LOCUS       NM_010274               5620 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus glycerol phosphate dehydrogenase 2, mitochondrial
            (Gpd2), transcript variant 2, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_010274
VERSION     NM_010274.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5620)
  AUTHORS   Clarke,R.A., Govindaraju,H., Beretta,M., Olzomer,E., Lawther,A.J.,
            Walker,A.K., Fang,Z., Eapen,V., Hyams,T.C., Killingsworth,M.,
            Bridge,W., Turner,N. and Siddiqui,K.S.
  TITLE     Immp2l Enhances the Structure and Function of Mitochondrial Gpd2
            Dehydrogenase
  JOURNAL   Int J Mol Sci 25 (2), 990 (2024)
   PUBMED   38256063
  REMARK    GeneRIF: Immp2l Enhances the Structure and Function of
            Mitochondrial Gpd2 Dehydrogenase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5620)
  AUTHORS   Liu,C., Zhao,K., Chen,Y., Yao,Y., Tang,J., Wang,J., Xu,C., Yang,Q.,
            Zheng,Y., Yuan,Y., Sun,H., Zhang,Y., Zhou,Y., Chen,J., Wang,Y.,
            Wu,C., Pei,R. and Chen,X.
  TITLE     Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV
            Replication via the TRIM28-Mediated Degradation of HBx
  JOURNAL   J Virol 97 (5), e0058023 (2023)
   PUBMED   37166302
  REMARK    GeneRIF: Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts
            HBV Replication via the TRIM28-Mediated Degradation of HBx.
REFERENCE   3  (bases 1 to 5620)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5620)
  AUTHORS   Ishihama,S., Yoshida,S., Yoshida,T., Mori,Y., Ouchi,N., Eguchi,S.,
            Sakaguchi,T., Tsuda,T., Kato,K., Shimizu,Y., Ohashi,K., Okumura,T.,
            Bando,Y.K., Yagyu,H., Wettschureck,N., Kubota,N., Offermanns,S.,
            Kadowaki,T., Murohara,T. and Takefuji,M.
  TITLE     LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and
            prevents cardiac dysfunction during ischemia
  JOURNAL   FASEB J 35 (12), e22048 (2021)
   PUBMED   34807469
  REMARK    GeneRIF: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia
            and prevents cardiac dysfunction during ischemia.
REFERENCE   5  (bases 1 to 5620)
  AUTHORS   Qu,H., Gong,X., Liu,X., Zhang,R., Wang,Y., Huang,B., Zhang,L.,
            Zheng,H. and Zheng,Y.
  TITLE     Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase
            Exacerbates Podocyte Injury and the Progression of Diabetic Kidney
            Disease
  JOURNAL   Diabetes 70 (6), 1372-1387 (2021)
   PUBMED   33741719
  REMARK    GeneRIF: Deficiency of Mitochondrial Glycerol 3-Phosphate
            Dehydrogenase Exacerbates Podocyte Injury and the Progression of
            Diabetic Kidney Disease.
REFERENCE   6  (bases 1 to 5620)
  AUTHORS   Eto,K., Tsubamoto,Y., Terauchi,Y., Sugiyama,T., Kishimoto,T.,
            Takahashi,N., Yamauchi,N., Kubota,N., Murayama,S., Aizawa,T.,
            Akanuma,Y., Aizawa,S., Kasai,H., Yazaki,Y. and Kadowaki,T.
  TITLE     Role of NADH shuttle system in glucose-induced activation of
            mitochondrial metabolism and insulin secretion
  JOURNAL   Science 283 (5404), 981-985 (1999)
   PUBMED   9974390
REFERENCE   7  (bases 1 to 5620)
  AUTHORS   Niedermeyer,J., Enenkel,B., Park,J.E., Lenter,M., Rettig,W.J.,
            Damm,K. and Schnapp,A.
  TITLE     Mouse fibroblast-activation protein--conserved Fap gene
            organization and biochemical function as a serine protease
  JOURNAL   Eur J Biochem 254 (3), 650-654 (1998)
   PUBMED   9688278
REFERENCE   8  (bases 1 to 5620)
  AUTHORS   Koza,R.A., Kozak,U.C., Brown,L.J., Leiter,E.H., MacDonald,M.J. and
            Kozak,L.P.
