LOCUS       NM_175644               1614 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glycoprotein hormone beta 5 (Gphb5), mRNA.
ACCESSION   NM_175644 XM_890099 XM_917030
VERSION     NM_175644.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Bassett,J.H., van der Spek,A., Logan,J.G., Gogakos,A.,
            Bagchi-Chakraborty,J., Williams,A.J., Murphy,E., van Zeijl,C.,
            Down,J., Croucher,P.I., Boyde,A., Boelen,A. and Williams,G.R.
  TITLE     Thyrostimulin Regulates Osteoblastic Bone Formation During Early
            Skeletal Development
  JOURNAL   Endocrinology 156 (9), 3098-3113 (2015)
   PUBMED   26018249
  REMARK    GeneRIF: expressed in newborn skulls and long bones but declined
            rapidly thereafter
            Erratum:[Endocrinology. 2018 Apr 1;159(4):1762. doi:
            10.1210/en.2018-00190.. PMID: 29529189]
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   van Zeijl,C.J., Surovtseva,O.V., Kwakkel,J., van Beeren,H.C.,
            Bassett,J.H., Williams,G.R., Wiersinga,W.M., Fliers,E. and
            Boelen,A.
  TITLE     Thyrostimulin deficiency does not alter peripheral responses to
            acute inflammation-induced nonthyroidal illness
  JOURNAL   Am J Physiol Endocrinol Metab 307 (6), E527-E537 (2014)
   PUBMED   25117405
  REMARK    GeneRIF: lacking GPB5 during acute illness does not affect the
            LPS-induced decrease of serum thyroid hormones
            Erratum:[Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E856.
            Duncan Bassett, J H [corrected to Bassett, J H Duncan]]
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   van Zeijl,C.J., Surovtseva,O.V., Wiersinga,W.M., Fliers,E. and
            Boelen,A.
  TITLE     Acute inflammation increases pituitary and hypothalamic
            glycoprotein hormone subunit B5 mRNA expression in association with
            decreased thyrotrophin receptor mRNA expression in mice
  JOURNAL   J Neuroendocrinol 23 (4), 310-319 (2011)
   PUBMED   21314737
  REMARK    GeneRIF: Results demonstrate in vivo regulation of central GPB5
            transcription during acute illness.
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   van Zeijl,C.J., Surovtseva,O.V., Wiersinga,W.M., Boelen,A. and
            Fliers,E.
  TITLE     Transient hypothyroxinemia in juvenile glycoprotein hormone subunit
            B5 knock-out mice
  JOURNAL   Mol Cell Endocrinol 321 (2), 231-238 (2010)
   PUBMED   20223276
REFERENCE   5  (bases 1 to 1614)
  AUTHORS   Okada,S.L., Ellsworth,J.L., Durnam,D.M., Haugen,H.S.,
            Holloway,J.L., Kelley,M.L., Lewis,K.E., Ren,H., Sheppard,P.O.,
            Storey,H.M., Waggie,K.S., Wolf,A.C., Yao,L.Y. and Webster,P.J.
  TITLE     A glycoprotein hormone expressed in corticotrophs exhibits unique
            binding properties on thyroid-stimulating hormone receptor
  JOURNAL   Mol Endocrinol 20 (2), 414-425 (2006)
   PUBMED   16210345
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Macdonald,L.E., Wortley,K.E., Gowen,L.C., Anderson,K.D.,
            Murray,J.D., Poueymirou,W.T., Simmons,M.V., Barber,D.,
            Valenzuela,D.M., Economides,A.N., Wiegand,S.J., Yancopoulos,G.D.,
            Sleeman,M.W. and Murphy,A.J.
  TITLE     Resistance to diet-induced obesity in mice globally overexpressing
            OGH/GPB5
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2496-2501 (2005)
   PUBMED   15699348
  REMARK    GeneRIF: when GPB5-TG mice are challenged with a high-fat diet,
            they gain significantly less weight and body fat than their WT
            littermates
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124414.3.
