LOCUS       NM_029771               2525 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus G protein-coupled estrogen receptor 1 (Gper1), mRNA.
ACCESSION   NM_029771 XM_355659
VERSION     NM_029771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Kusewitt,D.F., Sharma,G., Woods,C.D., Rosas,E., Hathaway,H.J. and
            Prossnitz,E.R.
  TITLE     GPER expression prevents estrogen-induced urinary retention in
            obese mice
  JOURNAL   J Steroid Biochem Mol Biol 244, 106607 (2024)
   PUBMED   39197539
  REMARK    GeneRIF: GPER expression prevents estrogen-induced urinary
            retention in obese mice.
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Zhang,Y.Q., Sun,T., Zhao,Z., Fu,J., Yang,L., Xu,Y., Zhao,J.F.,
            Tang,X.L., Liu,A. and Zhao,M.G.
  TITLE     Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion
            Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling
            Pathway
  JOURNAL   Neuromolecular Med 26 (1), 33 (2024)
   PUBMED   39138706
  REMARK    GeneRIF: Activation of GPR30 Ameliorates Cerebral
            Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through
            Nrf2/GPX4 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Ko,R.F., Davidson,O.Q.C., Ahmed,M.A., Clark,R.M., Brandenburg,J.S.,
            Pankratz,V.S., Sharma,G., Hathaway,H.J., Prossnitz,E.R. and
            Howdieshell,T.R.
  TITLE     GPER deficiency impedes murine myocutaneous revascularization and
            wound healing
  JOURNAL   Sci Rep 14 (1), 18400 (2024)
   PUBMED   39117675
  REMARK    GeneRIF: GPER deficiency impedes murine myocutaneous
            revascularization and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Hixon,J.C., Rivas Zarete,J.I., White,J., Hilaire,M., Muhammad,A.,
            Yusuf,A.P., Adu-Addai,B., Yates,C.C. and Mahavadi,S.
  TITLE     Epigenetic Modulation of GPER Expression in Gastric and Colonic
            Smooth Muscle of Male and Female Non-Obese Diabetic (NOD) Mice:
            Insights into H3K4me3 and H3K27ac Modifications
  JOURNAL   Int J Mol Sci 25 (10), 5260 (2024)
   PUBMED   38791299
  REMARK    GeneRIF: Epigenetic Modulation of GPER Expression in Gastric and
            Colonic Smooth Muscle of Male and Female Non-Obese Diabetic (NOD)
            Mice: Insights into H3K4me3 and H3K27ac Modifications.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Machado,G.D.B., Schnitzler,A.L., Fleischer,A.W., Beamish,S.B. and
            Frick,K.M.
  TITLE     G protein-coupled estrogen receptor (GPER) in the dorsal
            hippocampus regulates memory consolidation in gonadectomized male
            mice, likely via different signaling mechanisms than in female mice
  JOURNAL   Horm Behav 161, 105516 (2024)
   PUBMED   38428223
  REMARK    GeneRIF: G protein-coupled estrogen receptor (GPER) in the dorsal
            hippocampus regulates memory consolidation in gonadectomized male
            mice, likely via different signaling mechanisms than in female
            mice.
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Wang,C., Dehghani,B., Magrisso,I.J., Rick,E.A., Bonhomme,E.,
            Cody,D.B., Elenich,L.A., Subramanian,S., Murphy,S.J., Kelly,M.J.,
            Rosenbaum,J.S., Vandenbark,A.A. and Offner,H.
  TITLE     GPR30 contributes to estrogen-induced thymic atrophy
  JOURNAL   Mol Endocrinol 22 (3), 636-648 (2008)
   PUBMED   18063692
  REMARK    GeneRIF: GPR30 is indispensable for thymocyte apoptosis that
            preferentially occurs in T-cell receptor beta chain double-positive
            thymocytes.
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Filardo,E., Quinn,J., Pang,Y., Graeber,C., Shaw,S., Dong,J. and
            Thomas,P.