  TITLE     Sequence and tissue-dependent RNA expression of mouse FAD-linked
            glycerol-3-phosphate dehydrogenase
  JOURNAL   Arch Biochem Biophys 336 (1), 97-104 (1996)
   PUBMED   8951039
REFERENCE   9  (bases 1 to 5620)
  AUTHORS   Ishihara,H., Nakazaki,M., Kanegae,Y., Inukai,K., Asano,T.,
            Katagiri,H., Yazaki,Y., Kikuchi,M., Miyazaki,J., Saito,I. and
            Oka,Y.
  TITLE     Effect of mitochondrial and/or cytosolic glycerol 3-phosphate
            dehydrogenase overexpression on glucose-stimulated insulin
            secretion from MIN6 and HIT cells
  JOURNAL   Diabetes 45 (9), 1238-1244 (1996)
   PUBMED   8772729
REFERENCE   10 (bases 1 to 5620)
  AUTHORS   Matsutani,A., Takeuchi,Y., Ishihara,H., Kuwano,S. and Oka,Y.
  TITLE     Molecular cloning of human mitochondrial glycerophosphate
            dehydrogenase gene: genomic structure, chromosomal localization,
            and existence of a pseudogene
  JOURNAL   Biochem Biophys Res Commun 223 (3), 481-486 (1996)
   PUBMED   8687421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238564.1, AK144716.1, AK032044.1 and AK080240.1.
            
            On Mar 12, 2009 this sequence version replaced NM_010274.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034353.1, SRR1660821.151400.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               BY238564.1         1-391
            392-2500            AK144716.1         518-2626
            2501-4789           AK032044.1         222-2510
            4790-5620           AK080240.1         1506-2336
FEATURES             Location/Qualifiers
     source          1..5620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 31.66 cM"
     gene            1..5620
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /note="glycerol phosphate dehydrogenase 2, mitochondrial"
                     /db_xref="GeneID:14571"
                     /db_xref="MGI:MGI:99778"
     exon            1..186
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            187..296
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            297..468
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            469..593
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            594..691
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            692..855
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1020
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1165
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1359
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1494
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1670
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1802
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1961
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2074
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2153
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2252
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..5620
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /note="hexamer: AATAAA"
     polyA_site      5620
                     /gene="Gpd2"
                     /gene_synonym="Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38"
                     /note="major polyA site"
ORIGIN      
        1 gaagtggccg ggaggggcgt cggcgggcgg gtcgggttac ggtggccccg cctgacccgg
       61 tgacatcccg gcgcgctcgc cgcgagctca gggccactct ggttctcggt gaggccgact
      121 ccgttctggc tggaggatcc tgactccctt gctcgccgac cccttgcgcg tgacgaccga
