
  AUTHORS   Kawakami,H., Chen,K.Q., Zhang,R., Pappas,M.P., Bailey,A.,
            Reisz,J.A., Corcoran,D., Nishinakamura,R., D'Alessandro,A. and
            Kawakami,Y.
  TITLE     Sall4 restricts glycolytic metabolism in limb buds through
            transcriptional regulation of glycolytic enzyme genes
  JOURNAL   Dev Biol 501, 28-38 (2023)
   PUBMED   37301463
REFERENCE   2  (residues 1 to 558)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 558)
  AUTHORS   Zhu,M., Wang,Q., Tian,P., Cheng,L., Sun,Z., Hong,Q., Lv,P., Ji,L.,
            Liu,Y., Tang,Q.Q. and Wen,B.
  TITLE     A long non-coding RNA specifically expressed in early embryos
            programs the metabolic balance in adult mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (1), 165988 (2021)
   PUBMED   33059001
REFERENCE   4  (residues 1 to 558)
  AUTHORS   Lin,H., Zhu,L., Baker,S.S., Baker,R.D. and Lee,T.
  TITLE     Secreted phosphoglucose isomerase is a novel biomarker of
            nonalcoholic fatty liver in mice and humans
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1101-1105 (2020)
   PUBMED   32819571
  REMARK    GeneRIF: Secreted phosphoglucose isomerase is a novel biomarker of
            nonalcoholic fatty liver in mice and humans.
REFERENCE   5  (residues 1 to 558)
  AUTHORS   Watanabe,H., Takehana,K., Date,M., Shinozaki,T. and Raz,A.
  TITLE     Tumor cell autocrine motility factor is the
            neuroleukin/phosphohexose isomerase polypeptide
  JOURNAL   Cancer Res 56 (13), 2960-2963 (1996)
   PUBMED   8674049
  REMARK    GeneRIF: PGI is a moonlighting protein that functions as a
            cytosolic enzyme involved in glycolysis and gluconeogenesis, and as
            cytokine through binding to its cell surface receptor.
REFERENCE   6  (residues 1 to 558)
  AUTHORS   Faik,P., Walker,J.I., Redmill,A.A. and Morgan,M.J.
  TITLE     Mouse glucose-6-phosphate isomerase and neuroleukin have identical
            3' sequences
  JOURNAL   Nature 332 (6163), 455-457 (1988)
   PUBMED   3352745
REFERENCE   7  (residues 1 to 558)
  AUTHORS   Soares,E.R.
  TITLE     TEM-induced gene mutations at enzyme loci in the mouse
  JOURNAL   Environ Mutagen 1 (1), 19-25 (1979)
   PUBMED   162283
REFERENCE   8  (residues 1 to 558)
  AUTHORS   Padua,R.A., Bulfield,G. and Peters,J.
  TITLE     Biochemical genetics of a new glucosephosphate isomerase allele
            (Gpi-1c) from wild mice
  JOURNAL   Biochem Genet 16 (1-2), 127-143 (1978)
   PUBMED   25645
REFERENCE   9  (residues 1 to 558)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (residues 1 to 558)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY350616.1, AK147124.1 and
            AK031081.1.
            
            On Jul 22, 2009 this sequence version replaced NP_032181.1.
            
            Summary: This gene encodes a member of the glucose phosphate
            isomerase protein family. The encoded protein has been identified
            as a moonlighting protein based on its ability to perform
            mechanistically distinct functions. In the cytoplasm, the gene
            product functions as a glycolytic enzyme (glucose-6-phosphate
            isomerase) that interconverts glucose-6-phosphate and
            fructose-6-phosphate. Extracellularly, the encoded protein (also
            referred to as neuroleukin) functions as a neurotrophic factor that
            promotes survival of skeletal motor neurons and sensory neurons,
            and as a lymphokine that induces immunoglobulin secretion. The
            encoded protein is also referred to as autocrine motility factor
            based on an additional function as a tumor-secreted cytokine and
            angiogenic factor. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031081.1, BC086640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 3352745, 8674049
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.46 cM"
     Protein         1..558
                     /product="glucose-6-phosphate isomerase"
                     /EC_number="5.3.1.9"
                     /note="autocrine motility factor; neuroleukin;
                     phosphohexose isomerase; phosphoglucose isomerase; glucose
                     phosphate isomerase 1, temporal; glucose phosphate
                     isomerase 1, regulatory; glucose phosphate isomerase 1,
                     structural; maturation factor; glucose phosphate isomerase
                     1 complex"
                     /calculated_mol_wt=62636
     Region          1..554
                     /region_name="pgi"
                     /note="glucose-6-phosphate isomerase; Reviewed; PRK00179"
                     /db_xref="CDD:234679"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P06744; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            12
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P06744; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6P6V0; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06744; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P06744; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            142
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P06744; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6P6V0; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            454
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     Site            455
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P06745.4)"
     CDS             1..558
                     /gene="Gpi1"
                     /gene_synonym="Amf; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t;
                     Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Nlk; Org;
                     Pgi; Phi"
                     /coded_by="NM_008155.4:124..1800"
                     /db_xref="CCDS:CCDS21138.1"
                     /db_xref="GeneID:14751"
                     /db_xref="MGI:MGI:95797"
ORIGIN      
        1 maaltrnpqf qkllewhran sanlklrelf eadperfnnf slnlntnhgh ilvdysknlv
       61 nkevmqmlve laksrgveaa rdnmfsgski nytenravlh valrnrsntp ikvdgkdvmp
      121 evnrvldkmk sfcqrvrsgd wkgytgksit diinigiggs dlgplmvtea lkpyskggpr
      181 vwfvsnidgt hiaktlasls petslfiias ktfttqetit naetakewfl eaakdpsava
      241 khfvalstnt akvkefgidp qnmfefwdwv ggryslwsai glsialhvgf dhfeqllsga
      301 hwmdqhflkt pleknapvll allgiwyinc ygcethallp ydqymhrfaa yfqqgdmesn
      361 gkyitksgar vdhqtgpivw gepgtngqha fyqlihqgtk mipcdflipv qtqhpirkgl
      421 hhkillanfl aqtealmkgk lpeearkelq aagkspedle kllphkvfeg nrptnsivft
      481 kltpfilgal iamyehkifv qgimwdinsf dqwgvelgkq lakkiepele gssavtshds
      541 stnglisfik qqrdtkle
//