  TITLE     Activation of the novel estrogen receptor G protein-coupled
            receptor 30 (GPR30) at the plasma membrane
  JOURNAL   Endocrinology 148 (7), 3236-3245 (2007)
   PUBMED   17379646
  REMARK    GeneRIF: Results suggest that GPR30 functions as a plasma membrane
            receptor.
REFERENCE   8  (bases 1 to 2525)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   9  (bases 1 to 2525)
  AUTHORS   Ylikomi,T., Vienonen,A. and Ahola,T.M.
  TITLE     G protein-coupled receptor 30 down-regulates cofactor expression
            and interferes with the transcriptional activity of glucocorticoid
  JOURNAL   Eur J Biochem 271 (21), 4159-4168 (2004)
   PUBMED   15511221
  REMARK    GeneRIF: G protein-coupled receptor 30 down-regulates cofactor
            expression and interferes with the transcriptional activity of
            glucocorticoid
REFERENCE   10 (bases 1 to 2525)
  AUTHORS   Feng,Y. and Gregor,P.
  TITLE     Cloning of a novel member of the G protein-coupled receptor family
            related to peptide receptors
  JOURNAL   Biochem Biophys Res Commun 231 (3), 651-654 (1997)
   PUBMED   9070864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030375.1, BC138616.1 and CX204119.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_029771.4.
            
            On Jul 23, 2009 this sequence version replaced NM_029771.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030375.1, AK018203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AK030375.1         2-308
            308-2069            BC138616.1         163-1924
            2070-2525           CX204119.1         44-499
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.58 cM"
     gene            1..2525
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /note="G protein-coupled estrogen receptor 1"
                     /db_xref="GeneID:76854"
                     /db_xref="MGI:MGI:1924104"
     exon            1..176
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /inference="alignment:Splign:2.1.0"
     exon            177..388
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /inference="alignment:Splign:2.1.0"
     exon            389..2509
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..1738
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /note="mER; membrane estrogen receptor; G-protein coupled
                     receptor 30; chemoattractant receptor-like 2;
                     constitutively expressed peptide-like receptor like"
                     /codon_start=1
                     /product="G-protein coupled estrogen receptor 1"
                     /protein_id="NP_084047.2"
                     /db_xref="CCDS:CCDS19811.1"
                     /db_xref="GeneID:76854"
                     /db_xref="MGI:MGI:1924104"
                     /translation="MDATTPAQTVGVEIYLGPVWPAPSNSTPLALNLSLALREDAPGN
                     LTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLA
                     AADLILVADSLIEVFNLDEQYYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALA
                     KAMRCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLRHTEEACFCFADVREVQWLE
                     VTLGFIMPFAIIGLCYSLIVRALIRAHRHRGLRPRRQKALRMIFAVVLVFFICWLPEN
                     VFISVHLLQWTQPGDTPCKQSFRHAYPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDK
                     LRLYVEQKTSLPALNRFCHATLKAVIPDSTEQSEVRFSSAV"