      181 tctcaggctg agcaatggcg tttcaaaagg cagtgaaggg gactattctt gtgggtggag
      241 gagctctggc cactgttttg ggactctctc cgtttgctca ttacagaagg aagcaagtga
      301 gcctggcata tgtggaagca gcaggatacc tcacggagcc tgtgaacagg gaacctccct
      361 ccagagaagc tcagctcatg actttgaaga acacacccga atttgacatc cttgttatcg
      421 gaggcggagc cacagggtgt ggctgtgcac tagatgccgt caccagagga ctgaaaacag
      481 cccttgtaga gagagatgac ttctcatcgg ggactagcag tagaagcact aaattgatcc
      541 acggtggtgt gcgatacctc cagaaggcta tcatgaactt ggatgttgag cagtatagga
      601 tggtgaaaga agcccttcac gaacgtgcca acttactaga aatcgctcct catttatcag
      661 ctccgttgcc tatcatgctt ccactttaca agtggtggca gttaccttat tactgggtgg
      721 gaatcaagat gtatgacctg gttgcaggga gtcaatgcct gaagagcagt tacgtcctca
      781 gcaaatcccg agccctggag cattttccca tgctccagaa ggacaagctg gtaggcgcca
      841 ttgtctacta tgacggacaa cacaacgatg cacggatgaa cctcgccatc gccctcactg
      901 ctgccaggta cggggctgcc acggccaatt acatggaggt ggtgagcttg ctcaagaaga
      961 cagaccctga aaccggcaaa gagcgagtga gcggtgcgcg gtgcaaggat gtgctcacag
     1021 ggcaggaatt tgacgtgaga gccaaatgcg ttatcaatgc ctccggccct ttcacagact
     1081 ccgtgcgcaa aatggatgat aaaaacgttg ttcccatctg ccagcccagt gccggggtcc
     1141 atattgtgat gcccggatac tacagccctg agaacatggg acttcttgat cctgcaacca
     1201 gtgatggcag agtgattttc ttcttgcctt gggagaagat gacaattgct ggcaccactg
     1261 atacgccaac ggacgtcacg caccatccta ttccttcaga agaagacatt aacttcatcc
     1321 tgaatgaagt gcggaactac ctgagttctg acgttgaagt gagaagaggg gatgtcttgg
     1381 cagcctggag tggtatccgt ccccttgtta ccgatcccaa gtctgcagac actcagtcca
     1441 tctctcgaaa tcatgttgtg gacatcagtg acagcggact catcacaata gcaggtggga
     1501 agtggaccac ctaccgctcc atggcagaag ataccgtgga tgcagctgtc aagtttcaca
     1561 acttgaatgc gggaccgagt aggactgttg ggctgttcct tcaaggaggc aaagactgga
     1621 gccccacact ctacatcagg cttgtccagg attatgggct tgagagcgag gttgcacaac
     1681 atctggccaa aacctatggt gacaaggctt tcgaggtggc caaaatggca agtgtgactg
     1741 gaaagcggtg gcctgttgtt ggagtgcgtc ttgtgtcaga atttccatac attgaagcag
     1801 aggtgaaata cgggattaag gagtatgcct gcactgcagt tgacatgatc tcacggcgca
     1861 cccgcctggc ctttctcaat gttcaggctg cagaggaagc cctgcctagg attgttgaac
     1921 taatgggaag agagttgaac tggagtgaat tgaggaaaca ggaagaactt gaaacagcca
     1981 cgagatttct gtactatgaa atgggctaca agtctcgaac agaacaactt acagatagca
     2041 ctgaaatcag cctgctgcct tcagacatcg ataggtacaa gaagagattt cacaagtttg
     2101 atgaagatga aaaaggcttc attaccattg ttgatgttca gcgtgtccta gagagtatca
     2161 atgtacaaat ggacgaaaac acactgcatg aaattctctg cgaagtagat ttgaacaaaa
     2221 atggacaggt tgagctgcac gagtttctgc agctgatgag cgcagttcag aaaggaaggg
     2281 tctctggaag ccgacttgcc atcctgatga aaactgccga ggagaacttg gaccgcagag
     2341 ttccaatccc cgtggaccgt agttgtggag gattgtgagt ctgaccagta aatccgccac
     2401 cagcaagcat aggacagcca gcgctatgta caaccagaga tgacttaaac tctaaaatag
     2461 tggatctcgt agctgccttt tttaaaacaa acaaacaagg aaaaaaaaaa aaacaaaatc
     2521 aaagaaagga aagggataag caaataaaca acactggaaa acattccaaa acttaagatg
     2581 ttggtgtgtt tgccaactta ctttgccaat actttattta tatttgccac tcagtctggc
     2641 ttctacaaag cgcttttctt attttttagt gcgcactgat gtactgtttt gtatccattt
     2701 tgtaccctgt cagacttgac actctgcctg ctcattcatt cattcaaact agttttagag
     2761 gcagaccccg tatagattgg aatgatgcta gaaagacttt gtgagcaccc aagagctcag
     2821 gagctcgagc ctggagagag cattctttct ttttttttct agaaaatcat ttgatctctt
