LOCUS       NM_130453                624 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glycoprotein hormone alpha 2 (Gpha2), mRNA.
ACCESSION   NM_130453
VERSION     NM_130453.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Ge,X., Weis,K. and Raetzman,L.
  TITLE     Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem
            cell-expressed gene associated with NOTCH2 signaling
  JOURNAL   Mol Cell Endocrinol 586, 112163 (2024)
   PUBMED   38246572
REFERENCE   2  (bases 1 to 624)
  AUTHORS   Bassett,J.H., van der Spek,A., Logan,J.G., Gogakos,A.,
            Bagchi-Chakraborty,J., Williams,A.J., Murphy,E., van Zeijl,C.,
            Down,J., Croucher,P.I., Boyde,A., Boelen,A. and Williams,G.R.
  TITLE     Thyrostimulin Regulates Osteoblastic Bone Formation During Early
            Skeletal Development
  JOURNAL   Endocrinology 156 (9), 3098-3113 (2015)
   PUBMED   26018249
  REMARK    GeneRIF: expressed in newborn skulls and long bones but declined
            rapidly thereafter
            Erratum:[Endocrinology. 2018 Apr 1;159(4):1762. doi:
            10.1210/en.2018-00190.. PMID: 29529189]
REFERENCE   3  (bases 1 to 624)
  AUTHORS   Hsu,S.Y., Nakabayashi,K. and Bhalla,A.
  TITLE     Evolution of glycoprotein hormone subunit genes in bilateral
            metazoa: identification of two novel human glycoprotein hormone
            subunit family genes, GPA2 and GPB5
  JOURNAL   Mol Endocrinol 16 (7), 1538-1551 (2002)
   PUBMED   12089349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062804.1.
            
            On Oct 31, 2009 this sequence version replaced NM_130453.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062804.1, AF260740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               BC062804.1         1-624
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.35 cM"
     gene            1..624
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /note="glycoprotein hormone alpha 2"
                     /db_xref="GeneID:170458"
                     /db_xref="MGI:MGI:2156541"
     exon            1..25
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /inference="alignment:Splign:2.1.0"
     exon            26..135
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..422
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /note="thyrostimulin subunit alpha; putative secreted
                     protein Zsig51"
                     /codon_start=1
                     /product="glycoprotein hormone alpha-2 precursor"
                     /protein_id="NP_569720.1"
                     /db_xref="CCDS:CCDS29498.1"
                     /db_xref="GeneID:170458"
                     /db_xref="MGI:MGI:2156541"
                     /translation="MPMAPRVLLLCLLGLAVTEGHSPETAIPGCHLHPFNVTVRSDRL
                     GTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSSSQCCTISSLRKVRVWLQC
                     VGNQRGELEIFTARACQCDMCRFSRY"
     exon            136..320
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /inference="alignment:Splign:2.1.0"
     exon            321..588
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      568..573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="Gpha2"
                     /gene_synonym="GPA2; zsig51"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcttca gttgctgttg gactgtcctt tgcagatgcc catggcacca cgagtcttgc
       61 tcctttgcct gctgggcctg gcagtcactg aagggcatag cccagagaca gccatcccag
      121 gctgccactt gcaccccttc aatgtgacgg tgcgcagtga tcgcctcggc acttgccagg
      181 gctcccacgt ggcacaggcc tgtgtaggac actgtgagtc tagtgctttc ccttcccggt
      241 actctgtgct ggtggccagt ggctatcggc acaacatcac ctcttcctcc cagtgctgca
      301 ccatcagcag cctcagaaag gtgagggtgt ggctgcagtg cgtggggaac cagcgtgggg
      361 agcttgagat ctttactgca agggcctgcc agtgtgatat gtgccgtttc tcccgctact
      421 agtccccgaa gggctcaggc tccggtcctg ccactgacat gtcatgggta tctcaaactc
      481 ggggctctga ccctctttat cgtctgtgaa gatgaggttg gccctctcag cagtctcctt
      541 gctacattct ccttcgctcc tgtcctcaat aaagcaagca atgcttgaaa aaaaaaaaaa
      601 aaaaaaaaaa aaaaaaaaaa aaaa
//