     regulatory      2488..2493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /note="hexamer: ATTAAA"
     polyA_site      2505
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgct ggacggccac aggcatccat ccccaggcat cgggcgggtg cttctgttcc
       61 tctcctgctg ggtccctgct gggcaccgtc cccaaagtgc tgcaagtcca gggtccatcc
      121 ctggagcaag ctccaggagc acctccagca gatggcctgg taacgccacg gcacagatca
      181 ggacacccaa cagaaaatca gaaggacact aagtctgatc gttagattaa cagagcagcg
      241 atctggacca aggacagaag ccagggtgtc atttctgcca tgcacccacc aaaacagctg
      301 atcagatcta gggagaaagc catccaagga ctctgctccc cttaagctgc tggaattgtg
      361 gccaagcctc aacactcaca cactctgggt gcccagaagg tgagcaggca gcaggtgtgc
      421 ctgcccagca ccagcccaga catcagacac cctgtccacc cttctggttt tctgagacta
      481 acaggctccc aggacgattc ttcctgcctc acaaatgcct ggtttatctt tctttgtgaa
      541 gatggagctg tcacataaaa cagctttctg tgaccctttc agcaaatcct gaaaactgcc
      601 gagggaagcc atggatgcga ctactccagc ccaaactgtt ggggtggaga tctacctagg
      661 tcccgtgtgg ccagcccctt ccaacagcac ccctctggcc ctcaacttgt ccctggcact
      721 gcgggaagat gccccgggga acctcactgg ggacctctct gagcatcagc agtacgtgat
      781 tgccctcttc ctctcctgcc tctacaccat cttcctcttt cctattggct ttgtgggcaa
      841 catcctcatc ctggtggtga acatcagctt ccgggagaag atgaccatcc cagacctgta
      901 cttcatcaac ctggcggcgg ccgacctcat cctggtggct gactccctga ttgaggtgtt
      961 caacctggac gagcagtact acgacatcgc agtgctctgc accttcatgt ccctcttcct
     1021 gcagatcaac atgtacagca gcgtcttctt cctcacctgg atgagcttcg acaggtacct
     1081 agcgctggcc aaggccatgc gctgtggcct cttccgcacc aagcaccacg cacggctcag
     1141 ctgtggcctc atctggatgg cctcagtgtc cgccacgctg gtgcccttca cagcggtgca
     1201 cctgcggcac acggaggagg cctgcttctg ctttgctgat gtcagggagg tgcagtggct
     1261 ggaggtcaca ctgggcttca tcatgccctt cgccatcatt ggcctctgct actccctcat
     1321 cgtgcgagcc ctcatccggg cccacaggca ccgcggcctg cgcccacgca ggcagaaagc
     1381 cctgaggatg atcttcgcag tggtccttgt tttcttcatc tgctggctgc cggagaacgt
     1441 cttcatcagt gtccacctac tgcagtggac gcagccaggg gacactccct gcaagcagtc
     1501 tttccgtcac gcctacccct tgacaggcca catagtcaac cttgcagcct tctccaacag
     1561 ctgcctgaat cccctcatct acagcttcct gggagagacc ttcagggaca agctcaggct
     1621 ctatgtggag cagaagacga gcctgccggc tctgaaccgc ttctgccatg ccacgctcaa
     1681 ggccgtcatt ccagacagca cagagcagtc agaggtcagg ttcagcagtg ctgtgtgaga
     1741 ggaaaaggtc aggggcgcag gctggtgctc aggacttgca cacacctagc acaggtggtg
     1801 agtgggctaa gctatgtcat actctcaaac cccagtggct tggggaagac gtcacattgc
     1861 ggggtcatct ctggagctgc tggcatcctt cctgactgtc cagctcatgg atgctgccat
     1921 ccagattcaa ggtcccaagg cagcgggcca cgtgacattg acctctgacc tcaaagggca
     1981 ccaggcgggc ctgctgcttg gctttctttc catagcctac gttcccagaa cacaagtctg
     2041 ctgttgatac gaggacaggc catgctatgg gagcaccatg ttacatgcct gctacgtgga
     2101 ggagtctaga gacagacttt atgtaccaga cccaaactgg ctaccttccc tttgcttgtg
     2161 atgtgtaact gaccatgtat acaccgtcca gtgcagccag agccttcttc ctgtcttcca
     2221 gaaggctgtg aggtcacccc agatgccact cctaactcct gagtgaacag cgtgtctgac
     2281 tgagaaaggc cctttaacaa aacgccttcc tgctctggga tgctcctctc acaaagtttg
     2341 tttacaaagg tgtttgccct tccgtgaagg tggaaggaga ctgggtgctg ctgtgcaggc
     2401 tggtgggatg ccgccataag atgtgtggta gaaggactta ccaccacaga aaatcatact
     2461 gggaacagcg agctgtaaat ggatctcatt aaaacgtgaa aagaaccaaa aaaaaaaaaa
     2521 aaaaa
//