     2881 gacctgttaa tattttggga gacttctcag ccccgtcttg ctacccaccc ccttccgatt
     2941 aaaactgcac acttttctgt ctggagcaac tctggctaat ctggagaggg aagacaaagt
     3001 ttagatctgg ttgagatttg gttacatttc taaaagagaa cctccaaaag cttccagatt
     3061 tgcaggcgta agataaagac agccctgaca tttgccggga ggtacggtga tcgctgcttc
     3121 tcagcagttc attttttttc ccccaggcac tgctggcttc ctttgactat tatagttgcc
     3181 agaaaaatcc ttgctttttt tactttacaa ccagcatttg agtggcaagt tggatataat
     3241 gggatgagac caaatctctc cattcctcct gggagcaatg atgggacaca atttccagtc
     3301 ccacaagttc tgaatcttgt agcgtgtagc actgtcaggc ctgttcttgt cggggtgggc
     3361 agtagtgacg gtatttgcaa agagataata aaaaagaact gggcagactt ccgttaactt
     3421 taattatgaa attgaaataa ggcatgccac tttaatattg gaggctggtc tgtttgccaa
     3481 aggcccttct ctttgtgtac tcactggaaa aactctcttt ctaacaaaaa aaaatacaat
     3541 aaaataaaaa tccaagatag acatcagaca tatacgtagg aatacacaca aatcaaaccc
     3601 caaagtcggt gtcctttgaa ctcagcaaat aatgcacaga ctggagatgc ccgccaggtg
     3661 gaatgttttt tgttatattc tgttggcatt ataactagta atcttaatac ttaattaatt
     3721 ggcttccctt ttctgaaact accagtgatg agatccctgt gcatcatagg aggtggaccc
     3781 cttcgttccc acttctctcc cggcagcctt tcttgcacag gctgtgtctc agctttgtga
     3841 actgatccat aaagcaccct tgtgctgcta ttctgcctgt gcaaacattg tgtctctctg
     3901 cctcattcat tatgggttat gagtccacat atcataatat gagctgggag gtctcagccc
     3961 ccgtcccact ccacccccac ccctgaaata tgcagacttc aggaatagac agctcaactc
     4021 attattaaat gaagtatcga tacttccact tctatttccg ggaagcctga caccggacaa
     4081 gtgatgtcac agcagatgtc actgtgaaat ctttttttct ttcaaagtgt caatttttta
     4141 cactggtttt taatctttat attttttaaa atagatggaa gcatgtggct ttgagattta
     4201 gtgggttttt ttccctatca tgacaataaa gttcacttta tacctcgtga cagtcaagtc
     4261 ggcagaaaaa gctgtccttt aagacatccc agcagatata tcacaacatt ctacatcact
     4321 actcctttcc cctctctctt tctctctctc tctctctttc tagttagatc aagataacgg
     4381 tggcttgtgt catcccgatt ctcttacagt agggaccggg ctcagaatgt gacttgctta
     4441 ggccgatgtg ggcttggcaa gcacgtctcg tttgtatatg ttttgctgtg aatgaagttc
     4501 ctttaaggac aaagggaagt gcactgtgct tcatttgagc atatctgcct tggcttagca
     4561 tctgcttatt ctaagacacg ctccttcacc cgtcccagag actcacgttg gacatgaaat
     4621 acttttatca cgttcctgtg agtaaagcaa cccgggattt tcctgagttc ccaattaaac
     4681 ctgtacaggt tttcacattt taaatccaat ttaagcaaag agggaaagga cacaggggaa
     4741 agaagcccct ttaaaactca ttcagagaat aaaccatgtt tgctttttca tataaacctg
     4801 gtatttgttg attttgtttg ggtgtgggag tgggtgcgca gagctcacct tttatcatcg
     4861 agtgatttat ttcctttgac gggattcagg tgaaggaagc ccatctgtgc cggagagctc
     4921 tatatgcctt gaactagcct agcctctgtc ccagttgtga tgacagcgat aacgctggat
     4981 tactggttta gctacagttg tctgcctctg agtcctcatg ctgcatattc ctgctttcca
     5041 gtctgttcct actgagtgtg atgtcacatc tctgctctca aatgcatgct tcctaatctg
     5101 cttcaggtta tgcctcgagt ttggtctatt tcagaatgtg gacaacaaaa atgttcattc
     5161 tggttttaac tcagtacaaa tagaggttgt cattgatttc tctttccctc ttttccttat
     5221 ttgtaaaaag tctttttgca tatgaatgta atcacaccaa cgtcaccaat gctgtgaact
     5281 tgcactgcct agggagcgga aaaaagccct actgtgttta aaaagaacat ccgctgttaa
     5341 cccagccctg gagcggacac acttgctgca tgttctctta cttcctcagt tttaggtgtt
     5401 gtgttgggtt atcgttctag actggactgt taaatgccgt ctgtgaggct ggactgtcac
     5461 ttttataact gtcttcgtat tttatcacca ttatttatta cttttgatat acagaatgag
     5521 ccgcatgcat ttatagagcc ataagaagat gtatttaatg tgccttgttt ttaactgagt
     5581 aagagctgaa agcatgaatc aataaaactg attaaagcgc
//