            
            On Nov 17, 2006 this sequence version replaced NM_175644.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078727.1, BB624070.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC124414.3         125294-125406
            114-318             AC124414.3         126261-126465
            319-1614            AC124414.3         129060-130355
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.71 cM"
     gene            1..1614
                     /gene="Gphb5"
                     /gene_synonym="OGH; Zlut1"
                     /note="glycoprotein hormone beta 5"
                     /db_xref="GeneID:217674"
                     /db_xref="MGI:MGI:2156540"
     exon            1..113
                     /gene="Gphb5"
                     /gene_synonym="OGH; Zlut1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..318
                     /gene="Gphb5"
                     /gene_synonym="OGH; Zlut1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..507
                     /gene="Gphb5"
                     /gene_synonym="OGH; Zlut1"
                     /note="glycoprotein hormone beta subunit; thyrostimulin
                     subunit beta"
                     /codon_start=1
                     /product="glycoprotein hormone beta-5 precursor"
                     /protein_id="NP_783575.2"
                     /db_xref="CCDS:CCDS25982.1"
                     /db_xref="GeneID:217674"
                     /db_xref="MGI:MGI:2156540"
                     /translation="MKLVYLVLGAVALLLLGGPDSVLSSSSGNLHTFVGCAVREFTFM
                     AKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPG
                     VDPFYTYPMAVRCDCGACSTATTECETI"
     exon            319..1614
                     /gene="Gphb5"
                     /gene_synonym="OGH; Zlut1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagaaagg agagacactt acccagagtg aactttctcc actcattgca acttttgaaa
       61 gcctggggta caagtgtcag ctctccaaga agagttgatt ccagcaaggt cagcatgaag
      121 ttggtatacc ttgtccttgg tgcagtggcc ctccttctcc tgggtggccc tgactctgtc
      181 ctcagcagct ccagtgggaa cctgcacact tttgtgggct gtgctgtgag ggaattcact
      241 ttcatggcca agaagccagg ctgcagggga cttcggatca ccacagatgc ctgctggggc
      301 cgctgcgaga cctgggagaa acccatcctg gagcctccct acattgaagc ctatcatcga
      361 gtgtgtacat acaatgagac cagacaggtg acagtgaagc tgcctaactg tgcccctgga
      421 gtcgatcctt tctacaccta ccctatggct gtccgatgtg actgtggggc gtgttccact
      481 gccaccactg agtgtgagac catctgaagc cagcgttgtc acagctggtg acccaaacct
      541 cacacatcca ctggctccag gaatatatct gctttatccc ctgcattcaa tctgggccag
      601 cccaagttac ctgccttctt ctatgtagct taggcacaag gttcaggtgc cgcacactta
      661 acactgaaga tgtaaagcaa tagtggccct tccccagaat aatctctctg gtgcatagga
      721 ctgtagattc ggttttcttt gcttgacttt tggaacgtga attgtatatt gcaaccctct
      781 cccaggttct gttgctactg tgcctttatt tgaaggagtt gggtatcatt aagcggtgga
      841 aagcctttaa atccccacat cctgccattg agcttggact ggatttatga ttaaagggca
      901 aaggatgatc aaaaccaaag cgctttcttc ctggctcaca aggatgccca tccgcgggtg
      961 ttcttacaga gagcagccca tttccctttg aaccaagtga ttacctaaac aagaggcaag
     1021 gacggcccag actgttagga aaaggtggtt ttggtgtggc tgattcatct cccaagcaaa
     1081 attctctaag ttccctcaag tcccttatgg aagtgtctgc ttgccaatta cagcaacaac
     1141 aacaacaatg acaacaacaa caacaacaac aacgacaaca acaaccaccc tcacaaagta
     1201 caattaggag ctatctttca ggtttaaaaa caccagagac taaatttccc atttgagtgt
     1261 tcccccacag ccacagtgag gtgaccagtt acaaatgccc ttccctcttt agtgtatttt
     1321 aaatcgaaat ggcattttat tagactcaga atccggagtg tttacagcag taagatggcc
     1381 ctgcctgccc agagggggag gtgtgctcgc ctgccactgg gttgctttct ctgaagtctt
     1441 acagcagctg attctgtgac cttcttttta aactccaatt ttatgcaaac atttttagtt
     1501 ttggcatctg gggcaggggt tgggtttaat ctttgttctt tttttatatg ccaggagcac
     1561 ctgtacgatg tcaataaagt gtggtccctg ccatcgggat ccacgcaaac tttc
//
